11 research outputs found
Preventing adolescentsâ externalizing and internalizing symptoms : effects of the Penn Resiliency Program
This study reports secondary outcome analyses from a past study of the Penn Resiliency
Program (PRP), a cognitive-behavioral depression prevention program for middle-school
aged children. Middle school students (N = 697) were randomly assigned to PRP, PEP
(an alternate intervention), or control conditions. Gillham et al., (2007) reported analyses
examining PRPâs effects on average and clinical levels of depression symptoms. We
examine PRPâs effects on parent-, teacher-, and self-reports of adolescentsâ externalizing
and broader internalizing (depression/anxiety, somatic complaints, and social
withdrawal) symptoms over three years of follow-up. Relative to no intervention control,
PRP reduced parent-reports of adolescentsâ internalizing symptoms beginning at the first
assessment after the intervention and persisting for most of the follow-up assessments.
PRP also reduced parent-reported conduct problems relative to no-intervention. There
was no evidence that the PRP program produced an effect on teacher- or self-report of
adolescentsâ symptoms. Overall, PRP did not reduce symptoms relative to the alternate
intervention, although there is a suggestion of a delayed effect for conduct problems.
These findings are discussed with attention to developmental trajectories and the
importance of interventions that address common risk factors for diverse forms of
negative outcomes.peer-reviewe
EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI) : Study protocol for a multicentre, observational trial
More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. However, there is a large variation in the incidence of reported AKI rates. The establishment of an accurate epidemiology of surgery-associated AKI is important for healthcare policy, quality initiatives, clinical trials, as well as for improving guidelines. The objective of the Epidemiology of Surgery-associated Acute Kidney Injury (EPIS-AKI) trial is to prospectively evaluate the epidemiology of AKI after major surgery using the latest Kidney Disease: Improving Global Outcomes (KDIGO) consensus definition of AKI. EPIS-AKI is an international prospective, observational, multicentre cohort study including 10 000 patients undergoing major surgery who are subsequently admitted to the ICU or a similar high dependency unit. The primary endpoint is the incidence of AKI within 72 hours after surgery according to the KDIGO criteria. Secondary endpoints include use of renal replacement therapy (RRT), mortality during ICU and hospital stay, length of ICU and hospital stay and major adverse kidney events (combined endpoint consisting of persistent renal dysfunction, RRT and mortality) at day 90. Further, we will evaluate preoperative and intraoperative risk factors affecting the incidence of postoperative AKI. In an add-on analysis, we will assess urinary biomarkers for early detection of AKI. EPIS-AKI has been approved by the leading Ethics Committee of the Medical Council North Rhine-Westphalia, of the Westphalian Wilhelms-University MĂŒnster and the corresponding Ethics Committee at each participating site. Results will be disseminated widely and published in peer-reviewed journals, presented at conferences and used to design further AKI-related trials. Trial registration number NCT04165369