1,567 research outputs found
The teaching of grammar in grades 7-8-9-10
Thesis (M.A.)--Boston Universit
Anderson's ethical vulnerability: animating feminist responses to sexual violence
Pamela Sue Anderson argues for an ethical vulnerability which âactivates an openness to becoming changedâ that âcan make possible a relational accountability to one another on ethical mattersâ. In this essay I pursue Andersonâs solicitation that there is a positive politics to be developed from acknowledging and affirming vulnerability. I propose that this politics is one which has a specific relevance for animating the terms of feminist responses to sexual violence, something which has proved difficult for feminist theorists and activists alike. I will demonstrate the contribution of Andersonâs work to such questions by examining the way in which âethical vulnerabilityâ as a framework can illuminate the intersectional feminist character of Tarana Burkeâs grassroots Me Too movement when compared with the mainstream, viral version of the movement. I conclude by arguing that Andersonâs âethical vulnerabilityâ contains ontological insights which can allay both activist and academic concerns regarding how to respond to sexual violence
Transnational Motherhood and the Production of Subjectivity: Experiences of migrant Brazilian women living in London
This study explores how transnational motherhood is experienced by a group of Brazilian women participating in the global care chain. Our analysis indicates that transnational motherhood is an experience ripe with contradictions and emotional constraints. On one hand, transnational motherhood can subjugate women for not conforming to conventional motherhood norms. On the other hand, the migratory experience allows women to (re)negotiate their maternal roles, producing new meanings for care and mothering practices
Creating a space for young women's voices: Using participatory 'video drama' in Uganda
This article draws upon research that explored the experiences of young women in relation to sexual health in Uganda with a view to enhancing gender-sensitive strategies. We have coined the phrase âparticipatory video dramaâ to describe the exploratory methodology that the young women participants in our research used to present stories about their lives. The aim of this article is to suggest that âparticipatory videoâ (PV) and âparticipatory video dramaâ (PVD) are innovative methodological tools to utilise when working with participants who experience voicelessness in their everyday lives. We contribute to an emerging body of work around this methodology by suggesting that the process of PV provides a novel and engaging platform for participants to express their experiences. PVD further creates spaces for the performative exploration of embedded power relations and is therefore informative and has the potential to be transformatory and empowering
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling. © 2018 The Author(s).Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling. © 2018 The Author(s).Peer reviewe
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