169 research outputs found
Summer habitat use and movements of invasive wild pigs (Sus scrofa) in Canadian agro-ecosystems
Resource selection informs understanding of a speciesâ ecology and is especially pertinent for invasive species. Since introduced to Canada, wild pigs (Sus scrofa Linnaeus, 1978) remain understudied despite recognized negative impacts on native and agricultural systems globally. Elsewhere in North America, pigs typically use forests and forage in agricultural crops. We hypothesized Canadian wild pigs would behave similarly, and using GPS locations from 15 individuals, we examined diel and seasonal resource selection and movement in the Canadian prairie region. Forests were predominately selected during the day, while corn (Zea mays L.), oilseeds, and wheat (Triticum aestivum L.) were predominately selected at night. Forests and corn were consistently selected throughout the growing season.Wetlands and forests showed greater use rates than other habitats, with evident trade-offs as crop use increased with the timing of maturation. Activity was consistent with foraging in growing crops. Results indicate diel patterns were likely a function of short-term needs to avoid daytime anthropogenic risk, while seasonal patterns demonstrate how habitats that fill multiple functional rolesââfood, cover, and thermoregulationââcan be optimized. Understanding selection by invasive species is an important step in understanding their potential environmental impacts in novel environments and informs their management
TOI-3984 A b and TOI-5293 A b: two temperate gas giants transiting mid-M dwarfs in wide binary systems
We confirm the planetary nature of two gas giants discovered by TESS to
transit M dwarfs with stellar companions at wide separations. TOI-3984 A
() is an M4 dwarf hosting a short-period (
days) gas giant ( and
) with a wide separation white dwarf companion.
TOI-5293 A () is an M3 dwarf hosting a short-period ( days) gas giant ( and
) with a wide separation M dwarf companion. We
characterize both systems using a combination of ground-based and space-based
photometry, speckle imaging, and high-precision radial velocities from the
Habitable-zone Planet Finder and NEID spectrographs. TOI-3984 A b
( K and ) and TOI-5293 A b
( K and ) are two of the coolest
gas giants among the population of hot Jupiter-sized gas planets orbiting M
dwarfs and are favorable targets for atmospheric characterization of temperate
gas giants and three-dimensional obliquity measurements to probe system
architecture and migration scenarios.Comment: Submitted to AJ, 42 pages, 14 figures. arXiv admin note: substantial
text overlap with arXiv:2201.0996
The unusual M-dwarf Warm Jupiter TOI-1899~b: Refinement of orbital and planetary parameters
TOI-1899~b is a rare exoplanet, a temperate Warm Jupiter orbiting an M-dwarf,
first discovered by \citet{Canas2020_toi1899} from a TESS single-transit event.
Using new radial velocities (RVs) from the precision RV spectrographs HPF and
NEID, along with additional TESS photometry and ground-based transit follow-up,
we are able to derive a much more precise orbital period of ~d, along with a radius of ~\unit{R_{J}}. We have also improved the constraints on planet
mass, ~\unit{M_{J}}, and eccentricity, which is consistent
with a circular orbit at 2 (). TOI-1899~b
occupies a unique region of parameter space as the coolest known ( 380~K) Jovian-sized transiting planet around an M-dwarf; we show that
it has great potential to provide clues regarding the formation and migration
mechanisms of these rare gas giants through transmission spectroscopy with JWST
as well as studies of tidal evolution.Comment: 19 pages, 7 figures, 3 tables, submitted to AJ (comments welcome
Telavancin versus Vancomycin for Hospital-Acquired Pneumonia due to Gram-positive Pathogens
The results from two methodologically identical double-blind studies indicate that telavancin is noninferior to vancomycin based on clinical response in the treatment of hospital-acquired pneumonia due to Gram-positive pathogens
Genome-Wide Screen in Saccharomyces cerevisiae Identifies Vacuolar Protein Sorting, Autophagy, Biosynthetic, and tRNA Methylation Genes Involved in Life Span Regulation
The study of the chronological life span of Saccharomyces cerevisiae, which measures the survival of populations of non-dividing yeast, has resulted in the identification of homologous genes and pathways that promote aging in organisms ranging from yeast to mammals. Using a competitive genome-wide approach, we performed a screen of a complete set of approximately 4,800 viable deletion mutants to identify genes that either increase or decrease chronological life span. Half of the putative short-/long-lived mutants retested from the primary screen were confirmed, demonstrating the utility of our approach. Deletion of genes involved in vacuolar protein sorting, autophagy, and mitochondrial function shortened life span, confirming that respiration and degradation processes are essential for long-term survival. Among the genes whose deletion significantly extended life span are ACB1, CKA2, and TRM9, implicated in fatty acid transport and biosynthesis, cell signaling, and tRNA methylation, respectively. Deletion of these genes conferred heat-shock resistance, supporting the link between life span extension and cellular protection observed in several model organisms. The high degree of conservation of these novel yeast longevity determinants in other species raises the possibility that their role in senescence might be conserved
Sex-Specific Growth and Reproductive Dynamics of Red Drum in the Northern Gulf of Mexico
The Red Drum Sciaenops ocellatus stock is heavily targeted in the Gulf of Mexico (GOM) by recreational fishers and supports a small commercial fishery in Mississippi. Despite their popularity, little recent work has been done to describe their life history. In this work, we describe sexâspecific growth and reproductive dynamics of Red Drum collected from the northern GOM from September 2016 through October 2017. We evaluated seven candidate growth models and found that the threeâparameter von Bertalanffy growth function (VBGF) was the best candidate lengthâatâage model. No significant difference in growth between sexes was observed with the threeâparameter VBGF, despite the femaleâspecific curve having a larger mean asymptotic length than the maleâspecific curve. All seven candidate growth models predicted similar mean lengthâatâage estimates, and four of them exhibited significant differences in sexâspecific mean length at age, with females reaching a larger length at age than males after age 5. There was no significant difference between the sexâspecific weightâatâlength relationships. Red Drum are batch spawners that spawn in northern GOM coastal waters during August and September. We estimated 3.7 d between spawns and 10.5 spawning events per female in 2017. Nearly 20% of fish collected during the spawning season were sexually mature but reproductively inactive, indicating the possibility of skipped spawning. The age at 50% maturity was around 3 years (length at 50% maturity = 670 mm TL) in both sexes, but fish were not spawning capable until age 4.5 (703 mm TL) in males and age 5.8 (840 mm TL) in females. Furthermore, elevated gonadosomatic indices were not observed until around age 5â6. The updated life history information presented in this work helps to address current data limitations and provides critical information for future assessments of Red Drum stocks in the northern GOM
Effect of variable transmission rate on the dynamics of HIV in sub-Saharan Africa
<p>Abstract</p> <p>Background</p> <p>The cause of the high HIV prevalence in sub-Saharan Africa is incompletely understood, with heterosexual penile-vaginal transmission proposed as the main mechanism. Heterosexual HIV transmission has been estimated to have a very low probability; but effects of cofactors that vary in space and time may substantially alter this pattern.</p> <p>Methods</p> <p>To test the effect of individual variation in the HIV infectiousness generated by co-infection, we developed and analyzed a mathematical sexual network model that simulates the behavioral components of a population from Malawi, as well as the dynamics of HIV and the co-infection effect caused by other infectious diseases, including herpes simplex virus type-2, gonorrhea, syphilis and malaria.</p> <p>Results</p> <p>The analysis shows that without the amplification effect caused by co-infection, no epidemic is generated, and HIV prevalence decreases to extinction. But the model indicates that an epidemic can be generated by the amplification effect on HIV transmission caused by co-infection.</p> <p>Conclusion</p> <p>The simulated sexual network demonstrated that a single value for HIV infectivity fails to describe the dynamics of the epidemic. Regardless of the low probability of heterosexual transmission per sexual contact, the inclusion of individual variation generated by transient but repeated increases in HIV viral load associated with co-infections may provide a biological basis for the accelerated spread of HIV in sub-Saharan Africa. Moreover, our work raises the possibility that the natural history of HIV in sub-Saharan Africa cannot be fully understood if individual variation in infectiousness is neglected.</p
HIV/AIDS epidemiology, pathogenesis, prevention, and treatment.
The HIV-1 pandemic is a complex mix of diverse epidemics within and between countries and regions of the world,
and is undoubtedly the defining public-health crisis of our time. Research has deepened our understanding of how
the virus replicates, manipulates, and hides in an infected person. Although our understanding of pathogenesis and
transmission dynamics has become more nuanced and prevention options have expanded, a cure or protective vaccine
remains elusive. Antiretroviral treatment has transformed AIDS from an inevitably fatal condition to a chronic,
manageable disease in some settings. This transformation has yet to be realised in those parts of the world that
continue to bear a disproportionate burden of new HIV-1 infections and are most affected by increasing morbidity
and mortality. This Seminar provides an update on epidemiology, pathogenesis, treatment, and prevention
interventions pertinent to HIV-1
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