Motivation to quit as a predictor of smoking cessation and abstinence maintenance among treated Spanish smokers

Introduction: Although quitting motivation predicts smoking cessation, there have been inconsistent findings regarding motivation predicting long-term maintenance of abstinence. Moreover, most such research has been conducted in North America and the United Kingdom. The aim of this study was to examine motivation to quit as a predictor of smoking cessation and of abstinence maintenance in a Spanish sample. Method: The sample comprised 286 Spanish smokers undergoing psychological treatment for smoking cessation. Motivation to quit was assessed pre-treatment and post-treatment with the Readiness to Quit Ladder. Abstinence post-treatment and at 6 month follow-up was biochemically verified. Results: Participants with higher levels of pre-treatment and post-treatment motivation were more likely to be abstinent at the end of the treatment (OR. = 1.36) and at 6 month follow-up (OR. = 4.88). Among abstainers at the end of the treatment (61.9%), higher levels of motivation to quit post-treatment predicted maintaining abstinence at 6 months (OR. = 2.83). Furthermore, participants who failed to quit smoking reported higher levels of motivation to quit post-treatment than they had pretreatment (p<. .001). Conclusions: Motivation to quit smoking predicted short and long-term cessation, and also predicted long-term maintenance of abstinence. These results have implications for understanding motivational processes of smoking cessation in general, while extending research to Spanish smokers. They may also help in the design of cessation and relapse-prevention interventions. Specifically, the results suggest that motivational enhancement is important throughout the cessation and maintenance periods

An online framework for fitting fast transient light curves

The identification of extragalactic fast optical transients (eFOTs) as potential multimessenger sources is one of the main challenges in time-domain astronomy. However, recent developments have allowed for probes of rapidly evolving transients. With the increasing number of alert streams from optical time-domain surveys, the next paradigm is building technologies to rapidly identify the most interesting transients for follow-up. One effort to make this possible is the fitting of objects to a variety of eFOT light curve models such as kilonovae and γ -ray burst (GRB) afterglows. In this work, we describe a new framework designed to efficiently fit transients to light curve models and flag them for further follow-up. We describe the pipeline’s workflow and a handful of performance metrics, including the nominal sampling time for each model. We highlight as examples ZTF20abwysqy, the shortest long gamma-ray burst discovered to date, and ZTF21abotose, a core-collapse supernova initially identified as a potential kilonova candidate

Age at first birth in women is genetically associated with increased risk of schizophrenia

Prof. Paunio on PGC:n jäsenPrevious studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to estimate the genetic correlation between schizophrenia and AFB in women stratified into younger and older groups. We find evidence for an association between predicted genetic risk of schizophrenia and AFB in women (P-value = 1.12E-05), and we show genetic heterogeneity between younger and older AFB groups (P-value = 3.45E-03). The genetic correlation between schizophrenia and AFB in the younger AFB group is -0.16 (SE = 0.04) while that between schizophrenia and AFB in the older AFB group is 0.14 (SE = 0.08). Our results suggest that early, and perhaps also late, age at first birth in women is associated with increased genetic risk for schizophrenia in the UK Biobank sample. These findings contribute new insights into factors contributing to the complex bio-social risk architecture underpinning the association between parental age and offspring mental health.Peer reviewe

Effectiviteit van telefonische coaching om te stoppen met roken

Item does not contain fulltextWe tested the effectiveness of tailored quitline (telephone) counselling among smoking parents recruited into cessation support through their children’s primary schools. We conducted a two-arm randomized controlled trial with 3-month and 12-month follow- up. Smoking parents were recruited through their children’s primary schools and received either quitline counseling in combination with tailored supplementary materials or a standard self-help brochure. Parents who received quitline counseling were more likely to report 7-day point prevalence abstinence at 12month assessment than those who received a standard self-help brochure. Parents who received quitline counseling were more likely to use nicotine replacement therapy than those who received a standard self-help brochure. Among parents who did not achieve abstinence, those who received quitline counseling smoked fewer cigarettes at 3-months assessment and 12-month assessment, were more likely to make a quit attempt, to achieve 24hours abstinence, and to implement a complete home smoking ban than those who received a standard self-help brochure. Quit-line counseling tailored to smoking parents is an effective method for helping parents quit smoking and promoting parenting practices that protect their children from adverse effects of smoking

Linking creativity to psychological well-being: integrative insights from the instrumental emotion regulation theory

Research has recognized that people regulate their emotions not only for seeking pleasurable experiences but also for receiving instrumental gains. We draw on the theoretical framework of instrumental emotion regulation (IER; Tamir, 2005, 2009) to shed new light on the relationships among creativity, emotion, and psychological well-being. We outline propositions that explain why there are concurrent creative and well-being benefits when people experience emotional states that are consistent with their personality trait (e.g., worrisome emotions being consistent with trait neuroticism) even if such trait-consistent emotions are negative. The IER perspective offers new interpretations of the creativity—well-being relationship through motivating a more holistic view of emotion regulation and well-being. We present an integrative theoretical model explicating that instrumental regulation toward trait-consistent emotions engages people in emotional states that feel affectively right (affective path), motivate them intrinsically (motivational path), and boost cognitive efficiency (cognitive path), thus yielding potential downstream benefits on creativity and well-being

Mechanical properties of ceramic matrix composites Final report

The interfacial properties of fiber-reinforced ceramic matrix composites are being investigated using the Slice Compression Test (SCT). Internal stresses have now been included in the calculation of the interfacial shear stress, resulting in better agreement with the results reported elsewhere. A method for investigating the interfacial properties of these composites at elevated temperature was developed and a hot-stage was designed and built. Some results for the slice compression test performed at 600 C are presented. The available range of compressive stress (the working window) for some candidate SCT metal replica materials, both at room temperature and at 600 C, was determined. Extended room temperature SCT experiments resulted in large sets of data of fiber residual protrusion after loading to various stresses, to calculate the interfacial shear stress. The structure of the composite was characterized for the same group of neighbouring fibers whose protrusion lengths had been measured, to enable our co-workers at the University of Karlsruhe to attempt a correlation between the micro- and meso-structural parameters (local volume fractions of fiber and matrix, and fiber alignment) with the fiber protrusion. The application of the SCT to elevated temperatures is reported. (orig.)SIGLEAvailable from TIB Hannover: F95B1263 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Forschung und Technologie (BMFT), Bonn (Germany); Ministry of Science and Technology, Jerusalem (Israel)DEGerman

NMMA: A nuclear-physics and multi-messenger astrophysics framework to analyze binary neutron star mergers

The multi-messenger detection of the gravitational-wave signal GW170817, the corresponding kilonova AT2017gfo and the short gamma-ray burst GRB170817A, as well as the observed afterglow has delivered a scientific breakthrough. For an accurate interpretation of all these different messengers, one requires robust theoretical models that describe the emitted gravitational-wave, the electromagnetic emission, and dense matter reliably. In addition, one needs efficient and accurate computational tools to ensure a correct cross-correlation between the models and the observational data. For this purpose, we have developed the NMMA (Nuclear-physics and Multi-Messenger Astrophysics) framework. The code allows incorporation of nuclear-physics constraints at low densities as well as X-ray and radio observations of isolated neutron stars. It also enables us to classify electromagnetic observations, e.g., to distinguish between supernovae and kilonovae. In previous works, the NMMA code has allowed us to constrain the equation of state of supranuclear dense matter, to measure the Hubble constant, and to compare dense-matter physics probed in neutron-star mergers and in heavy-ion collisions. The extension of the NMMA code presented here is the first attempt of analysing the gravitational-wave signal, the kilonovae, and the GRB afterglow simultaneously, which reduces the uncertainty of our constraints. Incorporating all available information, we estimate the radius of a 1.4 solar mass neutron star to be $R=11.98^{+0.35}_{-0.40}$ km

NMMA: A nuclear-physics and multi-messenger astrophysics framework to analyze binary neutron star mergers

The multi-messenger detection of the gravitational-wave signal GW170817, the corresponding kilonova AT2017gfo and the short gamma-ray burst GRB170817A, as well as the observed afterglow has delivered a scientific breakthrough. For an accurate interpretation of all these different messengers, one requires robust theoretical models that describe the emitted gravitational-wave, the electromagnetic emission, and dense matter reliably. In addition, one needs efficient and accurate computational tools to ensure a correct cross-correlation between the models and the observational data. For this purpose, we have developed the NMMA (Nuclear-physics and Multi-Messenger Astrophysics) framework. The code allows incorporation of nuclear-physics constraints at low densities as well as X-ray and radio observations of isolated neutron stars. It also enables us to classify electromagnetic observations, e.g., to distinguish between supernovae and kilonovae. In previous works, the NMMA code has allowed us to constrain the equation of state of supranuclear dense matter, to measure the Hubble constant, and to compare dense-matter physics probed in neutron-star mergers and in heavy-ion collisions. The extension of the NMMA code presented here is the first attempt of analysing the gravitational-wave signal, the kilonovae, and the GRB afterglow simultaneously, which reduces the uncertainty of our constraints. Incorporating all available information, we estimate the radius of a 1.4 solar mass neutron star to be $R=11.98^{+0.35}_{-0.40}$ km

Surgical stabilization of rib fractures versus nonoperative treatment in patients with multiple rib fractures following cardiopulmonary resuscitation: An international, retrospective matched case-control study

BACKGROUND: The presence of six or more rib fractures or a displaced rib fracture due to cardiopulmonary resuscitation (CPR) has been associated with longer hospital and intensive care unit (ICU) length of stay (LOS). Evidence on the effect of surgical stabilization of rib fractures (SSRF) following CPR is limited. This study aimed to evaluate outcomes after SSRF versus nonoperative management in patients with multiple rib fractures after CPR. METHODS: An international, retrospective study was performed in patients who underwent SSRF or nonoperative management for multiple rib fractures following CPR between January 1, 2012, and July 31, 2020. Patients who underwent SSRF were matched to nonoperative controls by cardiac arrest location and cause, rib fracture pattern, and age. The primary outcome was ICU LOS. RESULTS: Thirty-nine operatively treated patient were matched to 66 nonoperatively managed controls with comparable CPR-related characteristics. Patients who underwent SSRF more often had displaced rib fractures (n = 28 [72%] vs. n = 31 [47%]; p = 0.015) and a higher median number of displaced ribs (2 [P 25 -P 75 , 0-3] vs. 0 [P 25 -P 75 , 0-3]; p = 0.014). Surgical stabilization of rib fractures was performed at a median of 5 days (P 25 -P 75 , 3-8 days) after CPR. In the nonoperative group, a rib fixation specialist was consulted in 14 patients (21%). The ICU LOS was longer in the SSRF group (13 days [P 25 -P 75 , 9-23 days] vs. 9 days [P 25 -P 75 , 5-15 days]; p = 0.004). Mechanical ventilator-free days, hospital LOS, thoracic complications, and mortality were similar. CONCLUSION: Despite matching, those who underwent SSRF over nonoperative management for multiple rib fractures following CPR had more severe consequential chest wall injury and a longer ICU LOS. A benefit of SSRF on in-hospital outcomes could not be demonstrated. A low consultation rate for rib fixation in the nonoperative group indicates that the consideration to perform SSRF in this population might be associated with other nonradiographic or injury-related variables. LEVEL OF EVIDENCE: Therapeutic/Care Management; Level III