Fellowships in Community Pharmacy Research: Experiences of Five Schools and Colleges of Pharmacy

Objective To describe common facilitators, challenges, and lessons learned in 5 schools and colleges of pharmacy in establishing community pharmacy research fellowships. Setting: Five schools and colleges of pharmacy in the United States. Practice description: Schools and colleges of pharmacy with existing community partnerships identified a need and ability to develop opportunities for pharmacists to engage in advanced research training. Practice innovation: Community pharmacy fellowships, each structured as 2 years long and in combination with graduate coursework, have been established at the University of Pittsburgh, Purdue University, East Tennessee State University, University of North Carolina at Chapel Hill, and The Ohio State University. Evaluation: Program directors from each of the 5 community pharmacy research fellowships identified common themes pertaining to program structure, outcomes, and lessons learned to assist others planning similar programs. Results: Common characteristics across the programs include length of training, prerequisites, graduate coursework, mentoring structure, and immersion into a pharmacist patient care practice. Common facilitators have been the existence of strong community pharmacy partnerships, creating a fellowship advisory team, and networking. A common challenge has been recruitment, with many programs experiencing at least one year without filling the fellowship position. All program graduates (n = 4) have been successful in securing pharmacy faculty positions. Conclusion: Five schools and colleges of pharmacy share similar experiences in implementing community pharmacy research fellowships. Early outcomes show promise for this training pathway in growing future pharmacist-scientists focused on community pharmacy practice

Global Antifungal Profile Optimization of Chlorophenyl Derivatives against Botrytis cinerea and Colletotrichum gloeosporioides

Twenty-two aromatic derivatives bearing a chlorine atom and a different chain in the para or meta position were prepared and evaluated for their in vitro antifungal activity against the phytopathogenic fungi Botrytis cinerea and Colletotrichum gloeosporioides. The results showed that maximum inhibition of the growth of these fungi was exhibited for enantiomers S and R of 1-(40-chlorophenyl)- 2-phenylethanol (3 and 4). Furthermore, their antifungal activity showed a clear structure-activity relationship (SAR) trend confirming the importance of the benzyl hydroxyl group in the inhibitory mechanism of the compounds studied. Additionally, a multiobjective optimization study of the global antifungal profile of chlorophenyl derivatives was conducted in order to establish a rational strategy for the filtering of new fungicide candidates from combinatorial libraries. The MOOPDESIRE methodology was used for this purpose providing reliable ranking models that can be used later

The Quark-Hadron Phase Transition, QCD Lattice Calculations and Inhomogeneous Big-Bang Nucleosynthesis

We review recent lattice QCD results for the surface tension at the finite temperature quark-hadron phase transition and discuss their implications on the possible scale of inhomogeneities. In the quenched approximation the average distance between nucleating centers is smaller than the diffusion length of a protron, so that inhomogeneities are washed out by the time nucleosynthesis sets in. Consequently the baryon density fluctuations formed by a QCD phase transition in the early universe cannot significantly affect standard big-bang nucleosynthesis calculations and certainly cannot allow baryons to close the universe. At present lattice results are inconclusive when dynamical fermions are included.Comment: 8 pages, LaTe

Anti-cancer effects and mechanism of actions of aspirin analogues in the treatment of glioma cancer

INTRODUCTION: In the past 25 years only modest advancements in glioma treatment have been made, with patient prognosis and median survival time following diagnosis only increasing from 3 to 7 months. A substantial body of clinical and preclinical evidence has suggested a role for aspirin in the treatment of cancer with multiple mechanisms of action proposed including COX 2 inhibition, down regulation of EGFR expression, and NF-κB signaling affecting Bcl-2 expression. However, with serious side effects such as stroke and gastrointestinal bleeding, aspirin analogues with improved potency and side effect profiles are being developed. METHOD: Effects on cell viability following 24 hr incubation of four aspirin derivatives (PN508, 517, 526 and 529) were compared to cisplatin, aspirin and di-aspirin in four glioma cell lines (U87 MG, SVG P12, GOS – 3, and 1321N1), using the PrestoBlue assay, establishing IC50 and examining the time course of drug effects. RESULTS: All compounds were found to decrease cell viability in a concentration and time dependant manner. Significantly, the analogue PN517 (IC50 2mM) showed approximately a twofold increase in potency when compared to aspirin (3.7mM) and cisplatin (4.3mM) in U87 cells, with similar increased potency in SVG P12 cells. Other analogues demonstrated similar potency to aspirin and cisplatin. CONCLUSION: These results support the further development and characterization of novel NSAID derivatives for the treatment of glioma

Do differences in understory light contribute to species distributions along a tropical rainfall gradient?

In tropical forests, regional differences in annual rainfall correlate with differences in plant species composition. Although water availability is clearly one factor determining species distribution, other environmental variables that covary with rainfall may contribute to distributions. One such variable is light availability in the understory, which decreases towards wetter forests due to differences in canopy density and phenology. We established common garden experiments in three sites along a rainfall gradient across the Isthmus of Panama in order to measure the differences in understory light availability, and to evaluate their influence on the performance of 24 shade-tolerant species with contrasting distributions. Within sites, the effect of understory light availability on species performance depended strongly on water availability. When water was not limiting, either naturally in the wetter site or through water supplementation in drier sites, seedling performance improved at higher light. In contrast, when water was limiting at the drier sites, seedling performance was reduced at higher light, presumably due to an increase in water stress that affected mostly wet-distribution species. Although wetter forest understories were on average darker, wet-distribution species were not more shade-tolerant than dry-distribution species. Instead, wet-distribution species had higher absolute growth rates and, when water was not limiting, were better able to take advantage of small increases in light than dry-distribution species. Our results suggest that in wet forests the ability to grow fast during temporary increases in light may be a key trait for successful recruitment. The slower growth rates of the dry-distribution species, possibly due to trade-offs associated with greater drought tolerance, may exclude these species from wetter forests

Indoor Air Quality (IAQ) in Naturally-ventilated Primary Schools in the UK:Occupant-Related Factors

Indoor Air Quality (IAQ) is affected by Context, Occupant and Building (COB) related factors. This paper evaluates IAQ as a function of occupant-related factors including occupants' Adaptive Behaviours (ABs), occupancy patterns, occupant's CO2 generation rates and occupancy density. This study observed occupant-related factors of 805 children in 29 naturally-ventilated (NV) classrooms in UK primary schools during Non-Heating and Heating seasons. Occupant-related factors affecting IAQ include occupants' adaptive behaviours, occupancy patterns, occupants' CO2 generation rate and occupancy densities. Results of this study suggest that a classroom with high potentials for natural ventilation does not necessarily provide adequate IAQ, however, occupants’ good practice of ABs is also required. Average occupancy densities to have CO2 levels of 1000 ± 50 ppm are suggested to be 2.3 ± 0.05m2/p and 7.6 ± 0.25 m3/p. These values correspond to the classroom area of 62.1 ± 1.35 m2 and volume of 205.2 ± 6.75 m3 with a height of 3.3 m. Mean CO2 level is maintained below 900 ppm when all occupant-related factors are in the favour of IAQ, however, it exceeds 1300 ppm when none of the occupant-related factors are in favour of IAQ. It is shown that 17% of CO2 variations are explained by open area (m2), 14% by occupants' generation rates (cm3/s) and 11% by occupancy density (m3/p). IAQ is mostly affected by occupants’ adaptive behaviours than other occupant-related factors in naturally-ventilated classrooms

Identification of Amazonian Trees with DNA Barcodes

International audienc