5 research outputs found
Santos: Religious Folk Art of New Mexico, 1750 to 1850
- Author
- Publication venue
- 'Oklahoma State University Library'
- Publication date
- 01/05/1980
- Field of study
This study was begun out of a sincere love for the art of the santos. It will cover the santos' beginnings in New Mexico around 1750 and discuss the historical causes for both the santos' rise to popularity and their later demise. This study will attempt to cover all of the factors that had an effect on their creation and style and to discuss what the santos' contribution to folk art in America might be.Housing, Design, and Consumer Resource
Mapping the human genetic architecture of COVID-19
- Author
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- Xue X.
- Yadav A.
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- Yoshida S.
- Yoshida T.
- Yoshihara T.
- Yoshiya K.
- Yoshiyama T.
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- Yun N.
- Zak A.
- Zaki A.
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- Zanella A.
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- Zoller H.
- Zollner S.
- Zongo O.
- Zucchi P.
- Zyndorf M.
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease
A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer.
- Author
- A Cox
- A Gusev
- A Gusev
- A Kramer
- A. Heather Eliassen
- Abigail Thomas
- AD Beggs
- AD Treszezamsky
- Alexander Gusev
- Alexander Hein
- Alfons Meindl
- Alice S. Whittemore
- Alicja Wolk
- Alison M. Dunning
- AM Dunning
- AN Barbeira
- Andreas Schneeweiss
- Angela Cox
- Anglian Breast Cancer Study Group.
- Anja Rudolph
- Ann Smeets
- Anna González-Neira
- Anna Jakubowska
- Anna Marie Mulligan
- Anthony J. Swerdlow
- Antoinette Hollestelle
- Argyrios Ziogas
- Arto Mannermaa
- AT Shaw
- Atocha Romero
- Audrey Jung
- B Devlin
- B He
- B Zhang
- Barbara Burwinkel
- Belynda Hicks
- Bingshan Li
- BN Howie
- Brian D. Carter
- Brigitte Rack
- Børge G. Nordestgaard
- C Page Le
- C Roadmap Epigenomics
- Camilla Wendt
- Carl Blomqvist
- Caroline Baynes
- Celine Vachon
- Chenjie Zeng
- Christine L. Clarke
- Christoph Engel
- Christopher A. Haiman
- Christopher G. Scott
- Clarice R. Weinberg
- Craig Luccarini
- D Hnisz
- D Lee
- Dale P. Sandler
- Daniel C. Tessier
- Daniel Vincent
- David Cox
- David E. Goldgar
- David J. Hunter
- David Van Den Berg
- Diana M. Eccles
- Diana Torres
- Dieter Flesch-Janys
- Diether Lambrechts
- Dijana Plaseska-Karanfilska
- Dimitrios Mavroudis
- DM Glubb
- Douglas F. Easton
- DS DeLuca
- E Marouli
- Elad Ziv
- Elinor J. Sawyer
- Elza Khusnutdinova
- Emily Hallberg
- Emmanouil Saloustros
- ER Gamazon
- Eric Hahnen
- Esdy Rozali
- Esther M. John
- F Kamangar
- Fares Al-Ejeh
- Federico Canzian
- Fergus J. Couch
- Gad Rennert
- Georgia Chenevix-Trench
- Graham G. Giles
- Guanmengqian Huang
- H Darabi
- H Darabi
- Hanne Meijers-Heijboer
- Hans Christiansen
- Hans Wildiers
- Harald Surowy
- Hedy S. Rennert
- Heli Nevanlinna
- Helian Feng
- Henrik Flyger
- Hermann Brenner
- Hiltrud Brauch
- HK Finucane
- Hoda Anton-Culver
- Håkan Olsson
- Irene L. Andrulis
- Isabel dos-Santos-Silva
- Ivana Maleva Kostovska
- J Yang
- J Yang
- J. Esteban Castelao
- Jack A. Taylor
- Jacques Simard
- Jan Lubinski
- Jane Romm
- Janet E. Olson
- Javier Benitez
- JD French
- JD Hoffman
- Jeffery Meyer
- Jennifer Stone
- Jenny Chang-Claude
- Jingmei Li
- Jirong Long
- JL Caswell
- JL Koh
- JoAnn E. Manson
- Joe Dennis
- John J. Spinelli
- John L. Hopper
- Jolanta Lissowska
- Jonathan Beesley
- Jonine Figueroa
- Julian Peto
- Julie M. Cunningham
- K Lawrenson
- K Michailidou
- K Michailidou
- K Michailidou
- Kamila Czene
- Kathrin Thöne
- Katri Pylkäs
- Keith Humphreys
- KH Walen
- Kimberly F. Doheny
- KL Nathanson
- Kristan J. Aronson
- Kristine Jones
- Kyriaki Michailidou
- L Kan
- LA Hindorff
- Lang Wu
- Laura Fachal
- Lin Fritschi
- Loic Le Marchand
- Louise Brinton
- Lucy Xia
- M Garcia-Closas
- M Ghoussaini
- M Ghoussaini
- M Melé
- Manjeet K. Bolla
- Manuela Gago-Dominguez
- Margriet Collée
- Marike Gabrielson
- Marina Bermisheva
- Marjanka K. Schmidt
- Mark S. Goldberg
- Martha J. Shrubsole
- Martine Dumont
- Mary B. Daly
- Mary Beth Terry
- Matthias W. Beckmann
- Maya Ghoussaini
- MC Southey
- Melissa C. Southey
- MH Kim
- Mia M. Gaudet
- Michael E. Jones
- Michael J. Kerin
- Michael P. Lux
- Michael Untch
- Mikael Eriksson
- Miriam Dwek
- Mitul Shah
- ML Freedman
- Montserrat García-Closas
- Myrto Barrdahl
- Nadege Presneau
- Natalia V. Bogdanova
- Nazneen Rahman
- Nichola Johnson
- Niclas Håkansson
- NJ Camp
- O Corradin
- O Delaneau
- O Stegle
- Olivia Fletcher
- Olufunmilayo I. Olopade
- P Casbas-Hernandez
- Paolo Peterlongo
- Paolo Radice
- Pascal Guénel
- Patricia Harrington
- Patrick Neven
- Paul D. P. Pharoah
- Paul L. Auer
- Per Broberg
- Per Hall
- Peter A. Fasching
- Peter Devilee
- Peter Hillemanns
- Peter Kraft
- Q Cai
- Q Li
- Q Li
- Qin Wang
- Qiuyin Cai
- Quinten Waisfisz
- R Marcotte
- Richard T. Barfield
- Rita K. Schmutzler
- RL Milne
- Rob A. E. M. Tollenaar
- Robert J. MacInnis
- Robert N. Hoover
- Robert Winqvist
- Rodney J. Scott
- Roger L. Milne
- Ross Prentice
- Rudolf Kaaks
- Rulla M. Tamimi
- S McCarthy
- Sara Lindström
- Sara Margolin
- Sara Y. Brucker
- Sheila Seal
- Sibylle Loibl
- Simon S. Cross
- SS Rao
- Stacey L. Edwards
- Sten Cornelissen
- Stig E. Bojesen
- Sune F. Nielsen
- Susan L. Neuhausen
- Susan M. Gapstur
- The ENCODE Project Consortium
- The FANTOM Consortium and the RIKEN PMI and CLST (DGT).
- The GTEx Consortium.
- Thilo Dörk
- Thérèse Truong
- Ting-Yuan David Cheng
- Tom Maishman
- Trinidad Caldés
- Ursula Eilber
- Usha Menon
- Ute Hamann
- V Turcot
- Valerie Rhenius
- Veli-Matti Kosma
- Vessela N. Kristensen
- Volker Arndt
- W Zheng
- Walter C. Willett
- Wei Shi
- Wei Zheng
- William Tapper
- Wing-Yee Lo
- Wolfgang Janni
- WY Lin
- X Guo
- X Huang
- Xiao-Ou Shu
- Xiaohong R. Yang
- Xiaoqing Chen
- Xingyi Guo
- Y Li
- Y Sanchez
- Y Sekine
- Yingchang Lu
- Z Zhu
- Publication venue
- Nat Genet
- Publication date
- 01/01/2018
- Field of study
The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify novel risk loci and likely causal genes, we performed a transcriptome-wide association study evaluating associations of genetically predicted gene expression with breast cancer risk in 122,977 cases and 105,974 controls of European ancestry. We used data from the Genotype-Tissue Expression Project to establish genetic models to predict gene expression in breast tissue and evaluated model performance using data from The Cancer Genome Atlas. Of the 8,597 genes evaluated, significant associations were identified for 48 at a Bonferroni-corrected threshold of P < 5.82 × 10-6, including 14 genes at loci not yet reported for breast cancer. We silenced 13 genes and showed an effect for 11 on cell proliferation and/or colony-forming efficiency. Our study provides new insights into breast cancer genetics and biology
Whole-genome sequencing reveals host factors underlying critical COVID-19
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- Abd Elghafar Mohamed S.
- Abdel-Aziz Mahmoud
- Abdelrazik Marwa
- Abdollahi Hamed
- Abdullah T.
- Abecasis Goncalo
- Abedalthagafi M.
- Abel Lynn
- Abernathy C.
- Abraheem Azmeralde
- Abul-Husn Noura S.
- Acquilini D.
- Adams C.
- Adams Emma L.
- Adams K.
- Adamsara Alireza
- Adanini Olurenke
- Adeleye O.
- Adra D.
- Afilalo J.
- Afilalo M.
- Afolabi D.
- Afrasiabi Z.
- Agasou A.
- Agrawal Shruti
- Agüero D.
- Ahmad N.
- Ahmadi Saeideh
- Ahmed A.
- Ahmed Cecilia
- Akeroyd L.
- Akhtar M.N.
- Akinkugbe O.
- Aksentijevich Alexandra
- Al-Afghani H.
- Al-Awdah L.
- Alaamery M.
- Alahmadey Z.Z.
- Alaverdian D.
- Alavere H.
- Albader A.
- Albaiceta G.M.
- Albakri J.K.
- AlBardis H.
- Albeladi M.
- Albesher N.
- Albrich W.
- AlDhawi N.
- Aldridge J.
- Aleagha Afshar Etemadi
- Alexander Peter.
- Alfonso J.
- Alghamdi B.
- Alghamdi J.
- Ali A.
- Ali Altaf
- Ali I.A.M.
- Ali Syamlan
- Aliannejad Rasoul
- Aljawini N.
- AlJohani S.
- Alkwai S.
- Allan A.
- Allan E.
- Allan J.
- Alldis Zoe
- Allen L.
- Allen Meryem
- Allen Schvearn
- Allibone S.
- Allison K.S.
- Allos R.
- Ally S.M.
- AlMalik A.
- Almalki F.
- Almohammed I.
- Almutairi M.
- Alotaibi S.
- Alowayn A.M.
- Alqahtani S.
- Alqubaishi F.
- Alrashed M.
- Alshareef A.
- Alsolm E.
- Alswailm M.
- Altabaibeh A.
- Alvaro A.
- AlZahrani D.
- Amin V.
- Amirsavadkouhi Ali
- Amitrano Sara
- Anastasescu E.
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- Anderson J.
- Anderson Madeleine
- Anderson Peter
- Anderson S.
- Anderson S.
- Anderson T.
- Andolfo I.
- Andretta F.
- Andreucci E.
- Andrew Angela
- Andrew B.
- Andrew Gratrix
- Andrews E.
- Andrews Shea J.
- Anedda F.
- Anemoli V.
- Annis A.
- Antcliffe David
- Antinori Andrea
- Antoni M.D.
- Anumakonda V.
- Apetri E.
- Aquino Maia
- Arabi Y.M.
- Aravindan Latha
- Arbane Gill
- Archer Katie
- Arden T.
- Arias Sonia Sousa
- Arif S.
- Armstrong Jacob
- Armstrong Lisa
- Armstrong Ruth
- Arning N.
- Arnold Sophie
- Arranz María Jesús
- Arribas E.
- Artuso R.
- Arumugam Prabhu
- Ascolillo Steven
- Ashraf Saima
- Ashton L.
- Aslibekyan S.
- Astin-Chamberlain Raine
- Atkinson E.G.
- Attwood B.
- Aucella F.
- Auld D.
- Auld F.
- Austin Karen
- Austin Pauline
- Auton A.
- Ayers A.
- Azarzar S.
- Bachetti T.
- Baikady R.R.
- Baillie John Kenneth
- Baines Balvinder
- Baines D.
- Baines K.
- Baird Yolanda
- Bakthavatsalam Dhanalakshmi
- Balaconis Mary K.
- Baldassarri M.
- Ball C.A.
- Baltzell A.H.
- Bamford A.
- Bamford Peter
- Banach Dorota
- Bancroft Hollie
- Band G.
- Bandini M.
- Bandla Nageswar
- Bano S.
- Baptista David
- Barakeh D.
- Baras Aris
- Baratti S.
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- Barberis L.
- Barbieri C.
- Barclay Lucy
- Bargagli E.
- Barhoush E.
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- Barnes K.C.
- Baroni S.
- Barrett F.
- Barron A.
- Barry P.
- Bartels M.
- Bartley Shauna
- Baruah R.
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- Basikolo C.
- Bassetti M.
- Bastion V.
- Bates H.
- Bates Michelle
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- Bayo L.A.
- Beadle Jane
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- Beavis S.
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- Bedini J. L.
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- Beech E.
- Beech Valerie
- Beekes M.
- Beesley K.
- Begg Colin
- Beguin Y.
- Behan T.
- Beith C.M.
- Belagodu Zakaula
- Belbin Gillian Morven
- Belfield H.
- Belhaj Y.
- Beligni G.
- Belisle A.
- Bell D.
- Bell G.
- Bell M.
- Bell S.
- Bellamy Mary
- Belli M.A.
- Bellini A.
- Bellwood R.
- Below Jennifer
- Bemand T.
- Benetti E.
- Benham Leonie
- Bennett D.
- Bennett Sara
- Bentley David
- Bentley M.
- Benyon S.
- Beranova E.
- Bercades G.
- Bergantini L.
- Bergomi P.
- Berkowitz Nathan
- Bernardo D.
- Bevan E.
- Bewley J.
- Bhatia Nikhil
- Bhatterjee Ravi
- Bhuie Parminder
- Bi R.
- Biagio A.D.
- Bianchi F.
- Bibert S.
- Bibi Fatima
- Biddle Jack
- Biggs Heather
- Birch J.
- Birch J.
- Birch Sophie.
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- Birchall K.
- Bird S.
- Birkinshaw Isobel
- Birt M.
- Biscarini F.
- Black E.
- Black K.
- Blackledge B.
- Blackman H.
- Blakemore H.
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- Blow Sara
- Blunt M.
- Board S.
- Bochud P.Y.
- Bociek Aneta
- Boezen M.
- Boillat N.
- Bokhari M.
- Bolton Matthew
- Bolton Rachel
- Bonner Stephen
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- Bottà G.
- Bouab M.
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- Chariyavilaskul Pajaree
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- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Department of Health and Social Care (DHSC); Illumina; LifeArc; Medical Research Council (MRC); UKRI; Sepsis Research (the Fiona Elizabeth Agnew Trust); the Intensive Care Society, Wellcome Trust Senior Research Fellowship (223164/Z/21/Z); BBSRC Institute Program Support Grant to the Roslin Institute (BBS/E/D/20002172, BBS/E/D/10002070, BBS/E/D/30002275); UKRI grants (MC_PC_20004, MC_PC_19025, MC_PC_1905, MRNO2995X/1); UK Research and Innovation (MC_PC_20029); the Wellcome PhD training fellowship for clinicians (204979/Z/16/Z); the Edinburgh Clinical Academic Track (ECAT) programme; the National Institute for Health Research, the Wellcome Trust; the MRC; Cancer Research UK; the DHSC; NHS England; the Smilow family; the National Center for Advancing Translational Sciences of the National Institutes of Health (CTSA award number UL1TR001878); the Perelman School of Medicine at the University of Pennsylvania; National Institute on Aging (NIA U01AG009740); the National Institute on Aging (RC2 AG036495, RC4 AG039029); the Common Fund of the Office of the Director of the National Institutes of Health; NCI; NHGRI; NHLBI; NIDA; NIMH; NINDS.Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care or hospitalization after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes-including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)-in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
Mapping the human genetic architecture of COVID-19
- Author
- Abdelrazik M
- Abdullah T
- Abe R
- Abe S
- Abecasis GR
- Abel L
- Abernathy C
- Abraheem A
- Abul-Husn NS
- Acosta-Herrera M
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- Afrasiabi Z
- Afset JE
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- De la Horra C
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- zu Bentrup FM
- Zucchi P
- Zwinderman AHK
- Zyndorf M
- Publication venue
- Publication date
- 01/01/2021
- Field of study
The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3,4,5,6,7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease