934 research outputs found
Multi-sensor electrometer
An array of triboelectric sensors is used for testing the electrostatic properties of a remote environment. The sensors may be mounted in the heel of a robot arm scoop. To determine the triboelectric properties of a planet surface, the robot arm scoop may be rubbed on the soil of the planet and the triboelectrically developed charge measured. By having an array of sensors, different insulating materials may be measured simultaneously. The insulating materials may be selected so their triboelectric properties cover a desired range. By mounting the sensor on a robot arm scoop, the measurements can be obtained during an unmanned mission
Protocolised early de-resuscitation in septic shock (REDUCE): protocol for a randomised controlled multicentre feasibility trial.
BACKGROUND
Fluid overload is associated with excess mortality in septic shock. Current approaches to reduce fluid overload include restrictive administration of fluid or active removal of accumulated fluid. However, evidence on active fluid removal is scarce. The aim of this study is to assess the efficacy and feasibility of an early de-resuscitation protocol in patients with septic shock.
METHODS
All patients admitted to the intensive care unit (ICU) with a septic shock are screened, and eligible patients will be randomised in a 1:1 ratio to intervention or standard of care.
INTERVENTION
Fluid management will be performed according to the REDUCE protocol, where resuscitation fluid will be restricted to patients showing signs of poor tissue perfusion. After the lactate has peaked, the patient is deemed stable and assessed for active de-resuscitation (signs of fluid overload). The primary objective of this study is the proportion of patients with a negative cumulative fluid balance at day 3 after ICU. Secondary objectives are cumulative fluid balances throughout the ICU stay, number of patients with fluid overload, feasibility and safety outcomes and patient-centred outcomes. The primary outcome will be assessed by a logistic regression model adjusting for the stratification variables (trial site and chronic renal failure) in the intention-to-treat population.
ETHICS AND DISSEMINATION
The study was approved by the respective ethical committees (No 2020-02197). The results of the REDUCE trial will be published in an international peer-reviewed medical journal regardless of the results.
TRIAL REGISTRATION NUMBER
ClinicalTrials.gov, NCT04931485
The nature of the silicaphilic fluorescence of PDMPO
PDMPO (2-(4-pyridyl)-5-((4-(2-dimethylaminoethylaminocarbamoyl)methoxy)phenyl)oxazole), has unique silica specific fluorescence and is used in biology to understand biosilicification. This ‘silicaphilic’ fluorescence is not well understood nor is the response to local environmental variables like solvent and pH. We investigated PDMPO in a range of environments: using UV-vis and fluorescence spectroscopy supported by computational data, (SPARC, molecular dynamics simulations, density functional theory calculations), dynamic light scattering and zeta potential measurements to understand the PDMPO–silica interaction. From absorption data, PDMPO exhibited a pKa of 4.20 for PDMPOH22+ to PDMPOH+ . Fluorescence emission measurements revealed large shifts in excited state pKa* values with different behaviour when bound to silica (pKa* of 10.4). PDMPO bound to silica particles is located in the Stern layer with the dye exhibiting pH dependent depolarising motion. In aqueous solution, PDMPO showed strong chromaticity with correlation between the maximum emission wavelength for PDMPOH+* and dielectric constant (4.8–80). Additional chromatic effects were attributed to changes in solvent accessible surface area. Chromatic effects were also observed for silica bound dye which allow its use as a direct probe of bulk pH over a range far in excess of what is possible for the dye alone (3–5.2). The unique combination of chromaticity and excited state dynamics allows PDMPO to monitor pH from 3 to 13 while also reporting on surface environment opening a new frontier in the quantitative understanding of (bio)silicification
Development and validation of a prognostic model for the early identification of COVID-19 patients at risk of developing common long COVID symptoms
Background: The coronavirus disease 2019 (COVID-19) pandemic demands reliable prognostic models for estimating the risk of long COVID. We developed and validated a prediction model to estimate the probability of known common long COVID symptoms at least 60 days after acute COVID-19.
Methods: The prognostic model was built based on data from a multicentre prospective Swiss cohort study. Included were adult patients diagnosed with COVID-19 between February and December 2020 and treated as outpatients, at ward or intensive/intermediate care unit. Perceived long-term health impairments, including reduced exercise tolerance/reduced resilience, shortness of breath and/or tiredness (REST), were assessed after a follow-up time between 60 and 425 days. The data set was split into a derivation and a geographical validation cohort. Predictors were selected out of twelve candidate predictors based on three methods, namely the augmented backward elimination (ABE) method, the adaptive best-subset selection (ABESS) method and model-based recursive partitioning (MBRP) approach. Model performance was assessed with the scaled Brier score, concordance c statistic and calibration plot. The final prognostic model was determined based on best model performance.
Results: In total, 2799 patients were included in the analysis, of which 1588 patients were in the derivation cohort and 1211 patients in the validation cohort. The REST prevalence was similar between the cohorts with 21.6% (n = 343) in the derivation cohort and 22.1% (n = 268) in the validation cohort. The same predictors were selected with the ABE and ABESS approach. The final prognostic model was based on the ABE and ABESS selected predictors. The corresponding scaled Brier score in the validation cohort was 18.74%, model discrimination was 0.78 (95% CI: 0.75 to 0.81), calibration slope was 0.92 (95% CI: 0.78 to 1.06) and calibration intercept was -0.06 (95% CI: -0.22 to 0.09).
Conclusion: The proposed model was validated to identify COVID-19-infected patients at high risk for REST symptoms. Before implementing the prognostic model in daily clinical practice, the conduct of an impact study is recommended.
Keywords: Clinical prediction model; Long COVID; Prognostic factors; Stratified medicin
Constraints on the Cosmic-Ray Density Gradient beyond the Solar Circle from Fermi gamma-ray Observations of the Third Galactic Quadrant
We report an analysis of the interstellar -ray emission in the third
Galactic quadrant measured by the {Fermi} Large Area Telescope. The window
encompassing the Galactic plane from longitude 210\arcdeg to 250\arcdeg has
kinematically well-defined segments of the Local and the Perseus arms, suitable
to study the cosmic-ray densities across the outer Galaxy. We measure no large
gradient with Galactocentric distance of the -ray emissivities per
interstellar H atom over the regions sampled in this study. The gradient
depends, however, on the optical depth correction applied to derive the \HI\
column densities. No significant variations are found in the interstellar
spectra in the outer Galaxy, indicating similar shapes of the cosmic-ray
spectrum up to the Perseus arm for particles with GeV to tens of GeV energies.
The emissivity as a function of Galactocentric radius does not show a large
enhancement in the spiral arms with respect to the interarm region. The
measured emissivity gradient is flatter than expectations based on a cosmic-ray
propagation model using the radial distribution of supernova remnants and
uniform diffusion properties. In this context, observations require a larger
halo size and/or a flatter CR source distribution than usually assumed. The
molecular mass calibrating ratio, , is
found to be
in the Local-arm clouds and is not significantly sensitive to the choice of
\HI\ spin temperature. No significant variations are found for clouds in the
interarm region.Comment: Corresponding authors: I. A. Grenier ([email protected]); T.
Mizuno ([email protected]); L. Tibaldo
([email protected]) accepted for publication in Ap
Detection of the Small Magellanic Cloud in gamma-rays with Fermi/LAT
The flux of gamma rays with energies >100MeV is dominated by diffuse emission
from CRs illuminating the ISM of our Galaxy through the processes of
Bremsstrahlung, pion production and decay, and inverse-Compton scattering. The
study of this diffuse emission provides insight into the origin and transport
of CRs. We searched for gamma-ray emission from the SMC in order to derive
constraints on the CR population and transport in an external system with
properties different from the Milky Way. We analysed the first 17 months of
continuous all-sky observations by the Large Area Telescope of the Fermi
mission to determine the spatial distribution, flux and spectrum of the
gamma-ray emission from the SMC. We also used past radio synchrotron
observations of the SMC to study the population of CR electrons specifically.
We obtained the first detection of the SMC in high-energy gamma rays, with an
integrated >100MeV flux of (3.7 +/-0.7) x10e-8 ph/cm2/s, with additional
systematic uncertainty of <16%. The emission is steady and from an extended
source ~3{\deg} in size. It is not clearly correlated with the distribution of
massive stars or neutral gas, nor with known pulsars or SNRs, but a certain
correlation with supergiant shells is observed. The observed flux implies an
upper limit on the average CR nuclei density in the SMC of ~15% of the value
measured locally in the Milky Way. The population of high-energy pulsars of the
SMC may account for a substantial fraction of the gamma-ray flux, which would
make the inferred CR nuclei density even lower. The average density of CR
electrons derived from radio synchrotron observations is consistent with the
same reduction factor but the uncertainties are large. From our current
knowledge of the SMC, such a low CR density does not seem to be due to a lower
rate of CR injection and rather indicates a smaller CR confinement volume
characteristic size.Comment: 14 pages, 6 figures, accepted for publication in A&
Quantitative Treatment of Decoherence
We outline different approaches to define and quantify decoherence. We argue
that a measure based on a properly defined norm of deviation of the density
matrix is appropriate for quantifying decoherence in quantum registers. For a
semiconductor double quantum dot qubit, evaluation of this measure is reviewed.
For a general class of decoherence processes, including those occurring in
semiconductor qubits, we argue that this measure is additive: It scales
linearly with the number of qubits.Comment: Revised version, 26 pages, in LaTeX, 3 EPS figure
Improved W boson mass measurement with the D0 detector
We have measured the W boson mass using the D0 detector and a data sample of
82 pb^-1 from the Tevatron collider. This measurement used W -> e nu decays,
where the electron is close to a boundary of a central electromagnetic
calorimeter module. Such 'edge' electrons have not been used in any previous D0
analysis, and represent a 14% increase in the W boson sample size. For these
electrons, new response and resolution parameters are determined, and revised
backgrounds and underlying event energy flow measurements are made. When the
current measurement is combined with previous D0 W boson mass measurements, we
obtain M_W = 80.483 +/- 0.084 GeV. The 8% improvement from the previous D0
measurement is primarily due to the improved determination of the response
parameters for non-edge electrons using the sample of Z bosons with non-edge
and edge electrons.Comment: submitted to Phys. Rev. D; 20 pages, 18 figures, 9 table
Higgs boson gluon-fusion production beyond threshold in N3LO QCD
In this article, we compute the gluon fusion Higgs boson cross-section at
N3LO through the second term in the threshold expansion. This calculation
constitutes a major milestone towards the full N3LO cross section. Our result
has the best formal accuracy in the threshold expansion currently available,
and includes contributions from collinear regions besides subleading
corrections from soft and hard regions, as well as certain logarithmically
enhanced contributions for general kinematics. We use our results to perform a
critical appraisal of the validity of the threshold approximation at N3LO in
perturbative QCD
Wild Skylarks Seasonally Modulate Energy Budgets but Maintain Energetically Costly Inflammatory Immune Responses throughout the Annual Cycle
A central hypothesis of ecological immunology is that immune defences are traded off against competing physiological and behavioural processes. During energetically demanding periods, birds are predicted to switch from expensive inflammatory responses to less costly immune responses. Acute phase responses (APRs) are a particularly costly form of immune defence, and, hence, seasonal modulations in APRs are expected. Yet, hypotheses about APR modulation remain untested in free-living organisms throughout a complete annual cycle. We studied seasonal modulations in the APRs and in the energy budgets of skylarks Alauda arvensis, a partial migrant bird from temperate zones that experiences substantial ecological changes during its annual cycle. We characterized throughout the annual cycle changes in their energy budgets by measuring basal metabolic rate (BMR) and body mass. We quantified APRs by measuring the effects of a lipopolysaccharide injection on metabolic rate, body mass, body temperature, and concentrations of glucose and ketone. Body mass and BMR were lowest during breeding, highest during winter and intermediate during spring migration, moult and autumn migration. Despite this variation in energy budgets, the magnitude of the APR, as measured by all variables, was similar in all annual cycle stages. Thus, while we find evidence that some annual cycle stages are relatively more energetically constrained, we find no support for the hypothesis that during these annual cycle stages birds compromise an immune defence that is itself energetically costly. We suggest that the ability to mount an APR may be so essential to survival in every annual cycle stage that skylarks do not trade off this costly form of defence with other annual cycle demands
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