STONE 6: Artificial Sedimentary Meteorites in Space

The STONE 6 experiment demonstrated the survivability of carbonaceous and microfossiliferous martian analogue sediments during atmospheric re-entry. Doped endoliths died but their carbonised cells remained

Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia

High frequencies of blasts in primary acute lymphoblastic leukaemia (ALL) samples have the potential to induce leukaemia and to engraft mice. However, it is unclear how individual ALL cells each contribute to drive leukaemic development in a bulk transplant and the extent to which these blasts vary functionally. We used cellular barcoding as a fate mapping tool to track primograft ALL blasts in vivo. Our results show that high numbers of ALL founder cells contribute at similar frequencies to leukaemic propagation over serial transplants, without any clear evidence of clonal succession. These founder cells also exhibit equal capacity to home and engraft to different organs, although stochastic processes may alter the composition in restrictive niches. Our findings enhance the stochastic stem cell model of ALL by demonstrating equal functional abilities of singular ALL blasts and show that successful treatment strategies must eradicate the entire leukaemic cell population

Light and Life: Exotic Photosynthesis in Binary Star Systems

The potential for hosting photosynthetic life on Earth-like planets within binary/multiple stellar systems was evaluated by modelling the levels of photosynthetically active radiation (PAR) such planets receive. Combinations of M and G stars in: (i) close-binary systems; (ii) wide-binary systems and (iii) three-star systems were investigated and a range of stable radiation environments found to be possible. These environmental conditions allow for the possibility of familiar, but also more exotic forms of photosynthetic life, such as infrared photosynthesisers and organisms specialised for specific spectral niches.Comment: Accepted for publication in: Astrobiolog

Primary and secondary eclipse spectroscopy with JWST: exploring the exoplanet parameter space

Eclipse exoplanet spectroscopy has yielded detection of H_2O, CH_4, CO_2 and CO in the atmosphere of hot jupiters and neptunes. About 40 large terrestrial planets are announced or confirmed, two of which are transiting, and another deemed habitable. Hence the potential for eclipse spectroscopy of terrestrial planets with James Webb Space Telescope (JWST) has become an active field of study. We explore the parameter space (type of stars, planet orbital periods and types, and instruments/wavelengths) in terms of the signal-to-noise ratio (S/N) achievable on the detection of spectroscopic features. We use analytic formula and model data for both the astrophysical scene and the instrument, to plot S/N contour maps, while indicating how the S/N scales with the fixed parameters. We systematically compare stellar photon noise-only figures with ones including detailed instrumental and zodiacal noises. Likelihood of occurring targets is based both on model and catalog star population of the solar neighborhood. The 9.6 micron ozone band is detectable (S/N = 3) with JWST, for a warm super-earth 6.7 pc away, using ~2% of the 5-year nominal mission time (summing observations, M4V and lighter host star for primary eclipses, M5V for secondary). If every star up to this mass limit and distance were to host a habitable planet, there should be statistically ~1 eclipsing case. Investigation of systematic noises in the co-addition of 5 years worth-, tens of days separated-, hours-long observations is critical, complemented by dedicated characterisation of the instruments, currently in integration phase. The census of nearby transiting habitable planets must be complete before the beginning of science operations.Comment: Accepted for publication in A&A, 16 pages, 19 figure

Transcriptomics and proteomics show that selenium affects inflammation, ctoskeleton, and cancer pathways in human rectal biopsies

Epidemiologic studies highlight the potential role of dietary selenium (Se) in colorectal cancer prevention. Our goal was to elucidate whether expression of factors crucial for colorectal homoeostasis is affected by physiologic differences in Se status. Using transcriptomics and proteomics followed by pathway analysis, we identified pathways affected by Se status in rectal biopsies from 22 healthy adults, including 11 controls with optimal status (mean plasma Se = 1.43 μM) and 11 subjects with suboptimal status (mean plasma Se = 0.86 μM). We observed that 254 genes and 26 proteins implicated in cancer (80%), immune function and inflammatory response (40%), cell growth and proliferation (70%), cellular movement, and cell death (50%) were differentially expressed between the 2 groups. Expression of 69 genes, including selenoproteins W1 and K, which are genes involved in cytoskeleton remodelling and transcription factor NFκB signaling, correlated significantly with Se status. Integrating proteomics and transcriptomics datasets revealed reduced inflammatory and immune responses and cytoskeleton remodelling in the suboptimal Se status group. This is the first study combining omics technologies to describe the impact of differences in Se status on colorectal expression patterns, revealing that suboptimal Se status could alter inflammatory signaling and cytoskeleton in human rectal mucosa and so influence cancer risk

Thermal phase curves of non-transiting terrestrial exoplanets 2. Characterizing airless planets

Context. The photometric signal we receive from a star hosting a planet is modulated by the variation of the planet signal with its orbital phase. Such phase variations are observed for transiting hot Jupiters with current instrumentation, and have also been measured for one transiting terrestrial planet (Kepler 10 b) and one non-transiting gas giant (Ups A b). Future telescopes (JWST and EChO) will have the capability to measure thermal phase curves of exoplanets including hot rocky planets in transiting and non-transiting configurations, and at different wavelengths. Short-period planets with a mass below 10 R_EARTH are indeed frequent and nearby targets (within 10 pc) are already known and more are to be found. Aims. To test the possibility to use multi-wavelengths infrared phase curves to constrain the radius, the albedo and the orbital inclination of a non-transiting planet with no atmosphere and on a 1:1 spin orbit resonance. Methods. We model the thermal emission of a synchronous rocky planet with no atmosphere and its apparent variation with the orbital phase for a given orbital inclination. We assume that the planet is detected by radial velocity so its orbital period and minimum mass are known. We simulate observed noisy phase curves and then apply a procedure to retrieve the radius and albedo of the planet and the inclination of the orbit. Results. Airless planets can be distinguished from planets having a dense atmosphere and their radius, albedo and inclination (and therefore true mass) can be retrieved from multiband observations with MIRI-JWST and EChO in the 5-15 {\mu}m range. [...] As inclination above 60{\deg} represents half of randomly oriented orbits, the growing population of short-period terrestrial-sized planets detected by radial velocity surveys and transits should offer several nearby promising targets for this method [...]. See full abstract in the paper.Comment: 18 pages, 11 figures Accepted 13 October 2011 in A&

Investigation of Performance and Cavitation Treatment in a Kaplan Hydro Turbine

Cavitation is a phenomenon that occurs in various turbomachinery applications causing drawbacks on the. Some of these downsides are damaging the components of the system, generating noise and vibration, and loss of the turbine efficiency over time. Thus, it is imperative to address issue of cavitation to increase the life span of the equipment in addition to improve the system performance. This thesis introduces a method used to mitigate the cavitation phenomenon in a 3-inch Kaplan hydro turbine via injecting air at the leading edge of the rotor blades. The study is based on modeling the turbine using Computational Fluid Dynamics (CFD) software as well as carrying out experimental tests. The simulations were conducted at different air injection pressures over a spectrum of rotational speeds using Large Eddy Simulation (LES) for turbulence and volume of fluid for multiphase interactions: water, vapor water and air. The cavitation behavior was observed first without aeration, then followed by air injection simulations to investigate the effect of aeration. Each case was simulated for 12 cycles at rotational speeds of 1000, 2000, 3000, 4000, and 5000 rpm. The Vapor Volume Fraction (VVF) and the output mechanical power were monitored throughout the simulations. The data acquired from the simulations were compared to the experimental results for verifications. It was observed that the cavitation was mitigated in both the computer simulations and the experiment testing reaching up to 49.7% as an average reduction, while the output power was reduced by 6.6%

Searching for life with rovers: exploration methods and science results from the 2004 field campaign of the “Life in the Atacama” project and applications to future Mars Missions

LITA develops and field tests a long-range automated rover and a science payload to search for microbial life in the Atacama. The Atacama's evolution provides a unique training ground for designing and testing exploration strategies and life detection methods for the search for life on Mars

Habitable Zones and UV Habitable Zones around Host Stars

Ultraviolet radiation is a double-edged sword to life. If it is too strong, the terrestrial biological systems will be damaged. And if it is too weak, the synthesis of many biochemical compounds can not go along. We try to obtain the continuous ultraviolet habitable zones, and compare the ultraviolet habitable zones with the habitable zones of host stars. Using the boundary ultraviolet radiation of ultraviolet habitable zone, we calculate the ultraviolet habitable zones of host stars with masses from 0.08 to 4.00 \mo. For the host stars with effective temperatures lower than 4,600 K, the ultraviolet habitable zones are closer than the habitable zones. For the host stars with effective temperatures higher than 7,137 K, the ultraviolet habitable zones are farther than the habitable zones. For hot subdwarf as a host star, the distance of the ultraviolet habitable zone is about ten times more than that of the habitable zone, which is not suitable for life existence.Comment: 5 pages, 3 figure

Opening a new window to other worlds with spectropolarimetry

A high level of diversity has already been observed among the planets of our own Solar System. As such, one expects extrasolar planets to present a wide range of distinctive features, therefore the characterisation of Earth- and super Earth-like planets is becoming of key importance in scientific research. The SEARCH (Spectropolarimetric Exoplanet AtmospheRe CHaracerisation) mission proposal of this paper represents one possible approach to realising these objectives. The mission goals of SEARCH include the detailed characterisation of a wide variety of exoplanets, ranging from terrestrial planets to gas giants. More specifically, SEARCH will determine atmospheric properties such as cloud coverage, surface pressure and atmospheric composition, and may also be capable of identifying basic surface features. To resolve a planet with a semi major axis of down to 1.4AU and 30pc distant SEARCH will have a mirror system consisting of two segments, with elliptical rim, cut out of a parabolic mirror. This will yield an effective diameter of 9 meters along one axis. A phase mask coronagraph along with an integral spectrograph will be used to overcome the contrast ratio of star to planet light. Such a mission would provide invaluable data on the diversity present in extrasolar planetary systems and much more could be learned from the similarities and differences compared to our own Solar System. This would allow our theories of planetary formation, atmospheric accretion and evolution to be tested, and our understanding of regions such as the outer limit of the Habitable Zone to be further improved.Comment: 23 pages, accepted for publication in Experimental Astronom