2,657 research outputs found

    Compressed representation of a partially defined integer function over multiple arguments

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    In OLAP (OnLine Analitical Processing) data are analysed in an n-dimensional cube. The cube may be represented as a partially defined function over n arguments. Considering that often the function is not defined everywhere, we ask: is there a known way of representing the function or the points in which it is defined, in a more compact manner than the trivial one

    MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: A randomised, double-blind, placebo-controlled study.

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    BACKGROUND: Treatment with MD1003 (high-dose biotin) showed promising results in progressive multiple sclerosis (MS) in a pilot open-label study. OBJECTIVE: To confirm the efficacy and safety of MD1003 in progressive MS in a double-blind, placebo-controlled study. METHODS: Patients (n = 154) with a baseline Expanded Disability Status Scale (EDSS) score of 4.5-7 and evidence of disease worsening within the previous 2 years were randomised to 12-month MD1003 (100 mg biotin) or placebo thrice daily, followed by 12-month MD1003 for all patients. The primary endpoint was the proportion of patients with disability reversal at month 9, confirmed at month 12, defined as an EDSS decrease of ⩾1 point (⩾0.5 for EDSS 6-7) or a ⩾20% decrease in timed 25-foot walk time compared with the best baseline among screening or randomisation visits. RESULTS: A total of 13 (12.6%) MD1003-treated patients achieved the primary endpoint versus none of the placebo-treated patients (p = 0.005). MD1003 treatment also reduced EDSS progression and improved clinical impression of change compared with placebo. Efficacy was maintained over follow-up, and the safety profile of MD1003 was similar to that of placebo. CONCLUSION: MD1003 achieves sustained reversal of MS-related disability in a subset of patients with progressive MS and is well tolerated.journal article2016 Nov2016 09 01importe

    Measurement of the single top quark and antiquark production cross sections in the t channel and their ratio in proton-proton collisions at \sqrt{s} = 13 TeV

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    Measurements of the cross sections for the production of single top quarks and antiquarks in the t channel, and their ratio, are presented for proton-proton collisions at a center-of-mass energy of 13 TeV. The data set used was recorded in 2016 by the CMS detector at the LHC and corresponds to an integrated luminosity of 35.9 fb^{-1}. Events with one muon or electron are selected, and different categories of jet and b jet multiplicity and multivariate discriminators are applied to separate the signal from the background. The cross sections for the t-channel production of single top quarks and antiquarks are measured to be 130 ± 1(stat) ± 19(syst) pb and 77 ± 1(stat) ± 12(syst) pb, respectively, and their ratio is 1.68 ± 0.02(stat) ± 0.05(syst). The results are in agreement with the predictions from the standard model
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