124 research outputs found
Magneto Acoustic Spin Hall Oscillators
This paper introduces a novel oscillator that combines the tunability of spin
Hall-driven nano oscillators with the high quality factor (Q) of high overtone
bulk acoustic wave resonators (HBAR), integrating both reference and tunable
oscillators on the same chip with CMOS. In such magneto acoustic spin Hall
(MASH) oscillators, voltage oscillations across the magnetic tunnel junction
(MTJ) that arise from a spin-orbit torque (SOT) are shaped by the transmission
response of the HBAR that acts as a multiple peak-bandpass filter and a delay
element due to its large time constant, providing delayed feedback. The
filtered voltage oscillations can be fed back to the MTJ via a) strain, b)
current, or c) magnetic field. We develop a SPICE-based circuit model by
combining experimentally benchmarked models including the stochastic
Landau-Lifshitz-Gilbert (sLLG) equation for magnetization dynamics and the
Butterworth Van Dyke (BVD) circuit for the HBAR. Using the self-consistent
model, we project up to 50X enhancement in the oscillator linewidth with
Q reaching up to 52825 at 3 GHz, while preserving the tunability by locking the
STNO to the nearest high Q peak of the HBAR. We expect that our results will
inspire MEMS-based solutions to spintronic devices by combining attractive
features of both fields for a variety of applications
Autonomous Probabilistic Coprocessing with Petaflips per Second
In this paper we present a concrete design for a probabilistic (p-) computer
based on a network of p-bits, robust classical entities fluctuating between -1
and +1, with probabilities that are controlled through an input constructed
from the outputs of other p-bits. The architecture of this probabilistic
computer is similar to a stochastic neural network with the p-bit playing the
role of a binary stochastic neuron, but with one key difference: there is no
sequencer used to enforce an ordering of p-bit updates, as is typically
required. Instead, we explore \textit{sequencerless} designs where all p-bits
are allowed to flip autonomously and demonstrate that such designs can allow
ultrafast operation unconstrained by available clock speeds without
compromising the solution's fidelity. Based on experimental results from a
hardware benchmark of the autonomous design and benchmarked device models, we
project that a nanomagnetic implementation can scale to achieve petaflips per
second with millions of neurons. A key contribution of this paper is the focus
on a hardware metric flips per second as a problem and
substrate-independent figure-of-merit for an emerging class of hardware
annealers known as Ising Machines. Much like the shrinking feature sizes of
transistors that have continually driven Moore's Law, we believe that flips per
second can be continually improved in later technology generations of a wide
class of probabilistic, domain specific hardware.Comment: 13 pages, 8 figures, 1 tabl
A population-based survey of Chronic REnal Disease In Turkey—the CREDIT study
Background. Chronic kidney disease (CKD) is a growing health problem worldwide that leads to end-stage kidney failure and cardiovascular complications. We aimed to determine the prevalence of CKD in Turkey, and to evaluate relationships between CKD and cardiovascular risk factors in a population-based survey
Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications
Superparamagnetic iron oxide nanoparticles
can providemultiple benefits for biomedical applications
in aqueous environments such asmagnetic separation or
magnetic resonance imaging. To increase the colloidal
stability and allow subsequent reactions, the introduction
of hydrophilic functional groups onto the particles’
surface is essential. During this process, the original
coating is exchanged by preferably covalently bonded
ligands such as trialkoxysilanes. The duration of the
silane exchange reaction, which commonly takes more
than 24 h, is an important drawback for this approach. In
this paper, we present a novel method, which introduces
ultrasonication as an energy source to dramatically
accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove
the generic character, different functional groups were
introduced on the surface including polyethylene glycol
chains, carboxylic acid, amine, and thiol groups. Their
colloidal stability in various aqueous buffer solutions as
well as human plasma and serum was investigated to
allow implementation in biomedical and sensing
applications.status: publishe
Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial
Aims The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisin–kexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (≥1.8 mmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and results Median follow-up was 2.8 years. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (n = 2) or Type 5 (n = 5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77–0.95; P = 0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77–0.99; P = 0.032) and Type 2 (0.77, 0.61–0.97; P = 0.025), but not Type 4 MI. Conclusion After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.For complete list of authors see http://dx.doi.org/10.1093/eurheartj/ehz299</p
Safety of intravenous ferric carboxymaltose versus oral iron in patients with nondialysis-dependent CKD: an analysis of the 1-year FIND-CKD trial.
Background: The evidence base regarding the safety of intravenous (IV) iron therapy in patients with chronic kidney disease (CKD) is incomplete and largely based on small studies of relatively short duration. Methods: FIND-CKD (ClinicalTrials.gov number NCT00994318) was a 1-year, open-label, multicenter, prospective study of patients with nondialysis-dependent CKD, anemia and iron deficiency randomized (1:1:2) to IV ferric carboxymaltose (FCM), targeting higher (400-600 µg/L) or lower (100-200 µg/L) ferritin, or oral iron. A post hoc analysis of adverse event rates per 100 patient-years was performed to assess the safety of FCM versus oral iron over an extended period. Results: The safety population included 616 patients. The incidence of one or more adverse events was 91.0, 100.0 and 105.0 per 100 patient-years in the high ferritin FCM, low ferritin FCM and oral iron groups, respectively. The incidence of adverse events with a suspected relation to study drug was 15.9, 17.8 and 36.7 per 100 patient-years in the three groups; for serious adverse events, the incidence was 28.2, 27.9 and 24.3 per 100 patient-years. The incidence of cardiac disorders and infections was similar between groups. At least one ferritin level ≥800 µg/L occurred in 26.6% of high ferritin FCM patients, with no associated increase in adverse events. No patient with ferritin ≥800 µg/L discontinued the study drug due to adverse events. Estimated glomerular filtration rate remained the stable in all groups. Conclusions: These results further support the conclusion that correction of iron deficiency anemia with IV FCM is safe in patients with nondialysis-dependent CKD
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