227 research outputs found
Portland Stone: a nomination for "Global Heritage Stone Resource" from the United Kingdom
Portland Stone, a well known ooidal limestone of Jurassic age from the United Kingdom is here nominated as a suitable "Global Heritage Stone Resource". Portland Stone is considered to ideally fit the newly proposed designation as it has been utilised since Roman times in England and since the Middle Ages in the construction of major historic buildings including St Pauls Cathedral, British Museum and Bank of England in London. It was also the preferred building stone of Sir Christopher Wren, England's most famous architect. The international use of Portland Stone during the 20th century includes the United Nations building in New York City and the war graves of British and British Commonwealth soldiers. Portland Stone also continues to be quarried today in an environmentally sensitive manner whilst coastal outcrops of the material form a part of the "Dorset and East Devon Coast" World Heritage area (aka The Jurassic Heritage Coast)
The cost effectiveness of peginterferon alfa and ribavirin for the treatment of hepatitis C in children and young people
OBJECTIVES: To assess the cost-effectiveness of peginterferon ?-2a and peginterferon ?-2b in combination with ribavirin compared to best supportive care (BSC), for the treatment of chronic hepatitis C virus (HCV) in children and young people aged 3 to 17 years. METHODS: A Markov state-transition economic model of chronic HCV in children and young people was developed that extrapolated the impact of sustained virological response (SVR) on life expectancy, quality-adjusted life expectancy and lifetime costs. The model was adapted from one previously developed for adults. A systematic review was conducted of the clinical effectiveness of the treatments, and the health related quality of life for patients with hepatitis C. Uncertainty was explored through probabilistic and deterministic sensitivity analyses. RESULTS: Seven studies were identified that were relatively small and of generally poor quality. Estimates of SVR were similar for for peginterferon ?-2a (60%) and peginterferon ?-2b (58%) was similar, whilst the SVR for no treatment was assumed to be zero. From this model, peginterferon alfa (?-2a or ?-2b) in combination with ribavirin was more effective and cheaper than BSC. Sensitivity analyses suggest that the results were generally robust to all changes to the structural assumptions and input parameters. The model results were most sensitive to changes to the discount rate, time horizon, SVR and baseline fibrosis of the cohort. CONCLUSIONS: Treatment of children and young people with peginterferon alfa (?-2a or ?-2b) and ribavirin may be an effective therapy. Peginterferon alfa (?-2a or ?-2b) in combination with ribavirin is cost-effective compared with BSC. However, the available evidence is of poor quality. The views expressed in this paper are those of the authors and do not necessarily represent the views or policies of the UK HTA programme or Department of Health
Improved algebraic cryptanalysis of QUAD, Bivium and Trivium via graph partitioning on equation systems
We present a novel approach for preprocessing systems of polynomial equations via graph partitioning. The variable-sharing graph of a system of polynomial equations is defined. If such graph is disconnected, then the corresponding system of equations can be split into smaller ones that can be solved individually. This can provide a tremendous speed-up in computing the solution to the system, but is unlikely to occur either randomly or in applications. However, by deleting certain vertices on the graph, the variable-sharing graph could be disconnected in a balanced fashion, and in turn the system of polynomial equations would be separated into smaller systems of near-equal sizes. In graph theory terms, this process is equivalent to finding balanced vertex partitions with minimum-weight vertex separators. The techniques of finding these vertex partitions are discussed, and experiments are performed to evaluate its practicality for general graphs and systems of polynomial equations. Applications of this approach in algebraic cryptanalysis on symmetric ciphers are presented: For the QUAD family of stream ciphers, we show how a malicious party can manufacture conforming systems that can be easily broken. For the stream ciphers Bivium and Trivium, we nachieve significant speedups in algebraic attacks against them, mainly in a partial key guess scenario. In each of these cases, the systems of polynomial equations involved are well-suited to our graph partitioning method. These results may open a new avenue for evaluating the security of symmetric ciphers against algebraic attacks
Multi-level Dynamical Systems: Connecting the Ruelle Response Theory and the Mori-Zwanzig Approach
In this paper we consider the problem of deriving approximate autonomous
dynamics for a number of variables of a dynamical system, which are weakly
coupled to the remaining variables. In a previous paper we have used the Ruelle
response theory on such a weakly coupled system to construct a surrogate
dynamics, such that the expectation value of any observable agrees, up to
second order in the coupling strength, to its expectation evaluated on the full
dynamics. We show here that such surrogate dynamics agree up to second order to
an expansion of the Mori-Zwanzig projected dynamics. This implies that the
parametrizations of unresolved processes suited for prediction and for the
representation of long term statistical properties are closely related, if one
takes into account, in addition to the widely adopted stochastic forcing, the
often neglected memory effects.Comment: 14 pages, 1 figur
Energy States of Colored Particle in a Chromomagnetic Field
The unitary transformation, which diagonalizes squared Dirac equation in a
constant chromomagnetic field is found. Applying this transformation, we find
the eigenfunctions of diagonalized Hamiltonian, that describe the states with
definite value of energy and call them energy states. It is pointed out that,
the energy states are determined by the color interaction term of the particle
with the background chromofield and this term is responsible for the splitting
of the energy spectrum.
We construct supercharge operators for the diagonal Hamiltonian, that ensure
the superpartner property of the energy states.Comment: 25 pages, some calculation details have been removed, typos correcte
The position of graptolites within Lower Palaeozoic planktic ecosystems.
An integrated approach has been used to assess the palaeoecology of graptolites both as a discrete group and also as a part of the biota present within Ordovician and Silurian planktic realms. Study of the functional morphology of graptolites and comparisons with recent ecological analogues demonstrates that graptolites most probably filled a variety of niches as primary consumers, with modes of life related to the colony morphotype. Graptolite coloniality was extremely ordered, lacking any close morphological analogues in Recent faunas. To obtain maximum functional efficiency, graptolites would have needed varying degrees of coordinated automobility. A change in lifestyle related to ontogenetic changes was prevalent within many graptolite groups. Differing lifestyle was reflected by differing reproductive strategies, with synrhabdosomes most likely being a method for rapid asexual reproduction. Direct evidence in the form of graptolithophage 'coprolitic' bodies, as well as indirect evidence in the form of probable defensive adaptations, indicate that graptolites comprised a food item for a variety of predators. Graptolites were also hosts to a variety of parasitic organisms and provided an important nutrient source for scavenging organisms
Lepton Flavor Non-Conservation
In the present work we review the most prominent lepton flavor violating
processes (\mu \ra e\gamma, \mu \ra 3e, conversion,
oscillations etc), in the context of unified gauge theories. Many currently
fashionable extensions of the standard model are considered, such as: {\it i)}
extensions of the fermion sector (right-handed neutrino); {\it ii)} minimal
extensions involving additional Higgs scalars (more than one isodoublets,
singly and doubly charged isosinglets, isotriplets with doubly charged members
etc.); {\it iii)} supersymmetric or superstring inspired unified models
emphasizing the implications of the renormalization group equations in the
leptonic sector. Special attention is given to the experimentaly most
interesting conversion in the presence of nuclei. The relevant
nuclear aspects of the amplitudes are discussed in a number of fashionable
nuclear models. The main features of the relevant experiments are also
discussed, and detailed predictions of the above models are compared to the
present experimental limits.Comment: (IOA-300/93, review article, 83p, 6 epsf figures , available upon
request from [email protected])
Astroparticle Physics with a Customized Low-Background Broad Energy Germanium Detector
The MAJORANA Collaboration is building the MAJORANA DEMONSTRATOR, a 60 kg
array of high purity germanium detectors housed in an ultra-low background
shield at the Sanford Underground Laboratory in Lead, SD. The MAJORANA
DEMONSTRATOR will search for neutrinoless double-beta decay of 76Ge while
demonstrating the feasibility of a tonne-scale experiment. It may also carry
out a dark matter search in the 1-10 GeV/c^2 mass range. We have found that
customized Broad Energy Germanium (BEGe) detectors produced by Canberra have
several desirable features for a neutrinoless double-beta decay experiment,
including low electronic noise, excellent pulse shape analysis capabilities,
and simple fabrication. We have deployed a customized BEGe, the MAJORANA
Low-Background BEGe at Kimballton (MALBEK), in a low-background cryostat and
shield at the Kimballton Underground Research Facility in Virginia. This paper
will focus on the detector characteristics and measurements that can be
performed with such a radiation detector in a low-background environment.Comment: Submitted to NIMA Proceedings, SORMA XII. 9 pages, 4 figure
Hidden secrets of deformation: Impact-induced compaction within a CV chondrite
The CV3 Allende is one of the most extensively studied meteorites in worldwide collections. It is currently classified as S1—essentially unshocked—using the classification scheme of Stöffler et al. (1991), however recent modelling suggests the low porosity observed in Allende indicates the body should have undergone compaction-related deformation. In this study, we detail previously undetected evidence of impact through use of Electron Backscatter Diffraction mapping to identify deformation microstructures in chondrules, AOAs and matrix grains. Our results demonstrate that forsterite-rich chondrules commonly preserve crystal-plastic microstructures (particularly at their margins); that low-angle boundaries in deformed matrix grains of olivine have a preferred orientation; and that disparities in deformation occur between chondrules, surrounding and non-adjacent matrix grains. We find heterogeneous compaction effects present throughout the matrix, consistent with a highly porous initial material. Given the spatial distribution of these crystal-plastic deformation microstructures, we suggest that this is evidence that Allende has undergone impact-induced compaction from an initially heterogeneous and porous parent body. We suggest that current shock classifications (Stöffler et al., 1991) relying upon data from chondrule interiors do not constrain the complete shock history of a sample
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