1,989 research outputs found
What do parents of children with dysphagia think about their MDT? A qualitative study
Objectives: To seek the experiences and perspectives of parents caring for children with dysphagia, with emphasis on their experiences of working within their childâs multidisciplinary team (MDT) Setting: This research was completed in community settings, within familiesâ homes across the UK. Participants: Fourteen families self-selected to participate in the study. Criteria specified that participants must care for a child under the age of 18 and to decrease ambiguity the term âdiagnosis of dysphagiaâ was defined as the need for modified (thickened) fluids. Exclusion criteria: caring for an adult over the age of 18; diet and fluid modifications for reasons other than dysphagia (e.g. for symptomatic treatment of Gastro-oesophageal reflux disease (GORD). Participants were interviewed within their homes using a semi-structured questionnaire and data was analysed using a descriptive phenomenological approach through use of thematic coding and constant comparison. Themes and relationships were inductively generated from the data. Results: Participants universally expressed a desire to be involved with their childâs multidisciplinary team; this study identified the following facilitators and barriers to collaboration: Accessing Services, Professional Knowledge, and Professional Skillset. Participants described three means of responding to these barriers: Reacting Emotionally, Seeking Solutions, and Making Decisions. Conclusions: This study recorded in-depth reports of participantsâ experiences of working with healthcare providers. Despite government-driven efforts towards person-centred health and social care, participants shared accounts of times when this has not occurred, describing a negative impact on the well-being and quality of life of their child and family
Recommended from our members
Serotonergic innervation of the amygdala is increased in autism spectrum disorder and decreased in Williams syndrome.
BackgroundWilliams syndrome (WS) and autism spectrum disorder (ASD) are neurodevelopmental disorders that demonstrate overlapping genetic associations, dichotomous sociobehavioral phenotypes, and dichotomous pathological differences in neuronal distribution in key social brain areas, including the prefrontal cortex and the amygdala. The serotonergic system is critical to many processes underlying neurodevelopment and is additionally an important neuromodulator associated with behavioral variation. The amygdala is heavily innervated by serotonergic projections, suggesting that the serotonergic system is a significant mediator of neuronal activity. Disruptions to the serotonergic system, and atypical structure and function of the amygdala, are implicated in both WS and ASD.MethodsWe quantified the serotonergic axon density in the four major subdivisions of the amygdala in the postmortem brains of individuals diagnosed with ASD and WS and neurotypical (NT) brains.ResultsWe found opposing directions of change in serotonergic innervation in the two disorders, with ASD displaying an increase in serotonergic axons compared to NT and WS displaying a decrease. Significant differences (pâ<â0.05) were observed between WS and ASD data sets across multiple amygdala nuclei.LimitationsThis study is limited by the availability of human postmortem tissue. Small sample size is an unavoidable limitation of most postmortem human brain research and particularly postmortem research in rare disorders.ConclusionsDifferential alterations to serotonergic innervation of the amygdala may contribute to differences in sociobehavioral phenotype in WS and ASD. These findings will inform future work identifying targets for future therapeutics in these and other disorders characterized by atypical social behavior
Thickened fluids: Investigation of users' experiences and perceptions.
Background & aims: Fluid thickeners are an important and commonly-used strategy to manage swallowing
difficulties however there are no reports of the perceptions and experiences of parents of children
using thickeners.
Methods: Semi-structured interviews of 14 parents having a child using fluid thickeners due to swallowing
difficulties.
Results: Parents reported improvements in quality of life and health through the use of thickeners. They
also reported persistent difficulties in the use of thickeners.
Conclusions: Results showed unanimous goodwill and positive attitudes towards thickeners and their
observed benefits, tempered by common difficulties with thickeners (variability and unpredictability).
There remains scope for improvements of commercial thickeners and in information conveyed to users
Sequential Star Formation in RCW 34: A Spectroscopic Census of the Stellar Content of High-mass Star-forming Regions
We present VLT/SINFONI integral field spectroscopy of RCW 34 along with
Spitzer/IRAC photometry of the surroundings. RCW 34 consists of three different
regions. A large bubble has been detected on the IRAC images in which a cluster
of intermediate- and low-mass class II objects is found. At the northern edge
of this bubble, an HII region is located, ionized by 3 OB stars. Intermediate
mass stars (2 - 3 Msun) are detected of G- and K- spectral type. These stars
are still in the pre-main sequence (PMS) phase. North of the HII region, a
photon-dominated region is present, marking the edge of a dense molecular cloud
traced by H2 emission. Several class 0/I objects are associated with this
cloud, indicating that star formation is still taking place. The distance to
RCW 34 is revised to 2.5 +- 0.2 kpc and an age estimate of 2 - 1 Myrs is
derived from the properties of the PMS stars inside the HII region. The most
likely scenario for the formation of the three regions is that star formation
propagates from South to North. First the bubble is formed, produced by
intermediate- and low-mass stars only, after that, the HII region is formed
from a dense core at the edge of the molecular cloud, resulting in the
expansion as a champagne flow. More recently, star formation occurred in the
rest of the molecular cloud. Two different formation scenarios are possible:
(a) The bubble with the cluster of low- and intermediate mass stars triggered
the formation of the O star at the edge of the molecular cloud which in turn
induces the current star-formation in the molecular cloud. (b) An external
triggering is responsible for the star-formation propagating from South to
North. [abridged]Comment: 19 pages, 11 figures, accepted by Ap
A Monte Carlo Study of the Dynamical-Flucautation Property of the Hadronic System Inside Jets
A study of the dynamical fluctuation property of jets is carried out using
Monte Carlo method. The results suggest that, unlike the average properties of
the hadronic system inside jets, the anisotropy of dynamical fluctuations in
these systems changes abruptly with the variation of the cut parameter \yct.
A transition point exists, where the dynamical fluctuations in the hadronic
system inside jet behave like those in soft hadronic collisions, i.e. being
circular in the transverse plan with repect to dynamical fluctuations. This
finding obtained from Jetset and Herwig Monte Carlo is encouraged to be checked
by experiments.Comment: 8 pages, 3 figure
Phonon-assisted radiofrequency absorption by gold nanoparticles resulting in hyperthermia
It is suggested that in gold nanoparticles (GNPs) of about 5 nm sizes used in
the radiofrequency (RF) hyperthermia, an absorption of the RF photon by the
Fermi electron occurs with involvement of the longitudinal acoustic vibrational
mode (LAVM), the dominating one in the distribution of vibrational density of
states (VDOS). This physical mechanism helps to explain two observed phenomena:
the size dependence of the heating rate (HR) in GNPs and reduced heat
production in aggregated GNPs. The argumentation proceeds within the
one-electron approximation, taking into account the discretenesses of energies
and momenta of both electrons and LAVMs. The heating of GNPs is thought to
consist of two consecutive processes: first, the Fermi electron absorbs
simultaneously the RF photon and the LAVM available in the GNP; hereafter the
excited electron gets relaxed within the GNP's boundary, exciting a LAVM with
the energy higher than that of the previously absorbed LAVM. GNPs containing
the Ta and/or Fe impurities are proposed for the RF hyperthermia as promising
heaters with enhanced HRs, and GNPs with rare-earth impurity atoms are also
brought into consideration. It is shown why the maximum HR values should be
expected in GNPs with about 5-7 nm size.Comment: proceedings at the NATO Advanced Research workshop FANEM-2015 (Minsk,
May 25-27, 2015). To be published in the final form in: "Fundamental and
Applied NanoElectroMagnetics" (Springer Science + Business Media B.V.
Denitrification and nitrous oxide emissions from riparian forests soils exposed to prolonged nitrogen runoff
Compared to upland forests, riparian forest soils have greater potential to remove nitrate (NO3) from agricultural run-off through denitrification. It is unclear, however, whether prolonged exposure of riparian soils to nitrogen (N) loading will affect the rate of denitrification and its end products. This research assesses the rate of denitrification and nitrous oxide (N2O) emissions from riparian forest soils exposed to prolonged nutrient run-off from plant nurseries and compares these to similar forest soils not exposed to nutrient run-off. Nursery run-off also contains high levels of phosphate (PO4). Since there are conflicting reports on the impact of PO4 on the activity of denitrifying microbes, the impact of PO4 on such activity was also investigated. Bulk and intact soil cores were collected from N-exposed and non-exposed forests to determine denitrification and N2O emission rates, whereas denitrification potential was determined using soil slurries. Compared to the non-amended treatment, denitrification rate increased 2.7- and 3.4-fold when soil cores collected from both N-exposed and non-exposed sites were amended with 30 and 60 ÎŒg NO3-N g-1 soil, respectively. Net N2O emissions were 1.5 and 1.7 times higher from the N-exposed sites compared to the non-exposed sites at 30 and 60 ÎŒg NO3-N g-1 soil amendment rates, respectively. Similarly, denitrification potential increased 17 times in response to addition of 15 ÎŒg NO3-N g-1 in soil slurries. The addition of PO4 (5 ÎŒg PO4âP g-1) to soil slurries and intact cores did not affect denitrification rates. These observations suggest that prolonged N loading did not affect the denitrification potential of the riparian forest soils; however, it did result in higher N2O emissions compared to emission rates from non-exposed forests
Towards Quantum Repeaters with Solid-State Qubits: Spin-Photon Entanglement Generation using Self-Assembled Quantum Dots
In this chapter we review the use of spins in optically-active InAs quantum
dots as the key physical building block for constructing a quantum repeater,
with a particular focus on recent results demonstrating entanglement between a
quantum memory (electron spin qubit) and a flying qubit (polarization- or
frequency-encoded photonic qubit). This is a first step towards demonstrating
entanglement between distant quantum memories (realized with quantum dots),
which in turn is a milestone in the roadmap for building a functional quantum
repeater. We also place this experimental work in context by providing an
overview of quantum repeaters, their potential uses, and the challenges in
implementing them.Comment: 51 pages. Expanded version of a chapter to appear in "Engineering the
Atom-Photon Interaction" (Springer-Verlag, 2015; eds. A. Predojevic and M. W.
Mitchell
Decrease in alarm call response among tufted capuchins in competitive feeding contexts: possible evidence for counterdeception
Animal signals function to elicit behaviors in receivers that ultimately benefit the signaler, while receivers should respond in a way that maximizes their own fitness. However, the best response may be difficult for receivers to determine when unreliable signaling is common. âDeceptiveâ alarm calling is common among tufted capuchins (Cebus apella nigritus) in competitive feeding contexts, and responding to these calls is costly. Receivers should thus vary their responses based on whether a call is likely to be reliable. If capuchins are indeed able to assess reliability, I predicted that receivers will be less likely to respond to alarms that are given during competitive feeding contexts than in noncompetitive contexts, and, within feeding contexts, that individuals inside or adjacent to a food patch will be less likely to respond to alarms than those further from the resource. I tested these predictions in a group of wild capuchins by observing the reactions of focal animals to alarm calls in both noncompetitive contexts and experimental feeding contexts. Antipredator escape reactions, but not vigilance reactions, occurred significantly less often in competitive feeding contexts than in noncompetitive contexts and individuals adjacent to food patches were more likely to respond to alarm calls than were those inside or further from food patches. Although not all predictions were fully supported, the findings demonstrate that receivers vary their behavior in a way that minimizes the costs associated with âdeceptiveâ alarms, but further research is needed to determine whether or not this can be attributed to counterdeception
Effectiveness of a complex, pre-conception intervention to reduce the risk of diabetes by reducing adiposity in young adults in Malaysia:The Jom Mama project - A randomised controlled trial
Background: Pre-conception interventions have the potential to lower non-communicable disease risk in prospective parents and reduce transmission of risk factors such as obesity to the next generation. The Jom Mama project in Malaysia investigated the effectiveness of a combined behaviour change communication and e-health intervention in young married couples prior to first pregnancy. This paper reports the evaluation of the effectiveness of this trial. Methods: Jom Mama was a non-blinded, randomised controlled trial (RCT) conducted in Seremban, Malaysia, over a period of 33 weeks, covering six contact points between trained community health workers and newly married couples before the conception of a first child. Out of 2075 eligible nulliparous women, 549 participated and 305 completed the intervention, with 145 women in the intervention and 160 in the control group. The intervention group received a complex behavioural change intervention, combining behaviour change communication provided by community health promoters and access to a habit formation mobile application, while the control group received the standard care provided by public health clinics in Malaysia. The primary outcome was a change in the woman's waist circumference. Secondary outcomes were anthropometric and metabolic measures, dietary intake (Food Frequency Questionnaire, FFQ), physical activity (International Physical Activity Questionnaire, IPAQ) and mental health (Depression Anxiety Stress Scale, DASS 21). An extensive process evaluation was conducted alongside the trial in order to aid the interpretation of the main findings. Results: There were no significant differences of change in the woman's waist circumference between intervention and control groups at the start and end of the intervention. While the weight, waist circumference and Body Mass Index (BMI) of women in both groups increased, there was a significantly lower increase in the intervention vs the control group over the period of the trial among women who are obese (0.1 kg vs 1.7 kg; Pâ=â0.023, in the intervention and control group respectively). In terms of BMI, the obese intervention subgroup showed a slight reduction (0.01) compared to the obese control subgroup whose BMI increased by 0.7 (Pâ=â0.015). There were no changes in the other secondary outcomes. Conclusions: The Jom Mama pre-conception intervention did not lead to a reduction in waist circumference or significant changes in other secondary outcomes over the eight months prior to conception. However, there was a significantly smaller weight gain in the intervention vs the control group, predominantly in women with pre-existing obesity
- âŠ