Considerations For A Teaming Agreement To Propose On Government Prime Contracts

The subcontractor\u27s task responsibilities must be adequately defined along with documentation requirements and other areas of support. Cost, Technical and Management Proposal format must be defined. (Include RFP requirements plus other necessary information.) Any promise to a potential subcontractor that he will get a subcontract, if the other party gets the prime contract must be made subject to Government approval, mutually acceptable terms, conditions, prices and statement of work. The mutually acceptable terms and conditions include those in the prime contract and other Government provisions required to be included in subcontracts. In addition, the promise must be predicated on the availability of funding. It must be made clear to the subcontractor that the prime contractor will pay neither any subcontractor expenses for the pre-proposal nor any negotiating expenses related to the definitization of the prime contract or instant subcontract. The subcontractor must be ready to support and participate as required, in negotiations between the Government Agency and the prime contractor

The Virasoro vertex algebra and factorization algebras on Riemann surfaces

This paper focuses on the connection of holomorphic two-dimensional factorization algebras and vertex algebras which has been made precise in the forthcoming book of Costello-Gwilliam. We provide a construction of the Virasoro vertex algebra starting from a local Lie algebra on the complex plane. Moreover, we discuss an extension of this factorization algebra to a factorization algebra on the category of Riemann surfaces. The factorization homology of this factorization algebra is computed as are the correlation functions. We provide an example of how the Virasoro factorization algebra implements conformal symmetry of the beta-gamma system using the method of effective BV quantization

Preliminary acoustic and oceanographic observations from the ASIAEX 2001 South China Sea Experiment

The Asian Seas International Experiment (ASIAEX) was a very successful scientific collaboration between the United States of America (USA), the People’s Republic of China (PRC), Taiwan (ROC), the Republic of Korea (ROK), Japan, Russia, and Singapore. Preliminary field experiments associated with ASIAEX began in spring of 2000. The main experiments were performed in April-August, 2001. The scientific plan called for two major acoustics experiments, the first a bottom interaction experiment in the East China Sea (ECS) and the second a volume interaction experiment in the South China Sea (SCS). In addition to the acoustics efforts, there were also extremely strong physical oceanography and geology and geophysics components to the experiments. This report will concentrate on describing the moored component of the South China Sea portion of ASIAEX 2001 performed from the Taiwan Fisheries research vessel FR1 (Fisheries Researcher 1). Information on the environmental moorings deployed from the Taiwanese oceanographic research vessel OR1 (Oceanographic Researcher 1) will also be listed here for completeness, so that the reader can pursue later analyses of the data. This report does not pursue any data analyses per se.Funding was provided by the Office of Naval Research under Grant Numbers N00014-01-1-0772, N00014-98-1-0413 and N00014-00-1-0206

A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide

Glioblastoma is the most malignant brain tumor, exhibiting remarkable resistance to treatment. Here we investigated the oncogenic potential of HOXA9 in gliomagenesis, the molecular and cellular mechanisms by which HOXA9 renders glioblastoma more aggressive, and how HOXA9 affects response to chemotherapy and survival. The prognostic value of HOXA9 in glioblastoma patients was validated in two large datasets from TCGA and Rembrandt, where high HOXA9 levels were associated with shorter survival. Transcriptomic analyses identified novel HOXA9-target genes with key roles in cancer-related processes, including cell proliferation, DNA repair, and stem cell maintenance. Functional studies with HOXA9-overexpressing and HOXA9-silenced glioblastoma cell models revealed that HOXA9 promotes cell viability, stemness and invasion, and inhibits apoptosis. Additionally, HOXA9 promoted the malignant transformation of human immortalized astrocytes in an orthotopic in vivo model, and caused tumor-associated death. HOXA9 also mediated resistance to temozolomide treatment in vitro and in vivo via upregulation of BCL2. Importantly, the pharmacological inhibition of BCL2 with the BH3 mimetic ABT-737 reverted temozolomide resistance in HOXA9-positive cells. These data establish HOXA9 as a driver of glioma initiation, aggressiveness and resistance to therapy. In the future, the combination of BH3 mimetics with temozolomide should be further explored as an alternative treatment for glioblastoma.The authors would like to acknowledge the funding agencies that supported this work: Fundação para a Ciência e Tecnologia (PTDC/SAU-GMG/113795/2009 and SFRH/ BPD/33612/2009 to B.M.C.; SFRH/BD/81042/2011 to M.P.; SFRH/BD/88220/2012 to A.X.M.; PTDC/SAUGMG/ 113795/2009 to A.I.O. and C.S.G.), Fundação Calouste Gulbenkian (B.M.C.), and Liga Portuguesa Contra o Cancro (B.M.C.), and Schering-Plough Farma (R.M.R), Portugal. Project co-financed by Programa Operacional Regional do Norte (ON.2—O Novo Norte), Quadro de Referência Estratégico Nacional (QREN), Fundo Europeu de Desenvolvimento Regional (FEDER). The authors would like to extend their appreciation to Dr. Chris Jones and Dr. Sergey Popov (ICR, UK) for helpful assistance regarding histopathological analysis of xenograft tumors, Dr. Russell Pieper for sharing the hTERT/E6/E7 cell line (UCSF, USA), and Dr. Joseph Costello (UCSF, USA) for critical review of the manuscript

“Excellence R Us”: university research and the fetishisation of excellence

The rhetoric of “excellence” is pervasive across the academy. It is used to refer to research outputs as well as researchers, theory and education, individuals and organisations, from art history to zoology. But does “excellence” actually mean anything? Does this pervasive narrative of “excellence” do any good? Drawing on a range of sources we interrogate “excellence” as a concept and find that it has no intrinsic meaning in academia. Rather it functions as a linguistic interchange mechanism. To investigate whether this linguistic function is useful we examine how the rhetoric of excellence combines with narratives of scarcity and competition to show that the hypercompetition that arises from the performance of “excellence” is completely at odds with the qualities of good research. We trace the roots of issues in reproducibility, fraud, and homophily to this rhetoric. But we also show that this rhetoric is an internal, and not primarily an external, imposition. We conclude by proposing an alternative rhetoric based on soundness and capacity-building. In the final analysis, it turns out that that “excellence” is not excellent. Used in its current unqualified form it is a pernicious and dangerous rhetoric that undermines the very foundations of good research and scholarship

Institutional inertia and climate change: a review of the new institutionalist literature

Peer reviewe

Seeking and accessing professional support for child anxiety in a community sample

There is a lack of current data on help-seeking, and barriers to accessing professional support for child anxiety disorders. This study aimed to provide current data on the frequency and type of parental help-seeking, professional support received, and parent-reported barriers/facilitators in the context of child anxiety, and to explore factors associated with help-seeking, and parent-reported barriers among help-seekers and non help-seekers. We conducted a survey of help-seeking in parents of 222 children (aged 7-11) with elevated anxiety symptoms identified through screening in schools, 138 children of whom met diagnostic criteria for an anxiety disorder. Almost two-thirds (64.5%) of parents of children with an anxiety disorder reported seeking help from a professional; in 38.4% of cases parents reported that their child had received support from a professional to help manage and overcome their anxiety difficulties, and < 3% had received evidence-based treatment (CBT). Frequently reported parental barriers related to difficulties differentiating between developmentally appropriate and clinically significant anxiety, a lack of help-seeking knowledge, perceived negative consequences of help-seeking, and limited service provision. Non-help seekers were more likely than help seekers to report barriers related to thinking a child's anxiety may improve without professional support, and the absence of professional recognition. Findings identify the need for (i) tools for parents and primary school staff to help identify children who may benefit from professional support to overcome difficulties with anxiety; and (ii) increased evidence-based provision for child anxiety disorders, including delivery within schools and direct support for parents