Demographic Factors Associated with Hantavirus Infection in Bank Voles (Clethrionomys glareolus)

The bank vole (Clethrionomys glareolus) is the natural reservoir of Puumala virus (PUUV), a species in the genus Hantavirus. PUUV is the etiologic agent of nephropathia epidemica, a mild form of hemorrhagic fever with renal syndrome. Factors that influence hantavirus transmission within host populations are not well understood. We evaluated a number of factors influencing on the association of increased PUUV infection in bank voles captured in a region in northern Sweden endemic for the virus. Logistic regression showed four factors that together correctly predicted 80% of the model outcome: age, body mass index, population phase during sampling (increase, peak, or decline/low), and gender. This analysis highlights the importance of population demography in the successful circulation of hantavirus. The chance of infection was greatest during the peak of the population cycle, implying that the likelihood of exposure to hantavirus increases with increasing population density

Anthrax outbreak in a Swedish beef cattle herd - 1st case in 27 years: Case report

After 27 years with no detected cases, an outbreak of anthrax occurred in a beef cattle herd in the south of Sweden. The outbreak was unusual as it occurred in winter, in animals not exposed to meat-and-bone meal, in a non-endemic country

New psychoactive substances (NPS) on cryptomarket fora: An exploratory study of characteristics of forum activity between NPS buyers and vendors

Background The continual diversification of new psychoactive substances (NPS) circumventing legislation creates a public health and law enforcement challenge, and one particularly challenged by availability on Hidden Web cryptomarkets. Methods This is the first study of its kind which aimed to explore and characterise cryptomarket forum members’ views and perspectives on NPS vendors and products within the context of Hidden Web community dynamics. An internal site search was conducted on two cryptomarkets popular with NPS vendors and hosting fora; Alphabay and Valhalla, using the search terms of 40 popular NPS in the seven categories of stimulant/cathinone; GABA activating; hallucinogen, dissociative, cannabinoid, opioid and other/unspecified/uncategorised NPS. 852 identified threads relating to the discussion of these NPS were generated. Following exclusion of duplicates, 138 threads remained. The Empirical Phenomenological Psychological method of data analysis was applied. Four themes and 32 categories emerged. Results 120 vendors selling NPS were visible on Alphabay, and 21 on Valhalla. Themes were ‘NPS Cryptomarkets and Crypto-community interest in NPS’ ‘Motives for NPS use’ ‘Indigenous Crypto Community Harm Reduction’ and ‘Cryptomarket Characteristics underpinning NPS trafficking’, with two higher levels of abstraction centring on ‘NPS vendor reputation’ and ‘NPS transactioning for personal use’. NPS cryptomarket characteristics centred on generation of trust, honesty and excellent service. Users appeared well informed, with harm reduction and vendor information exchange central to NPS market dynamics. GABA activating substances appeared most popular in terms of buyer interest on cryptomarkets. Interest in sourcing ‘old favorite’ stimulant and dissociative NPS was evident, alongside the sequential and concurrent poly use of NPS, and use of NPS with illicit drugs such as MDMA. Conclusion Continued monitoring of new trends in NPS within Surface Web and cryptomarkets are warranted. A particular focus on the rising market in prescribed benzodiazepine and Z-hypnotic drugs should be included. © 2016 Elsevier B.V

Early Intervention for Children Aged 0 to 2 Years With or at High Risk of Cerebral Palsy International Clinical Practice Guideline Based on Systematic Reviews:International Clinical Practice Guideline Based on Systematic Reviews

IMPORTANCE: Cerebral palsy (CP) is the most common childhood physical disability. Early intervention for children younger than 2 years with or at risk of CP is critical. Now that an evidence-based guideline for early accurate diagnosis of CP exists, there is a need to summarize effective, CP-specific early intervention and conduct new trials that harness plasticity to improve function and increase participation. Our recommendations apply primarily to children at high risk of CP or with a diagnosis of CP, aged 0 to 2 years. OBJECTIVE: To systematically review the best available evidence about CP-specific early interventions across 9 domains promoting motor function, cognitive skills, communication, eating and drinking, vision, sleep, managing muscle tone, musculoskeletal health, and parental support. EVIDENCE REVIEW: The literature was systematically searched for the best available evidence for intervention for children aged 0 to 2 years at high risk of or with CP. Databases included CINAHL, Cochrane, Embase, MEDLINE, PsycInfo, and Scopus. Systematic reviews and randomized clinical trials (RCTs) were appraised by A Measurement Tool to Assess Systematic Reviews (AMSTAR) or Cochrane Risk of Bias tools. Recommendations were formed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework and reported according to the Appraisal of Guidelines, Research, and Evaluation (AGREE) II instrument. FINDINGS: Sixteen systematic reviews and 27 RCTs met inclusion criteria. Quality varied. Three best-practice principles were supported for the 9 domains: (1) immediate referral for intervention after a diagnosis of high risk of CP, (2) building parental capacity for attachment, and (3) parental goal-setting at the commencement of intervention. Twenty-eight recommendations (24 for and 4 against) specific to the 9 domains are supported with key evidence: motor function (4 recommendations), cognitive skills (2), communication (7), eating and drinking (2), vision (4), sleep (7), tone (1), musculoskeletal health (2), and parent support (5). CONCLUSIONS AND RELEVANCE: When a child meets the criteria of high risk of CP, intervention should start as soon as possible. Parents want an early diagnosis and treatment and support implementation as soon as possible. Early intervention builds on a critical developmental time for plasticity of developing systems. Referrals for intervention across the 9 domains should be specific as per recommendations in this guideline

Restaurering av sekelskifteshus

The purpose of this work is Restoration of Old Grand Hotel in Gävle, Sweden, with a focus on the attic. The focus of this thesis is the cultural-historical values seen from an engineer’s point of view when restoring old buildings. In the case study, the important parameters will be the cultural-historical values in the building, combined with ventilation and evacuation.The architect of The Old Grand Hotel was Ture Stenberg and the building was finished in 1901. The building is U-formed and has five stores and a cellar. The culture-historical values worth saving in the attic are the brick floor, the east wing and the round original windows. A preliminary investigation of what is worth saving has been made of a curator from Gävle museum. To be successful when renovating an attic you need a lot of flexible solutions.In the summer of 2011 Elite Hotels bought Old Grand Hotel from Diös fastigheter AB to re-establish the building to a hotel. The MD and only owner of Elite Hotels of Sweden is Bicky Chakraborty. Mr. Chakraborty was born 1941 in a city close to Calcutta, India, and he came to Sweden in 1965. Elite Hotel´s concept is to offer modern and efficient business in traditional hotels and restaurants of high quality.The purpose of this case study is to plan the attic according to culture-historical values and also combining it with technical solutions of today. When restoring old buildings it´s important to care for both historical and environmental values.If you are going to be successful as an engineer in this kind of projects you need a lot of knowledge and experience from similar projects and it´s also good to have a personal interest. The more historical information you can get about the building, the better. If no one cared about the old values nothing would be saved for the future and we would lose a part of our history.Elite Hotels demanded at least 120 hotel rooms in the building and this will be fulfilled. There are 127 rooms today. In the attic there will be nine ordinary rooms and one penthouse. Parts of the attic are saved in original; the brick floor, most of the windows and timber beams for example.I think the planning of the attic turn out very well and all the demands concerning ventilation and evacuation were achieved. We couldn´t at all times avoid conflicts between the three focus parts. But in our final solution we managed to save everything that the curator wanted saved.Validerat; 20120429 (anonymous