50 research outputs found
An Optically Dark GRB Observed by HETE-2: GRB 051022
- Author
- Arimoto Makoto
- Atteia Jean-Luc
- Boer Michel
- Butler Nat
- Crew Geoff B.
- Donaghy Timothy Q.
- Doty John
- Fenimore Edward E.
- Galassi Mark
- Graziani Carlo
- Hatsukade Isamu
- Ishikawa Nobuyuki
- Jernigan J. Garret
- Kawai Nobuyuki
- Kotoku Jun'ichi
- Lamb Donald Q.
- Maetou Miki
- Matsuoka Masaru
- Nakagawa Yujin E.
- Olive Jean-Francois
- Pelangeon Alexandre
- Pizzichini Graziella
- Ricker George R.
- Sakamoto Takanori
- Sato Rie
- Shirasaki Yuji
- Sugita Satoshi
- Suzuki Motoko
- Takagishi Kunio
- Tamagawa Toru
- Tanaka Kaoru
- Vanderspek Roland
- Villasenor Joel S.
- Woosley Stanford E.
- Yamauchi Makoto
- Yoshida Atsumasa
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 06/07/2006
- Field of study
GRB 051022 was detected at 13:07:58 on 22 October 2005 by HETE-2. The
location of GRB 051022 was determined immediately by the flight localization
system. This burst contains multiple pulses and has a rather long duration of
about 190 seconds. The detections of candidate X-ray and radio afterglows were
reported, whereas no optical afterglow was found. The optical spectroscopic
observations of the host galaxy revealed the redshift z = 0.8. Using the data
derived by HETE-2 observation of the prompt emission, we found the absorption
N_H = 8.8 -2.9/+3.1 x 10^22 cm^-2 and the visual extinction A_V = 49 -16/+17
mag in the host galaxy. If this is the case, no detection of any optical
transient would be quite reasonable. The absorption derived by the Swift XRT
observations of the afterglow is fully consistent with those obtained from the
early HETE-2 observation of the prompt emission. Our analysis implies an
interpretation that the absorbing medium could be outside external shock at R ~
10^16 cm, which may be a dusty molecular cloud.Comment: 6 pages, 2 figures, accepted for publication in PASJ lette
Geophysical investigation of the neolithic Calanais landscape
- Author
- Publication venue
- 'MDPI AG'
- Publication date
- 11/12/2019
- Field of study
YesThe northern and western isles of Scotland have proved fertile ground for archaeological investigation over the last 100 years. However, the nature of the landscape with its rugged coastlines and irregular topography, together with rapid peat growth rates, make for challenging surveying. Commonly, an archaeological monument or series of monuments is identified but little is known about the surrounding areas and, in particular, the palaeo-landscapes within which the monuments are located. This situation is exemplified by the standing stones of Calanais in Lewis. Here, surrounding peat bogs have buried a significant portion of the landscape around which the stones were first erected. This project identifies remote sensing geophysical techniques that are eïŹective in mapping the buried (lost) landscape and thus aid better contextualisation of the stone monuments within it. Further, the project demonstrates the most appropriate techniques for prospecting across these buried landscapes for as yet unidentified stone features associated with the lives of the people who constructed the monuments.Scottish EnterpriseResearch Development Fund Publication Prize Award winner, December 2019
HETE-2 Observations of the X-Ray Flash XRF 040916
- Author
- Arimoto Makoto
- Atteia Jean-Luc
- Boer Michel
- Braga Joao
- Butler Nat
- Crew Geoffrey B.
- Dezalay Jean-Pascal
- Donaghy Timothy Q.
- Doty John P.
- Fenimore Edward E.
- Galassi Mark
- Graziani Carlo
- Hatsukade Isamu
- Hurley Kevin
- Ishikawa Nobuyuki
- Ishimura Takuto
- Jernigan J. Garrett
- Kawai Nobuyuki
- Kobayashi Akina
- Kotoku Jun'ichi
- Kuwahara Makoto
- Lamb Donald Q.
- Levine Al
- Manchanda Ravi
- Matsuoka Masaru
- Nakagawa Yujin
- Olive Jean-Francios
- Pazmino Nicolas Vasquez
- Pelangeon Alexandre
- Pizzichini Graziella
- Prigozhin Gregory
- Ricker George R.
- Sakamoto Takanori
- Sato Rie
- Shimokawabe Takashi
- Shirasaki Yuji
- Sugita Satoshi
- Suzuki Motoko
- Takagishi Kunio
- Takahashi Ichiro
- Tamagawa Toru
- Vanderspek Roland
- Villasenor Joel
- Woosley Stanford E.
- Yamauchi Makoto
- Yoshida Atsumasa
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 02/03/2007
- Field of study
A long X-ray flash was detected and localized by the instruments aboard the
High Energy Transient Explorer II (HETE-2) at 00:03:30 UT on 2004 September 16.
The position was reported to the GRB Coordinates Network (GCN) approximately 2
hours after the burst. This burst consists of two peaks separated by 200 s,
with durations of 110 s and 60 s. We have analyzed the energy spectra of the
1st and 2nd peaks observed with the Wide Field X-Ray Monitor (WXM) and the
French Gamma Telescope (FREGATE). We discuss the origin of the 2nd peak in
terms of flux variabilities and timescales. We find that it is most likely part
of the prompt emission, and is explained by the long-acting engine model. This
feature is similar to some bright X-ray flares detected in the early afterglow
phase of bursts observed by the Swift satellite.Comment: 9 pages, 4 figures, Accepted for publication in PAS
A ring-like accretion structure in M87 connecting its black hole and jet
- Author
- Akiyama Kazunori
- Alef Walter
- Algaba Juan Carlos
- Allardi Alexander
- Asada Keiichi
- Bach Uwe
- Berthold Ryan
- Bintley Dan
- Bremer Michael
- Britzen Silke
- Broderick Avery E.
- Byun Do-Young
- Casadio Carolina
- Chang Chih-Cheng
- Chang Shu-Hao
- Chang Song-Chu
- Chen Chung-Chen
- Chen Ming-Tang
- Chilson Ryan
- Chuter Tim C.
- Conway John
- Crew Geoffrey B.
- de Vicente Pablo
- Dempsey Jessica T.
- Doi Akihiro
- Dornbusch Sven
- Faber Aaron
- Friberg Per
- GarcĂa Javier GonzĂĄlez
- Garrido Miguel GĂłmez
- Giovannini Gabriele
- Giroletti Marcello
- Gómez José L.
- Hada Kazuhiro
- Han Chih-Chiang
- Han Kuo-Chang
- Hasegawa Yutaka
- Herrero-Illana Ruben
- Ho Paul T. P.
- Honma Mareki
- Huang Chih-Wei L.
- Huang Yau-De
- Hughes David H.
- Impellizzeri Violette
- Inoue Makoto
- Jiang Homin
- Jiang Wu
- Jinchi Hao
- Jung Taehyun
- Kallunki Juha
- Kawashima Tomohisa
- Kim Jae-Young
- Kimura Kimihiro
- Kino Motoki
- Kirves Petri
- Koay Jun Yi
- Koch Patrick M.
- Koyama Shoko
- Kramer Carsten
- Kraus Alex
- Krichbaum Thomas P.
- Kubo Derek
- Kuo Cheng-Yu
- Li Chao-Te
- Lin Lupin Chun-Che
- Lindqvist Michael
- Liu Ching-Tang
- Liu Jun
- Liu Kuan-Yu
- Lo Wen-Ping
- Lobanov Andrei
- Lu Li-Ming
- Lu Ru-Sen
- MacDonald Nicholas
- Marscher Alan P.
- Marti-Vidal Ivan
- Martin-Cocher Pierre
- Matsushita Satoki
- Messias Hugo
- Meyer-Zhao Zheng
- Minter Anthony
- Nagai Hiroshi
- Nair Dhanya G.
- Nakamura Masanori
- Nishioka Hiroaki
- Norton Timothy J.
- Nystrom George
- Ogawa Hideo
- Oshiro Peter
- Park Jongho
- Patel Nimesh A
- Pen Ue-Li
- Pidopryhora Yurii
- Pradel Nicolas
- Pu Hung-Yi
- Raffin Philippe A.
- Rao Ramprasad
- Ros Eduardo
- Rottmann Helge
- Ruiz Ignacio
- Sanchez Salvador
- Savolainen Tuomas
- Schuster Karl-Friedrich
- Shaw Paul
- Shen Zhi-Qiang
- Snow William
- Sridharan T. K.
- Srinivasan Ranjani
- Tazaki Fumie
- Tercero Belén
- Torne Pablo
- Traianou Efthalia
- Wagner Jan
- Walker R. Craig
- Walther Craig
- Wei Ta-Shun
- Yang Hai
- Yang Jun
- Yu Chen-Yu
- Yuan Feng
- Zensus J. Anton
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2023
- Field of study
The nearby radio galaxy M87 is a prime target for studying black hole
accretion and jet formation^{1,2}. Event Horizon Telescope observations of M87
in 2017, at a wavelength of 1.3 mm, revealed a ring-like structure, which was
interpreted as gravitationally lensed emission around a central black hole^3.
Here we report images of M87 obtained in 2018, at a wavelength of 3.5 mm,
showing that the compact radio core is spatially resolved. High-resolution
imaging shows a ring-like structure of 8.4_{-1.1}^{+0.5} Schwarzschild radii in
diameter, approximately 50% larger than that seen at 1.3 mm. The outer edge at
3.5 mm is also larger than that at 1.3 mm. This larger and thicker ring
indicates a substantial contribution from the accretion flow with absorption
effects in addition to the gravitationally lensed ring-like emission. The
images show that the edge-brightened jet connects to the accretion flow of the
black hole. Close to the black hole, the emission profile of the jet-launching
region is wider than the expected profile of a black-hole-driven jet,
suggesting the possible presence of a wind associated with the accretion flow.Comment: 50 pages, 18 figures, 3 tables, author's version of the paper
published in Natur
A ring-like accretion structure in M87 connecting its black hole and jet
- Author
- Akiyama Kazunori
- Alef Walter
- Algaba Juan Carlos
- Allardi Alexander
- Asada Keiichi
- Bach Uwe
- Berthold Ryan
- Bintley Dan
- Bremer Michael
- Britzen Silke
- Broderick Avery E.
- Byun Do Young
- Casadio Carolina
- Chang Chih Cheng
- Chang Shu Hao
- Chang Song Chu
- Chen Chung Chen
- Chen Ming Tang
- Chilson Ryan
- Chuter Tim C.
- Conway John
- Crew Geoffrey B.
- de Vicente Pablo
- Dempsey Jessica T.
- Doi Akihiro
- Dornbusch Sven
- Faber Aaron
- Friberg Per
- GarcĂa Javier GonzĂĄlez
- Garrido Miguel GĂłmez
- Giovannini Gabriele
- Giroletti Marcello
- Gómez José L.
- Hada Kazuhiro
- Han Chih Chiang
- Han Kuo Chang
- Hasegawa Yutaka
- Herrero-Illana Ruben
- Ho Paul T.P.
- Honma Mareki
- Huang Chih Wei L.
- Huang Yau De
- Hughes David H.
- Impellizzeri Violette
- Inoue Makoto
- Jiang Homin
- Jiang Wu
- Jinchi Hao
- Jung Taehyun
- Kallunki Juha
- Kawashima Tomohisa
- Kim Jae Young
- Kimura Kimihiro
- Kino Motoki
- Kirves Petri
- Koay Jun Yi
- Koch Patrick M.
- Koyama Shoko
- Kramer Carsten
- Kraus Alex
- Krichbaum Thomas P.
- Kubo Derek
- Kuo Cheng Yu
- Li Chao Te
- Lin Lupin Chun Che
- Lindqvist Michael
- Liu Ching Tang
- Liu Jun
- Liu Kuan Yu
- Lo Wen Ping
- Lobanov Andrei
- Lu Li Ming
- Lu Ru Sen
- MacDonald Nicholas
- Marscher Alan P.
- Marti-Vidal Ivan
- Martin-Cocher Pierre
- Matsushita Satoki
- Messias Hugo
- Meyer-Zhao Zheng
- Minter Anthony
- Nagai Hiroshi
- Nair Dhanya G.
- Nakamura Masanori
- Nishioka Hiroaki
- Norton Timothy J.
- Nystrom George
- Ogawa Hideo
- Oshiro Peter
- Park Jongho
- Patel Nimesh A.
- Pen Ue Li
- Pidopryhora Yurii
- Pradel Nicolas
- Pu Hung Yi
- Raffin Philippe A.
- Rao Ramprasad
- Ros Eduardo
- Rottmann Helge
- Ruiz Ignacio
- Sanchez Salvador
- Savolainen Tuomas
- Schuster Karl Friedrich
- Shaw Paul
- Shen Zhi Qiang
- Snow William
- Sridharan T. K.
- Srinivasan Ranjani
- Tazaki Fumie
- Tercero Belén
- Torne Pablo
- Traianou Efthalia
- Wagner Jan
- Walker R. Craig
- Walther Craig
- Wei Ta Shun
- Yang Hai
- Yang Jun
- Yu Chen Yu
- Yuan Feng
- Zensus J. Anton
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2023
- Field of study
The nearby radio galaxy M87 is a prime target for studying black hole accretion and jet formation1,2. Event Horizon Telescope observations of M87 in 2017, at a wavelength of 1.3âmm, revealed a ring-like structure, which was interpreted as gravitationally lensed emission around a central black hole3. Here we report images of M87 obtained in 2018, at a wavelength of 3.5âmm, showing that the compact radio core is spatially resolved. High-resolution imaging shows a ring-like structure of [Formula: see text] Schwarzschild radii in diameter, approximately 50% larger than that seen at 1.3âmm. The outer edge at 3.5âmm is also larger than that at 1.3âmm. This larger and thicker ring indicates a substantial contribution from the accretion flow with absorption effects, in addition\ua0to the gravitationally lensed ring-like emission. The images show that the edge-brightened jet connects to the accretion flow of the black hole. Close to the black hole, the emission profile of the jet-launching region is wider than the expected profile of a black-hole-driven jet, suggesting the possible presence of a wind associated with the accretion flow
Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans
- Author
- Abbasi Z
- Abdul-Hamid M Akhlil
- Abel Paul D
- Abrams Paul H
- Adab Fawzi A
- Adamson Andrew
- Adeyoju A
- Adolfson Jan
- Afzal Naveed
- Ahiaku Ernest K N
- Ahmed Munir
- Al Sudani Mohammed L
- Al-Samarraie Amir S M
- Al-Samerraie [Unknown]
- Al-Singary Waleed
- Al-Sudani [Unknown]
- Alcock Christopher
- Alexander Kimberly
- Ali Zulfiqar
- Almond David J
- Alonzi Roberto
- Aly Markus
- Amin Al Olama Ali
- Anderson John
- Andrews Henry
- Andrews Steven
- Anjum Iqbal
- Anson Ken
- Anyamene Nicola A
- Apakama Ike
- Aparcia F
- Archbold J A A
- Arndt Volker
- Ash D
- Ashford Richard F U
- Auvinen Anssi
- Azzabi A
- Badenoch David
- Bahl Amit
- Bailey Karen
- Bailey M J
- Ball Andrew J
- Banerjee G
- Barber Jim
- Barber N
- Baria [Unknown]
- Barnes Douglas G
- Barros-Silva Joao
- Barwell Julian
- Bashir J
- Basu Pradip
- Bates Christopher A
- Batra Jyotsna
- Bax N A
- Baxter-Smith D
- Bdesha Amar
- Beacock Christopher J M
- Beaney Ronald P
- Beard Ralph
- Beatty John D
- Beck Rupert
- Beese Gail
- Beesley Sharon
- Bell C Richard W
- Bellringer James
- Benlloch Garcia Sara
- Benson Richard
- Beresford [Unknown]
- Bevis Christopher R A
- Bhana Rajanee
- Bhanot S
- Bhatnagar A
- Bhatt R I
- Birch Brian
- Birtle Alison
- Bishop M
- Biyani C Shekhar
- Blacklock A R E
- Blades Rosemary
- Bliss Peter
- Bloomfield David J
- Boddy S
- Bollina Prasad
- Bonnington Sue
- Booth C M
- Bose Pradeep
- Bott Michael C
- Bottomley David
- Boucher Nigel R
- Bowen J
- Bower Mark
- Bowsher W G
- Boyd P J R
- Bradshaw Lynne
- Bramble F James
- Brenner Hermann
- Brewster Simon F
- Briggs Tim
- Brock Cathryn
- Brock Sue
- Bromage Stephen
- Broms Michael
- Brough Richard
- Brown Andrew A
- Brown Paul
- Brown Paul M
- Brown Richard
- Brown Stephen
- Browning Tony J
- Bryan N
- Burgess Neil A
- Burns-Cox Nicholas
- Butterbach Katja
- Butterworth Paul C
- Cahill D
- Callaghan P S
- Calleary John
- Calleja M
- Calman Frances
- Camilleri Philip
- Campbell Alister
- Cannon Andrea
- Cannon-Albright Lisa
- Carnell Dawn M
- Carr T W
- Carter Adam C
- Carter Charles J M
- Carter Simon
- Castle Bruce M
- Catto James
- Cavalli-Bjoerkman Carin
- Chadwick David
- Chahal Rohit
- Chakraborti P
- Chappell [Unknown]
- Charig C
- Chetiyawardana Anula D
- Chilton Christopher
- Chinegwundoh F I
- Chong Irene
- Choudhury Ananya
- Chow Wai-Man
- Christmas Timothy J
- Christova Svetlana
- Churn Mark J
- Cieza-Borrella Clara
- Clarke Noel W
- Clavijo-Eisele Jorge
- Clements Judith A
- Coe M
- Coetzee Gerhard A
- Cohen N P
- Coker C
- Cole David J
- Cole O
- Cole Trevor
- Collins Angus
- Collins Gerald
- Collinson Matthew
- Conn I
- Connell C
- Conti David V
- Cook Audrey
- Cook Margaret
- Cooke Peter
- Cooksey Graeme
- Coombs L
- Cooper Debbie
- Copland Robert F
- Cornaby Andrew J
- Cornford P A
- Corolis [Unknown]
- Corr John
- Costello C B
- Coull Mrs N
- Cowan Richard
- Cox Angela
- Cox Robert
- Coyle C
- Crew Jeremy
- Crisp John C
- Cross W
- Cruger Dorthe
- Crundwell Malcolm
- Cummings [Unknown]
- Cybulski Cezary
- Dadaev Tokhir
- Dahar Nazeer
- Daniel Francis N
- Darrad J
- Daruwala Pallon
- Das Gautam
- Datta Shibendra
- Davidson S
- Davies Joseph
- Davis Michael
- Davison Owen W
- Dawkins Guy
- Dawson Chris
- De Bolla Alan R
- Dearnaley David
- Desai Ken M
- Deutsch George P
- Dick John
- Dickinson Andrew J
- Dickson Jeanette
- Dikov Tihomir
- Dinneen Michael
- Dixit Sanjay
- Dobbs H Jane
- Doble A
- Doble Andrew
- Dodds David
- Doherty Alan
- Donaldson P
- Donovan Jenny L
- Dooldeniya M
- Douglas S Fiona
- Down Liz
- Drake [Unknown]
- Duchesne Gill M
- Duffy Peter
- Dunn Michael
- Dunsmuir W D
- Durkan Garrett
- Durrani Sajid K
- Easton Douglas
- Eaton Alan C
- Eccles Diane
- Eckert Allison
- Eddy B
- Eden C D
- Edwards J
- Eeles Rosalind A
- El-Modir A
- Elkabir Jeremy
- Elliott Emma
- Elliott P Tony
- Ellis B W
- Ellis R
- Elves Andrew W S
- Elwell Christine
- Emberton Mark
- Emmerson Louise
- England Roland C D
- Errington R D
- Evans D Gareth
- Falconer Alison
- Fawcett Derek
- Featherston C
- Featherstone Carolyn J
- Feggetter Jeremy
- Ferguson C
- Fermont D
- Ferro Michael
- Fisher Cyril
- Fitzgerald Liesel
- Fitzgerlad Liesel M
- Fletcher Matthew
- Folkes A
- Ford Trevor F
- Foster Paul W
- Franks Kevin N
- Freedman Mathew
- Frim Olivera
- Gale Joanna
- Gallegos Christopher
- Gelister James S
- George Anne
- Ghana [Unknown]
- Gibbs Stephanie
- Gilbert Hugh
- Giles Graham G
- Gillatt David
- Glaholm John
- Glass Jonathan M
- Glenister James
- Goode Thomas D
- Gordon E M
- Govindasami Koveela
- Gower Richard L
- Graham John
- Green Damian
- Greenland Jonathan
- Grieve Robert
- Griffiths Thomas R L
- Gronberg Henrik
- Gujral Sandy
- Gupta Nishi
- Gurun Riza Murat
- Gustafsson Sven
- Guy Michelle
- Guy Peter J
- Haiman Christopher A
- Haldar Neil
- Halder N
- Haley James
- Hamdy F C
- Hamdy Freddie
- Hamilton C
- Hammonds John
- Hampson S J
- Hanbury Damien C
- Hardman P D John
- Harland Stephen J
- Harney John M
- Harper Peter
- Harris D
- Harris Sarah
- Harrison G S M
- Harriss D R
- Harvey-Hills N
- Hawkyard Simon
- Hazel Steve
- Hazelett Dennis J
- Heath Catherine M
- Heathcote Peter
- Hehir Michael
- Hellawell Giles O
- Henderson Brian E
- Hendry David
- Henley Mike
- Henrique Rui
- Henry Ann
- Herbert Pippa
- Herkommer Kathleen
- Hetherington John
- Hickish Tamas
- Hicks James A
- Hilman Serena
- Hindley Richard
- Hindmarsh John R
- Hines John
- Hingorani M
- Ho Edwin T S
- Hodgson Shirley
- Hoffman U
- Holden David
- Holding Peter
- Hollingdale A
- Hollins Graham W
- Holmes Simon A V
- Holt Sarah
- Hopper John L
- Horan Gail
- Horwich Alan
- Hoskin Peter
- Howell Graham P
- Howson Joanne
- Hrouda D
- Huddart Robert
- Hudson Liz
- Hughes Michael
- Hughes Owen
- Hughes Rob
- Humber Caroline
- Iacovou John W
- Ibrahim A
- Inglis John A
- Irving Stuart
- Irwin C
- Iversen Peter
- Izatt Louise
- Izegbu Victor
- Jameel Basharat
- James Michael J
- James N
- James R Lester
- Javle Pradip
- Jenkins P
- Jhavar Sameer
- Johansson Jan-Erik
- Jones Chris R
- Jones David A
- Jones Gareth
- Jones Mandy
- Joseph J
- Joss Shelagh
- Jugurnauth-Little Sara
- Kachakova Darina
- Kaisary Amir
- Kaliski Alexandre L
- Kaneva Radka
- Kapur G
- Karim O
- Karlsson Ami
- Karp Stephen J
- Kedda Mary-Anne
- Keeley F X
- Kelkar Anand R
- Kelleher J P
- Kelly John
- Kenwrick Sue
- Kerr Kris
- Key Tim J
- Khan F
- Khaw Kay-Tee
- Khoo Vincent
- Kibel Adam S
- Kierzek Andrzej
- Kimber Rachel M
- Kinder R
- Kirby Roger S
- Kirk David
- Kirkbride Peter
- Kirollos Magdi M
- Klarskov Peter
- Kluzniak Wojciech
- Kockelbergh Roger
- Koenig Philip C W C
- Kooiman Gordon G
- Koreich O
- Kote-Jarai Zsofia
- Koupparis Anthony
- Kourah Mohamed
- Kraus Sigurd
- Kujala Paula
- Kujawa Magda L
- Kulkarni Ravi
- Kumar M
- Kumar Rajeev
- Kunkler Ian H
- Kynaston H
- Kynaston Howard
- Lachlan Katherine L
- Laing Robert
- Lalloo Fiona
- Lancashire M
- Lane Athene
- Langley Stephen E M
- Laniado Marc
- Larner T R
- Lau Maurice W
- Lawrence W T
- Lawson Anne
- Le Roux Pieter J
- Leader Mary
- Lee A
- Lee J O
- Lee L
- Lemburger R John
- Lennon Teresa
- Leone Priscilla
- Leongamornlert Daniel
- Lester Jason
- Leung Hing
- Lewis D Christopher
- Lewis J
- Li Qiuyan
- Lim Hui-Yi
- Lin Hui-Yi
- Liston Thomas
- Livni Naomi
- Livsey Jacqueline
- Lloyd S
- Locke Imogen
- Lodge Richard
- Logue John
- Longmuir Mark
- Lophatananon Artitaya
- Lophatonanon Artitaya
- Lubinski Jan
- Lucas Malcolm G
- Luedeke Manuel
- Luscombe C J
- Lydon Anna
- Lynch Michael
- Lynn Naing N K
- Lyons Norma
- MacDermott James P A
- Macdonagh Ruaraidh P
- Macdonald [Unknown]
- Madaan Sanjeev
- Madhava Kudingila R
- Maeaettaenen Liisa
- Maguire Joseph
- Maher E R
- Mahmood Rana
- Maia Sofia
- Maier Christiane
- Mair Graeme H M
- Malone Greg
- Malone Peter R
- Mangar Stephen A
- Mantle Mark
- Mark I
- Marsden Gemma
- Mason M D
- Mason Malcolm
- Mason Robert
- Matanhelia [Unknown]
- Matenhelia Shyam
- Matthews Philip N
- McAleese J
- McBride Donna
- Mcdonnell Shannon K
- McDonnell Shannon K
- McFarlane Jonathan
- McGrath [Unknown]
- McIlhenny Craig
- McInerney Paul
- McIntosh Gregor
- McKinna F
- McLaren Duncan
- McLarty Esther
- McMenemin Rhona
- McNeill Alan
- McNicholas T A
- Meddings Robert N
- Mee A David
- Melcher Lucinda
- Memon [Unknown]
- Menzes Pravin
- Michael Agnieszka
- Miller Marek
- Mills Robert
- Mitchell S
- Mitev Vanio
- Mithal Natasha
- Mitkova Atanaska
- Mitra Anita
- Mobb Gillian E
- Moffat Leslie E F
- Mokete [Unknown]
- Money-Kyrle Julian
- Montgomery Bruce
- Moody Hilary
- Moody Martin P
- Morgan Angela
- Morley Roland
- Morris Sean B
- Morrison Patrick
- Mort Diana
- Mostafid Amir H
- Motiwala Hanif
- Mufti Gulzar
- Muir Gordon
- Muir Kenneth
- Mumtaz Faiz
- Murphy Michael
- Murray Alexandra
- Murray Keith W
- Murrell Shirley
- Murtola Teemu
- Muthukumar D
- Naerger Harry
- Namasivayam Siva
- Nargund Vinod
- Nawrocki [Unknown]
- Neal David E
- Neilson Donald
- Nethersell A
- Newby Jacqueline C
- Newman Hugh
- Newton R
- Nielsen Sune F
- Nordestgaard BĂžrge G
- O'Boyle P J
- O'Brien J
- O'Brien Tim S
- O'Donnell H
- O'Donoghue E
- O'Donoghue Neil
- O'Reilly P
- O'Rourke J S
- O'Sullivan Joe
- O'Sullivan Patricia
- Oakley Neil
- Ogden Chris
- Ohja Hemant
- Oliver Tim
- Omara Tracy
- Ong Eng K
- Osborn David
- Ostler Peter
- Owen J
- Palfrey Edward
- Panades Miguel
- Panakis Niki
- Pancharatnam M
- Pandha Hardev
- Pantelides Michalakis L
- Panwar U
- Parikh Omi
- Park Hyun
- Park Jong Y
- Parker Chris
- Parker Christopher H
- Parys Bohdan T
- Pascoe Sarah
- Pashayan Nora
- Patel Anup
- Paterson Joan
- Pathack S
- Pati Jhumur
- Patterson Helen
- Pattu [Unknown]
- Paul A
- Paul Alan
- Paulo Paula
- Payne Heather
- Peake David
- Pedersen John
- Pedley I
- Pengelly A
- Peracha Amjad M
- Perry Matthew
- Persad Raj
- Peters John
- Pharoah Paul
- Philp N H
- Philp T
- Pickering Lisa M
- Pigott Katharine
- Pinto Pedro
- Plail R
- Plowman P Nicholas
- Pocock Richard D
- Pope A J
- Popert Rick
- Popov Elenko
- Porter Tim
- Potter John M
- Pow-Sang Julio
- Powell Christopher
- Powell Philip
- Powles Thomas B
- Prasad Krishna
- Prasad Seshadri Sri
- Prejbisz J W
- Prescott Stephen
- Protheroe Andrew
- Qureshi Khaver N
- Raby Nigel
- Radlein Selina
- Ragavan Narasimhan
- Raju Palaniappa G S
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- Raman R
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- Rao Y
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- Read [Unknown]
- Reddy Paul J
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- Rinckleb Antje
- Rincon Maria
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- Rosario Derek
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- Rothwell Neil
- Rowbotham Carl
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- Rowley Kathryn
- Ruddy Deborah
- Rundle John
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- Sabharwal A
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- Samanci Ali
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- Saunders Edward J
- Saunders Pamela
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- Scrase Christopher
- Selim [Unknown]
- Sellers Thomas
- Sells Henry
- Sethia Krishna K
- Severi Gianluca
- Shackley David C
- Shaffer [Unknown]
- Shah Nihil
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- Shanley Sue
- Sharma Neerah K
- Sheehan Denise J
- Sherwin Elizabeth
- Shum Poh Lin
- Side Lucy
- Sidek Norma
- Signorello Lisa B
- Sikora Karol
- Simcock R
- Sinclair Andrew M
- Singh Pravin
- Siva M
- Slavov Chavdar
- Smith James
- Smith Michael F
- Sokal Michael
- Sole Graham M
- Southey Melissa C
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- Sreenivasan Thiagarajan
- Srihari Narayanan N
- Srinivasan [Unknown]
- Sriram Rajagopalan
- Staffurth John N
- Stanford Janet L
- Stattin Paer
- Stegmaier Christa
- Stephens Sarah
- Stewart D
- Stockdale Andrew
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- Strachan John R
- Stuart Nicholas S A
- Sugden Elaine
- Summerton Duncan
- Sundar Santhanam
- Sundaram S K
- Suresh Gokarakonda
- Susnerwala Shabbir
- Swami Kuchibhotla S
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- Tahir Saad
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- Tammela Teuvo L J
- Tanquay J
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- Taylor John W
- Teixeira Manuel R
- Terry T
- Thibodeau Stephen N
- Thomas Robert J
- Thomas Stephen A
- Thompson Alan
- Thompson Pauline
- Thomson Alastair H
- Thurston A
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- Tillmans Lori
- Tilsley Owen
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- Tong [Unknown]
- Toussi Hamid
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- Trembath Richard C
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- Turner Kevin J
- Turner Megan
- Tweedle James
- Tymrakiewicz Malgorzata
- Tyrell C J
- Umez-Eronini N
- Urwin Graeme H
- Vale Justin A
- Van As [Unknown]
- Van As Nicholas
- Vasanthan Subramaniam
- Vesey Sean
- Vilarino-Varela Maria
- Violet John
- Virdi Jaspal
- Viñuela Ana
- Vlahova Aleksandrina
- Vogel Walther
- Wade Robert
- Wahlfors Tiina
- Waite Katherine
- Walker E M
- Walker Roger
- Wallace David M A
- Wallinder Hans
- Wang Liang
- Watkin Nicholas A
- Watson M E
- Waxman J H
- Waymont Brian
- Weaver Andrew
- Webb Ralph J
- Wedderburn Andrew
- Weischer Maren
- Wells Paula
- Wemyss-Holden G D
- Weston P M T
- Wheatley Duncan
- Whelan P
- Whillis D
- Whitmore Ian
- Wiklund Fredrik
- Wilde Adam D
- Wiles Vicki
- Wilkins Marie
- Wilkinson Rosemary
- Williams John H
- Williams Simon
- Willis Michael
- Wills Michael I
- Wilson J R
- Wilson Richard
- Winkler Mathias H
- Wise Marcus
- Wokozorczyk Dominika
- WokoĆorczyk Dominika
- Wood Glenn
- Woodhams Simon
- Woodhouse C
- Woodward Cathryn
- Woolf [Unknown]
- Woolfenden K A
- Worlding Jane
- Wright Mark
- Wu Huihai
- WYLIE [Unknown]
- Wylie James P
- Wynne Chris
- Yeadon Trina
- Zachariah Babu
- Zang Angelika
- Zarkar A
- Zheng Wei
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2015
- Field of study
Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have
fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in
25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16
regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of
correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP,
while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in
Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium
(LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region.
Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant
enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the
refined data for existing association signals, we estimate that these loci now explain âŒ38.9% of the familial relative risk of PrCa,
an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of
PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent
signals within the same regio
The James Webb Space Telescope Mission
- Author
- Abbott Randy
- Abell James S.
- Abernathy Mark
- Abney Faith E.
- Abraham John G.
- Abraham Roberto
- Abul-Huda Yasin M.
- Acton Scott
- Adams Cynthia K.
- Adams Evan
- Adler David S.
- Adriaensen Maarten
- Aguilar Jonathan Albert
- Ahmed Mansoor
- Ahmed Nasif S.
- Ahmed Tanjira
- Alarcon Rafael Ramos
- Albat RĂŒdeger
- Albert LoĂŻc
- Alberts Stacey
- Aldridge David
- Allen Mary Marsha
- Allen Shaune S.
- Altenburg Martin
- Altunc Serhat
- Alvarez Jose Lorenzo
- Ambrose Leslie L.
- Anandakrishnan Satya M.
- Andersen Gregory C.
- Anderson Harry James
- Anderson Jay
- Anderson Kristen
- Anderson Sara M.
- Aprea Julio
- Archer Benita J.
- Arenberg Jonathan W.
- Argyriou Ioannis
- Arribas Santiago
- Artigau Ătienne
- Arvai Amanda Rose
- Atcheson Paul
- Atkinson Charles B.
- Averbukh Jesse
- Aymergen Cagatay
- Bacinski John J.
- Baggett Wayne E.
- Bagnasco Giorgio
- Baker Lynn L.
- Balzano Vicki Ann
- Banks Kimberly A.
- Baran David A.
- Barker Elizabeth A.
- Barrett Larry K.
- Barringer Bruce O.
- Barto Allison
- Bast William
- Baudoz Pierre
- Baum Stefi
- Beatty Thomas G.
- Beaulieu Mathilde
- Bechtold Kathryn
- Beck Tracy
- Beddard Megan M.
- Beichman Charles
- Bellagama Larry
- Bely Pierre
- Berger Timothy W.
- Bergeron Louis E.
- Bertch Maria D.
- Beskow Charlotte
- Betz Laura E.
- Biagetti Carl P.
- Birkmann Stephan
- Bjorklund Kurt F.
- Blackwood James D.
- Blazek Ronald Paul
- Blossfeld Stephen
- Bluth Marcel
- Boccaletti Anthony
- Boegner Jr. Martin E.
- Bohlin Ralph C.
- Boia John Joseph
- Bonaventura N.
- Bond Nicholas A.
- Bosley Kari Ann
- Boucarut Rene A.
- Bouchet Patrice
- Bouwman Jeroen
- Bower Gary
- Bowers Ariel S.
- Bowers Charles W.
- Boyce Leslye A.
- Boyer Christine T.
- Boyer Martha L.
- Boyer Michael
- Boyer Robert
- Bradley Larry D.
- Brady Gregory R.
- Brandl Bernhard R.
- Brannen Judith L.
- Breda David
- Bremmer Harold G.
- Brennan David
- Bresnahan Pamela A.
- Bright Stacey N.
- Broiles Brian J.
- Bromenschenkel Asa
- Brooks Brian H.
- Brooks Keira J.
- Brown Bob
- Brown Bruce
- Brown Thomas M.
- Bruce Barry W.
- Bryson Jonathan G.
- Bujanda Edwin D.
- Bullock Blake M.
- Bunker A. J.
- Bureo Rafael
- Burt Irving J.
- Bush James Aaron
- Bushouse Howard A.
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- Böker Torsten
- Cabaud Olivier
- Cale Steven
- Calhoon Charles D.
- Calvani Humberto
- Canipe Alicia M.
- Caputo Francis M.
- Cara Mihai
- Carey Larkin
- Case Michael Eli
- Cesari Thaddeus
- Cetorelli Lee D.
- Chance Don R.
- Chandler Lynn
- Chaney Dave
- Chapman George N.
- Charlot S.
- Chayer Pierre
- Cheezum Jeffrey I.
- Chen Bin
- Chen Christine H.
- Cherinka Brian
- Chichester Sarah C.
- Chilton Zachary S.
- Chittiraibalan Dharini
- Clampin Mark
- Clark Charles R.
- Clark Kerry W.
- Clark Stephanie M.
- Claybrooks Edward E.
- Cleveland Keith A.
- Cohen Andrew L.
- Cohen Lester M.
- Coleman Benee L.
- Colina Luis
- ColĂłn Knicole D.
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- Connolly Dennis C.
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- Contos Adam R.
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- Cooper James L.
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- Cossou Christophe
- Costanza Brian F.
- Costas Maria Begoña Vila
- Coulais Alain
- Cox Colin R.
- Coyle Ray T.
- Cracraft Misty M.
- Crew Keith A.
- Curtis Gary J.
- Cusveller Bianca
- Dailey Christopher T.
- Darveau-Bernier Antoine
- Daugeron Frédéric
- Davidson Greg S.
- Davies James E.
- Davis Katherine Anne
- Davis Michael S.
- Day Ratna
- de Chambure Daniel
- de Jong Pauline
- De Marchi Guido
- De Meester Wim
- de Oliveira Catarina Alves
- Dean Bruce H.
- Decker John E.
- del Pino Bruno RodrĂguez
- Delisa Amy S.
- Dell Lawrence C.
- Dellagatta Gail
- Dembinska Franciszka
- Demosthenes Sandor
- Dencheva Nadezhda M.
- Deneu Philippe
- DePriest William W.
- Deschenes Jeremy
- Dethienne Nathalie
- Detre Ărs Hunor
- Diaz Rosa Izela
- Dicken Daniel
- DiFelice Audrey S.
- Dillman Matthew
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- Dixon William V.
- Doggett Jesse B.
- Dominguez Keisha L.
- Donaldson Thomas S.
- Doria-Warner Cristina M.
- Doty Heather
- Douglas Jr. Robert E.
- Doyon René
- Dressler Alan
- Driggers Jennifer
- Driggers Phillip A.
- Dunn Jamie L.
- DuPrie Kimberly C.
- Dupuis Jean
- Durning John
- Dutta Sanghamitra B.
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- Egami Eiichi
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- Eisenhamer Jonathan D.
- Eisenhower Michael
- Eisenstein Daniel J.
- Elie Michelle L.
- Elliott James
- Elliott Kyle Wesley
- Engesser Michael
- Espinoza NĂ©stor
- Etienne Odessa
- Etxaluze Mireya
- Evans Leah
- Fabreguettes Luce
- Falcolini Massimo
- Falini Patrick R.
- Fatig Curtis
- Feeney Matthew
- Feinberg Lee D.
- Fels Raymond
- Ferdous Nazma
- Ferguson Henry C.
- Ferrarese Laura
- Ferreira Marie-Héléne
- Ferruit Pierre
- Ferry Malcolm
- Filippazzo Joseph Charles
- Firre Daniel
- Fix Mees
- Flagey Nicolas
- Flanagan Kathryn A.
- Fleming Scott W.
- Florian Michael
- Flynn James R.
- Foiadelli Luca
- Fontaine Mark R.
- Fontanella Erin Marie
- Forshay Peter Randolph
- Fortner Elizabeth A.
- Fox Ori D.
- Framarini Alexandro P.
- Francisco John I.
- Franck Randy
- Franx Marijn
- Franz David E.
- Friedman Scott D.
- Friend Katheryn E.
- Frost James R.
- Fu Henry
- Fullerton Alexander W.
- Gaillard Lionel
- Galkin Sergey
- Gallagher Ben
- Galyer Anthony D.
- Gardner Jonathan P.
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- Garland Dennis
- Garrett Bruce Albert
- Gasman Danny
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- Gkountis Konstantinos
- Glasse Alistair
- Glassmire Kirk Zachary
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- Goldberg Joshua
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- Gonzaga Shireen P.
- Gordon Karl D.
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- Goudfrooij Paul
- Gough Michael J.
- Graham Adrian J.
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- Greene Gretchen R.
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- Greenhouse Matthew A.
- Greve Thomas R.
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- Groe Frank E.
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- Grundy Timothy
- Guillard Pierre
- Guldalian John
- Gunn Christopher A.
- Gurule Anthony
- Gutman Irvin Meyer
- Guy Paul D.
- Guyot Benjamin
- GĂĄspĂĄr AndrĂĄs
- GĂŒdel Manuel
- Hack Warren J.
- Haderlein Peter
- Hagan James B.
- Hagedorn Andria
- Hainline Kevin
- Haley Craig
- Hamel Zaky El
- Hami Maryam
- Hamilton Forrest Clifford
- Hammann Jeffrey
- Hammel Heidi B.
- Hanley Christopher J.
- Hansen Carl August
- Hardy Bruce
- Harnisch Bernd
- Harr Michael Hunter
- Harris Pamela
- Hart Jessica Ann
- Hartig George F.
- Hasan Hashima
- Hashim Kathleen Marie
- Hashimoto Ryan
- Haskins Sujee J.
- Hawkins Robert Edward
- Hayden Brian
- Hayden William L.
- Healy Mike
- Hecht Karen
- Heeg Vince J.
- Hejal Reem
- Helm Kristopher A.
- Hengemihle Nicholas J.
- Henning Thomas
- Henry Alaina
- Henry Ronald L.
- Henshaw Katherine
- Hernandez Scarlin
- Herrington Donald C.
- Heske Astrid
- Hesman Brigette Emily
- Hickey David L.
- Hilbert Bryan N.
- Hines Dean C.
- Hinz Michael R.
- Hirsch Michael
- Hitcho Robert S.
- Hodapp Klaus
- Hodge Philip E.
- Hoffman Melissa
- Holfeltz Sherie T.
- Holler Bryan Jason
- Hoppa Jennifer Rose
- Horner Scott
- Howard Joseph M.
- Howard Richard J.
- Huber Jean M.
- Hunkeler Joseph S.
- Hunter Alexander
- Hunter David Gavin
- Hurd Spencer W.
- Hurst Brendan J.
- Hutchings John B.
- Hylan Jason E.
- Ignat Luminita Ilinca
- Illingworth Garth
- Irish Sandra M.
- Isaacs III John C.
- Jackson Jr. Wallace C.
- Jaffe Daniel T.
- Jahic Jasmin
- Jahromi Amir
- Jakobsen Peter
- James Bryan
- James John C.
- James LeAndrea Rae
- Jamieson William Brian
- Jandra Raymond D.
- Jayawardhana Ray
- Jedrzejewski Robert
- Jeffers Basil S.
- Jensen Peter
- Joanne Egges
- Johns Alan T.
- Johnson Carl A.
- Johnson Eric L.
- Johnson Patricia
- Johnson Phillip Stephen
- Johnson Thomas K.
- Johnson Timothy W.
- Johnstone Doug
- Jollet Delphine
- Jones Danny P.
- Jones Gregory S.
- Jones Olivia C.
- Jones Ronald A.
- Jones Vicki
- Jordan Ian J.
- Jordan Margaret E.
- Jue Reginald
- Jurkowski Mark H.
- Justis Grant
- Justtanont Kay
- Kaleida Catherine C.
- Kalirai Jason S.
- Kalmanson Phillip Cabrales
- Kaltenegger Lisa
- Kammerer Jens
- Kan Samuel K.
- Kanarek Graham Childs
- Kao Shaw-Hong
- Karakla Diane M.
- Karl Hermann
- Kassin Susan A.
- Kauffman David D.
- Kavanagh Patrick
- Kelley Leigh L.
- Kelly Douglas M.
- Kendrew Sarah
- Kennedy Herbert V.
- Kenny Deborah A.
- Keski-Kuha Ritva A.
- Keyes Charles D.
- Khan Ali
- Kidwell Richard C.
- Kimble Randy A.
- King James S.
- King Richard C.
- Kinzel Wayne M.
- Kirk Jeffrey R.
- Kirkpatrick Marc E.
- Klaassen Pamela
- Klingemann Lana
- Klintworth Paul U.
- Knapp Bryan Adam
- Knight Scott
- Knollenberg Perry J.
- Knutsen Daniel Mark
- Koehler Robert
- Koekemoer Anton M.
- Kofler Earl T.
- Kontson Vicki L.
- Kovacs Aiden Rose
- Kozhurina-Platais Vera
- Krause Oliver
- Kriss Gerard A.
- Krist John
- Kristoffersen Monica R.
- Krogel Claudia
- Krueger Anthony P.
- Kulp Bernard A.
- Kumari Nimisha
- Kwan Sandy W.
- Kyprianou Mark
- Labador Aurora Gadiano
- Labiano Ălvaro
- LafreniĂšre David
- Lagage Pierre-Olivier
- Laidler Victoria G.
- Laine Benoit
- Laird Simon
- Lajoie Charles-Philippe
- Lallo Matthew D.
- Lam May Yen
- LaMassa Stephanie Marie
- Lambros Scott D.
- Lampenfield Richard Joseph
- Lander Matthew Ed
- Langston James Hutton
- Larson Kirsten
- Larson Melora
- LaVerghetta Robert Joseph
- Law David R.
- Lawrence Jon F.
- Lee David W.
- Lee Janice
- Lee Yat-Ning Paul
- Leisenring Jarron
- Leveille Michael Dunlap
- Levenson Nancy A.
- Levi Joshua S.
- Levine Marie B.
- Lewis Dan
- Lewis Jake
- Lewis Nikole
- Libralato Mattia
- Lidon Norbert
- Liebrecht Paula Louisa
- Lightsey Paul
- Lilly Simon
- Lim Frederick C.
- Lim Pey Lian
- Ling Sai-Kwong
- Link Lisa J.
- Link Miranda Nicole
- Lipinski Jamie L.
- Litten Oi In Tam
- Liu XiaoLi
- Lo Amy S.
- Lobmeyer Lynette
- Logue Ryan M.
- Long Chris A.
- Long Douglas R.
- Long Ilana D.
- Long Knox S.
- Lotz Jennifer M.
- Love-Pruitt Jennifer M.
- Lubskiy Michael
- Luers Edward B.
- Luetgens Robert A.
- Luevano Annetta J.
- Lui Sarah Marie G. Flores
- Lund III James M.
- Lundquist Ray A.
- Lunine Jonathan
- Lynch Richard J.
- LĂłpez-Caniego Marcos
- LĂŒtzgendorf Nora
- MacDonald Alex J.
- MacDonald Kenneth
- Macias Matthew J.
- Maciel Cleyciane Da Costa
- Macklis Keith I.
- Maghami Peiman
- Maharaja Rishabh Y.
- Maiolino Roberto
- Makrygiannis Konstantinos G.
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- Manjavacas Elena
- Marini Andrea
- Marrione Amanda
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- Maschmann Marc
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- Myers Andrew
- Myers Carey R.
- Myers Fred Richard R.
- Myers Richard
- Myrick Kaila
- MĂŒhlmann Prisca
- Nagle IV Adrian F.
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- Naylor Bret
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- Nella John
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- Nidhiry John Joseph
- Niedner Malcolm B.
- Nieto-Santisteban Maria
- Nikolov Nikolay K.
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- Nota Antonella
- O'Brien Marcus B.
- O'Mara Robyn C.
- O'Shaughnessy Brian Patrick
- O'Sullivan Brian
- Oboryshko Michael
- Ochs William R.
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- Osborne Shannon Barbara
- Otor O. Justin
- Ottens Richard
- Ouellette Nathalie N. -Q.
- Outlaw Daria J.
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- Pacifici Camilla
- Page James Christophe
- Paranilam James G.
- Park Sang
- Parrish Keith A.
- Paschal Laura
- Patapis Polychronis
- Patel Jignasha
- Patrick Keith
- Pattishall Jr. Robert A.
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- Pedder Andrew H.
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- Perriello Beth A.
- Perrin Marshall D.
- Perrine Richard F.
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- Pilchen Guy
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- Pirzkal Norbert
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- Player Danielle M.
- Plesha Rachel
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- Reis Carl A.
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- Ressler Michael
- Rest Armin W.
- Reynolds Paul J.
- Richon Joel G.
- Richon Karen V.
- Ridgaway Michael
- Riedel Adric Richard
- Rieke George H.
- Rieke Marcia
- Rifelli Richard E.
- Rigby Jane R.
- Riggs Catherine S.
- Ringel Nancy J.
- Ritchie Christine E.
- Rix Hans-Walter
- Robberto Massimo
- Robinson Michael S.
- Robinson Orion
- Rock Frank W.
- Rodriguez David R.
- Roellig Thomas
- Rohrbach Scott O.
- Roman Anthony J.
- Romelfanger Frederick J.
- Romo Jr. Felipe P.
- Rosales Jose J.
- Rose Perry
- Roteliuk Anthony F.
- Roth Marc N.
- Rothwell Braden Quinn
- Rouzaud Sylvain
- Rowe Jason
- Rowlands Neil
- Roy Arpita
- Royer Pierre
- Rui Chunlei
- Rumler Peter
- Rumpl William
- Russ Melissa L.
- Ryan Michael B.
- Ryan Richard M.
- Saad Karl
- Sabata Modhumita
- Sabatino Rick
- Sabbi Elena
- Sabelhaus Phillip A.
- Sabia Stephen
- Sahu Kailash C.
- Saif Babak N.
- Salvignol Jean-Christophe
- Samara-Ratna Piyal
- Samuelson Bridget S.
- Sanders Felicia A.
- Santos Tony Dos
- Sappington Bradley
- Sargent B. A.
- Sauer Arne
- Savadkin Bruce J.
- Sawicki Marcin
- Schappell Tina M.
- Scheffer Caroline
- Scheithauer Silvia
- Scherer Ron
- Schiff Conrad
- Schlawin Everett
- Schmeitzky Olivier
- Schmitz Tyler S.
- Schmude Donald J.
- Schneider Analyn
- Schreiber JĂŒrgen
- Schroeven-Deceuninck Hilde
- Schultz John J.
- Schwab Ryan
- Schwartz Curtis H.
- Scoccimarro Dario
- Scott John F.
- Scott Michelle B.
- Seaton Bonita L.
- Seely Bruce S.
- Seery Bernard
- Seidleck Mark
- Sembach Kenneth
- Shanahan Clare Elizabeth
- Shaughnessy Bryan
- Shaw Richard A.
- Shay Christopher Michael
- Sheehan Even
- Sheth Kartik
- Shih Hsin-Yi
- Shivaei Irene
- Siegel Noah
- Sienkiewicz Matthew G.
- Simmons Debra D.
- Simon Bernard P.
- Sirianni Marco
- Sivaramakrishnan Anand
- Slade Jeffrey E.
- Sloan G. C.
- Slocum Christine E.
- Slowinski Steven E.
- Smith Corbett T.
- Smith Eric P.
- Smith Erin C.
- Smith Koby
- Smith Robert
- Smith Stephanie J.
- Smolik John L.
- Soderblom David R.
- Sohn Sangmo Tony
- Sokol Jeff
- Sonneborn George
- Sontag Christopher D.
- Sooy Peter R.
- Soummer Remi
- Southwood Dana M.
- Spain Kay
- Sparmo Joseph
- Speer David T.
- Spencer Richard
- Sprofera Joseph D.
- Stallcup Scott S.
- Stanley Marcia K.
- Stansberry John A.
- Stark Christopher C.
- Starr Carl W.
- Stassi Diane Y.
- Steck Jane A.
- Steeley Christine D.
- Stephens Matthew A.
- Stephenson Ralph J.
- Stewart Alphonso C.
- Stiavelli Massimo
- Stockman Jr. Hervey
- Strada Paolo
- Straughn Amber N.
- Streetman Scott
- Strickland David Kendal
- Strobele Jingping F.
- Stuhlinger Martin
- Stys Jeffrey Edward
- Such Miguel
- Sukhatme Kalyani
- Sullivan Joseph F.
- Sullivan Pamela C.
- Sumner Sandra M.
- Sun Fengwu
- Sunnquist Benjamin Dale
- Swade Daryl Allen
- Swam Michael S.
- Swenton Diane F.
- Swoish Robby A.
- Tamas Laszlo
- Tao Andrew
- Taylor David K.
- Taylor Joanna M.
- Teague Kelly K.
- Telfer Randal C.
- Temim Tea
- Texter Scott C.
- Thatte Deepashri G.
- Thompson Christopher Lee
- Thompson Linda M.
- Thomson Shaun R.
- Thronson Harley
- Tierney C. M.
- Tikkanen Tuomo
- Tinnin Lee
- Tippet William Thomas
- Todd Connor William
- Tran Hien D.
- Trauger John
- Trejo Edwin Gregorio
- Truong Justin Hoang Vinh
- Tsukamoto Christine L.
- Tufail Yasir
- Tumlinson Jason
- Tustain Samuel
- Tyra Harrison
- Ubeda Leonardo
- Underwood Kelli
- Uzzo Michael A.
- Vaclavik Steven
- Valenduc Frida
- Valenti Jeff A.
- Van Campen Julie
- van de Wetering Inge
- Van Der Marel Roeland P.
- van Dishoeck Ewine F.
- van Haarlem Remy
- Van Tea Mason
- Vandenbussche Bart
- Vanterpool Dona D.
- Vernoy Michael R.
- Volk Kevin
- Voorzaat Piet
- Voyton Mark F.
- Vydra Ekaterina
- Waddy Darryl J.
- Waelkens Christoffel
- Wahlgren Glenn Michael
- Walker Jr. Frederick E.
- Wander Michel
- Warfield Christine K.
- Warner Gerald
- Wasiak Francis C.
- Wasiak Matthew F.
- Wehner James
- Weiler Kevin R.
- Weilert Mark
- Weiss Stanley B.
- Wells Martyn
- Welty Alan D.
- Wheate Lauren
- Wheeler Thomas P.
- White Christy L.
- Whitehouse Paul
- Whiteleather Jennifer Margaret
- Whitman William Russell
- Williams Christina C.
- Willmer Christopher N. A.
- Willott Chris J.
- Willoughby Scott P.
- Wilson Andrew
- Wilson Debra
- Wilson Donna V.
- Windhorst Rogier
- Wislowski Emily Christine
- Wolfe David J.
- Wolfe Michael A.
- Wolff Schuyler
- Wondel Amancio
- Woo Cindy
- Woods Robert T.
- Worden Elaine
- Workman William
- Wright Gillian S.
- Wu Carl
- Wu Chi-Rai
- Wun Dakin D.
- Wymer Kristen B.
- Yadetie Thomas
- Yan Isabelle C.
- Yang Keith C.
- Yates Kayla L.
- Yeager Christopher R.
- Yerger Ethan John
- Young Erick T.
- Young Gary
- Yu Gene
- Yu Susan
- Zak Dean S.
- Zeidler Peter
- Zepp Robert
- Zhou Julia
- Zincke Christian A.
- Zonak Stephanie
- Zondag Elisabeth
- Ălvarez-MĂĄrquez Javier
- Ăstlin Göran
- Publication venue
- Publication date
- 10/04/2023
- Field of study
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least 4m.
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the 6.5m James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
Genetic mechanisms of critical illness in COVID-19.
- Author
- A A Roger Thompson
- A Abraheem
- A Agasou
- A Ahmed
- A Ali
- A Allan
- A Altabaibeh
- A Alvaro
- A Aspinwall
- A Ayers
- A Bamford
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- A Daniels
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- Bruno Frediani
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- W Khaliq
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- W Woodyatt
- Walker Susan
- Walsh Timothy
- Wang Bo
- Wei Shen Lim
- Wendy S Barclay
- William A Paxton
- William Greenhalf
- Wilson James F
- Wrobel Nicola
- Wu Yang
- X Qiu
- Y Baird
- Y Choudhury
- Y Hussain
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- Y Thirlwall
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- Yang Zhijian
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- Z Fernandez
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- Z Omar
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- Z Scott
- Zechner Marie
- Zhai Ranran
- Zheng Chenqing
- Publication venue
- Nature
- Publication date
- 01/01/2020
- Field of study
Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, PÂ =Â 1.65Â ĂÂ 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, PÂ =Â 2.3Â ĂÂ 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, PÂ =Â 3.98Â ĂÂ Â 10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, PÂ =Â 4.99Â ĂÂ 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard VĂ©ronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
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- Atkinson Andrea
- Atkinson Barry
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- Benke J
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- Bercovitz John
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- Beugelsdijk Tony J.
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- Blomstrom David B.
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- Brandriff Brigitte F.
- Brannon Wade
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- Brettin Thomas
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- Bridgers Michael
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- Dunwell Erin
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- Durbin Kenneth J.
- Durbin Richard
- Durham Jillian
- Dutta Ireena
- Dwyer Ruth
- Dyer Lauren
- Dziuda Darius
- Earnhardt Christopher D.
- Earthrowl Mark
- Eastham Emma
- Eastham Timothy
- Eaves Kristy A.
- Eckenberg Ralph
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- Evans Gareth
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- Fujiyama Asao
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- Garnes Jeffrey A.
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- Hitchens Matthew Edward
- Ho Issac
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- Kou Zhaohui
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- Krawczyk Marie-Claude
- Kremitzki Colin
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- Kube Michael
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- Zhang Guohua
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- Zhang Haiqing
- Zhang Haiqing
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- Zhang Jingjing
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- Zhang Xianglin
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- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers âŒ99% of the euchromatic genome and is accurate to an error rate of âŒ1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): a randomised, double-blind, phase 3 trial
- Author
- Agarwal
- Akira Yokomizo
- Alejo Rodriguez-Vida
- Alejo RodrĂguez-Vida
- Alexandra Drakaki
- Alexandra Drakaki
- Alina Amalia Herzal
- Andrea Necchi
- Andrea Necchi
- Andrey Semenov
- Andrey Semenov
- Anghel Adrian Udrea
- Annamaria H Zimmermann
- Annemie Rutten
- Apolo
- Aristotelis Bamias
- Aristotelis Bamias
- Astra M Liepa
- Aude Flechon
- Aude Fléchon
- Avivit Peer
- Avivit Peer
- Balar
- Bellmunt
- Bellmunt
- Bellmunt
- Bellmunt
- Benjamin Herms
- Boris Alekseev
- Boris Alekseev
- Bozena Sikora-Kupis
- Brigitte Laguerre
- Camidge
- Catherine Becht
- Chia-Chi Lin
- Chien-Liang Lin
- Chikara Ohyama
- Chong Xian Pan
- Choueiri
- Christos Papandreou
- Claudia Lorena Urzua Flores
- Constance Thibault
- Cora N Sternberg
- Cora N Sternberg
- Crew
- Cristiano Ferrario
- Daniel Castellano
- Daniel Castellano Gauna
- Daniel Kejzman
- Daniel P Petrylak
- Daniel Petrylak
- David Sarid
- Devlin
- Dickinson
- Dimitrios Mavroudis
- Eli Rosenbaum
- Elizabeth Jane Hovey
- Enrique Grande Pulido
- Evan Y Yu
- F Xavier GarcĂa Del Muro
- Florence Joly
- Francesco Massari
- Fransiscus L G Erdkamp
- Fredrik Laestadius
- Fredrik Laestadius
- Fumimasa Fukuta
- Georgios Gakis
- Giampaolo Tortora
- Giampaolo Tortora
- Giorgio Vittorio Scagliotti
- Golan
- GĂŒnter Niegisch
- Hahn
- Hakan Harputluoglu
- Hakan Harputluoglu
- Haralambos Kalofonos
- Hasan Senol Coskun
- Hasan Senol Coskun
- Herbst
- Herlinde Dumez
- Hiroyuki Nishiyama
- Hiroyuki Tsunemori
- Hyo Jin Lee
- Igor Bondarenko
- Inoue
- Inoue
- Irfan Cicin
- Irfan Ăiçin
- Isabel Syndikus
- Ivan Sinielnikov
- Ivor J Percent
- Ivor Percent
- Jae-Lyun Lee
- Jae-Lyun Lee
- Jaeger
- James Schwarz
- Janos Révész
- Jean-Pascal Machiels
- Jeanny Aragon-Ching
- Jennifer Cultrera
- Joanna Wojcik-Tomaszewska
- John Hainsworth
- Juan Ignacio Delgado Mignorance
- Junichi Inokuchi
- Junji Yonese
- Katherine M Bell-McGuinn
- Katsuyoshi Hashine
- Kazuo Nishimura
- Kim N Chi
- Kim Nguyen Chi
- Koji Kawai
- Lajos Geczi
- Lajos GĂ©czi
- Langer
- Leticia Vazquez Cortés
- Lisa Sengeloev
- Loehrer
- Marc-Oliver Grimm
- Marcello Tucci
- Masafumi Oyama
- Masayoshi Nagata
- Masuda
- Maureen J B Aarts
- McCaffrey
- Michael Schenker
- Michael Stöckle
- Michiel S van der Heijden
- Michiel S van der Heijden
- Miriam Hegemann
- Motohide Uemura
- Mustafa Erman
- Mutsushi Kawakita
- Naoto Miyajima
- Naveed Sarwar
- Necchi
- Niels Viggo Jensen
- Nobuaki Matsubara
- Nobuaki Matsubara
- Nobuo Shinohara
- Oday Hamid
- Petr Karlov
- Petrylak
- Petrylak
- Petrylak
- Piotr Tomczak
- Raggi
- Raya Leibowitz-Amit
- Reinoud J B Blaisse
- Richard A Walgren
- Robert Huddart
- Roman Fomkin
- Ronald de Wit
- Ronald de Wit
- Rosenberg
- Ryan C Widau
- Santhanam Sundar
- Sato
- Satoshi Fukasawa
- Satoshi Nagamori
- Saxman
- Scott Tagawa
- Se Hoon Park
- Sergio Bracarda
- Sharma
- Shinichi Yamashita
- Simon Chowdhury
- Simon Crabb
- Siobhan Su Wan Ng
- Smith
- Sonpavde
- Spratlin
- Sternberg
- Stéphane Culine
- Su-Peng Yeh
- Suet-Lai Shirley Wong
- Sufia Safina
- Sufia Z Safina
- Sun Young Rha
- Susanna Yee-Shan Cheng
- Syed Hussain
- Takahiro Osawa
- Thean Hsiang Tan
- Thomas Flaig
- Thomas Lowe
- Thomas Powles
- Thomas Powles
- Timothy Dudley Clay
- Ulka Vaishampayan
- Vahdat
- Vasilis Karavasilis
- von der Maase
- Wataru Obara
- Wen-Pin Su
- Wen-Pin Su
- William Lawler
- Wolfgang Schultze-Seemann
- Xavier Garcia del Muro
- Xia
- Xia
- Yen-Chuan Ou
- Yen-Chuan Ou
- Yoshihiko Tomita
- Yu Jung Kim
- Yu-Li Su
- Yuksel Urun
- Yun-Gyoo Lee
- Yurii Golovko
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Few treatments with a distinct mechanism of action are available for patients with platinum-refractory advanced or metastatic urothelial carcinoma. We assessed the efficacy and safety of treatment with docetaxel plus either ramucirumab-a human IgG1 VEGFR-2 antagonist-or placebo in this patient population