Análisis de citas en la revista Adicciones

Correspondencia a Rafael Aleixandre Benavent: [email protected]ón: El análisis de citas permite conocer determinados patrones de consumo de información de los profesionales. El objetivo del presente trabajo es analizar las referencias bibliográficas de la revista Adicciones en 1999 y 2000. Material y Método: Las referencias se clasificaron en tipos documentales, países de origen, año de la cita, revistas y sus áreas temáticas. Como indicadores de envejecimiento de la literatura se calculó la vida media de las publicaciones citadas y el índice de Price. Resultados: Se analizaron 2.119 referencias, siendo los artículos de revista el tipo más citado (63%), seguido de los libros (33,5%). Las citas a publicaciones norteamericanas acapararon el 39,1%. Un núcleo central de cinco revistas recibieron más de treinta referencias, entre las que destacan las de adicciones y psiquiatría. Discusión: La enorme difusión alcanzada por la literatura científica norteamericana produce unos índices de citación de literatura europea bajos, en detrimento de la atención debida a la propia producción investigadora. El hecho de que la segunda revista más citada sea la propia revista fuente expresa la confianza que los autores otorgan a Adicciones y contribuye a reforzar su interés para lectores y futuros investigadores.Introduction: Citation analysis permits ascertaining determined information consumption patterns of professionals. The objective of this work is to analyse the bibliographical references in the Spanish journal, Adicciones, during 1999 and 2000. Material and Method: The bibliographical references were classified under the headings of document type, country of origin, citation date, journals and subject field. The average life of the publications cited and the Price Index were calculated, as indicators of the obsolescence of the literature Results: 2,119 references were analyzed, with articles in journals being most cited (63%), followed by books (33.5%). Citations of American publications accounted for 39.1%. There is a central nucleus of five journals, including those on addiction, and on general psychiatry, which received more than thirty citations. Discussion: The enormous dissemination of American scientific literature leads to a low European literature citation index, to the detriment of due attention to our own research. The fact that the second most cited journal is Adicciones is an indication of the reliance of authors on this journal and, at the same time, contributes to reinforcing its interest for readers and future researchers

Algorithm implementation in MATLAB for root measurement

Modern agriculture has a growing level of technification, through the incorporation of new technologies of great utility in other disciplines different from the agricultural sector. The use of remote sensing systems to monitor the physiological state of crops by observing the volume and appearance of the roots is another example of its application. These systems are based on the detection and recording of spectral variations of crops both in the range of visible radiation and within the electromagnetic spectrum in the infrared range. Thermography is a visual tool that has found applications in agriculture. The monitoring of water status through the observation of crop roots is essential to optimize the use of water in agriculture, as well as its development and final production. The efficiency of root growth in basil crops has been analysed in a chamber with controlled humidity and temperature. The aim of this work was to demonstrate a better efficiency of root analysis with a first non-invasive and environmentally friendly method, visually, using thermal imaging and digital processing in the evaluation of radical growth versus two other conventional methods: traditional standard analysis and invasive analysis with digital image treatment. The results also showed advantages in the use of thermographic images compared to the use of RGB images for roots smaller than 1 mm

Structural and Spectroscopic Properties of Two New Isostructural Complexes of Lapacholate with Cobalt and Copper

The molecular structures of two isostructural complexes of lapacholate (Lap) anion and dimethylformamide (DMF), M(Lap)2(DMF)2 with M: Co Cu, were determined by X-ray diffraction methods. The substances crystallize in the triclinic space group P1 with one molecule per unit cell and cell constants a = 7.7591(3), b = 10.3560(3), c = 11.2224(4) A, α = 95.110(2), β = 94.310(2), and γ = 107.704(2)◦ for the Co complex and a = 7.9308(2), b = 10.0033(4), c = 10.7508(4), α = 97.387(2), β = 93.621(2), and γ = 103.980(2)◦ for the Cu complex. The structures were solved from 2933 (Co) and 2888 (Cu) reflections with I > 2σ (I) and refined by full matrix least squares to agreement R1-factors of 0.041 (Co) and 0.033 (Cu). The metal M(II) ion is sited on a crystallographic inversion center in a MO6 distorted octahedral environment. This ion is coordinated equatorially to two lapacholate anions through their adjacent carbonyl and phenol oxygen atoms [M–O bond distances of 2.134(1) and 2.008(1) A˚ (Co) and 2.301(1) and 1.914(1) A (Cu)] and axially to two DMF molecules through oxygen atoms [M–O bond lengths of 2.143(1) ˚ A (Co) and 2.069(1) ˚ A (Cu)]. The solid state IR transmittance and solution electronic absorption spectra of both Co and Cu ˚ compounds are also reported and compared to each other and to the corresponding spectra of other members of the lapacholate metal family of complexes.Instituto de Física La Plat

Expression of sterol regulatory element-binding proteins in epicardial adipose tissue in patients with coronary artery disease and diabetes mellitus: preliminary study

[Abstract] Objectives: Sterol regulatory element-binding proteins (SREBP) genes are crucial in lipid biosynthesis and cardiovascular homeostasis. Their expression in epicardial adipose tissue (EAT) and their influence in the development of coronary artery disease (CAD) and type-2 diabetes mellitus remain to be determined. The aim of our study was to evaluate the expression of SREBP genes in EAT in patients with CAD according to diabetes status and its association with clinical and biochemical data. Methods: SREBP-1 and SREBP-2 mRNA expression levels were measured in EAT from 49 patients with CAD (26 with diabetes) and 23 controls without CAD or diabetes. Results: Both SREBPs mRNA expression were significantly higher in patients with CAD and diabetes (p<0.001) and were identified as independent cardiovascular risk factor for coronary artery disease in patients with type-2 diabetes (SREBP-1: OR 1.7, 95%CI 1.1-2.5, p=0.02; SREBP-2: OR 1.6, 95%CI 1.2-3, p=0.02) and were independently associated with the presence of multivessel CAD, left main and anterior descending artery stenosis, and higher total and LDL cholesterol levels, and lower HDL cholesterol levels, in patients with CAD and diabetes. Conclusions: SREBP genes are expressed in EAT and were higher in CAD patients with diabetes than those patients without CAD or diabetes. SREBP expression was associated as cardiovascular risk factor for the severity of CAD and the poor lipid control. In this preliminary study we suggest the importance of EAT in the lipid metabolism and cardiovascular homeostasis for coronary atherosclerosis of patients with diabetes and highlight a future novel therapeutic target.Instituto de Salud Carlos III; PI13/02542Instituto de Salud Carlos III; PI11/01661Red de Investigación Cardiovascular; RD12/0042/003

Implicaciones del desmantelamiento de un foco de compra y consumo de drogas en Valencia

Desde el año 2003 la Fundación Salud y Comunidad (FSC), con el patrocinio principal de la Generalitat Valenciana, ha trabajado en la zona de 'Las Cañas', lugar que ha sido el foco de compraventa de drogas más activo de Valencia, realizando programas de contacto y de reducción de riesgos y daños, con más de 9.000 usuarios diferentes atendidos. En el año 2008 se realizó una intervención policial en el área con el objetivo de reducir la oferta de drogas. La falta de coordinación y comunicación entre la policía y los agentes sanitarios y sociales generó una situación potencialmente muy peligrosa para la salud de los drogodependientes y el impacto comunitario, lo que motivó una investigación de urgencia para medir y valorar el impacto de dicha actuación. Los resultados, interpretados junto con los datos asistenciales de los años 2007, 2008 y 2009, sugieren que la intervención policial no disminuyó ni difi cultó el acceso a las sustancias como se esperaba, aunque se transformó la estructura de la oferta y la demanda, fomentando el uso de heroína y cocaína inyectada, frente a la anteriormente mayoritaria, y estimulando nuevos puntos de compraventa en otras áreas de la ciudad.Since 2003 Fundación Salud y Comunidad (FSC), under the auspices of the Valencian Regional Government, has been working in the area of 'Las Cañas' that has become the most active drug sale and purchase focal point in Valencia. Outreach programs were started to reduce risks and harm, with more than 9,000 different users helped. In 2008 police action took place in the area with the goal of reducing drug supply. The lack of coordination and communication between the police and health and social agents working in the area prompted an urgent investigation to measure and assess the impact of such action on the health of drug addicts and in the community. The results, interpreted together with data from the service records for the years 2007, 2008 and 2009, suggest that the police actions did not reduce nor hinder the access to substances as expected, although the structure of the supply and demand did indeed change, favouring the use of injected (instead of inhaled) heroin and cocaine, and stimulating new sale and purchase points in other areas of the city

Unravelling data for rapid evidence-based response to COVID-19: a summary of the unCoVer protocol

Introduction unCoVer - Unravelling data for rapid evidence-based response to COVID-19 - is a Horizon 2020-funded network of 29 partners from 18 countries capable of collecting and using real-world data (RWD) derived from the response and provision of care to patients with COVID-19 by health systems across Europe and elsewhere. unCoVer aims to exploit the full potential of this information to rapidly address clinical and epidemiological research questions arising from the evolving pandemic. Methods and analysis From the onset of the COVID-19 pandemic, partners are gathering RWD from electronic health records currently including information from over 22 000 hospitalised patients with COVID-19, and national surveillance and screening data, and registries with over 1 900 000 COVID-19 cases across Europe, with continuous updates. These heterogeneous datasets will be described, harmonised and integrated into a multi-user data repository operated through Opal-DataSHIELD, an interoperable open-source server application. Federated data analyses, without sharing or disclosing any individual-level data, will be performed with the objective to reveal patients' baseline characteristics, biomarkers, determinants of COVID-19 prognosis, safety and effectiveness of treatments, and potential strategies against COVID-19, as well as epidemiological patterns. These analyses will complement evidence from efficacy/safety clinical trials, where vulnerable, more complex/heterogeneous populations and those most at risk of severe COVID-19 are often excluded. Ethics and dissemination After strict ethical considerations, databases will be available through a federated data analysis platform that allows processing of available COVID-19 RWD without disclosing identification information to analysts and limiting output to data aggregates. Dissemination of unCoVer's activities will be related to the access and use of dissimilar RWD, as well as the results generated by the pooled analyses. Dissemination will include training and educational activities, scientific publications and conference communications.info:eu-repo/semantics/publishedVersio

Crowd computing as a cooperation problem: an evolutionary approach

Cooperation is one of the socio-economic issues that has received more attention from the physics community. The problem has been mostly considered by studying games such as the Prisoner's Dilemma or the Public Goods Game. Here, we take a step forward by studying cooperation in the context of crowd computing. We introduce a model loosely based on Principal-agent theory in which people (workers) contribute to the solution of a distributed problem by computing answers and reporting to the problem proposer (master). To go beyond classical approaches involving the concept of Nash equilibrium, we work on an evolutionary framework in which both the master and the workers update their behavior through reinforcement learning. Using a Markov chain approach, we show theoretically that under certain----not very restrictive-conditions, the master can ensure the reliability of the answer resulting of the process. Then, we study the model by numerical simulations, finding that convergence, meaning that the system reaches a point in which it always produces reliable answers, may in general be much faster than the upper bounds given by the theoretical calculation. We also discuss the effects of the master's level of tolerance to defectors, about which the theory does not provide information. The discussion shows that the system works even with very large tolerances. We conclude with a discussion of our results and possible directions to carry this research further.This work is supported by the Cyprus Research Promotion Foundation grant TE/HPO/0609(BE)/05, the National Science Foundation (CCF-0937829, CCF-1114930), Comunidad de Madrid grant S2009TIC-1692 and MODELICO-CM, Spanish MOSAICO, PRODIEVO and RESINEE grants and MICINN grant TEC2011-29688-C02-01, and National Natural Science Foundation of China grant 61020106002.Publicad

Real-world effectiveness of caplacizumab vs the standard of care in immune thrombotic thrombocytopenic purpura

Immune thrombotic thrombocytopenic purpura (iTTP) is a thrombotic microangiopathy caused by anti-ADAMTS13 antibodies. Caplacizumab is approved for adults with an acute episode of iTTP in conjunction with plasma exchange (PEX) and immunosuppression. The objective of this study was to analyze and compare the safety and efficacy of caplacizumab vs the standard of care and assess the effect of the concomitant use of rituximab. A retrospective study from the Spanish TTP Registry of patients treated with caplacizumab vs those who did not receive it was conducted. A total of 155 patients with iTTP (77 caplacizumab, 78 no caplacizumab) were included. Patients initially treated with caplacizumab had fewer exacerbations (4.5% vs 20.5%; P <.05) and less refractoriness (4.5% vs 14.1%; P <.05) than those who were not treated. Time to clinical response was shorter when caplacizumab was used as initial treatment vs caplacizumab used after refractoriness or exacerbation. The multivariate analysis showed that its use in the first 3 days after PEX was associated with a lower number of PEX (odds ratio, 7.5; CI, 2.3-12.7; P <.05) and days of hospitalization (odds ratio, 11.2; CI, 5.6-16.9; P <.001) compared with standard therapy. There was no difference in time to clinical remission in patients treated with caplacizumab compared with the use of rituximab. No severe adverse event was described in the caplacizumab group. In summary, caplacizumab reduced exacerbations and refractoriness compared with standard of care regimens. When administered within the first 3 days after PEX, it also provided a faster clinical response, reducing hospitalization time and the need for PEX

Real-world effectiveness of caplacizumab vs the standard of care in immune thrombotic thrombocytopenic purpura

Immune thrombotic thrombocytopenic purpura (iTTP) is a thrombotic microangiopathy caused by anti-ADAMTS13 antibodies. Caplacizumab is approved for adults with an acute episode of iTTP in conjunction with plasma exchange (PEX) and immunosuppression. The objective of this study was to analyze and compare the safety and efficacy of caplacizumab vs the standard of care and assess the effect of the concomitant use of rituximab. A retrospective study from the Spanish TTP Registry of patients treated with caplacizumab vs those who did not receive it was conducted. A total of 155 patients with iTTP (77 caplacizumab, 78 no caplacizumab) were included. Patients initially treated with caplacizumab had fewer exacerbations (4.5% vs 20.5%; P < .05) and less refractoriness (4.5% vs 14.1%; P < .05) than those who were not treated. Time to clinical response was shorter when caplacizumab was used as initial treatment vs caplacizumab used after refractoriness or exacerbation. The multivariate analysis showed that its use in the first 3 days after PEX was associated with a lower number of PEX (odds ratio, 7.5; CI, 2.3-12.7; P < .05) and days of hospitalization (odds ratio, 11.2; CI, 5.6-16.9; P < .001) compared with standard therapy. There was no difference in time to clinical remission in patients treated with caplacizumab compared with the use of rituximab. No severe adverse event was described in the caplacizumab group. In summary, caplacizumab reduced exacerbations and refractoriness compared with standard of care regimens. When administered within the first 3 days after PEX, it also provided a faster clinical response, reducing hospitalization time and the need for PEX