53 research outputs found
Fast and Accurate Simulation Technique for Large Irregular Arrays
A fast full-wave simulation technique is presented for the analysis of large
irregular planar arrays of identical 3-D metallic antennas. The solution method
relies on the Macro Basis Functions (MBF) approach and an interpolatory
technique to compute the interactions between MBFs. The Harmonic-polynomial
(HARP) model is established for the near-field interactions in a modified
system of coordinates. For extremely large arrays made of complex antennas, two
approaches assuming a limited radius of influence for mutual coupling are
considered: one is based on a sparse-matrix LU decomposition and the other one
on a tessellation of the array in the form of overlapping sub-arrays. The
computation of all embedded element patterns is sped up with the help of the
non-uniform FFT algorithm. Extensive validations are shown for arrays of
log-periodic antennas envisaged for the low-frequency SKA (Square Kilometer
Array) radio-telescope. The analysis of SKA stations with such a large number
of elements has not been treated yet in the literature. Validations include
comparison with results obtained with commercial software and with experiments.
The proposed method is particularly well suited to array synthesis, in which
several orders of magnitude can be saved in terms of computation time.Comment: The paper was submitted to IEEE Transaction on Antennas and
Propagation on 01 - Feb.- 2017. The paper is 12 pages with 18 figure
The insulin-like growth factor system and adenocarcinoma of the colon
The insulin-like growth factor (IGF) system is important in normal growth and development. However, it is also known to be involved with malignant transformation and cellular proliferation. IGF binding proteins modulate the biological activity of IGF-I, either potentiating or inhibiting its activity, as well as determining how much enters the circulation at any one time. IGF binding protein-4 (IGFBP-4), for example is believed to be inhibitory to the effects of IGF-I. This thesis shows that the colon cancer cell lines Colo 205, HT29 and WiDR proliferate in response to IGF-I, and that IGFBP-4 at high concentrations inhibits their growth. However, it was found that with lower concentrationsof IGFBP-4, proliferation in HT29 and WiDR cells increased. Nevertheless in two cell lines, IGFBP-4 partially negated the proliferative effects of IGF-I. An antibody against IGFBP-4 was used to show that endogenous IGFBP-4 plays an important role in modifying cell growth. In order to start in vivo experiments which required considerable quantities of IGFBP-4, this protein was produced in an expression system and purified using an immunoaffinity column method. The rhIGFBP-4 thus produced was shown to be functional and to inhibit colorectal cancer cell growth in vitro. A nude mouse model of colon cancer was produced and the expression of components of the IGF system in this model determined using PCR. Experiments were performed using conditioned medium from Colo 205 cells to investigate IGFBP-4 protease activity. This thesis shows that manipulation of the IGF system is a potential target for further research into treatment for adenocarcinoma of the colon
Rain-induced turbulence and air-sea gas transfer
Author Posting. © American Geophysical Union, 2009. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research 114 (2009): C07009, doi:10.1029/2008JC005008.Results from a rain and gas exchange experiment (Bio2 RainX III) at the Biosphere 2 Center demonstrate that turbulence controls the enhancement of the air-sea gas transfer rate (or velocity) k during rainfall, even though profiles of the turbulent dissipation rate ɛ are strongly influenced by near-surface stratification. The gas transfer rate scales with ɛ inline equation for a range of rain rates with broad drop size distributions. The hydrodynamic measurements elucidate the mechanisms responsible for the rain-enhanced k results using SF6 tracer evasion and active controlled flux technique. High-resolution k and turbulence results highlight the causal relationship between rainfall, turbulence, stratification, and air-sea gas exchange. Profiles of ɛ beneath the air-sea interface during rainfall, measured for the first time during a gas exchange experiment, yielded discrete values as high as 10−2 W kg−1. Stratification modifies and traps the turbulence near the surface, affecting the enhancement of the transfer velocity and also diminishing the vertical mixing of mass transported to the air-water interface. Although the kinetic energy flux is an integral measure of the turbulent input to the system during rain events, ɛ is the most robust response to all the modifications and transformations to the turbulent state that follows. The Craig-Banner turbulence model, modified for rain instead of breaking wave turbulence, successfully predicts the near-surface dissipation profile at the onset of the rain event before stratification plays a dominant role. This result is important for predictive modeling of k as it allows inferring the surface value of ɛ fundamental to gas transfer.This work was funded by a generous grant from the
David and Lucile Packard Foundation and the Lamont-Doherty Earth
Observatory Climate Center. Additional funding was provided by the
National Science Foundation (OCE-05-26677) and the Office of Naval
Research Young Investigator Program (N00014-04-1-0621)
Differentiation assays of bone marrow-derived Multipotent Adult Progenitor Cell (MAPC)-like cells towards neural cells cannot depend on morphology and a limited set of neural markers
Accelerated macro basis functions analysis of finite printed antenna arrays through 2D and 3D multipole expansions
An efficient technique is presented for the analysis of finite printed antenna arrays made of identical elements. It is based on a closed-form expression for the spatial-domain Green’s function (GF) given as a finite sum of cylindrical waves (obtained through rational function fitting) plus one spherical wave. From there, a multipole expansion can be obtained for planar layered medium GFs. The macro basis function (MBF) technique is applied to the method of moments (MoM) solution of a mixed-potential integral equation, this reduces the size of the MoM impedance matrix and allows for a direct solution. However, the evaluation of the entries of this reduced matrix becomes the dominant contribution to the total computation time. The aforementioned multipole expansion is exploited to provide a fast construction of the reduced MoM matrix, whose elements are the reaction integrals between the MBFs considered to characterize the currents on the array element. The complexity of evaluating the interactions between MBFs is found to be dominated by the calculations related to the spherical wave term. Thus, taking into account the layered medium does not increase the order of the complexity with respect to a multipole-accelerated computation of reaction integrals in a homogeneous medium
Interpolatory Macro Basis Functions Analysis of Non-Periodic Arrays
An efficient method-of-moments (MoM) technique for analyzing non-periodic antenna arrays of identical elements with fixed orientation is presented. The proposed method, which uses macro basis functions (MBFs), is based on a compact representation of the interactions between MBFs. These interactions are expressed via a low-order harmonic-polynomial function after an explicit pre-computation of the reaction integrals in a very limited set of relative positions. This is possible for arrays of arbitrary size thanks to three transformations- subtraction of the far-field expression for the interactions, phase correction and modified radial distance- applied successively to the pre-computed interactions. After obtaining the harmonic-polynomial expressions, the computation time for the reaction integral between two MBFs is independent from the complexity of the antenna array element
Accelerated Macro Basis Functions analysis of finite printed antenna arrays through 2D and 3D multipole expansions
An efficient technique is presented for the analysis of finite printed antenna arrays made of identical elements. It is based on a closed-form expression for the spatial-domain Green’s function (GF) given as a finite sum of cylindrical waves (obtained through rational function fitting) plus one spherical wave. From there, a multipole expansion can be obtained for planar layered medium GFs. The macro basis function (MBF) technique is applied to the method of moments (MoM) solution of a mixed-potential integral equation, this reduces the size of the MoM impedance matrix and allows for a direct solution. However, the evaluation of the entries of this reduced matrix becomes the dominant contribution to the total computation time. The aforementioned multipole expansion is exploited to provide a fast construction of the reduced MoM matrix, whose elements are the reaction integrals between the MBFs considered to characterize the currents on the array element. The complexity of evaluating the interactions between MBFs is found to be dominated by the calculations related to the spherical wave term. Thus, taking into account the layered medium does not increase the order of the complexity with respect to a multipole-accelerated computation of reaction integrals in a homogeneous medium
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