178 research outputs found
Declaring Racism a Public Health Crisis in the United States: Cure, Poison, or Both?
Declaring racism a public health crisis has the potential to shepherd meaningful anti-racism policy forward and bridge long standing divisions between policy-makers, community organizers, healers, and public health practitioners. At their best, the declarations are a first step to address long standing inaction in the face of need. At their worst, the declarations poison or sedate grassroots momentum toward anti-racism structural change by delivering politicians unearned publicity and slowing progress on health equity. Declaring racism as a public health crisis is a tool that must be used with clarity and caution in order to maximize impact. Key to holding public institutions accountable for creating declarations is the direct involvement of Black and Indigenous People of Color (BIPOC) led groups and organizers. Sharing power, centering their voices and working in tandem, these collaborations ensure that declarations push for change from the lens of those most impacted and authentically engage with the demands of communities and their legacies. Superficial diversity and inclusion efforts that bring BIPOC people and organizers into the conversation and then fail to implement their ideas repeat historical patterns of harm, stall momentum for structural change at best, and poison the strategy at worst. In this paper we will examine three declarations in the United States and analyze them utilizing evaluative criteria aligned with health equity and anti-racism practices. Finally, we offer recommendations to inform anti-racist public health work for meaningful systematic change toward decentralization and empowerment of communities in their health futures
Association of Race Consciousness With the Patient- Physician Relationship, Medication Adherence, and Blood Pressure in Urban Primary Care Patients
background Race consciousness (the frequency with which one thinks about his or her own race) is a measure that may be useful in assessing whether racial discrimination negatively impacts blood pressure (BP). However, the relation between race consciousness and BP has yet to be empirically tested, especially within the context of the patient-physician relationship and medication adherence
Generalized Flux Vacua
We consider type II string theory compactified on a symmetric T^6/Z_2
orientifold. We study a general class of discrete deformations of the resulting
four-dimensional supergravity theory, including gaugings arising from geometric
and "nongeometric'' fluxes, as well as the usual R-R and NS-NS fluxes. Solving
the equations of motion associated with the resulting N = 1 superpotential, we
find parametrically controllable infinite families of supersymmetric vacua with
all moduli stabilized. We also describe some aspects of the distribution of
generic solutions to the SUSY equations of motion for this model, and note in
particular the existence of an apparently infinite number of solutions in a
finite range of the parameter space of the four-dimensional effective theory.Comment: 30 pages, 4 .eps figures; v2, reference adde
Lectures on Nongeometric Flux Compactifications
These notes present a pedagogical review of nongeometric flux
compactifications. We begin by reviewing well-known geometric flux
compactifications in Type II string theory, and argue that one must include
nongeometric "fluxes" in order to have a superpotential which is invariant
under T-duality. Additionally, we discuss some elementary aspects of the
worldsheet description of nongeometric backgrounds. This review is based on
lectures given at the 2007 RTN Winter School at CERN.Comment: 31 pages, JHEP
Inflation in Realistic D-Brane Models
We find successful models of D-brane/anti-brane inflation within a string
context. We work within the GKP-KKLT class of type IIB string vacua for which
many moduli are stabilized through fluxes, as recently modified to include
`realistic' orbifold sectors containing standard-model type particles. We allow
all moduli to roll when searching for inflationary solutions and find that
inflation is not generic inasmuch as special choices must be made for the
parameters describing the vacuum. But given these choices inflation can occur
for a reasonably wide range of initial conditions for the brane and antibrane.
We find that D-terms associated with the orbifold blowing-up modes play an
important role in the inflationary dynamics. Since the models contain a
standard-model-like sector after inflation, they open up the possibility of
addressing reheating issues. We calculate predictions for the CMB temperature
fluctuations and find that these can be consistent with observations, but are
generically not deep within the scale-invariant regime and so can allow
appreciable values for as well as predicting a potentially
observable gravity-wave signal. It is also possible to generate some admixture
of isocurvature fluctuations.Comment: 39 pages, 21 figures; added references; identified parameters
combining successful inflation with strong warping, as needed for consistency
of the approximation
The Influence of Spatial Registration on Detection of Cerebral Asymmetries Using Voxel-Based Statistics of Fractional Anisotropy Images and TBSS
The sensitivity of diffusion tensor imaging (DTI) for detecting microstructural white matter alterations has motivated the application of voxel-based statistics (VBS) to fractional anisotropy (FA) images (FA-VBS). However, detected group differences may depend on the spatial registration method used. The objective of this study was to investigate the influence of spatial registration on detecting cerebral asymmetries in FA-VBS analyses with reference to data obtained using Tract-Based Spatial Statistics (TBSS). In the first part of this study we performed FA-VBS analyses using three single-contrast and one multi-contrast registration: (i) whole-brain registration based on T2 contrast, (ii) whole-brain registration based on FA contrast, (iii) individual-hemisphere registration based on FA contrast, and (iv) a combination of (i) and (iii). We then compared the FA-VBS results with those obtained from TBSS. We found that the FA-VBS results depended strongly on the employed registration approach, with the best correspondence between FA-VBS and TBSS results when approach (iv), the “multi-contrast individual-hemisphere” method was employed. In the second part of the study, we investigated the spatial distribution of residual misregistration for each registration approach and the effect on FA-VBS results. For the FA-VBS analyses using the three single-contrast registration methods, we identified FA asymmetries that were (a) located in regions prone to misregistrations, (b) not detected by TBSS, and (c) specific to the applied registration approach. These asymmetries were considered candidates for apparent FA asymmetries due to systematic misregistrations associated with the FA-VBS approach. Finally, we demonstrated that the “multi-contrast individual-hemisphere” approach showed the least residual spatial misregistrations and thus might be most appropriate for cerebral FA-VBS analyses
Genome Sequence of the Pea Aphid Acyrthosiphon pisum
Aphids are important agricultural pests and also biological models for studies of insect-plant interactions, symbiosis, virus vectoring, and the developmental causes of extreme phenotypic plasticity. Here we present the 464 Mb draft genome assembly of the pea aphid Acyrthosiphon pisum. This first published whole genome sequence of a basal hemimetabolous insect provides an outgroup to the multiple published genomes of holometabolous insects. Pea aphids are host-plant specialists, they can reproduce both sexually and asexually, and they have coevolved with an obligate bacterial symbiont. Here we highlight findings from whole genome analysis that may be related to these unusual biological features. These findings include discovery of extensive gene duplication in more than 2000 gene families as well as loss of evolutionarily conserved genes. Gene family expansions relative to other published genomes include genes involved in chromatin modification, miRNA synthesis, and sugar transport. Gene losses include genes central to the IMD immune pathway, selenoprotein utilization, purine salvage, and the entire urea cycle. The pea aphid genome reveals that only a limited number of genes have been acquired from bacteria; thus the reduced gene count of Buchnera does not reflect gene transfer to the host genome. The inventory of metabolic genes in the pea aphid genome suggests that there is extensive metabolite exchange between the aphid and Buchnera, including sharing of amino acid biosynthesis between the aphid and Buchnera. The pea aphid genome provides a foundation for post-genomic studies of fundamental biological questions and applied agricultural problems
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