Supramolecular behaviour and fluorescence of rhodamine-functionalised ROMP polymers

Inherently fluorescent polymers are of interest in materials and medicine. We report a ring-opening metathesis polymerisation (ROMP) platform for creation of amphiphilic block copolymers in which one block is formed from rhodamine B-containing monomers. The polymers self-assemble into well-defined micelles which are able to sequester molecular dyes and further interact with them by energy transfer. Despite incorporating a cationic dye known to bind DNA, the polymer micelles do not interact with DNA, indicating that they are potentially safe for use in bioanalytical applications

Polycatechol Nanoparticle MRI Contrast Agents

Amphiphilic triblock copolymers containing Fe III -catecholate complexes formulated as spherical- or cylindrical-shaped micellar nanoparticles ( SMN and CMN , respectively) are described as new T 1 -weighted agents with high relaxivity, low cytotoxicity, and long-term stability in biological fl uids. Relaxivities of both SMN and CMN exceed those of established gadolinium chelates across a wide range of magnetic fi eld strengths. Interestingly, shape-dependent behavior is observed in terms of the particles\u2019 interactions with HeLa cells, with CMN exhibiting enhanced uptake and contrast via magnetic resonance imaging (MRI) compared with SMN . These results suggest that control over soft nanoparticle shape will provide an avenue for optimization of particle-based contrast agents as biodiagnostics. The polycatechol nanoparticles are proposed as suitable for preclinical investigations into their viability as gadolinium-free, safe, and effective imaging agents for MRI contrast enhancement

Annemarie and Liselott Callmann Collection; 1915-1957

The bulk of the collection consists of correspondence between Grete Callmann in Berlin and her two daughters, Annemarie and Liselott in England: in 1941 via direct mail and in 1942 until February 1943 via the Red Cross.Also included are German birth certificates, 1915, 1917; British Army's 'Soldier's service and pay books' and naturalization papers, 1941-1948; and US naturalization certificates, 1956, 1957.Annemarie Callmann and Liselott Callmann were born on Feb. 5, 1910 in Berlin, Germany, daughters of Siegfried Callmann and Grete Callmann, née Bein. Grete Callmann died in a concentration camp. Annemarie and Liselott Callmann served 1941 in the British Army; they became British citizens in 1947 before immigrating to the US.Vital statisticsdigitize