Exploring the potential of the living lab as an addition to the open innovation ecosystem of the the firm: a case study for EDP open innovation

The firm of 2018 must not only remain agile in its innovative offerings, but must also recognise trends of peer-to-peer sharing, which begs the question: where do utility providers envision their business models amidst new demands to remain innovative in the new wave of collaborative consumption? If providing consumers with products via innovative services is the new currency upon which a firm is to be valued, then the extent of potential streams of innovation research available to a firm ought never be underestimated. Through a comprehensive analysis of the firm and the DNA of its open innovation ecosystem as well as a thorough investigation into the objectives driving Living Labs, we begin to discuss the feasibility of the Living Lab as a potential addition to the ecosystem of the firm in context

Analysis of Rainfall in the Locality of Babahoyo, for the Programming of Cultivation of Rice (Oryza Sativa L.)

The work was carried out with the objective of knowing the precipitation regime of Babahoyo, Los Ríos in Ecuador and in this way contribute to the improvement of the cropping calendar of “rainfed rice", as this information is commonly required by farmers and agricultural professionals who work as agricultural advisers. A serie of record’s rainfalls were processed in about 35 years belonging to the Babahoyo’s Weather Station of the National Institute of Meteorology and Hydrology situated on the premises of the Faculty of Agricultural Sciences of theTechnical University of Babahoyo (UTB), the methodology applied focuses on the identification of statistics such as the mean, standard deviation, variance, coefficient of variation, asymmetry coefficient and kurtosis coefficient; then on the basis of average is determined dry and wet periods, the frequency and the intensity in which they occur. It was found that in this town from 1980 to 2014 occurred eight dry periods and seven wet periods, that occured with a frequency of 3.4 and 3.7 years respectively. Based on the results, the wet season is defined between the months from December to May and the dry season from June to November. The sheet available average cumulative rainfall, which is determined for wet and dry periods, has the following valuables: 1001,3 mm, 3169 mm and an average of 2167,7 mm. The rainfed rice in the area should be planted from the month of December, to be taken advantage of all the rain of the wet season

Perfil de negocio para la implementación de un restaurante casual food gourmet peruano

El presente trabajo propone un plan de negocios para la implementación en el mercado americano, específicamente en la ciudad de Miami, de un restaurante casual food gourmet peruano, el cual surge tomando como base el crecimiento de este sector y el reconocimiento del sabor peruano a nivel internacional. Para ello se plantea “Sipán”, un negocio que tendrá como visión permitir a nuestros clientes vivir una experiencia de sabor y placer, y permitirles disfrutar de un ambiente de distensión, acogedor, cálido, de moda y funcional. Con el fin de conocer el entorno del sector de restaurantes en los Estados Unidos, se revisan las últimas publicaciones especializadas, las cuales nos brindaron indicadores que muestran que el sector casual food ha sido el menos afectado, así como identifican sus puntos fuertes, ventajas y los riesgos que presenta. Además, se realizó un análisis del entorno político, económico, social y tecnológico de la ciudad de Miami, información con la cual se plantea un mercado objetivo preliminar, la que se valida con las encuestas realizadas in- situ durante el mes de octubre del 2009 a potenciales clientes, a la salida de los establecimientos de los competidores de la zona y en los alrededores del mercado objetivo. Se preparó un análisis de los principales competidores en cada una de las categorías del sector, tales como: Panera Bread (panes), Chipotle Mexican Grill (étnico), Buffalo Wild Wings (tradicional), con el fin de identificar el elemento diferenciador de cada una de sus propuestas. En base a ello, se plantea una estrategia de diferenciación por producto, teniendo en cuenta que “Sipan Gourmet Casual Food” se centrará en brindar una alternativa estilizada de platos de la comida peruana, los cuales mantendrán el sabor original de los mismos pero serán presentados en formatos más modernos e innovadores. En base al análisis realizado se plantean opciones de menú que serán del gusto de nuestros clientes y se propone ubicarnos en la zona de South Miami por la información demográfica y comercial que se recopiló, la cual abarca el público objetivo a enfocar. Finalmente, como resultados de la evaluación financiera se determinó que el negocio resulta viable, ya que los flujos de efectivo pronosticados generan rentabilidad.Tesi

A comparison of maximal acceleration between the “tic-tac” parkour action, drop jump and lay-up shot in youth basketball players: A preliminary study towards the donor sport concept

The aim of this cross-sectional study was to compare acceleration outputs of the parkour-style “tic tac” action with those of the drop jump and the lay-up shot in youth basketball players. A total of 25 participants (17 males, 13.80 ± 1.30 years of age; and 8 females, 15.00 ± 0.80 years of age) completed three trials of each action while wearing a single inertial motion capture unit with a sampling frequency of 200 Hz, positioned at the lumbar spine. All data was captured in a single session, using the same test order for all participants. Maximum resultant acceleration was calculated from the raw data for each action. Using sex and maturation status as covariates, data were analysed using a Bayesian one-way repeated measures ANCOVA. Results revealed the jump + sex model to be the best fitting (BF10 = 9.22 x 105). Post hoc comparisons revealed that the tic tac produced greater maximal acceleration than the drop jump and the lay-up. These findings provide a biomechanical basis for the potential use of the parkour tic tac as an activity that could be used within the athletic development of youth basketball players

Reconciling timber extraction with biodiversity conservation in tropical forests using reduced-impact logging

Over 20% of the world's tropical forests have been selectively logged, and large expanses are allocated for future timber extraction. Reduced-impact logging (RIL) is being promoted as best practice forestry that increases sustainability and lowers CO2 emissions from logging, by reducing collateral damage associated with timber extraction. RIL is also expected to minimize the impacts of selective logging on biodiversity, although this is yet to be thoroughly tested. We undertake the most comprehensive study to date to investigate the biodiversity impacts of RIL across multiple taxonomic groups. We quantified birds, bats and large mammal assemblage structures, using a before-after control-impact (BACI) design across 20 sample sites over a 5-year period. Faunal surveys utilized point counts, mist nets and line transects and yielded >250 species. We examined assemblage responses to logging, as well as partitions of feeding guild and strata (understorey vs. canopy), and then tested for relationships with logging intensity to assess the primary determinants of community composition. Community analysis revealed little effect of RIL on overall assemblages, as structure and composition were similar before and after logging, and between logging and control sites. Variation in bird assemblages was explained by natural rates of change over time, and not logging intensity. However, when partitioned by feeding guild and strata, the frugivorous and canopy bird ensembles changed as a result of RIL, although the latter was also associated with change over time. Bats exhibited variable changes post-logging that were not related to logging, whereas large mammals showed no change at all. Indicator species analysis and correlations with logging intensities revealed that some species exhibited idiosyncratic responses to RIL, whilst abundance change of most others was associated with time. Synthesis and applications. Our study demonstrates the relatively benign effect of reduced-impact logging (RIL) on birds, bats and large mammals in a neotropical forest context, and therefore, we propose that forest managers should improve timber extraction techniques more widely. If RIL is extensively adopted, forestry concessions could represent sizeable and important additions to the global conservation estate – over 4 million km2

La reingeniería de los procesos en las industrias manufactureras en tiempos de postpandemia

Reengineering is the redesign of processes in organizations that seeks to improve either quality, time or cost reduction. The COVID-19 pandemic, known as the coronavirus, caused by the SARS-CoV-2 virus, has impacted and generated effects in different sectors, mainly health and the economy. The objective of this article is to analyze the role of process reengineering in manufacturing industries in post-pandemic times. Documentary and bibliographical research was used. Among the results is that there is a new reality that changed the way of doing business and working, that reengineering within the industrial field highlights the competitive advantages through the approach of strategic management, it is even necessary to apply reengineering to the objectives of sustainable development attending to the new world order post pandemic. In conclusion, process reengineering allowed companies to reinvent themselves and accelerate digital transformation in post-pandemic times in order to meet customer needs and survive. Similarly, it improves the visibility of the supply chain, including digital commerce. In short, COVID-19 has brought a disruption to organizations and therefore businesses must achieve that resilience in order to survive throughout this global crisis. Keywords: Reengineering, Covid-19, manufacturing industries, post-pandemic.La reingeniería es el rediseño de los procesos en organizaciones que busca mejorar ya sea la calidad, los tiempos o la reducción de costos. La pandemia del COVID-19, conocida como el coronavirus, ocasionada por el virus SARS-CoV-2 ha impactado y generado efectos en los diferentes sectores, principalmente la salud y economía. El objetivo de este artículo es analizar el rol  de la reingeniería de los procesos en las industrias manufactureras en  tiempos de postpandemia. Se uso la investigación tipo documental y bibliográfica. Entre los resultados se tiene que hay una nueva realidad que cambio la forma de hacer negocios y de trabajar, que  la reingeniería dentro del ámbito industrial destaca las ventajas competitivas mediante el planteamiento de gestiones estratégicas, inclusive  es necesario aplicar reingeniería a los objetivos  de desarrollo sostenible atendiendo al nuevo orden mundial post pandemia. En conclusión, la reingeniería de procesos permitió en tiempos de postpandemia, que las empresas se reinventen y aceleren la transformación digital para poder cubrir las necesidades de los clientes y sobrevivir. De igual forma, mejora la visibilidad de la cadena de suministro, incluyendo el comercio digital. En fin, el COVID-19 ha traído una disrupción en las organizaciones y por tanto los negocios deben lograr esa resiliencia para poder subsistir a lo largo de esta crisis mundial. Palabras clave: reingeniería, Covid- 19, industrias manufactureras, postpandemia. Abstract Reengineering is the redesign of processes in organizations that seeks to improve either quality, time or cost reduction. The COVID-19 pandemic, known as the coronavirus, caused by the SARS-CoV-2 virus, has impacted and generated effects in different sectors, mainly health and the economy. The objective of this article is to analyze the role of process reengineering in manufacturing industries in post-pandemic times. Documentary and bibliographical research was used. Among the results is that there is a new reality that changed the way of doing business and working, that reengineering within the industrial field highlights the competitive advantages through the approach of strategic management, it is even necessary to apply reengineering to the objectives of sustainable development attending to the new world order post pandemic. In conclusion, process reengineering allowed companies to reinvent themselves and accelerate digital transformation in post-pandemic times in order to meet customer needs and survive. Similarly, it improves the visibility of the supply chain, including digital commerce. In short, COVID-19 has brought a disruption to organizations and therefore businesses must achieve that resilience in order to survive throughout this global crisis. Keywords: Reengineering, Covid-19, manufacturing industries, post-pandemic. Información del manuscrito:Fecha de recepción: 02 de febrero de 2023.Fecha de aceptación: 22 de marzo de 2023.Fecha de publicación: 10 de julio de 2023

Revisión histórica de los estudios sobre la biología, ecología y toxicología del tiburón azul Prionace glauca en aguas del Pacífico ecuatoriano / Historical review of studies on the biology, ecology and toxicology of blue shark Prionace glauca in the Ecuadorian Pacific waters

El tiburón azul Prionace glauca es una especie que representa gran importancia económica y ecológica. A pesar de dicha relevancia, la información acerca de biología y demás aspectos relacionados con esta población son escasos, la misma que es necesaria para un manejo adecuado de sus pesquerías. El objetivo de este trabajo fue elaborar una revisión histórica de todos los estudios biológicos, ecológicos y toxicólogicos llevados a cabo en los ecosistemas costeros y marinos del Pacífico ecuatoriano. Se realizó una revisión bibliográfica de diversos documentos como tesis, informes técnicos, publicaciones científicas, entre otros. De acuerdo con resultados obtenidos, en Ecuador se han efectuado cuatro estudios de investigación científica a partir de 2012: dos de Biología (uno de aspectos reproductivos para Santa Rosa de Salinas y otro de edad y crecimiento para Manta), y dos de Ecología y Toxicología (uno sobre la bioacumulación y biomagnificación de mercurio, y otro sobre la concentración de mercurio y cadmio; ambos realizados en Santa Rosa de Salinas). Los trabajos fueron desarrollados por universidades estatales y privadas a través de tesis, mientras que un borrador de publicación científica estaba en preparación, como parte de un proyecto de investigación de una institución de educación superior particular. Abstract Blue shark Prionace glauca is a species that represents a great economic and ecological importance. However, the information related to its biology and others aspects of its population is limited. Nevertheless these kinds of studies are very important for a suitable management of fishery activities. The aim of this research was to develop a historical review for all biological, ecological and toxicological studies made in the coastal and marine ecosystems of the Ecuadorian Pacific. A review of the specialized literature was carried out for many documents such as thesis, technical reports, scientific papers, and others. According to results obtained, in Ecuador there have been four scientific research studies from 2012: These were two of Biology (one of reproductive aspects in Santa Rosa de Salinas and another about age and growth in Manta) and the others two of Ecology and Toxicology (one on mercury bioaccumulation and bio-magnification of mercury, and another on the concentration of mercury and cadmium; both conducted in Santa Rosa de Salinas). The works were developed by state and private universities through thesis, while a draft was in preparation for scientific publication as part of a research project in a private institution of higher education.

Circular RNA CpG island hypermethylation-associated silencing in human cancer

Noncoding RNAs (ncRNAs), such as microRNAs and long noncoding RNAs (lncRNAs), participate in cellular transformation. Work done in the last decade has also demonstrated that ncRNAs with growth-inhibitory functions can undergo promoter CpG island hypermethylation-associated silencing in tumorigenesis. Herein, we wondered whether circular RNAs (circRNAs), a type of RNA transcripts lacking 5′-3′ ends and forming closed loops that are gaining relevance in cancer biology, are also a target of epigenetic inactivation in tumors. To tackle this issue, we have used cancer cells genetically deficient for the DNA methyltransferase enzymes in conjuction with circRNA expression microarrays. We have found that the loss of DNA methylation provokes a release of circRNA silencing. In particular, we have identified that promoter CpG island hypermethylation of the genes TUSC3 (tumor suppressor candidate 3), POMT1 (protein O-mannosyltransferase 1), ATRNL1 (attractin-like 1) and SAMD4A (sterile alpha motif domain containing 4A) is linked to the transcriptional downregulation of both linear mRNA and the hosted circRNA. Although some circRNAs regulate the linear transcript, we did not observe changes in TUSC3 mRNA levels upon TUSC3 circ104557 overexpression. Interestingly, we found circRNA-mediated regulation of target miRNAs and an in vivo growth inhibitory effect upon TUSC3 circ104557 transduction. Data mining for 5′-end CpG island methylation of TUSC3, ATRNL1, POMT1 and SAMD4A in cancer cell lines and primary tumors showed that the epigenetic defect was commonly observed among different tumor types in association with the diminished expression of the corresponding transcript. Our findings support a role for circRNA DNA methylation-associated loss in human cancer

Fermented Goat’s Milk Consumption Improves Duodenal Expression of Iron Homeostasis Genes during Anemia Recovery

Despite the crucial roles of duodenal cytochrome b (Dcytb), divalent metal transporter 1 (DMT1), ferritin light chain (Ftl1), ferroportin 1 (FPN1), transferrin receptor 1 (TfR1), and hepcidin antimicrobial peptide (Hamp) in Fe metabolism, no studies have investigated the modulations of these genes during Fe repletion with fermented milks. Analysis included Fe status markers and gene and protein expression in enterocytes of control and anemic animals fed fermented milks. Fermented goat’s milk up-regulated enterocyte Dcytb, DMT1, FPN1, and Ftl1 and down-regulated TfR1 and Hamp gene expression in control and anemic animals. Anemia decreased Dcytb, DMT1, and Ftl1 in animals fed fermented cow’s milk and up-regulated TfR1 and Hamp expression. Fe overload down-regulated Dcytb and TfR1 in animals fed fermented cow’s milk and up-regulated DMT1 and FPN1 gene expression. Fermented goat’s milk increased expression of duodenal Dcytb, DMT1, and FPN1 and decreased Hamp and TfR1, improving Fe metabolism during anemia recovery