Tunisia at the Forefront of the Arab World: Two Waves of Gender Legislation

Starting in the 1950s and ever since, Tunisia has implemented gender legislation expanding women\u27s rights in family law. The ground breaking phase occurred with the promulgation of the Code of Personal Status in the mid-1950s during the formation of a national state in the aftermath of independence from French colonial rule. Another major phase occurred in the 1990s with citizenship law reforms as embodied in the Tunisian Code of Nationality. As a result of these two major phases, Tunisia has been at the fore front of woman friendly legislative changes in the Arab- Muslim world and is widely recognized as such. At a time when issues of women\u27s rights are not only highly debated, but sometimes violently contested in Muslim countries, the Tunisian case requires examination. This Article documents the two major phases of reforms in favor of women\u27s rights in Tunisia and outlines the conditions that permitted or encouraged the continuity over the last half century. The first wave of reforms in the 1950s transformed the legal construction of gender roles within the family. The second wave in the 1990s redefined the conditions for the transmission of Tunisian citizenship. In painting social change in broad strokes, I analyze the initial and pioneering phase of the 1950s as a reform resulting from the actions of a newly formed national state interested in building a new society at the end of colonial rule. By contrast, the role of women\u27s agency came into play in Tunisia starting in the 1980s and became more robust in the 1990s. The evidence suggests that different political configurations can be conducive to reform in different periods

Gendering the Politics of Alienation: Arab Revolution and Women’s Sentiments of Loss and Despair

The article suggests that from the start of the revolutions in the Arab region in late 2010 a connection between the law, state, political economy, gender norms and orientalist ideology has formed the foundation of women’s systematic exclusion from politics. As a consequence, women’s alienation from politics – a necessity for the restoration of old regimes of power – took on various forms, including: externalising, exceptionalising, and celebrating women’s revolutionary acts and contributions to revolutions. This article examines these processes that created the ideological and material conditions of women’s alienation, estranging their political involvement and exposing them to various forms of violence The article suggests that alienation of women from revolutions relied on gender normative ideology to create women’s supposedly unique and distinct interests; according to this ideology, women attempt to satisfy such interests through dancing, nikah al-jihad or the desire to be sexually harassed. Women’s power and needs were moulded as distinctly different from those of men. Hence, forms of alienation diminished women’s roles as initiators, producers of revolutions, rendering women apart. This article shows that, whilst forms of alienation differed in various political phases and often contradicted each other, the intent of each form of alienation was to show a defect, a mistake in women’s acts, and thus establish the supposedly ‘correct’ characteristics of women protesters based on women’s intrinsic nature. Through this, gender normativity was reproduced to serve the political class(s)’s specific interests, 2 determining the linkages between the alienation of women from politics, the alienation of the revolution from its people, and the entire sphere of politics. The sphere of politics not only relates to political activism and conflict between revolutions and counterrevolutions, it is also a battlefield for the (re)production of knowledge

Habitat-related seed germination traits in alpine habitats

Understanding the key aspects of plant regeneration from seeds is crucial in assessing species assembly to their habitats. However, the regenerative traits of seed dormancy and germination are underrepresented in this context. In the alpine zone, the large species and microhabitat diversity provide an ideal context to assess habitat-related regenerative strategies. To this end, seeds of 53 species growing in alpine siliceous and calcareous habitats (6230 and 6170 of EU Directive 92/43, respectively) were exposed to different temperature treatments under controlled laboratory conditions. Germination strategies in each habitat were identified by clustering with k-means. Then, phylogenetic least squares correlations (PGLS) were fitted to assess germination and dormancy differences between species' main habitat (calcareous and siliceous), microhabitat (grasslands, heaths, rocky, and species with no specific microhabitats), and chorology (arctic-alpine and continental). Calcareous and siliceous grasslands significantly differ in their germination behaviour with a slow, mostly overwinter germination and high germination under all conditions, respectively. Species with high overwinter germination occurs mostly in heaths and have an arctic-alpine distribution. Meanwhile, species with low or high germinability in general inhabit in grasslands or have no specific microhabitat (they belong to generalist), respectively. Alpine species use different germination strategies depending on habitat provenance, species' main microhabitat, and chorotype. Such differences may reflect adaptations to local environmental conditions and highlight the functional role of germination and dormancy in community ecology

The Patriarchal Bargain in a Context of Rapid Changes to Normative Gender Roles: Young Arab Women’s Role Conflict in Qatar

Social norms in patriarchal countries in the Middle East are changing at differing rates. In Qatar, expectations about education have shifted, and women’s participation in higher education is normative. However, women’s participation in the workforce remains relatively low, and women still are expected to perform all household and child-rearing activities. Interviews with 27 18–25 year-old Qatari women enrolled in college in Qatar are used to illustrate the conflict between norms about education, workforce, and family. Many young women resolve this normative conflict by giving preference to family over work and education. Other women hold conflicting norms and goals for their future without acknowledging the normative conflict. Overall, young women in this sample feared divorce, were uncertain about customary family safety nets, and thus desired financial independence so they would be able to support themselves if they were left alone later in life due to divorce, or the death of their husband. The Qatari government should revisit the appropriateness of continuing to emphasize the patriarchal family structure and socially conservative family norms, if they desire to advance women in their society

Epigenetic regulation of CD44 in Hodgkin and non-Hodgkin lymphoma

<p>Abstract</p> <p>Background</p> <p>Epigenetic inactivation of tumor suppressor genes (TSG) by promoter CpG island hypermethylation is a hallmark of cancer. To assay its extent in human lymphoma, methylation of 24 TSG was analyzed in lymphoma-derived cell lines as well as in patient samples.</p> <p>Methods</p> <p>We screened for TSG methylation using methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) in 40 lymphoma-derived cell lines representing anaplastic large cell lymphoma, Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), Hodgkin lymphoma and mantle cell lymphoma (MCL) as well as in 50 primary lymphoma samples. The methylation status of differentially methylated <it>CD44 </it>was verified by methylation-specific PCR and bisulfite sequencing. Gene expression of <it>CD44 </it>and its reactivation by DNA demethylation was determined by quantitative real-time PCR and on the protein level by flow cytometry. Induction of apoptosis by anti-CD44 antibody was analyzed by annexin-V/PI staining and flow cytometry.</p> <p>Results</p> <p>On average 8 ± 2.8 of 24 TSG were methylated per lymphoma cell line and 2.4 ± 2 of 24 TSG in primary lymphomas, whereas 0/24 TSG were methylated in tonsils and blood mononuclear cells from healthy donors. Notably, we identified that <it>CD44 </it>was hypermethylated and transcriptionally silenced in all BL and most FL and DLBCL cell lines, but was usually unmethylated and expressed in MCL cell lines. Concordant results were obtained from primary lymphoma material: <it>CD44 </it>was not methylated in MCL patients (0/11) whereas <it>CD44 </it>was frequently hypermethylated in BL patients (18/29). In cell lines with <it>CD44 </it>hypermethylation, expression was re-inducible at mRNA and protein levels by treatment with the DNA demethylating agent 5-Aza-2'-deoxycytidine, confirming epigenetic regulation of <it>CD44</it>. CD44 ligation assays with a monoclonal anti-CD44 antibody showed that CD44 can mediate apoptosis in CD44⁺lymphoma cells. <it>CD44 </it>hypermethylated, CD44^-lymphoma cell lines were consistently resistant towards anti-CD44 induced apoptosis.</p> <p>Conclusion</p> <p>Our data show that <it>CD44 </it>is epigenetically regulated in lymphoma and undergoes <it>de novo </it>methylation in distinct lymphoma subtypes like BL. Thus <it>CD44 </it>may be a promising new epigenetic marker for diagnosis and a potential therapeutic target for the treatment of specific lymphoma subtypes.</p

Structure and stability in TMC-1: Analysis of NH3molecular line andHerschelcontinuum data

Aims. We examined the velocity, density, and temperature structure of Taurus molecular cloud-1 (TMC-1), a filamentary cloud in a nearby quiescent star forming area, to understand its morphology and evolution. Methods. We observed high signal-to-noise (S/N), high velocity resolution NH3(1,1), and (2, 2) emission on an extended map. By fitting multiple hyperfine-split line profiles to the NH3(1, 1) spectra, we derived the velocity distribution of the line components and calculated gas parameters on several positions. Herschel SPIRE far-infrared continuum observations were reduced and used to calculate the physical parameters of the Planck Galactic Cold Clumps (PGCCs) in the region, including the two in TMC-1. The morphology of TMC-1 was investigated with several types of clustering methods in the parameter space consisting of position, velocity, and column density. Results. Our Herschel-based column density map shows a main ridge with two local maxima and a separated peak to the south-west. The H2 column densities and dust colour temperatures are in the range of 0.5−3.3 × 1022 cm−2 and 10.5−12 K, respectively. The NH3 column densities and H2 volume densities are in the range of 2.8−14.2 × 1014 cm−2 and 0.4−2.8 × 104 cm−3. Kinetic temperatures are typically very low with a minimum of 9 K at the maximum NH3 and H2 column density region. The kinetic temperature maximum was found at the protostar IRAS 04381+2540 with a value of 13.7 K. The kinetic temperatures vary similarly to the colour temperatures in spite of the fact that densities are lower than the critical density for coupling between the gas and dust phase. The k-means clustering method separated four sub-filaments in TMC-1 with masses of 32.5, 19.6, 28.9, and 45.9 Mo and low turbulent velocity dispersion in the range of 0.13−0.2 km s−1. Conclusions. The main ridge of TMC-1 is composed of four sub-filaments that are close to gravitational equilibrium. We label these TMC-1F1 through F4. The sub-filaments TMC-1F1, TMC-1F2, and TMC-1F4 are very elongated, dense, and cold. TMC-1F3 is a little less elongated and somewhat warmer, and probably heated by the Class I protostar, IRAS 04381+2540, which is embedded in it. TMC-1F3 is approximately 0.1 pc behind TMC1-F1. Because of its structure, TMC-1 is a good target to test filament evolution scenarios

Copy number signatures and mutational processes in ovarian carcinoma.

The genomic complexity of profound copy number aberrations has prevented effective molecular stratification of ovarian cancers. Here, to decode this complexity, we derived copy number signatures from shallow whole-genome sequencing of 117 high-grade serous ovarian cancer (HGSOC) cases, which were validated on 527 independent cases. We show that HGSOC comprises a continuum of genomes shaped by multiple mutational processes that result in known patterns of genomic aberration. Copy number signature exposures at diagnosis predict both overall survival and the probability of platinum-resistant relapse. Measurement of signature exposures provides a rational framework to choose combination treatments that target multiple mutational processes.NIHR, Ovarian Cancer Action, Cancer Research UK Cambridge Centre, Cambridge Experimental Cancer Medicine Centr