Processo multicomponente para síntese de compostos híbridos contendo os núcleos tetraidroacridina e imidazol 1,2,4,5-tetrassubstituídos para fins farmacológicos e produtos

Universidade Federal do Rio Grande do SulCiências Básicas da SaúdeQuímicaFarmáciaDepositad

Enantioselective synthesis of (R)-isocarvone from (S)-perillaldehyde

Este trabalho descreve a preparação enantiosseletiva da (R)-(+)-isocarvona, (S)-(-)-5-isopropenilcicloex-2-enona e (S)-(-)-3-isopropenilcicloexanona, a partir do (S)-(-)-perilaldeído. Estes compostos podem ser usados como blocos de construção importantes para a síntese orgânica.This work describes the enantioselective preparation of (R)-(+)-isocarvone, (S)-(-)-5-isopropenylcyclohex-2-enone and (S)-(-)-3-isopropenylcyclohexanone starting from (S)-(-)-perillaldehyde. These compounds hold the prospect of serving as useful chiral building blocks or intermediates in organic synthesis

Síntese e avaliação biológica de híbridos tacrina-tianeptina com potencial aplicação na doença de Alzheimer

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Síntese e avaliação biológica de híbridos tacrina-tianeptina com potencial aplicação na doença de Alzheimer

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Floating treatment wetland for nutrient removal and acute ecotoxicity improvement of untreated urban wastewater

Wastewater treatments are often expensive, and the resulting effluent can still harm the environment. Floating treatment wetland is an alternative low-cost eco-technology in which a hydroponic root network remediates polluted waters. This system has been broadly studied as a secondary treatment to remove nutrients and pollutants, but its application to improve raw wastewater quality is still incipient. Moreover, few studies have assessed acute ecotoxicity toward fish after treatment. Thus, this study aimed to evaluate the efficiency of a mesocosm floating treatment wetland to improve the raw wastewater quality from a university campus in South Brazil. Efficiency was assessed based on the improvement of physicochemical parameters (conductivity, pH, turbidity, color), nutrients (nitrogen and phosphorus), and heavy metals (zinc, chromium, copper, lead, and cadmium); Typha domingensis adaptability; and acute fish ecotoxicity reduction after wastewater treatment. Influent was treated with macrophytes tanks and their respective controls. T test was used to compare influent versus effluent samples, and macrophytes tanks versus controls. A Principal Component Analysis identified the main explanatory variables on the system, and a Two-way Cluster Analysis grouped samples before and after treatment. The results show floating mats efficiency in reducing most parameters compared to the influent, except phosphorus and zinc. Control tanks were also effective in improving wastewater quality due to microalgae and duckweed proliferation. In conclusion, floating treatment wetlands with Typha domingensis have the potential to treat raw wastewater. Further nitrogen removal in wastewater might improve acute ecotoxicity toward fish

Synthesis of tacrine-lophine hybrids via one-pot four component reaction and biological evaluation as acetyl- and butyrylcholinesterase inhibitors

A novel series of tacrine-lophine hybrids was synthesized and tested for their ability to inhibit acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) with IC50 in the nanomolar concentration scale. The key step is the one-pot four component condensation reaction of 9-aminoalkylamino-1,2,3,4- tetrahydroacridines, benzil, different substituted aromatic aldehydes and NH4OAc, using InCl3 as the best catalyst. Tacrine-lophine hybrids were found to be potent and selective inhibitors of cholinesterases. As an extension of the four component approach to tetrasubstituted imidazoles, a new series of bis-(2,4,5- triphenyl-1H-imidazoles) or bis(n)-lophines was tested against AChE and BuChE

Processo multicomponente para síntese de compostos híbridos contendo os núcleos tetraidroacridina e imidazol 1,2,4,5-tetrassubstituídos para fins farmacológicos e produtos

Universidade Federal do Rio Grande do SulCiências Básicas da SaúdeQuímicaFarmáciaDepositad

Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved