“They Always Make It Right. We Can Do That for Everybody”: Young Adolescents Considering (In)Justice When Reading

This paper draws on Bakhtin’s (1981) notions of discourse and ideological becoming to investigate how adolescents’ experiences with young adult literature and other texts might inform their thinking around issues of social justice. We engaged in a number of activities with the young adolescent participants: thought maps, illustrations of poignant scenes, written accounts of personal experiences, and focus group interviews. Using these activities as our data for this paper, we explain how the young adolescent participants called upon discourses of social justice to engage in the process of ideological becoming. Thus, the paper concludes that texts have the potential to affect students’ ways of thinking and being in profound ways

Engaged Hesitancy as (Queer) Activism

In this Teaching Note, I reflect on my experience with a parent's homophobia around her son's choice to read a book featuring LGBTQ+ characters. I contemplate my responses--or lack thereof--and, while considering various theories of gender, sexuality, and activism, I consider how else I might have responded to protect the student while promoting possible futures for him. Supporting students is not a one-size-fits-all endeavor but always requires thought and care

From Delhi to Mumbai, Apple Seeks a Bigger Slice of The Pie

From Delhi to Mumbai, Apple Seeks a Bigger Slice of The Pie in India: An International Marketing Case Study Mike Williams, Adam Pedraza, Taylor Greer, Brent Cassidy, Nick Hill, Chandler Burger, Steven Wehde, and Caleb Fortney Abstract Apple Inc., headquartered in the United States, is the world’s largest technology company with revenues of 265 billion as of 2018 (Johnson, 2012). Apple has been trying to compete in India’s smartphone market, the world’s fastest-growing and second-largest smartphone market globally, accounting for nearly 30 million purchases per quarter (Sheth, 2019). Despite its success in the U.S., Apple has not been able to overcome the unique challenges it faces in India. It faces entrenched Asian competitors like Xiaomi, Samsung, Vivo, and Oppo, who have a dominant share of the market. Indian consumers are very price sensitive and value deals (Lu, Yu, & Soman, 2016) which means Apple’s high-quality, premium pricing strategy only appeals to a small segment of affluent consumers. However, its competitors offer similar or even more localized features, at much lower prices. Indeed, over 75% of smartphones sold in India cost less than 250, whereas the iPhone is priced starting at $550 or higher (Cohan, 2018). Apple also faces other challenges in India, such as limited Internet connectivity, sourcing issues due to the government’s “Make in India” initiative, and limited consumer purchasing ability (Kashyap, 2017). This case study examines Apple’s overall marketing strategy in India in the context of the smartphone industry, competitors, consumer attitudes and government regulations. This case study will initiate discussions on how Apple must adapt its strategy to be able to succeed in India’s growing smartphone market. Keywords: Apple, iPhones, smartphones, India, mobile phones, emerging market, case study, international marketing Note: References available on request

City of Hitchcock Comprehensive Plan 2020-2040

Hitchcock is a small town located in Galveston County (Figure 1.1), nestled up on the Texas Gulf Coast. It lies about 40 miles south-east of Houston. The boundaries of the city encloses an area of land of 60.46 sq. miles, an area of water of 31.64 sq. miles at an elevation just 16 feet above sea level. Hitchcock has more undeveloped land (~90% of total area) than the county combined. Its strategic location gives it a driving force of opportunities in the Houston-Galveston Region.The guiding principles for this planning process were Hitchcock’s vision statement and its corresponding goals, which were crafted by the task force. The goals focus on factors of growth and development including public participation, development considerations, transportation, community facilities, economic development, parks, and housing and social vulnerabilityTexas Target Communitie

The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens

Background The Critical Assessment of Functional Annotation (CAFA) is an ongoing, global, community-driven effort to evaluate and improve the computational annotation of protein function. Results Here, we report on the results of the third CAFA challenge, CAFA3, that featured an expanded analysis over the previous CAFA rounds, both in terms of volume of data analyzed and the types of analysis performed. In a novel and major new development, computational predictions and assessment goals drove some of the experimental assays, resulting in new functional annotations for more than 1000 genes. Specifically, we performed experimental whole-genome mutation screening in Candida albicans and Pseudomonas aureginosa genomes, which provided us with genome-wide experimental data for genes associated with biofilm formation and motility. We further performed targeted assays on selected genes in Drosophila melanogaster, which we suspected of being involved in long-term memory. Conclusion We conclude that while predictions of the molecular function and biological process annotations have slightly improved over time, those of the cellular component have not. Term-centric prediction of experimental annotations remains equally challenging; although the performance of the top methods is significantly better than the expectations set by baseline methods in C. albicans and D. melanogaster, it leaves considerable room and need for improvement. Finally, we report that the CAFA community now involves a broad range of participants with expertise in bioinformatics, biological experimentation, biocuration, and bio-ontologies, working together to improve functional annotation, computational function prediction, and our ability to manage big data in the era of large experimental screens.Peer reviewe

The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens

BackgroundThe Critical Assessment of Functional Annotation (CAFA) is an ongoing, global, community-driven effort to evaluate and improve the computational annotation of protein function.ResultsHere, we report on the results of the third CAFA challenge, CAFA3, that featured an expanded analysis over the previous CAFA rounds, both in terms of volume of data analyzed and the types of analysis performed. In a novel and major new development, computational predictions and assessment goals drove some of the experimental assays, resulting in new functional annotations for more than 1000 genes. Specifically, we performed experimental whole-genome mutation screening in Candida albicans and Pseudomonas aureginosa genomes, which provided us with genome-wide experimental data for genes associated with biofilm formation and motility. We further performed targeted assays on selected genes in Drosophila melanogaster, which we suspected of being involved in long-term memory.ConclusionWe conclude that while predictions of the molecular function and biological process annotations have slightly improved over time, those of the cellular component have not. Term-centric prediction of experimental annotations remains equally challenging; although the performance of the top methods is significantly better than the expectations set by baseline methods in C. albicans and D. melanogaster, it leaves considerable room and need for improvement. Finally, we report that the CAFA community now involves a broad range of participants with expertise in bioinformatics, biological experimentation, biocuration, and bio-ontologies, working together to improve functional annotation, computational function prediction, and our ability to manage big data in the era of large experimental screens.</p

JAMI AND TENA - A FUSION OF GPS AND IP

The Joint Advanced Missile Instrumentation (JAMI) project has created a very effective high dynamic Time Space Position Information (TSPI) solution and the Test and Training Enabling Architecture (TENA) is a very effective way to share data over a network. Can JAMI and TENA work together? This paper answers that question.International Foundation for TelemeteringProceedings from the International Telemetering Conference are made available by the International Foundation for Telemetering and the University of Arizona Libraries. Visit http://www.telemetry.org/index.php/contact-us if you have questions about items in this collection

Evidence of selective reporting bias in hematology journals: A systematic review

<div><p>Introduction</p><p>Selective reporting bias occurs when chance or selective outcome reporting rather than the intervention contributes to group differences. The prevailing concern about selective reporting bias is the possibility of results being modified towards specific conclusions. In this study, we evaluate randomized controlled trials (RCTs) published in hematology journals, a group in which selective outcome reporting has not yet been explored.</p><p>Methods</p><p>Our primary goal was to examine discrepancies between the reported primary and secondary outcomes in registered and published RCTs concerning hematological malignancies reported in hematology journals with a high impact factor. The secondary goals were to address whether outcome reporting discrepancies favored statistically significant outcomes, whether a pattern existed between the funding source and likelihood of outcome reporting bias, and whether temporal trends were present in outcome reporting bias. For trials with major outcome discrepancies, we contacted trialists to determine reasons for these discrepancies. Trials published between January 1, 2010 and December 31, 2015 in <i>Blood</i>; <i>British Journal of Haematology</i>; <i>American Journal of Hematology</i>; <i>Leukemia</i>; and <i>Haematologica</i> were included.</p><p>Results</p><p>Of 499 RCTs screened, 109 RCTs were included. Our analysis revealed 118 major discrepancies and 629 total discrepancies. Among the 118 discrepancies, 30 (25.4%) primary outcomes were demoted, 47 (39.8%) primary outcomes were omitted, and 30 (25.4%) primary outcomes were added. Three (2.5%) secondary outcomes were upgraded to a primary outcome. The timing of assessment for a primary outcome changed eight (6.8%) times. Thirty-one major discrepancies were published with a <i>P</i>-value and twenty-five (80.6%) favored statistical significance. A majority of authors whom we contacted cited a pre-planned subgroup analysis as a reason for outcome changes.</p><p>Conclusion</p><p>Our results suggest that outcome changes occur frequently in hematology trials. Because RCTs ultimately underpin clinical judgment and guide policy implementation, selective reporting could pose a threat to medical decision making.</p></div