575 research outputs found
The European Space Analogue Rock Collection (ESAR) at the OSUC-Orleans for in situ planetary missions
International audienceThe ESAR is a collection of well-characterised planetary analogue rocks and minerals that can be used for testing in situ instrumentation for planetary exploration. An online database of all relevant structural, compositional and geotechnics information is also available to the instrument teams and to aid data interpretation during missions
Caregivers’ perceived emotional and feeding responsiveness toward preschool children: Associations and paths of influence
Although there is a large body of research connecting emotion to eating behaviors, little is
known about the role of caregivers’ responses to children’s emotions in the context of child feeding.
The purpose of this study was to analyze the relation between caregivers’ emotional responsiveness
and feeding responsiveness. The mothers of 137 children between 2 and 6 years of age reported on
their responses to children’s negative emotions using the Coping with Children’s Negative Emotions
Scale and on their feeding practices using the Comprehensive Feeding Practices Questionnaire. The
results showed that mothers’ supportive emotion responses (e.g., problem-focused, emotion-focused,
and expressive encouragement reactions) tend to be positively associated with responsive feeding
practices (e.g., encouraging, modelling, and teaching healthy food-related behaviors). Instead,
mothers’ unsupportive responses (e.g., distress, punitive and minimization reactions) tend to be
positively associated with nonresponsive feeding practices (e.g., food as reward or to regulate
emotions, and pressure to eat) and negatively associated with responsive feeding practices. Our
results suggest that emotional and feeding responsiveness may be intertwined and that differences
in parent’s emotional responsiveness may translate into differences in their feeding styles, setting the
stage for parents’ use of positive vs. negative feeding practices.Fundação para a Ciência e Tecnologia - FCTinfo:eu-repo/semantics/publishedVersio
The arithmetic of hyperelliptic curves
We summarise recent advances in techniques for solving Diophantine problems on hyperelliptic curves; in particular, those for finding the rank of the Jacobian, and the set of rational points on the curve
Stability conditions and positivity of invariants of fibrations
We study three methods that prove the positivity of a natural numerical
invariant associated to parameter families of polarized varieties. All
these methods involve different stability conditions. In dimension 2 we prove
that there is a natural connection between them, related to a yet another
stability condition, the linear stability. Finally we make some speculations
and prove new results in higher dimension.Comment: Final version, to appear in the Springer volume dedicated to Klaus
Hulek on the occasion of his 60-th birthda
Computation of the Transient in Max-Plus Linear Systems via SMT-Solving
This paper proposes a new approach, grounded in Satisfiability Modulo
Theories (SMT), to study the transient of a Max-Plus Linear (MPL) system, that
is the number of steps leading to its periodic regime. Differently from
state-of-the-art techniques, our approach allows the analysis of periodic
behaviors for subsets of initial states, as well as the characterization of
sets of initial states exhibiting the same specific periodic behavior and
transient. Our experiments show that the proposed technique dramatically
outperforms state-of-the-art methods based on max-plus algebra computations for
systems of large dimensions.Comment: The paper consists of 22 pages (including references and Appendix).
It is accepted in FORMATS 2020 First revisio
Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma
Copyright @ 2013 Macmillan Publishers Limited. This is the author's accepted manuscript. The final published article is available from the link below.Regulation of cell survival is a key part of the pathogenesis of multiple myeloma (MM). Jun N-terminal kinase (JNK) signaling has been implicated in MM pathogenesis, but its function is unclear. To elucidate the role of JNK in MM, we evaluated the specific functions of the two major JNK proteins, JNK1 and JNK2. We show here that JNK2 is constitutively activated in a panel of MM cell lines and primary tumors. Using loss-of-function studies, we demonstrate that JNK2 is required for the survival of myeloma cells and constitutively suppresses JNK1-mediated apoptosis by affecting expression of poly(ADP-ribose) polymerase (PARP)14, a key regulator of B-cell survival. Strikingly, we found that PARP14 is highly expressed in myeloma plasma cells and associated with disease progression and poor survival. Overexpression of PARP14 completely rescued myeloma cells from apoptosis induced by JNK2 knockdown, indicating that PARP14 is critically involved in JNK2-dependent survival. Mechanistically, PARP14 was found to promote the survival of myeloma cells by binding and inhibiting JNK1. Moreover, inhibition of PARP14 enhances the sensitization of MM cells to anti-myeloma agents. Our findings reveal a novel regulatory pathway in myeloma cells through which JNK2 signals cell survival via PARP14, and identify PARP14 as a potential therapeutic target in myeloma.Kay Kendall Leukemia Fund, NIH, Cancer Research UK, Italian Association for Cancer Research and the Foundation for Liver Research
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