Acute lung injury/acute respiratory distress syndrome (ALI/ARDS): the mechanism, present strategies and future perspectives of therapies

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS), which manifests as non-cardiogenic pulmonary edema, respiratory distress and hypoxemia, could be resulted from various processes that directly or indirectly injure the lung. Extensive investigations in experimental models and humans with ALI/ARDS have revealed many molecular mechanisms that offer therapeutic opportunities for cell or gene therapy. Herein the present strategies and future perspectives of the treatment for ALI/ARDS, include the ventilatory, pharmacological, as well as cell therapies

Search for heavy Majorana neutrinos in mu(+/-)mu(+/-) + jets events inproton-proton collisions at root s=8TeV

see paper for full list of authorsInternational audienceA search is performed for heavy Majorana neutrinos (N) using an event signature defined by two muons of the same charge and two jets (mu+/- mu+/- jj). The data correspond to an integrated luminosity of 19.7 inverse femtobarns of proton-proton collisions at a center-of-mass energy of 8 TeV, collected with the CMS detector at the CERN LHC. No excess of events is observed beyond the expected standard model background and upper limits are set on abs(V[mu,N])^2 as a function of Majorana neutrino mass m[N] for masses in the range of 40-500 GeV, where V[mu,N] is the mixing element of the heavy neutrino with the standard model muon neutrino. The limits obtained are abs(V[mu,N])^2 < 0.00470 for m[N] = 90 GeV, abs(V[mu,N])^2 < 0.0123 for m[N] = 200 GeV, and abs(V[mu,N])^2 < 0.583 for m[N] = 500 GeV. These results extend considerably the regions excluded by previous direct searches