Considering the role of cardiac vagal tone in adolescents' behaviors within friendships

Despite the theorized importance of cardiac vagal tone for functioning in close relationships (Porges, 2001) and the critical role of friendships in adolescents' development (Furman and Rose, 2015), there is a lack of research that considers vagal tone in relation to adolescents' friendship functioning. To address this gap, the currents study considers vagal tone (indexed using respiratory sinus arrythmia; RSA) in relation to adolescents' behaviors within the context of problem disclosures with a close friend. Participants were 200 adolescents (67 percent girls; Mage = 14.16 years; 79 percent White) who participated in a lab-based study with a same-gender friend (100 dyads). Adolescents' heart rate and respiration were continuously monitored to assess RSA during resting baseline tasks and a problem disclosure task with their friends. Researchers coded friendship interactions for supportive and unsupportive responses to problem disclosures. Results indicated that adolescents with higher levels of resting RSA activity received more support from friends during their interactions. During the interaction, providing friends with support was associated with subsequent RSA increases, and in turn, RSA increases were associated with subsequent provisions of support. Further, friends demonstrated RSA coregulation when the interaction was characterized by high levels of validation and empathy. Implications of vagal tone for adolescents' socioemotional development are discussed.Includes bibliographical references

The Significance of Early Temperamental Reactivity for Children's Social Competence With Peers: A Meta-Analytic Review and Comparison With the Role of Early Attachment

Early temperamental reactivity and attachment security are key predictors of children's social competence with peers. Leveraging meta-analytic evaluation of the significance of early attachment for social competence already available (Groh et al., 2014), this quantitative review examined the significance of early temperamental reactivity for social competence with peers and compared the strength of this association with that for attachment. Based on 140 independent samples (u = 382; N = 49,891), the meta-analytic association between early difficult temperament and (lower) social competence was significant (r = 0.13, z = 0.13; 95% CI [0.11, 0.16]), but decreased as time between assessments increased. Findings were similar for negative and positive emotionality. Greater negative emotionality was associated with lower social competence (r = 0.14, z = 0.14; 95% CI [0.11, 0.17], k = 93, u = 172), and greater positive emotionality was associated with better social competence (r = 0.18, z = 0.18; 95% CI [0.12, 0.24], k = 43, u = 54). Meta-analytic associations were reduced when overlapping informants and overlapping items in temperament and social competence assessments were excluded (difficult temperament: r = 0.10, z = 0.10; 95% CI [0.06, 0.13]; negative emotionality: r = 0.10, z = 0.10; 95% CI [0.05, 0.15]; positive emotionality: r = 0.10, z = 0.10; 95% CI [0.06, 0.14]). Meta-analytic associations between these broadband temperament dimensions and social competence were smaller than the meta-analytic association between attachment security and social competence. Discussion focuses on the developmental significance of early temperament for social competence and ways to reconcile literatures on early temperament and attachment in future research on the developmental antecedents of children's social competence. (PsycInfo Database Record (c) 2022 APA, all rights reserved)

The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy

Background: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations. Methods: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration. A multivariable binary logistic regression model was produced in order to identify significant independent predictors of long (> 90 min) operations. The resulting model was converted to a risk score, which was subsequently validated on second cohort of patients using ROC curves. Results: After exclusions, data were available for 7227 patients in the derivation (CholeS) cohort. The median operative duration was 60 min (interquartile range 45–85), with 17.7% of operations lasting longer than 90 min. Ten factors were found to be significant independent predictors of operative durations > 90 min, including ASA, age, previous surgical admissions, BMI, gallbladder wall thickness and CBD diameter. A risk score was then produced from these factors, and applied to a cohort of 2405 patients from a tertiary centre for external validation. This returned an area under the ROC curve of 0.708 (SE = 0.013, p  90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score. Conclusion: The scoring tool produced in this study was found to be significantly predictive of long operative durations on validation in an external cohort. As such, the tool may have the potential to enable organisations to better organise theatre lists and deliver greater efficiencies in care

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Quantitative 18F-AV1451 Brain Tau PET Imaging in Cognitively Normal Older Adults, Mild Cognitive Impairment, and Alzheimer's Disease Patients

Recent developments of tau Positron Emission Tomography (PET) allows assessment of regional neurofibrillary tangles (NFTs) deposition in human brain. Among the tau PET molecular probes, 18F-AV1451 is characterized by high selectivity for pathologic tau aggregates over amyloid plaques, limited non-specific binding in white and gray matter, and confined off-target binding. The objectives of the study are (1) to quantitatively characterize regional brain tau deposition measured by 18F-AV1451 PET in cognitively normal older adults (CN), mild cognitive impairment (MCI), and AD participants; (2) to evaluate the correlations between cerebrospinal fluid (CSF) biomarkers or Mini-Mental State Examination (MMSE) and 18F-AV1451 PET standardized uptake value ratio (SUVR); and (3) to evaluate the partial volume effects on 18F-AV1451 brain uptake.Methods: The study included total 115 participants (CN = 49, MCI = 58, and AD = 8) from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Preprocessed 18F-AV1451 PET images, structural MRIs, and demographic and clinical assessments were downloaded from the ADNI database. A reblurred Van Cittertiteration method was used for voxelwise partial volume correction (PVC) on PET images. Structural MRIs were used for PET spatial normalization and region of interest (ROI) definition in standard space. The parametric images of 18F-AV1451 SUVR relative to cerebellum were calculated. The ROI SUVR measurements from PVC and non-PVC SUVR images were compared. The correlation between ROI 18F-AV1451 SUVR and the measurements of MMSE, CSF total tau (t-tau), and phosphorylated tau (p-tau) were also assessed.Results:18F-AV1451 prominently specific binding was found in the amygdala, entorhinal cortex, parahippocampus, fusiform, posterior cingulate, temporal, parietal, and frontal brain regions. Most regional SUVRs showed significantly higher uptake of 18F-AV1451 in AD than MCI and CN participants. SUVRs of small regions like amygdala, entorhinal cortex and parahippocampus were statistically improved by PVC in all groups (p < 0.01). Although there was an increasing tendency of 18F-AV-1451 SUVRs in MCI group compared with CN group, no significant difference of 18F-AV1451 deposition was found between CN and MCI brains with or without PVC (p > 0.05). Declined MMSE score was observed with increasing 18F-AV1451 binding in amygdala, entorhinal cortex, parahippocampus, and fusiform. CSF p-tau was positively correlated with 18F-AV1451 deposition. PVC improved the results of 18F-AV-1451 tau deposition and correlation studies in small brain regions.Conclusion: The typical deposition of 18F-AV1451 tau PET imaging in AD brain was found in amygdala, entorhinal cortex, fusiform and parahippocampus, and these regions were strongly associated with cognitive impairment and CSF biomarkers. Although more deposition was observed in MCI group, the 18F-AV-1451 PET imaging could not differentiate the MCI patients from CN population. More tau deposition related to decreased MMSE score and increased level of CSF p-tau, especially in ROIs of amygdala, entorhinal cortex and parahippocampus. PVC did improve the results of tau deposition and correlation studies in small brain regions and suggest to be routinely used in 18F-AV1451 tau PET quantification

Conversion Discriminative Analysis on Mild Cognitive Impairment Using Multiple Cortical Features from MR Images

Neuroimaging measurements derived from magnetic resonance imaging provide important information required for detecting changes related to the progression of mild cognitive impairment (MCI). Cortical features and changes play a crucial role in revealing unique anatomical patterns of brain regions, and further differentiate MCI patients from normal states. Four cortical features, namely, gray matter volume, cortical thickness, surface area, and mean curvature, were explored for discriminative analysis among three groups including the stable MCI (sMCI), the converted MCI (cMCI), and the normal control (NC) groups. In this study, 158 subjects (72 NC, 46 sMCI, and 40 cMCI) were selected from the Alzheimer's Disease Neuroimaging Initiative. A sparse-constrained regression model based on the l2-1-norm was introduced to reduce the feature dimensionality and retrieve essential features for the discrimination of the three groups by using a support vector machine (SVM). An optimized strategy of feature addition based on the weight of each feature was adopted for the SVM classifier in order to achieve the best classification performance. The baseline cortical features combined with the longitudinal measurements for 2 years of follow-up data yielded prominent classification results. In particular, the cortical thickness produced a classification with 98.84% accuracy, 97.5% sensitivity, and 100% specificity for the sMCI–cMCI comparison; 92.37% accuracy, 84.78% sensitivity, and 97.22% specificity for the cMCI–NC comparison; and 93.75% accuracy, 92.5% sensitivity, and 94.44% specificity for the sMCI–NC comparison. The best performances obtained by the SVM classifier using the essential features were 5–40% more than those using all of the retained features. The feasibility of the cortical features for the recognition of anatomical patterns was certified; thus, the proposed method has the potential to improve the clinical diagnosis of sub-types of MCI and predict the risk of its conversion to Alzheimer's disease

Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis

Multifactorial mechanisms underlying late-onset Alzheimer's disease (LOAD) are poorly characterized from an integrative perspective. Here spatiotemporal alterations in brain amyloid-β deposition, metabolism, vascular, functional activity at rest, structural properties, cognitive integrity and peripheral proteins levels are characterized in relation to LOAD progression. We analyse over 7,700 brain images and tens of plasma and cerebrospinal fluid biomarkers from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Through a multifactorial data-driven analysis, we obtain dynamic LOAD–abnormality indices for all biomarkers, and a tentative temporal ordering of disease progression. Imaging results suggest that intra-brain vascular dysregulation is an early pathological event during disease development. Cognitive decline is noticeable from initial LOAD stages, suggesting early memory deficit associated with the primary disease factors. High abnormality levels are also observed for specific proteins associated with the vascular system's integrity. Although still subjected to the sensitivity of the algorithms and biomarkers employed, our results might contribute to the development of preventive therapeutic interventions

The two-week rule for suspected colorectal cancer: patient experience and psychological impact

Purpose – There has been considerable interest in the "two-week rule" referral pathway efficacy for patients with suspected colorectal cancer. This study aims to explore the psychological impact on these patients.\ud \ud Design/methodology/approach – Consecutive patients referred for urgent investigations under the "two-week rule" were invited to take part in semi-structured interviews using interpretative phenomenological analysis (IPA). Interviews were audio-taped, transcribed verbatim and analysed using investigator triangulation to enhance data trustworthiness.\ud \ud Findings – Ten out of 23 (43.5 per cent) patients consented to interviews; none were diagnosed with cancer. Four super-ordinate themes were explored, referring to the "making sense of the threat to health", impact on self, impact on others, reflections on the "two-week rule" referral, and its investigative process. Participants reported their anxiety, fear, vulnerability and coping mechanisms, but also raised concerns about the communication received during the "two-week rule" referral process. Female participants preferred a female endoscopist.\ud \ud Originality/value – This study is the first of its kind exploring the psychological effects of the "two-week rule" process for colorectal cancer, highlighting potential areas for improvement in patient information, and satisfaction with the referral process

The significance of early temperamental reactivity for children's social competence with peers: A meta-analytic review and comparison with the role of early attachment

Early temperamental reactivity and attachment security are key predictors of children's social competence with peers. Leveraging meta-analytic evaluation of the significance of early attachment for social competence already available (Groh et al., 2014), this quantitative review examined the significance of early temperamental reactivity for social competence with peers and compared the strength of this association with that for attachment. Based on 140 independent samples (u = 382; N = 49,891), the meta-analytic association between early difficult temperament and (lower) social competence was significant (r = 0.13, z = 0.13; 95% CI [0.11, 0.16]), but decreased as time between assessments increased. Findings were similar for negative and positive emotionality. Greater negative emotionality was associated with lower social competence (r = 0.14, z = 0.14; 95% CI [0.11, 0.17], k = 93, u = 172), and greater positive emotionality was associated with better social competence (r = 0.18, z = 0.18; 95% CI [0.12, 0.24], k = 43, u = 54). Meta-analytic associations were reduced when overlapping informants and overlapping items in temperament and social competence assessments were excluded (difficult temperament: r = 0.10, z = 0.10; 95% CI [0.06, 0.13]; negative emotionality: r = 0.10, z = 0.10; 95% CI [0.05, 0.15]; positive emotionality: r = 0.10, z = 0.10; 95% CI [0.06, 0.14]). Meta-analytic associations between these broadband temperament dimensions and social competence were smaller than the meta-analytic association between attachment security and social competence. Discussion focuses on the developmental significance of early temperament for social competence and ways to reconcile literatures on early temperament and attachment in future research on the developmental antecedents of children's social competence. (PsycInfo Database Record (c) 2022 APA, all rights reserved)