Entry-Level Competencies of New Student Affairs Professionals: A Delphi Study

The study examines the perceptions of 104 mid- and senior-level student affairs administrators of positions, responsibilities, competencies, and theories important for professional practice for new student affairs professionals. In regard to competencies, the results of this study provide important information about preprofessional abilities that are integral to professional practice, and participants also identified several competencies not identified in prior research that may be important to positions involving high contact with students. These results, then, provide vital information for curriculum development in graduate preparation programs and for professional development training for new professionals

The relative effectiveness of empirical and physical models for simulating the dense undercurrent of pyroclastic flows under different emplacement conditions

High concentration pyroclastic density currents (PDCs) are hot avalanches of volcanic rock and gas and are among the most destructive volcanic hazards due to their speed and mobility. Mitigating the risk associated with these flows depends upon accurate forecasting of possible impacted areas, often using empirical or physical models. TITAN2D, VolcFlow, LAHARZ, and ΔH/L or energy cone models each employ different rheologies or empirical relationships and therefore differ in appropriateness of application for different types of mass flows and topographic environments. This work seeks to test different statistically- and physically-based models against a range of PDCs of different volumes, emplaced under different conditions, over different topography in order to test the relative effectiveness, operational aspects, and ultimately, the utility of each model for use in hazard assessments. The purpose of this work is not to rank models, but rather to understand the extent to which the different modeling approaches can replicate reality in certain conditions, and to explore the dynamics of PDCs themselves. In this work, these models are used to recreate the inundation areas of the dense-basal undercurrent of all 13 mapped, land-confined, Soufrière Hills Volcano dome-collapse PDCs emplaced from 1996 to 2010 to test the relative effectiveness of different computational models. Best-fit model results and their input parameters are compared with results using observation- and deposit-derived input parameters. Additional comparison is made between best-fit model results and those using empirically-derived input parameters from the FlowDat global database, which represent “forward” modeling simulations as would be completed for hazard assessment purposes. Results indicate that TITAN2D is able to reproduce inundated areas well using flux sources, although velocities are often unrealistically high. VolcFlow is also able to replicate flow runout well, but does not capture the lateral spreading in distal regions of larger-volume flows. Both models are better at reproducing the inundated area of single-pulse, valley-confined, smaller-volume flows than sustained, highly unsteady, larger-volume flows, which are often partially unchannelized. The simple rheological models of TITAN2D and VolcFlow are not able to recreate all features of these more complex flows. LAHARZ is fast to run and can give a rough approximation of inundation, but may not be appropriate for all PDCs and the designation of starting locations is difficult. The ΔH/L cone model is also very quick to run and gives reasonable approximations of runout distance, but does not inherently model flow channelization or directionality and thus unrealistically covers all interfluves. Empirically-based models like LAHARZ and ΔH/L cones can be quick, first-approximations of flow runout, provided a database of similar flows, e.g., FlowDat, is available to properly calculate coefficients or ΔH/L. For hazard assessment purposes, geophysical models like TITAN2D and VolcFlow can be useful for producing both scenario-based or probabilistic hazard maps, but must be run many times with varying input parameters. LAHARZ and ΔH/L cones can be used to produce simple modeling-based hazard maps when run with a variety of input volumes, but do not explicitly consider the probability of occurrence of different volumes. For forward modeling purposes, the ability to derive potential input parameters from global or local databases is crucial, though important input parameters for VolcFlow cannot be empirically estimated. Not only does this work provide a useful comparison of the operational aspects and behavior of various models for hazard assessment, but it also enriches conceptual understanding of the dynamics of the PDCs themselves

Stat3 and c-Myc Genome-Wide Promoter Occupancy in Embryonic Stem Cells

Embryonic stem (ES) cell pluripotency is regulated in part by transcription factor (TF) pathways that maintain self-renewal and inhibit differentiation. Stat3 and c-Myc TFs are essential for maintaining mouse ES cell self-renewal. c-Myc, together with Oct4, Sox2, and Klf4, is a reprogramming factor. While previous studies have investigated core transcriptional circuitry in ES cells, other TF pathways that promote ES cell pluripotency have yet to be investigated. Therefore, to further understand ES cell transcriptional networks, we used genome-wide chromatin immunoprecipitation and microarray analysis (ChIP-chip) to map Stat3 and c-Myc binding targets in ES cells. Our results show that Stat3 and c-Myc occupy a significant number of genes whose expression is highly enriched in ES cells. By comparing Stat3 and c-Myc target genes with gene expression data from undifferentiated ES cells and embryoid bodies (EBs), we found that Stat3 binds active and inactive genes in ES cells, while c-Myc binds predominantly active genes. Moreover, the transcriptional states of Stat3 and c-Myc targets are correlated with co-occupancy of pluripotency-related TFs, polycomb group proteins, and active and repressive histone modifications. We also provide evidence that Stat3 targets are differentially expressed in ES cells following removal of LIF, where culture of ES cells in the absence of LIF resulted in downregulation of Stat3 target genes enriched in ES cells, and upregulation of lineage specific Stat3 target genes. Altogether, we reveal transcriptional targets of two key pluripotency-related genes in ES cells – Stat3 and c-Myc, thus providing further insight into the ES cell transcriptional network

"Not just merely different: Travelling Theories, post-feminism and the racialized politics of women of color"

I argue (with Samie, 2017) that when even the so-called “critical” scholarship about women of color mostly speaks to cultural tropes of difference, this limits the possibility of recovering alternative knowledges. For me, uncovering persistent problems is an essential step to urging contemporary researchers to better recover diverse representations of difference that are sometimes consciously, and other times inadvertently, erased. Adding my voice to a number of sport scholars who advocate a decolonising approach, this paper highlights the importance of centring the differential manifestation of power asymmetries through a transnational feminist approach, within and across the transient boundaries of space, belonging and knowledge production, in order to put the “critical” back into critical studies of race, sport and gender

Innovations to reduce demand and crowding in emergency care; a review study

Emergency Department demand continues to rise in almost all high-income countries, including those with universal coverage and a strong primary care network. Many of these countries have been experimenting with innovative methods to stem demand for acute care, while at the same time providing much needed services that can prevent Emergency Department attendance and later hospital admissions. A large proportion of patients comprise of those with minor illnesses that could potentially be seen by a health care provider in a primary care setting. The increasing number of visits to Emergency Departments not only causes delay in urgent care provision but also increases the overall cost. In the UK, the National Health Service (NHS) has made a number of efforts to strengthen primary healthcare services to increase accessibility to healthcare as well as address patients¿ needs by introducing new urgent care services. In this review, we describe efforts that have been ongoing in the UK and France for over a decade as well as specific programs to target the rising needs of emergency care in both England and France. Like many such programs, there have been successes, failures and unintended consequences. Thus, the urgent care system of other high-income countries can learn from these experiments

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Using data-informed decision making to improve student affairs practice

Comprend des références bibliographiques et un index.Is the data available on your college campus fully utilized? Analyzing data does not have to be a complex process, but there can be obstacles to putting data to good use: overworked staff or understaffed departments; silos that prevent crossing institutional boundaries; lack of research training; or simply being overwhelmed by the possibilities. Addressing these obstacles, this volume presents pragmatic ideas for implementing data-informed decision making to improve student affairs practice. It first illustrates how to easily analyze quantitative data and read assessment reports - demonstrating that advanced research knowledge is not necessary to make meaning of survey findings. It then provides suggestions for utilizing findings from large data sets typically available on campus and gives practical guidance for making sense of and using quantitative data to inform practice. Also included is how to use data to understand the experiences of non-dominant populations on campus, which is especially relevant given the diversity of today's college students. Several chapters speak directly to using data to understand marginalized groups based on race, religion, and sexual orientation, while others focus on using data to understand campus diversity experiences