59 research outputs found
Characterize the main adverse events with harm reported in a Teaching Hospital in Minas Gerais
Background and Objectives: adverse events are a major public health problem. The purpose of the study was to characterize the main adverse events with harm reported in a teaching hospital in Minas Gerais. Methods: this is a retrospective cross-sectional descriptive study with quantitative approach, which assessed the reports on adverse events, carried out between January 2015 and December 2018. Pearsonâs chi-square test was applied in order to verify the association between categorical variables. Cramerâs measure V was calculated to assess the degree of association between the respective variables. In the observation of statistically significant results, the Z test was applied to compare proportions with adjustments by the Bonferroni method. Results: a total of 445 adverse events were reported, being the highest number in 2018 (61.8%) involving âAbrasion and frictionâ process (44.7%), which correspond to grades 3 and 4 pressure injuries. Most adverse events were reported by the Emergency Unit (29.2%), and serious harm (7.6%) and deaths (1.3%) were more prevalent in this place. There was a statistically significant association between types of harm and types of incidents (
Framework for the Synthesis of Non-Randomised Studies and Randomised Controlled Trials: A Guidance on Conducting a Systematic Review and Meta-Analysis for Healthcare Decision Making
Introduction: High-quality randomised controlled trials (RCTs) provide the most reliable evidence on the comparative efficacy of new medicines. However, non-randomised studies (NRS) are increasingly recognised as a source of insights into the real-world performance of novel therapeutic products, particularly when traditional RCTs are impractical or lack generalisability. This means there is a growing need for synthesising evidence from RCTs and NRS in healthcare decision making, particularly given recent developments such as innovative study designs, digital technologies and linked databases across countries. Crucially, however, no formal framework exists to guide the integration of these data types. Objectives and Methods: To address this gap, we used a mixed methods approach (review of existing guidance, methodological papers, Delphi survey) to develop guidance for researchers and healthcare decision-makers on when and how to best combine evidence from NRS and RCTs to improve transparency and build confidence in the resulting summary effect estimates. Results: Our framework comprises seven steps on guiding the integration and interpretation of evidence from NRS and RCTs and we offer recommendations on the most appropriate statistical approaches based on three main analytical scenarios in healthcare decision making (specifically, âhigh-bar evidenceâ when RCTs are the preferred source of evidence, âmedium,â and âlowâ when NRS is the main source of inference). Conclusion: Our framework augments existing guidance on assessing the quality of NRS and their compatibility with RCTs for evidence synthesis, while also highlighting potential challenges in implementing it. This manuscript received endorsement from the International Society for Pharmacoepidemiology
GENERALIZED AND SPECIFIC EMOTION IMPAIRMENTS AS POTENTIAL MARKERS OF SEVERITY IN OBSESSIVECOMPULSIVE DISORDER: A PRELIMINARY STUDY USING FACIAL ACTION CODING SYSTEM (FACS)
Background: The role of emotional deficits in the poor outcomes of patients with Obsessive-Compulsive Disorder (OCD) has
been emphasized. Generalized and specific emotional abnormalities have been reported, often related to OCD severity and
functional disabilities. The objective of the present study was to assess the abilities of experiencing and displaying emotions in OCD
patients in response to specific stimuli in relation with the severity of their clinical condition.
Subjects and methods: Thirty-six individuals participated in the study: 10 OCD patients with severe symptoms, 11 with mildmoderate
symptoms, and 15 healthy controls. All participants watched emotion-eliciting video clips while their facial activity was
videotaped. The congruent/incongruent feeling of emotions and the facial expression in reaction to emotions were evaluated.
Results: The two subgroups of OCD patients presented similarly incongruent emotive feelings and facial expressions
(significantly worse than healthy participants). Moreover, OCD patients with severe symptoms expressed the emotion of happiness
and disgust significantly less appropriately than OCD patients with mild-moderate symptoms.
Conclusions: The present data support the hypothesis that impaired emotional processing may: (i) represent a potential
contributor to poor outcome in OCD; (ii) constitute a warning sign for clinicians to establish a more comprehensive protocol for
more severe cases; (iii) influence therapeutic strategies used to treat this disorder
Angular resolution at map level in the QUBIC instrument
Desde su descubrimiento en los años 1960, el fondo cĂłsmico de microondas (CMB, por sus siglas en ingles) se ha convertido en una importante herramienta observacional para entender la fĂsica del universo temprano. El parĂĄmetro r, definido como la amplitud de las perturbaciones tensoriales relativas a las escalares, estĂĄ acotado actualmente al rango r < 0.056. QUBIC es un instrumento terrestre diseñado para buscar señales muy dĂ©biles de los modos B en las anisotropĂas de la polarizaciĂłn a escalas angulares intermedias (l ⌠30 â 200). Para lograr este objetivo, QUBIC combina dos tĂ©cnicas muy usadas en la comunidad CMB: interferometrĂa y bolometrĂa. En este trabajo calculamos la resoluciĂłn angular de una simulaciĂłn end-to-end con dos mĂ©todos independientes: Fit y Sigma. Concluimos que la reconstrucciĂłn que realiza el software es apropiada ya que la resoluciĂłn medida con ambos mĂ©todos calibrados coincide con los valores teĂłricos de la resoluciĂłn esperada.Since its discovery in the 1960s, the cosmic microwave background (CMB) radiation has become a very important observational tool to understand the physics of the early universe. The parameter r, defined as the relative amplitude of tensor to scalar perturbations, is currently constrained to the range r < 0.056. QUBIC is a ground-based instrument designed to search for very weak B-mode signals in polarization anisotropies at intermediate angular scales (l ⌠30 â 200). To achieve this goal, QUBIC combines two widely used techniques in the CMB community: interferometry and bolometry. In this work, we compute the angular resolution for an end-to-end simulation using two independent methods: Fit and Sigma. We conclude that the reconstruction performed by the software is appropriate since the resolution measured with both calibrated methods coincides with the theoretical value of the expected resolution.Fil: Gamboa Lerena, MartĂn Miguel. Universidad Nacional de La Plata. Facultad de Ciencias AstronĂłmicas y GeofĂsicas; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Scoccola, Claudia Graciela. Universidad Nacional de La Plata. Facultad de Ciencias AstronĂłmicas y GeofĂsicas; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Ade, P.. Cardiff University; Reino UnidoFil: Alberro, JosĂ© Gabriel. Universidad Nacional de La Plata. Facultad de Ciencias AstronĂłmicas y GeofĂsicas; ArgentinaFil: Almela, Daniel Alejandro. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Parque Centenario. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. ComisiĂłn Nacional de EnergĂa AtĂłmica. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. Universidad Nacional de San MartĂn. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas; ArgentinaFil: Arnaldi, L. H.. ComisiĂłn Nacional de EnergĂa AtĂłmica; ArgentinaFil: Bonaparte, J.. ComisiĂłn Nacional de EnergĂa AtĂłmica; ArgentinaFil: Bottani, A.. Universidad Nacional de La Plata. Facultad de Ciencias AstronĂłmicas y GeofĂsicas; ArgentinaFil: Cobos Cerutti, Agustin Cleto. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Parque Centenario. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. ComisiĂłn Nacional de EnergĂa AtĂłmica. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. Universidad Nacional de San MartĂn. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas; ArgentinaFil: Duca, Clara. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Parque Centenario. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. ComisiĂłn Nacional de EnergĂa AtĂłmica. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. Universidad Nacional de San MartĂn. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas; ArgentinaFil: Etchegoyen, Alberto. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Parque Centenario. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. ComisiĂłn Nacional de EnergĂa AtĂłmica. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. Universidad Nacional de San MartĂn. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas; ArgentinaFil: Fasciszewski, A.. ComisiĂłn Nacional de EnergĂa AtĂłmica; ArgentinaFil: Ferreyro, Luciano Pablo. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Parque Centenario. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. ComisiĂłn Nacional de EnergĂa AtĂłmica. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. Universidad Nacional de San MartĂn. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas; ArgentinaFil: Fracchia, D.. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Parque Centenario. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. ComisiĂłn Nacional de EnergĂa AtĂłmica. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. Universidad Nacional de San MartĂn. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas; ArgentinaFil: Garcia, Beatriz Alicia. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Parque Centenario. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. ComisiĂłn Nacional de EnergĂa AtĂłmica. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. Universidad Nacional de San MartĂn. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas; ArgentinaFil: GarcĂa Redondo, Manuel ElĂas. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Parque Centenario. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. ComisiĂłn Nacional de EnergĂa AtĂłmica. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. Universidad Nacional de San MartĂn. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas; ArgentinaFil: Gomez Berisso, Mariano. ComisiĂłn Nacional de EnergĂa AtĂłmica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: GonzĂĄlez, Manuel. ComisiĂłn Nacional de EnergĂa AtĂłmica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Harari, Diego Dario. ComisiĂłn Nacional de EnergĂa AtĂłmica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Kristukat, C.. ComisiĂłn Nacional de EnergĂa AtĂłmica; ArgentinaFil: Mundo, Luis Mariano. Universidad Nacional de La Plata. Facultad de Ciencias AstronĂłmicas y GeofĂsicas; ArgentinaFil: Pastoriza, Hernan. ComisiĂłn Nacional de EnergĂa AtĂłmica; Argentina. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas; ArgentinaFil: Platino, Manuel. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Parque Centenario. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. ComisiĂłn Nacional de EnergĂa AtĂłmica. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. Universidad Nacional de San MartĂn. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas; ArgentinaFil: Ringegni, P.. Universidad Nacional de La Plata. Facultad de Ciencias AstronĂłmicas y GeofĂsicas; ArgentinaFil: Romero, Gustavo Esteban. Provincia de Buenos Aires. GobernaciĂłn. ComisiĂłn de Investigaciones CientĂficas. Instituto Argentino de RadioastronomĂa. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Centro CientĂfico TecnolĂłgico Conicet - La Plata. Instituto Argentino de RadioastronomĂa; ArgentinaFil: Salum, Juan Manuel. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Parque Centenario. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. ComisiĂłn Nacional de EnergĂa AtĂłmica. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. Universidad Nacional de San MartĂn. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas; ArgentinaFil: Supanitsky, Alberto Daniel. Consejo Nacional de Investigaciones CientĂficas y TĂ©cnicas. Oficina de CoordinaciĂłn Administrativa Parque Centenario. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. ComisiĂłn Nacional de EnergĂa AtĂłmica. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas. Universidad Nacional de San MartĂn. Instituto de TecnologĂa en DetecciĂłn y AstropartĂculas; ArgentinaFil: Wicek, F.. Institut National de Physique NuclĂ©aire et de Physique des Particules; FranciaFil: Zannoni, M.. Istituto Nazionale Di Fisica Nucleare; ItaliaFil: Zullo, A.. Istituto Nazionale Di Fisica Nucleare; ItaliaReuniĂłn Anual de la AsociaciĂłn Argentina de AstronomĂaViedmaArgentinaUniversidad Nacional de RĂo NegroInstituto Argentino de RadioastronomĂ
Inflammatory bowel disease nurse specialists for patients on biological therapies: a nationwide Italian survey
Background Management of inflammatory bowel disease (IBD) patients requires a multidisciplinary approach. Among the working team, the role of IBD nurse is expected to be particularly relevant when managing patients receiving biological therapies. We performed a survey to assess the presence of IBD nurse in centers where patients were receiving biologics. Methods For this Italian nationwide survey a specific questionnaire was prepared. IBD nurse was defined as a nurse directly involved in all phases of biological therapy, from pre-therapy screening, administration and monitoring during therapy, to follow up performed by a dedicated helpline, completed a specific training on biological therapy therapy, and observed international guidelines. Results A total of 53 Italian IBD centers participated in the survey, and 91 valid questionnaires were collected. Overall, 34 (37.4%) nurses could be classified as IBD specialists. IBD nurses had a significantly higher educational level than other nurses, they were more frequently operating in Central or Southern than in Northern Italy, they were working in an Academic center rather than in a General hospital, and in IBD centers with >25 patients on biological therapy. On the contrary, mean age, gender distribution, years of nursing, and years working in the IBD unit did not significantly differ between IBD and other nurses. Conclusions Our nationwide survey showed that the presence of an IBD nurse is still lacking in the majority of Italian IBD centers where patients receive biological therapies, suggesting a prompt implementation
Associations between depressive symptoms and disease progression in older patients with chronic kidney disease: results of the EQUAL study
Background Depressive symptoms are associated with adverse clinical outcomes in patients with end-stage kidney disease; however, few small studies have examined this association in patients with earlier phases of chronic kidney disease (CKD). We studied associations between baseline depressive symptoms and clinical outcomes in older patients with advanced CKD and examined whether these associations differed depending on sex. Methods CKD patients (>= 65 years; estimated glomerular filtration rate <= 20 mL/min/1.73 m(2)) were included from a European multicentre prospective cohort between 2012 and 2019. Depressive symptoms were measured by the five-item Mental Health Inventory (cut-off <= 70; 0-100 scale). Cox proportional hazard analysis was used to study associations between depressive symptoms and time to dialysis initiation, all-cause mortality and these outcomes combined. A joint model was used to study the association between depressive symptoms and kidney function over time. Analyses were adjusted for potential baseline confounders. Results Overall kidney function decline in 1326 patients was -0.12 mL/min/1.73 m(2)/month. A total of 515 patients showed depressive symptoms. No significant association was found between depressive symptoms and kidney function over time (P = 0.08). Unlike women, men with depressive symptoms had an increased mortality rate compared with those without symptoms [adjusted hazard ratio 1.41 (95% confidence interval 1.03-1.93)]. Depressive symptoms were not significantly associated with a higher hazard of dialysis initiation, or with the combined outcome (i.e. dialysis initiation and all-cause mortality). Conclusions There was no significant association between depressive symptoms at baseline and decline in kidney function over time in older patients with advanced CKD. Depressive symptoms at baseline were associated with a higher mortality rate in men
Detection chain and electronic readout of the QUBIC instrument
The Q and U Bolometric Interferometer for Cosmology (QUBIC) Technical Demonstrator (TD) aiming to shows the feasibility of the combination of interferometry and bolometric detection. The electronic readout system is based on an array of 128 NbSi Transition Edge Sensors cooled at 350mK readout with 128 SQUIDs at 1K controlled and amplified by an Application Specific Integrated Circuit at 40K. This readout design allows a 128:1 Time Domain Multiplexing. We report the design and the performance of the detection chain in this paper. The technological demonstrator unwent a campaign of test in the lab. Evaluation of the QUBIC bolometers and readout electronics includes the measurement of I-V curves, time constant and the Noise Equivalent Power. Currently the mean Noise Equivalent Power is ~ 2 x 10â»ÂčⶠW/âHz
Detection chain and electronic readout of the QUBIC instrument
The Q and U Bolometric Interferometer for Cosmology (QUBIC) Technical Demonstrator (TD) aiming to shows the feasibility of the combination of interferometry and bolometric detection. The electronic readout system is based on an array of 128 NbSi Transition Edge Sensors cooled at 350mK readout with 128 SQUIDs at 1K controlled and amplified by an Application Specific Integrated Circuit at 40K. This readout design allows a 128:1 Time Domain Multiplexing. We report the design and the performance of the detection chain in this paper. The technological demonstrator unwent a campaign of test in the lab. Evaluation of the QUBIC bolometers and readout electronics includes the measurement of I-V curves, time constant and the Noise Equivalent Power. Currently the mean Noise Equivalent Power is ~ 2 x 10â»ÂčⶠW/âHz
Simulations and performance of the QUBIC optical beam combiner
QUBIC, the Q & U Bolometric Interferometer for Cosmology, is a novel ground-based instrument that aims to measure the extremely faint B-mode polarisation anisotropy of the cosmic microwave background at intermediate angular scales (multipoles o
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