293 research outputs found
Focusing Vacuum Fluctuations II
The quantization of the scalar and electromagnetic fields in the presence of
a parabolic mirror is further developed in the context of a geometric optics
approximation. We extend results in a previous paper to more general
geometries, and also correct an error in one section of that paper. We
calculate the mean squared scalar and electric fields near the focal line of a
parabolic cylindrical mirror. These quantities are found to grow as inverse
powers of the distance from the focus. We give a combination of analytic and
numerical results for the mean squared fields. In particular, we find that the
mean squared electric field can be either negative or positive, depending upon
the choice of parameters. The case of a negative mean squared electric field
corresponds to a repulsive Van der Waals force on an atom near the focus, and
to a region of negative energy density. Similarly, a positive value corresponds
to an attractive force and a possibility of atom trapping in the vicinity of
the focus.Comment: 26 pages, 15 figures; additional discussion added in Sects. IV and I
Focusing Vacuum Fluctuations
The focusing of the vacuum modes of a quantized field by a parabolic mirror
is investigated. We use a geometric optics approximation to calculate the
energy density and mean squared field averages for scalar and electromagnetic
fields near the focus. We find that these quantities grow as an inverse power
of the distance to the focus. There is an attractive Casimir-Polder force on an
atom which will draw it into the focus. Some estimates of the magnitude of the
effects of this focusing indicate that it may be observable.Comment: 20 pages, 4 figures; typos corrected, two refs and some comments
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Moving Atom-Field Interaction: Correction to Casimir-Polder Effect from Coherent Back-action
The Casimir-Polder force is an attractive force between a polarizable atom
and a conducting or dielectric boundary. Its original computation was in terms
of the Lamb shift of the atomic ground state in an electromagnetic field (EMF)
modified by boundary conditions along the wall and assuming a stationary atom.
We calculate the corrections to this force due to a moving atom, demanding
maximal preservation of entanglement generated by the moving atom-conducting
wall system. We do this by using non-perturbative path integral techniques
which allow for coherent back-action and thus can treat non-Markovian
processes. We recompute the atom-wall force for a conducting boundary by
allowing the bare atom-EMF ground state to evolve (or self-dress) into the
interacting ground state. We find a clear distinction between the cases of
stationary and adiabatic motions. Our result for the retardation correction for
adiabatic motion is up to twice as much as that computed for stationary atoms.
We give physical interpretations of both the stationary and adiabatic atom-wall
forces in terms of alteration of the virtual photon cloud surrounding the atom
by the wall and the Doppler effect.Comment: 16 pages, 2 figures, clarified discussions; to appear in Phys. Rev.
The Milky Way Bulge: Observed properties and a comparison to external galaxies
The Milky Way bulge offers a unique opportunity to investigate in detail the
role that different processes such as dynamical instabilities, hierarchical
merging, and dissipational collapse may have played in the history of the
Galaxy formation and evolution based on its resolved stellar population
properties. Large observation programmes and surveys of the bulge are providing
for the first time a look into the global view of the Milky Way bulge that can
be compared with the bulges of other galaxies, and be used as a template for
detailed comparison with models. The Milky Way has been shown to have a
box/peanut (B/P) bulge and recent evidence seems to suggest the presence of an
additional spheroidal component. In this review we summarise the global
chemical abundances, kinematics and structural properties that allow us to
disentangle these multiple components and provide constraints to understand
their origin. The investigation of both detailed and global properties of the
bulge now provide us with the opportunity to characterise the bulge as observed
in models, and to place the mixed component bulge scenario in the general
context of external galaxies. When writing this review, we considered the
perspectives of researchers working with the Milky Way and researchers working
with external galaxies. It is an attempt to approach both communities for a
fruitful exchange of ideas.Comment: Review article to appear in "Galactic Bulges", Editors: Laurikainen
E., Peletier R., Gadotti D., Springer Publishing. 36 pages, 10 figure
Noise induced transitions in semiclassical cosmology
A semiclassical cosmological model is considered which consists of a closed
Friedmann-Robertson-Walker in the presence of a cosmological constant, which
mimics the effect of an inflaton field, and a massless, non-conformally coupled
quantum scalar field. We show that the back-reaction of the quantum field,
which consists basically of a non local term due to gravitational particle
creation and a noise term induced by the quantum fluctuations of the field, are
able to drive the cosmological scale factor over the barrier of the classical
potential so that if the universe starts near zero scale factor (initial
singularity) it can make the transition to an exponentially expanding de Sitter
phase. We compute the probability of this transition and it turns out to be
comparable with the probability that the universe tunnels from "nothing" into
an inflationary stage in quantum cosmology. This suggests that in the presence
of matter fields the back-reaction on the spacetime should not be neglected in
quantum cosmology.Comment: LaTex, 33.tex pages, no figure
Global Search for New Physics with 2.0/fb at CDF
Data collected in Run II of the Fermilab Tevatron are searched for
indications of new electroweak-scale physics. Rather than focusing on
particular new physics scenarios, CDF data are analyzed for discrepancies with
the standard model prediction. A model-independent approach (Vista) considers
gross features of the data, and is sensitive to new large cross-section
physics. Further sensitivity to new physics is provided by two additional
algorithms: a Bump Hunter searches invariant mass distributions for "bumps"
that could indicate resonant production of new particles; and the Sleuth
procedure scans for data excesses at large summed transverse momentum. This
combined global search for new physics in 2.0/fb of ppbar collisions at
sqrt(s)=1.96 TeV reveals no indication of physics beyond the standard model.Comment: 8 pages, 7 figures. Final version which appeared in Physical Review D
Rapid Communication
Observation of Orbitally Excited B_s Mesons
We report the first observation of two narrow resonances consistent with
states of orbitally excited (L=1) B_s mesons using 1 fb^{-1} of ppbar
collisions at sqrt{s} = 1.96 TeV collected with the CDF II detector at the
Fermilab Tevatron. We use two-body decays into K^- and B^+ mesons reconstructed
as B^+ \to J/\psi K^+, J/\psi \to \mu^+ \mu^- or B^+ \to \bar{D}^0 \pi^+,
\bar{D}^0 \to K^+ \pi^-. We deduce the masses of the two states to be m(B_{s1})
= 5829.4 +- 0.7 MeV/c^2 and m(B_{s2}^*) = 5839.7 +- 0.7 MeV/c^2.Comment: Version accepted and published by Phys. Rev. Let
Comprehensive long-term efficacy and safety of recombinant human alpha-mannosidase (velmanase alfa) treatment in patients with alpha-mannosidosis
Introduction Long-term outcome data provide important insights into the clinical utility of enzyme replacement therapies. Such
data are presented for velmanase alfa in the treatment of alpha-mannosidosis (AM).
Methods Patient data (n = 33; 14 adults, 19 paediatric) from the clinical development programme for velmanase alfa were
integrated in this prospectively-designed analysis of long-term efficacy and safety. Patients who participated in the phase I/II
or phase III trials and were continuing to receive treatment after completion of the trials were invited to participate in a
comprehensive evaluation visit to assess long-term outcomes. Primary endpoints were changes in serum oligosaccharide and
the 3-minute stair climb test (3MSCT).
Results Mean (SD) treatment exposure was 29.3 (15.2) months. Serum oligosaccharide levels were significantly reduced in the
overall population at 12 months (mean change: –72.7%, P < 0.001) and remained statistically significant at last observation
(−62.8%, P < 0.001). A mean improvement of +9.3% in 3MSCT was observed at 12 months (P = 0.013), which also remained
statistically significant at last observation (+13.8%, P = 0.004), with a more pronounced improvement detected in the paediatric
subgroup. No treatment-emergent adverse events were reported leading to permanent treatment discontinuation.
Conclusions Patients treated with velmanase alfa experienced improvements in biochemical and functional measures that were
maintained for up to 4 years. Long term follow-up is important and further supports the use of velmanase alfa as an effective and
well-tolerated treatment for AM. Based on the currently available data set, no baseline characteristic can be predictive of
treatment outcome. Early treatment during paediatric age showed better outcome in functional endpoints
Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,887 patients from 279 population-based registries in 67 countries (CONCORD-2)
BACKGROUND:
Worldwide data for cancer survival are scarce. We aimed to initiate worldwide surveillance of cancer survival by central analysis of population-based registry data, as a metric of the effectiveness of health systems, and to inform global policy on cancer control.
METHODS:
Individual tumour records were submitted by 279 population-based cancer registries in 67 countries for 25·7 million adults (age 15-99 years) and 75,000 children (age 0-14 years) diagnosed with cancer during 1995-2009 and followed up to Dec 31, 2009, or later. We looked at cancers of the stomach, colon, rectum, liver, lung, breast (women), cervix, ovary, and prostate in adults, and adult and childhood leukaemia. Standardised quality control procedures were applied; errors were corrected by the registry concerned. We estimated 5-year net survival, adjusted for background mortality in every country or region by age (single year), sex, and calendar year, and by race or ethnic origin in some countries. Estimates were age-standardised with the International Cancer Survival Standard weights.
FINDINGS:
5-year survival from colon, rectal, and breast cancers has increased steadily in most developed countries. For patients diagnosed during 2005-09, survival for colon and rectal cancer reached 60% or more in 22 countries around the world; for breast cancer, 5-year survival rose to 85% or higher in 17 countries worldwide. Liver and lung cancer remain lethal in all nations: for both cancers, 5-year survival is below 20% everywhere in Europe, in the range 15-19% in North America, and as low as 7-9% in Mongolia and Thailand. Striking rises in 5-year survival from prostate cancer have occurred in many countries: survival rose by 10-20% between 1995-99 and 2005-09 in 22 countries in South America, Asia, and Europe, but survival still varies widely around the world, from less than 60% in Bulgaria and Thailand to 95% or more in Brazil, Puerto Rico, and the USA. For cervical cancer, national estimates of 5-year survival range from less than 50% to more than 70%; regional variations are much wider, and improvements between 1995-99 and 2005-09 have generally been slight. For women diagnosed with ovarian cancer in 2005-09, 5-year survival was 40% or higher only in Ecuador, the USA, and 17 countries in Asia and Europe. 5-year survival for stomach cancer in 2005-09 was high (54-58%) in Japan and South Korea, compared with less than 40% in other countries. By contrast, 5-year survival from adult leukaemia in Japan and South Korea (18-23%) is lower than in most other countries. 5-year survival from childhood acute lymphoblastic leukaemia is less than 60% in several countries, but as high as 90% in Canada and four European countries, which suggests major deficiencies in the management of a largely curable disease.
INTERPRETATION:
International comparison of survival trends reveals very wide differences that are likely to be attributable to differences in access to early diagnosis and optimum treatment. Continuous worldwide surveillance of cancer survival should become an indispensable source of information for cancer patients and researchers and a stimulus for politicians to improve health policy and health-care systems
Measurement of the Bs Lifetime in Fully and Partially Reconstructed Bs -> Ds- (phi pi-)X Decays in pbar-p Collisions at sqrt(s) = 1.96 TeV
We present a measurement of the Bs lifetime in fully and partially
reconstructed Bs -> Ds(phi pi)X decays in 1.3 fb-1 of pbar-p collisions at
sqrt(s) = 1.96 TeV collected by the CDF II detector at the Fermilab Tevatron.
We measure tau(Bs) = 1.518 +/- 0.041 (stat.) +/- 0.027 (syst.) ps. The ratio of
this result and the world average B0 lifetime yields tau(Bs)/tau(B0) = 0.99
+/-0.03, which is in agreement with recent theoretical predictions.Comment: submitted to Phys. Rev. Let
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