Reversible to Irreversible Flow Transition in Periodically Driven Vortices

We show that periodically driven superconducting vortices in the presence of quenched disorder exhibit a transition from reversible to irreversible flow under increasing vortex density or cycle period. This type of behavior has recently been observed for periodically sheared colloidal suspensions and we demonstrate that driven vortex systems exhibit remarkably similar behavior. We also provide evidence that the onset of irreversible behavior is a dynamical phase transition.Comment: 4 pages, 4 postscript figures. Version to appear in Physical Review Letter

Landscape context mediates the relationship between plant functional traits and decomposition

Aims: It has been well demonstrated that several interacting endogenous and exogenous factors influence decomposition. However, teasing apart the direct and indirect effects of these factors to predict decomposition patterns in heterogenous landscapes remains a key challenge. Methods: At 157 locations in a temperate forest, we measured decomposition of a standard substrate (filter paper) over two years, the landscape context in which decomposition took place, and the functional composition of the woody species that contributed leaf litter to the forest floor where litter bags were placed. We tested for direct and indirect effects of landscape context and direct effects of forest functional composition on decay using structural equation modelling. Results: We found that landscape context had direct effects on decay and indirect effects on decay via its influence on the functional composition of the surrounding forest. Forest functional composition also had direct effects on decay, but these effects decreased or disappeared completely over time. Moreover, community weighted mean trait values were better predictors of decay than functional dispersion of leaf traits, and leaf nitrogen content and carbon content were better predictors of decay than leaf dry matter content or leaf toughness. Conclusions: Our results highlight the importance of an integrative approach that examines the direct and indirect effects of multiple factors for understanding and predicting decomposition patterns across heterogenous landscapes

Using sports infrastructure to deliver economic and social change: Lessons for London beyond 2012

Over the last two decades, there has been a new trend emerging within sport, which has seen a shift, from investment for the sake of sport, to investment in sport for good (Sport England, 2008). In the context of the latter approach, there has been an emergence of the use of sport to address regeneration objectives, largely stemming from the belief of government and other sporting and non-sporting organizations, that it can confer a wide range of economic and social benefits to individuals and communities beyond those of a purely physical sporting nature, and can contribute positively to the revitalization of declining urban areas (BURA, 2003). This commentary will examine regeneration legacy in the context of the London Olympic Games. In particular, it will focus on the use of sports stadia as a tool for delivering economic and social change, and by drawing upon previous examples, suggest lessons London can learn to enhance regeneration legacies beyond 2012

Transcriptional adaptation of Mycobacterium tuberculosis within macrophages: Insights into the phagosomal environment

Little is known about the biochemical environment in phagosomes harboring an infectious agent. To assess the state of this organelle we captured the transcriptional responses of Mycobacterium tuberculosis (MTB) in macrophages from wild-type and nitric oxide (NO) synthase 2–deficient mice before and after immunologic activation. The intraphagosomal transcriptome was compared with the transcriptome of MTB in standard broth culture and during growth in diverse conditions designed to simulate features of the phagosomal environment. Genes expressed differentially as a consequence of intraphagosomal residence included an interferon � – and NO-induced response that intensifies an iron-scavenging program, converts the microbe from aerobic to anaerobic respiration, and induces a dormancy regulon. Induction of genes involved in the activation and �-oxidation of fatty acids indicated that fatty acids furnish carbon and energy. Induction of �E-dependent, sodium dodecyl sulfate–regulated genes and genes involved in mycolic acid modification pointed to damage and repair of the cell envelope. Sentinel genes within the intraphagosomal transcriptome were induced similarly by MTB in the lungs of mice. The microbial transcriptome thus served as a bioprobe of the MTB phagosomal environment

On the convergence of quadrature formulas connected with multipoint Padé-type approximants

29 pages, no figures.-- MSC2000 codes: 41A55, 41A21.MR#: MR1408352 (97e:41066)Zbl#: Zbl 0856.41027^aLet $I(F)= \int^1_{- 1} F(x)\omega(x) dx$, where $\omega$ is a complex valued integrable function. We consider quadrature formulas for $I(F)$ which are exact with respect to rational functions with prescribed poles contained in \overline{\bbfC}\backslash [- 1, 1]. Their rate of convergence is studied.The research by the first three authors (P.G.-V., M.J.P., R.O.) was partially supported by the HCM project ROLLS, under Contract CHRX-CT93-0416. Research by the fourth author (G.L.L.) was carried out while on a visit at Universidad de La Laguna. This visit was made possible by a travel grant from CDE-IMU.Publicad

Patterns of subnet usage reveal distinct scales of regulation in the transcriptional regulatory network of Escherichia coli

The set of regulatory interactions between genes, mediated by transcription factors, forms a species' transcriptional regulatory network (TRN). By comparing this network with measured gene expression data one can identify functional properties of the TRN and gain general insight into transcriptional control. We define the subnet of a node as the subgraph consisting of all nodes topologically downstream of the node, including itself. Using a large set of microarray expression data of the bacterium Escherichia coli, we find that the gene expression in different subnets exhibits a structured pattern in response to environmental changes and genotypic mutation. Subnets with less changes in their expression pattern have a higher fraction of feed-forward loop motifs and a lower fraction of small RNA targets within them. Our study implies that the TRN consists of several scales of regulatory organization: 1) subnets with more varying gene expression controlled by both transcription factors and post-transcriptional RNA regulation, and 2) subnets with less varying gene expression having more feed-forward loops and less post-transcriptional RNA regulation.Comment: 14 pages, 8 figures, to be published in PLoS Computational Biolog

A statistical method for revealing form-function relations in biological networks

Over the past decade, a number of researchers in systems biology have sought to relate the function of biological systems to their network-level descriptions -- lists of the most important players and the pairwise interactions between them. Both for large networks (in which statistical analysis is often framed in terms of the abundance of repeated small subgraphs) and for small networks which can be analyzed in greater detail (or even synthesized in vivo and subjected to experiment), revealing the relationship between the topology of small subgraphs and their biological function has been a central goal. We here seek to pose this revelation as a statistical task, illustrated using a particular setup which has been constructed experimentally and for which parameterized models of transcriptional regulation have been studied extensively. The question "how does function follow form" is here mathematized by identifying which topological attributes correlate with the diverse possible information-processing tasks which a transcriptional regulatory network can realize. The resulting method reveals one form-function relationship which had earlier been predicted based on analytic results, and reveals a second for which we can provide an analytic interpretation. Resulting source code is distributed via http://formfunction.sourceforge.net.Comment: To appear in Proc. Natl. Acad. Sci. USA. 17 pages, 9 figures, 2 table

Dispelling the myths of online education: learning via the information superhighway

There continues to be a perception that online education is inferior to traditional education. In the U.S. online learning is more developed than in the U.K. This paper provides insights into a U.S. provision and takes a close look at what are perceived as weaknesses of on line learning and argues that these are not necessarily inherent weaknesses of this form of educational delivery. Then, results of two major studies, undertaken in the U.S. are provided comparing the effectiveness of online education to traditional education as perceived by current MBA students and past graduates. Results of these studies suggest that students of MBA modules and MBA graduates perceive the quality and effectiveness of online education to be similar to, if not higher than, the quality and effectiveness of traditional modules and programmes

The British Influence in the Birth of Spanish Sport

Sports started to gain relevance in Spain around the end of the nineteenth century and the beginning of the twentieth century as a leisure and health option of the upper classes imported from Britain. Its early development was intertwined with the spread of other kinds of physical activities with much more tradition on the continent: gymnastics and physical education. First played by the ruling classes – aristocracy and high bourgeoisie – sports permeated towards petty bourgeoisie and middle classes in urban areas such as Madrid, Barcelona, San Sebastián and Santander. This pattern meant that the expansion of sports was unavoidably tied to the degree of industrialisation and cultural modernisation of the country. Since 1910, and mainly during the 1920s, sport grew in popularity as a spectacle and, toa much lesser degree, as a practice among the Spanish population

Olympic legacy and cultural tourism: Exploring the facets of Athens' Olympic heritage

This study examines the effects of the Olympic Games on Athens’ cultural tourism and the city’s potential to leverage the Olympic legacy in synergy with its rich heritage in order to enhance its tourism product during the post-Games period. In doing so, a qualitative and interpretive approach was employed. This includes a literature review on Athens’ 2004 Olympics to identify the sport facilities and regeneration projects, which constitute the Olympic legacy and heritage. Based on that, an empirical analysis was undertaken, by collecting official documents about the 2004 Olympics, and conducting five semi-structured interviews with tourism/administrative officials. The findings indicate that the Olympiad contributed significantly to Athens’ built and human heritage, revealing the dimensions of new venues/facilities, infrastructure, transportation and aesthetic image of the city, and human capital enhancement. Hence, the Games affected to the multifaceted representation and reconstruction of the city’s identity and cultural heritage. However, the potential afforded from the post-Olympic Athens remains unrealised due to lack of strategic planning/management. The study concludes that there is a need to develop cross-leveraging synergies between the Olympic legacy and cultural tourism for the host city. Finally, a strategic planning framework for leveraging post-Games Olympic tourism is suggested in order to maximise the benefits of Olympic legacy and heritage in a host city’s tourism development