Inconstitucionalidad de la ordenanza 321 que regula el ejercicio de la potestad sancionadora en el Distrito Metropolitano de Quito en la aplicación de limitaciones de acceso a la justicia administrativa en las infracciones administrativas flagrantes

Disciplinary or Sanctioning Administrative Proceedings are part of Administrative Law; therefore their development should be subject to compliance with a direct application of rights, principles and constitutional guarantees. The lack of application of these rights, principles and constitutional guarantees in different stages of administrative proceedings, leads the Administration to carry out unconstitutional actions. The Metropolitan District of Quito, through the Metropolitan Ordinance No. 321, regulates the exercise of disciplinary powers to impose penalties as well as the administrative proceedings that must be followed. However, this administrative proceedings introduces a differentiation in cases of flagrant administrative offenses: the law provides that prior to the response of the bill of indictment, the possible offender shall deposit a security amount equivalent to the potential penalty or pecuniary sanction resulting of the disciplinary administrative proceedings, as a prerequisite for the investigating officer to process the response and continue with the legal procedure. The lack of escrow or deposit by the alleged offender is considered as acquiescence to the facts alleged. Under these circumstances, this research paper aims to establish that this differentiation that arises in administrative proceedings for cases of flagrant administrative offenses is unconstitutional, since it sets limits of access to administrative justice. Similarly, it will be stated and supported that this security deposit, does not fulfill its function as such and in practice it constitutes a concealed figure of advanced payment.Los procedimientos administrativos sancionadores, son parte del Derecho Administrativo, por ende su desarrollo debe basarse en el cumplimiento de una aplicación directa de derechos, principios y garantías constitucionales. La no aplicación de estos derechos, principios y garantías constitucionales en el desarrollo de los procedimientos administrativos, conllevan a la administración a realizar actuaciones inconstitucionales. El Distrito Metropolitano de Quito, a través de la Ordenanza Metropolitana No. 321, regula el ejercicio de la potestad sancionadora y el procedimiento administrativo a seguir. Sin embargo, este procedimiento administrativo presenta una diferenciación en los casos de infracciones administrativas flagrantes: La normativa establece que previo a la contestación del auto de inicio de proceso, el posible infractor deberá depositar un valor en garantía equivalente a la sanción pecuniaria resultado del procedimiento administrativo sancionador, como requisito previo para que el funcionario instructor le dé trámite a su contestación; indicando que la falta de depósito en garantía por parte del presunto infractor se considerará como allanamiento a los hechos imputados. Por lo que el presente trabajo de investigación tiene como finalidad establecer que esta diferenciación que se plantea en los procedimientos administrativos para los casos de infracciones administrativas flagrantes, es inconstitucional al establecer límites de acceso a la justicia administrativa. De igual forma, se sustentará que este depósito en garantía, no cumple su función como tal y en la práctica se esconde en figuras como el pago previo

La Forma Espacial de la Isla de Calor en la Ciudad de Guayaquil

Uno de los impactos ambientales de importancia macro-escalar quele conciernen a la ciudad de Guayaquil es el de la presencia delfenómeno “Isla de calor”, como consecuencia de la configuracióngeométrica de su casco empresarial que marca un pico de +5,32°Ccon respecto a los registros meteorológicos locales y que ha llegadoa comprometer la calidad del aire a nivel del suelo y los patrones detransferencia térmica con el que se encuentra inmediatamente sobrela cubierta de los edificios. El presente estudio confirma la existenciadel fenómeno con evidencia empírica y pretende ilustrar suaspecto espacial basado en la medición de variables geométricasque denotan una elevada intensidad de usos de suelo en callesdemasiado angostas en relación a la altura de las edificaciones quelas flanquean

Intratumoral Delivery of MDNA55, an Interleukin-4 Receptor Targeted Immunotherapy, by MRI-Guided Convective Delivery for the Treatment of Recurrent Glioblastoma

https://digitalcommons.psjhealth.org/other_pubs/1047/thumbnail.jp

AGREE-S: AGREE II extension for surgical interventions - United European Gastroenterology and European Association for Endoscopic Surgery methodological guide

The Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument has been developed to inform the methodology, reporting and appraisal of clinical practice guidelines. Evidence suggests that the quality of surgical guidelines can be improved, and the structure and content of AGREE II can be modified to help enhance the quality of guidelines of surgical interventions

Cistoadenoma Mucinoso gigante de ovario asociado a adenomucinosis peritoneal diseminada.

Introduction: Mucinous cystadenoma is a multilocular tumor that secretes mucin in the epithelium, is most often formed in the ovary, but can also be located in the pancreas, appendix and very rarely in the urinary bladder or retroperitoneal level. Mucinous neoplasms are mostly benign tumors, however in smaller percentages they may be borderline or potentially malignant. Objectives: This research aims to report a clinical case of giant ovarian mucinous cystoadenoma associated with disseminated peritoneal adenomucinosis. Materials and Methods: A descriptive, retrospective study was performed to describe a clinical case of giant ovarian mucinous cystoadenoma associated with disseminated peritoneal adenomucinosis. Obtained informed consent from the patient and authorization from the Teaching and Research Department, for the review of clinical records and access to images, for the publication of the present case.Clinical case:A 70-year-old female patient who presented a clinical picture of 1 year of evolution characterized by pelvic pain, progressive increase in the abdominal perimeter and abnormal uterine bleeding. To the physical examination in abdomen: presents a large mass that occupies all quadrants of the abdomen and that causes compression and breathing difficulty. as a surgical finding: giant tumor of ovary was found measuring 32x24 x15 cm, weighing approximately 20,000 grams. According to a pathological report, it was a low-grade mucinous cystoadenoma associated with disseminated peritoneal adenomucinosis, which provides a better prognosis. Results: As a benign neoplasm, satisfactory results were obtained. Patient with a good prognosis who is currently in stable clinical conditions, with follow-up at regular checkups. Conclusion: Mucinous cystadenoma is a neoplasm that can originate in the ovary and that can grow much more than other annex masses, Behaving as benign but also recognized as precursors of ovarian cancer and can slowly transform into bordering tumors and evolve into invasive ovarian cancer, so prompt and accurate treatment is vital.Introducción: El Cistoadenoma Mucinoso es un tumor multilocular que secreta mucina en el epitelio, se forma con mayor frecuencia en el ovario, pero también puede localizarse en el páncreas, el apéndice y en muy raras ocasiones en vejiga urinaria o a nivel retroperitoneal. Las neoplasias mucinosas son tumores en su gran mayoría benignos, sin embargo en menor porcentaje pueden ser limítrofes o potencialmente malignos Objetivos: Esta investigación tiene como objetivo reportar un caso clínico de Cistoadenoma Mucinoso gigante de ovario asociado a adenomucinosis peritoneal diseminada. Materiales y Métodos: Se realizó un estudio descriptivo, retrospectivo para descripción de un caso clínico de Cistoadenoma Mucinoso gigante de ovario asociado a adenomucinosis peritoneal diseminada. Se obtuvo consentimiento informado de la paciente y autorización del departamento de Docencia e Investigación, para la revisión de historias clínicas y el acceso a las imágenes, para la publicación del presente caso. Caso clínico: Paciente femenino de 70 años de edad que presentó cuadro clínico de 1 año de evolución caracterizado por dolor pélvico , aumento progresivo del perímetro abdominal y sangrado uterino anormal. Al examen físico en abdomen: presenta una gran masa queocupa todos los cuadrantes del abdomen y que provoca compresión y dificultad respiratoria. como hallazgo quirúrgico: se encontró tumoración gigante de ovario que midió 32 x24 x15 cm, con un peso de 20.000 gramos aproximadamente. Según reporte de anatomía patológica se trató de un cistoadenoma Mucinoso de bajo grado de malignidad, asociado a adenomucinosis peritoneal diseminada, lo que brinda un mejor pronóstico. Resultados: Por tratarse de una neoplasia benigna se obtuvieron resultados satisfactorios. Paciente con pronóstico bueno que actualmente se encuentra en condiciones clínicas estables, con seguimiento en los controles periódicos. Conclusión: El cistoadenoma mucinoso es una neoplasia que puede originarse en el ovario y que puede crecer mucho más que otras masas anexiales, comportándose como benigna pero que también se reconocen como precursores del cáncer de ovario y pueden transformarse lentamente en tumores limítrofes y evolucionar hasta cáncer de ovario invasivo, por lo que, el tratamiento rápido y preciso es vital

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe

Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV

Probing effective field theory operators in the associated production of top quarks with a Z boson in multilepton final states at root s=13 TeV

Peer reviewe

Measurements of Higgs boson production cross sections and couplings in the diphoton decay channel at root s=13 TeV

Measurements of Higgs boson production cross sections and couplings in events where the Higgs boson decays into a pair of photons are reported. Events are selected from a sample of proton-proton collisions at root s = 13TeV collected by the CMS detector at the LHC from 2016 to 2018, corresponding to an integrated luminosity of 137 fb(-1). Analysis categories enriched in Higgs boson events produced via gluon fusion, vector boson fusion, vector boson associated production, and production associated with top quarks are constructed. The total Higgs boson signal strength, relative to the standard model (SM) prediction, is measured to be 1.12 +/- 0.09. Other properties of the Higgs boson are measured, including SM signal strength modifiers, production cross sections, and its couplings to other particles. These include the most precise measurements of gluon fusion and vector boson fusion Higgs boson production in several different kinematic regions, the first measurement of Higgs boson production in association with a top quark pair in five regions of the Higgs boson transverse momentum, and an upper limit on the rate of Higgs boson production in association with a single top quark. All results are found to be in agreement with the SM expectations.Peer reviewe

Measurements of the Electroweak Diboson Production Cross Sections in Proton-Proton Collisions at root s=5.02 TeV Using Leptonic Decays

The first measurements of diboson production cross sections in proton-proton interactions at a center-of-mass energy of 5.02 TeV are reported. They are based on data collected with the CMS detector at the LHC, corresponding to an integrated luminosity of 302 pb(-1). Events with two, three, or four charged light leptons (electrons or muons) in the final state are analyzed. The WW, WZ, and ZZ total cross sections are measured as sigma(WW) = 37:0(-5.2)(+5.5) (stat)(-2.6)(+2.7) (syst) pb, sigma(WZ) = 6.4(-2.1)(+2.5) (stat)(-0.3)(+0.5)(syst) pb, and sigma(ZZ) = 5.3(-2.1)(+2.5)(stat)(-0.4)(+0.5) (syst) pb. All measurements are in good agreement with theoretical calculations at combined next-to-next-to-leading order quantum chromodynamics and next-to-leading order electroweak accuracy