63 research outputs found

    La reestructuración en la industria: los casos de Chile, México y Venezuela

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    Optimized hybrid nanospheres immobilizing Rhizomucor miehei lipase for chiral biotransformation

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    [EN] In this study, the immobilization of Rhizomucor miehei lipase into hybrid nanospheres containing a liposomal core was reported. Organic internal liposomal enzyme phase was protected by inorganic silica matrix, obtained with and without surfactant, that stabilizes the internal organic phase and isolates and protects the bioactive molecules. The optimized heterogeneous catalyst thus prepared was used for enantioselective esterification of (R,S)-ibuprofen. The influence of several catalytic parameters on the activity of hybrid nanospheres (type of solvent, nature of the alcohol, reaction temperature, etc.,) was investigated. The heterogeneous biocatalysts best performed at 37 degrees C, using isooctane as solvent and 1-propanol as alcohol (with ester yield ranging between 78 and 93%). High activity and stability (up to nine reaction cycles) of enzyme-immobilized hybrid nanospheres, with respect to the free form, were observed. R. miehei lipase, both in its free and immobilized forms, reacts only with the S(+) enantiomer of (R,S)-ibuprofen, in all the tested reaction conditions. (C) 2015 Elsevier Ltd. All rights reserved.The authors thank the financial support from Consolider-Ingenio MULTICAT CSD2009-00050, MAT2014-52085-C2-1-P, and Severo Ochoa Excellence Program SEV-2012-0267.Verri, F.; Díaz Morales, UM.; Macario, A.; Corma Canós, A.; Giordano, G. (2016). Optimized hybrid nanospheres immobilizing Rhizomucor miehei lipase for chiral biotransformation. Process Biochemistry. 51(2):240-248. https://doi.org/10.1016/j.procbio.2015.11.020S24024851

    Brazilian Foods and Territories Digital Platform: Conceptual Bases for Development / Plataforma Digital Alimentos e Territórios Brasileiros: Bases Conceituais para o Desenvolvimento

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    There is limited and segmented access to information regarding the diversity of responsible and sustainable agrifood products in Brazil. There is a growing need to bridge the communication gap between farmers and consumers who wish to consume such differentiated products. This article aims to present the conceptual bases for the development of a Brazilian Digital Platform for Food and Territories involved bibliographic research methodology, analysis of international platforms and technical-scientific discussions between Brazilian and French research groups. The main result obtained was the modeling of the digital platform based on a multiscale view associated with the confluence of six conceptual aspects: Territories, Localized Food Systems, Brazilian Regional Foods, Adding Value, Consumer Empowerment, Technological and Knowledge Convergence. The results contribute to the physical development of the Platform, with literature and insights on digital innovations in agrifood for researchers, developers, public and private managers, creating new development opportunities for Brazilian rural territories

    Universal Screening of SARS-CoV-2 of Oncology Healthcare Workers — a Brazilian experience

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    The first confirmed case of coronavirus disease 2019 (COVID-19) in Brazil and Latin America was reported on February 26, 2020, in São Paulo. The outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has placed unprecedented strain on health-care services worldwide. Asymptomatic health-care workers (HCW) are a potential source of SARS-CoV-2 transmission, especially to immunocompromised Oncology patients. Screening of these HCWs may help contain transmission and isolate only those who require it. At Centro de Terapia Oncológica (CTO), an Oncology clinic in Petrópolis, RJ —Brazil, all HCWs were screened for SARS-CoV-2 in order to isolate those who were asymptomatic/symptomatic and positive for the virus. They were all tested through IgM/IgG rapid testing and those who had symptoms were also tested with nasopharyngeal swabs for reverse transcription polymerase chain reaction (RT-PCR) tests besides IgM/IgG reactivity. Amongst the 60 tested employees, 4 were positive for SARS-CoV-2 and were isolated. This method may be useful for health-care services to detect asymptomatic HCW and maintain workers’ and patients’ health, as transmission probability could be reduced while avoiding becoming short-staffed during this time of crisis

    Hide and seek between Andromeda's halo, disk, and giant stream

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    Photometry in B, V (down to V ~ 26 mag) is presented for two 23' x 23' fields of the Andromeda galaxy (M31) that were observed with the blue channel camera of the Large Binocular Telescope during the Science Demonstration Time. Each field covers an area of about 5.1kpc x 5.1kpc at the distance of M31 ((m-M)o ~ 24.4 mag), sampling, respectively, a northeast region close to the M31 giant stream (field S2), and an eastern portion of the halo in the direction of the galaxy minor axis (field H1). The stream field spans a region that includes Andromeda's disk and the giant stream, and this is reflected in the complexity of the color magnitude diagram of the field. One corner of the halo field also includes a portion of the giant stream. Even though these demonstration time data were obtained under non-optimal observing conditions the B photometry, acquired in time-series mode, allowed us to identify 274 variable stars (among which 96 are bona fide and 31 are candidate RR Lyrae stars, 71 are Cepheids, and 16 are binary systems) by applying the image subtraction technique to selected portions of the observed fields. Differential flux light curves were obtained for the vast majority of these variables. Our sample includes mainly pulsating stars which populate the instability strip from the Classical Cepheids down to the RR Lyrae stars, thus tracing the different stellar generations in these regions of M31 down to the horizontal branch of the oldest (t ~ 10 Gyr) component.Comment: 59 pages, 26 figures, 12 tables, ApJ in pres

    Food Patterns According to Sociodemographics, Physical Activity, Sleeping and Obesity in Portuguese Children

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    Our study aimed to describe the association between food patterns and gender, parental education, physical activity, sleeping and obesity in 1976 children aged 5−10 years old. Dietary intake was measured by a semi quantitative food frequency questionnaire; body mass index was calculated and categorized according to the IOTF classification. Factor analysis and generalized linear models were applied to identify food patterns and their associations. TV viewing and male gender were significant positive predictors for fast-food, sugar sweetened beverages and pastry pattern, while a higher level of maternal education and longer sleeping duration were positively associated with a dietary patterns that included fruit and vegetables
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