The SINS/zC-SINF survey of z~2 galaxy kinematics: Outflow properties

Based on SINFONI Ha, [NII] and [SII] AO data of 30 z \sim 2 star-forming galaxies (SFGs) from the SINS and zcSINF surveys, we find a strong correlation of the Ha broad flux fraction with the star formation surface density of the galaxy, with an apparent threshold for strong outflows occurring at 1 Msun yr^-1 kpc^-2. Above this threshold, we find that SFGs with logm_\ast>10 have similar or perhaps greater wind mass loading factors (eta = Mdotout/SFR) and faster outflow velocities than lower mass SFGs. This trend suggests that the majority of outflowing gas at z \sim 2 may derive from high-mass SFGs, and that the z \sim 2 mass-metallicity relation is driven more by dilution of enriched gas in the galaxy gas reservoir than by the efficiency of outflows. The mass loading factor is also correlated with the SFR and inclination, such that more star-forming and face-on galaxies launch more powerful outflows. For galaxies that have evidence for strong outflows, we find that the broad emission is spatially extended to at least the half-light radius (\sim a few kpc). We propose that the observed threshold for strong outflows and the observed mass loading of these winds can be explained by a simple model wherein break-out of winds is governed by pressure balance in the disk. Using the ratio of the [SII] doublet in a broad and narrow component, we find that outflowing gas has a density of \sim10-100 cm^-3, significantly less than that of the star forming gas (600 cm^-3).Comment: 7 pages, 3 figures, accepted by Ap

Subsequent Event Risk in Individuals with Established Coronary Heart Disease:Design and Rationale of the GENIUS-CHD Consortium

BACKGROUND: The "GENetIcs of sUbSequent Coronary Heart Disease" (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185,614 participants with either acute coronary syndrome, stable CHD or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events. RESULTS: Enrollment into the individual studies took place between 1985 to present day with duration of follow up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (HR 1.15 95% CI 1.14-1.16) per 5-year increase, male sex (HR 1.17, 95% CI 1.13-1.21) and smoking (HR 1.43, 95% CI 1.35-1.51) with risk of subsequent CHD death or myocardial infarction, and differing associations with other individual and composite cardiovascular endpoints. CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and non-genetic determinants of subsequent event risk in individuals with established CHD, in order to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators

Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

GA-NIFS: Early-stage feedback in a heavily obscured AGN at z=4.76z=4.76

International audienceDust-obscured galaxies are thought to represent an early evolutionary phase of massive galaxies in which the active galactic nucleus (AGN) is still deeply buried in significant amounts of dusty material and its emission is strongly suppressed. The unprecedented sensitivity of the James Webb Space Telescope enables us for the first time to detect the rest-frame optical emission of heavily obscured AGN and unveil the properties of the hidden accreting super-massive black holes (BHs). In this work, we present the JWST/NIRSpec IFS data of ALESS073.1, a massive, dusty, star-forming galaxy at $z = 4.76$ hosting an AGN at its center. The detection of a very broad $H_\alpha$ emission associated with the Broad Line Region (BLR) confirms the presence of a BH ($\log(M_{BH}/M_\odot)>8.7$) accreting at less than 15% of its Eddington limit and classifies the target as a Type 1 AGN. The rest-frame optical emission lines also reveal a fast ionized gas outflow marginally resolved in the galaxy center. The high sensitivity of NIRSpec allows us to perform the kinematic analysis of the narrow H$\alpha$ component which indicates that the warm ionized gas velocity field is consistent with disk rotation. We also find that, in the innermost nuclear regions ($< 1.5$ kpc), the intrinsic velocity dispersion of the disk reaches $\sim 150$ km/s, $\sim 2-3$ times higher than the velocity dispersion inferred from the [CII] 158$\mu$m line tracing mostly cold gas. Since, at large radii, the velocity dispersion of the warm and cold gas are comparable, we conclude that the outflows are injecting turbulence in the warm ionized gas in the central region, but they are not sufficiently powerful to disrupt the dense gas and quench star formation. These findings support the scenario that dust-obscured galaxies represent the evolutionary stage preceding the unobscured quasar when all gas and dust are removed from the host

A systematic search for warm molecular gas in AGN and star forming galaxies at z=2 with MIRI

Feedback from Active Galactic Nuclei (AGN) have become the cornerstones of cosmological hydrodynamical simulations and they are believed to regulate the star formation in their host galaxies. A promising way to gauge the impact of AGN on the interstellar medium is by tracing their molecular gas content, as the gas experiences an immediate impact of the radiation, jets or outflows from the AGN, compared to star formation. Recent ALMA observations targeting CO emission in mass-matched sample of AGN and non-AGN host galaxies at high redshift have suggested that AGN display lower cold molecular gas content compared to their non-AGN counterparts. One of the hypothesis to explain this difference is the molecular gas in AGN host galaxies could be present in the warm molecular gas phase, traced using rest-frame near-infrared ro-vibrational transitions. This proposal aims to trace warm molecular gas via rest-frame H2 2.12 um transition in a mass-matched sample of AGN and non-AGN host galaxies at z~2.2 using MIRI/MRS. The selected sample is complemented by ground-based ionised gas and cold molecular gas observations. We will test if AGN host galaxies show a systematic difference in their warm molecular gas content compared to the non-AGN galaxies. We will also compute the total gas mass (ionised+molecular) in these galaxies which will provide a key input to current models of AGN feedback...

Stellar Population Survey Using 4MOST (4MOST-StePS)

Galaxy spectra encode in their continuum and absorption/emission features a wealth of information on galaxy physics, mass assembly and chemical enrichment history. The 4MOST-StePS survey will collect high-quality spectra (with a median signal-to-noise ratio of about 30 Å–1, and resolution R ~ 5000) for a sample of about 3300 galaxies brighter than IAB = 20.5 within the RA-Dec-z footprint of the WAVES-Deep survey. These spectra will provide a precise empirical description of the evolutionary path of massive galaxies in the intermediate redshift range (0.3 < z < 0.7) between the LEGA-C and SDSS surveys. The locations of the galaxies within the cosmic web, unveiled by WAVES-Deep, will disclose the connection between galaxy properties and environment, down to the scales of galaxy pairs