Neutrino-Lepton Masses, Zee Scalars and Muon g-2

Evidence for neutrino oscillations is pointing to the existence of tiny but finite neutrino masses. Such masses may be naturally generated via radiative corrections in models such as the Zee model where a singlet Zee-scalar plays a key role. We minimally extend the Zee model by including a right-handed singlet neutrino \nu_R. The radiative Zee-mechanism can be protected by a simple U(1)_X symmetry involving only the \nu_R and a Zee-scalar. We further construct a class of models with a single horizontal U(1)_FN (a la Frogatt-Nielsen) such that the mass patterns of the neutrinos and leptons are naturally explained. We then analyze the muon anomalous magnetic moment (g-2) and the flavor changing \mu --> e\gamma decay. The \nu_R interaction in our minimal extension is found to induce the BNL g-2 anomaly, with a light charged Zee-scalar of mass 100-300 GeV.Comment: Version for Phys. Rev. Lett. (typos corrected, minor refinements

Effects of spatial size, lattice doubling and source operator on the hadron spectrum with dynamical staggered quarks

We have extended our previous study of the lattice QCD spectrum with 2 flavors of staggered dynamical quarks at $6/g^2=5.6$ and $am_q=0.025$ and 0.01 to larger lattices, with better statistics and with additional sources for the propagators. The additional sources allowed us to estimate the $\Delta$ mass and to measure the masses of all mesons whose operators are local in time. These mesons show good evidence for flavor symmetry restoration, except for the masses of the Goldstone and non-Goldstone pions. PCAC is observed in that $m_\pi^2 \propto m_q$, and $f_\pi$ is estimated. Use of undoubled lattices removes problems with the pion propagator found in our earlier work. Previously we found a large change in the nucleon mass at a quark mass of $am_q=0.01$ when we increased the spatial size from 12 to 16. No such effect is observed at the larger quark mass, $am_q=0.025$. Two kinds of wall source were used, and we have found difficulties in getting consistent results for the nucleon mass between the two sources.Comment: 30 pages PostScript fil

Dynamical Fermions with Fat Links

We present and test a new method for simulating dynamical fermions with fat links. Our construction is based on the introduction of auxiliary but dynamical gauge fields and works with any fermionic action and can be combined with any fermionic updating. In our simulation we use an over-relaxation step which makes it effective. For four flavors of staggered fermions first results indicate that flavor symmetry at a lattice spacing a~0.2 fm is restored to a few percent. With the standard action this amount of flavor symmetry restoration is achieved at a~0.07 fm. We estimate that the overall computational cost is reduced by at least a factor 10.Comment: 11 pages, 4 figures, detailed description of over-relaxation and references added, figures with more statistic

Cluster Hybrid Monte Carlo Simulation Algorithms

We show that addition of Metropolis single spin-flips to the Wolff cluster flipping Monte Carlo procedure leads to a dramatic {\bf increase} in performance for the spin-1/2 Ising model. We also show that adding Wolff cluster flipping to the Metropolis or heat bath algorithms in systems where just cluster flipping is not immediately obvious (such as the spin-3/2 Ising model) can substantially {\bf reduce} the statistical errors of the simulations. A further advantage of these methods is that systematic errors introduced by the use of imperfect random number generation may be largely healed by hybridizing single spin-flips with cluster flipping.Comment: 16 pages, 10 figure

REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis

The nuclear receptor REV-ERBα shapes the daily activity profile of Sterol Response Element Binding Protein (SREBP) and thereby participates in the circadian control of cholesterol and bile acid synthesis in the liver

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Characterization of Vadose Zone Sediments Below the T Tank Farm: Boreholes C4104, C4105, 299-W10-196, and RCRA Borehole 299-W11-39

This report was revised in September 2008 to remove acid-extractable sodium data from Tables 4.8, 4.28, and 4.52. The sodium data was removed due to potential contamination introduced during the acid extraction process. The rest of the text remains unchanged from the original report issued in September 2004. The overall goal of the Tank Farm Vadose Zone Project, led by CH2M HILL Hanford Group, Inc., is to define risks from past and future single-shell tank farm activities at Hanford. To meet this goal, CH2M HILL Hanford Group, Inc. tasked scientists from Pacific Northwest National Laboratory to perform detailed analyses on vadose zone sediments from within Waste Management Area (WMA) T-TX-TY. This report is the second of two reports written to present the results of these analyses. Specifically, this report contains all the geologic, geochemical, and selected physical characterization data collected on vadose zone sediment recovered from boreholes C4104 and C4105 in the T Tank Farm, and from borehole 299-W-11-39 installed northeast of the T Tank Farm. Finally, the measurements on sediments from borehole C4104 are compared with a nearby borehole drilled in 1993, 299- W10-196, through the tank T-106 leak plume

Landscape Ecology of Sylvatic Chikungunya Virus and Mosquito Vectors in Southeastern Senegal

The risk of human infection with sylvatic chikungunya (CHIKV) virus was assessed in a focus of sylvatic arbovirus circulation in Senegal by investigating distribution and abundance of anthropophilic Aedes mosquitoes, as well as the abundance and distribution of CHIKV in these mosquitoes. A 1650 km2 area was classified into five land cover classes: forest, barren, savanna, agriculture and village. A total of 39,799 mosquitoes was sampled from all classes using human landing collections between June 2009 and January 2010. Mosquito diversity was extremely high, and overall vector abundance peaked at the start of the rainy season. CHIKV was detected in 42 mosquito pools. Our data suggest that Aedes furcifer, which occurred abundantly in all land cover classes and landed frequently on humans in villages outside of houses, is probably the major bridge vector responsible for the spillover of sylvatic CHIKV to humans

Complexity absorption : A processual strategic approach to corporate entrepreneurship strategy

The author Haina Zhang acknowledges the support of research grant received from the Lancaster University Research Committee (award reference: SGS21/33). The author is also grateful to Professor David Brown for his suggestions on earlier version of this paper.Peer reviewedPublisher PD