Anamorphic Fractional Fourier Transforming--Optical Implementation and Applications

Cataloged from PDF version of article.An additional degree of freedom is introduced to fractional-Fourier-transform systems by use of anamorphic optics. A different fractional Fourier order along the orthogonal principal directions is performed. A laboratory experimental system shows preliminary results that demonstrate the proposed theory. Applications such as anamorphic fractional correlation and multiplexing in fractional domains are briefly suggested. (C) 1995 Optical Society of Americ

A computational analysis of lower bounds for big bucket production planning problems

In this paper, we analyze a variety of approaches to obtain lower bounds for multi-level production planning problems with big bucket capacities, i.e., problems in which multiple items compete for the same resources. We give an extensive survey of both known and new methods, and also establish relationships between some of these methods that, to our knowledge, have not been presented before. As will be highlighted, understanding the substructures of difficult problems provide crucial insights on why these problems are hard to solve, and this is addressed by a thorough analysis in the paper. We conclude with computational results on a variety of widely used test sets, and a discussion of future research

Spectral imaging of the Central Molecular Zone in multiple 3-mm molecular lines

We have mapped 20 molecular lines in the Central Molecular Zone (CMZ) around the Galactic Centre, emitting from 85.3 to 93.3 GHz. This work used the 22-m Mopra radio telescope in Australia, equipped with the 8-GHz bandwidth UNSW-MOPS digital filter bank, obtaining \sim 2 km/s spectral and \sim 40 arcsec spatial resolution. The lines measured include emission from the c-C3H2, CH3CCH, HOCO+, SO, H13CN, H13CO+, SO, H13NC, C2H, HNCO, HCN, HCO+, HNC, HC3N, 13CS and N2H+ molecules. The area covered is Galactic longitude -0.7 to 1.8 deg. and latitude -0.3 to 0.2 deg., including the bright dust cores around Sgr A, Sgr B2, Sgr C and G1.6-0.025. We present images from this study and conduct a principal component analysis on the integrated emission from the brightest 8 lines. This is dominated by the first component, showing that the large-scale distribution of all molecules are very similar. We examine the line ratios and optical depths in selected apertures around the bright dust cores, as well as for the complete mapped region of the CMZ. We highlight the behaviour of the bright HCN, HNC and HCO+ line emission, together with that from the 13C isotopologues of these species, and compare the behaviour with that found in extra-galactic sources where the emission is unresolved spatially. We also find that the isotopologue line ratios (e.g. HCO+/H13CO+) rise significantly with increasing red-shifted velocity in some locations. Line luminosities are also calculated and compared to that of CO, as well as to line luminosities determined for external galaxies.Comment: 27 pages, 15 figures, 12 tables, accepted by MNRA

Coupling the dynamics and the molecular chemistry in the Galactic center

The physical conditions of the Galactic center (GC) clouds moving with non-circular velocities are not well-known. We have studied the physical conditions of these clouds with the aim of better understanding the origin of the outstanding physical conditions of the GC molecular gas and the possible effect of the large scale dynamics on these physical conditions.Using published CO(1-0) data, we have selected a set of clouds belonging to all the kinematical components seen in the longitude-velocity diagram of the GC. We have done a survey of dense gas in all the components using the J=2-1 lines of CS and SiO as tracers of high density gas and shock chemistry. We have detected CS and SiO emission in all the kinematical components. The gas density and the SiO abundance of the clouds in non-circular orbits are similar those in the nuclear ring (GCR). Therefore, in all the kinematical components there are dense clouds that can withstand the tidal shear. However, there is no evidence of star formation outside the GCR. The high relative velocity and shear expected in the dust-lanes along the bar major axis could inhibit the star formation process, as observed in other galaxies. The high SiO abundances derived in the non-circular velocity clouds are likely due to the large-scale shocks that created the dust lanesComment: One figure as an independent PDF file. Accepted by A&

Kinetic temperatures toward X1/X2 orbit interceptions regions and Giant Molecular Loops in the Galactic center region

Context: It is well known that the kinetic temperatures, Tkin, of the molecular clouds in the Galactic center region are higher than in typical disk clouds. However, the Tkin of the molecular complexes found at higher latitudes towards the giant molecular loops in the central region of the Galaxy is so far unknown. The gas of these high latitude molecular clouds (hereafter referred to as halo clouds) is located in a region where the gas in the disk may interact with the gas in the halo in the Galactic center region. Aims: To derive Tkin in the molecular clouds at high latitude and understand the physical process responsible for the heating of the molecular gas both in the Central Molecular Zone (the concentration of molecular gas in the inner 500 pc) and in the giant molecular loops. Methods: We measured the metastable inversion transitions of NH3 from (1,1) to (6,6) toward six positions selected throughout the Galactic central disk and halo. We used rotational diagrams and large velocity gradient modeling to estimate the kinetic temperatures toward all the sources. We also observed other molecules like SiO, HNCO, CS, C34S, C18O, and 13CO, to derive the densities and to trace different physical processes (shocks, photodissociation, dense gas) expected to dominate the heating of the molecular gas. Results: We derive for the first time Tkin of the high latitude clouds interacting with the disk in the Galactic center region. We find high rotational temperatures in all the observed positions. We derive two kinetic temperature components (150 K and 40 K) for the positions in the Central Molecular Zone, and only the warm kinetic temperature component for the clouds toward the giant molecular loops. The fractional abundances derived from the different molecules suggest that shocks provide the main heating mechanism throughout the Galactic center, also at high latitudesComment: accepted for publication in A&A 06/09/201

The rise of noncommunicable diseases in Latin America and the Caribbean: challenges for public health policies

The health landscape in Latin America and the Caribbean is changing quickly. The region is undergoing a demographic and epidemiological transition in which health problems are highly concentrated on noncommunicable diseases (NCDs). In light of this, the region faces two main challenges: (1) develop cost-effective policies to prevent NCD risk factors, and (2) increase access to quality healthcare in a scenario in which a large share of the labor force is employed in the informal sector. This paper describes both alternative interventions to expand health insurance coverage and their trade-off with labor informality and moral hazard problems. The paper also focuses on obesity as a case example of an NCD, and emphasizes how lack of knowledge along with self-control problems would lead people to make suboptimal decisions related to food consumption, which may later manifest in obesity problems.Fil: Anauati, Maria Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; ArgentinaFil: Galiani, Sebastian. University of Maryland; Estados UnidosFil: Weinschelbaum, Federico. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de San Andrés; Argentin

Pembrolizumab for patients with non-Hodgkin lymphoma: phase 1b KEYNOTE-013 study

The multicohort phase 1b KEYNOTE-013 study (NCT01953692) evaluated the safety and efficacy of pembrolizumab in patients with relapsed or refractory NHL who were ineligible for or failed hematopoietic cell transplantation (HCT). Patients received pembrolizumab (cohort 4) or pembrolizumab plus lenalidomide (cohort 5). Primary end points were safety and objective response rate (ORR) per IWG 2007 criteria. Cohort 4 included 89 patients. ORR was 22% (19/86; 90% CI 15–31; 10 CR, nine PR); ORRs by disease type were 48% (10/21), 10% (2/20), 12% (5/41), and 50% (2/4), for PMBCL, FL, DLBCL, and ‘other’ NHL, respectively. Toxicity was as predicted. Cohort 5 included 19 patients. ORR was 39% (90% CI 20–61; four CR, three PR). Hematologic toxicities were the most common treatment-related AEs. In conclusion, pembrolizumab following HCT ineligibility/failure confirms prior experience in PMBCL but not with NHL subtypes in this study. Additional analyses in DLBCL may not be warranted

Scheduling with Sequencing Flexibility *

This study examines the effects of sequencing flexibility on the performance of rules used to schedule operations in manufacturing systems. The findings show that taking advantage of even low levels of sequencing flexibility in the set of operations required to do a job results in substantial improvement in the performance of scheduling rules with respect to mean flowtime. Differences in the mean flowtime measure for various rules also diminish significantly with increasing sequencing flexibility. Performance improvements additionally result for such due-date related performance measures as mean tardiness and the proportion of jobs tardy. At high levels of sequencing flexibility, some nonparametric scheduling rules outperform the shortest processing time rule in terms of the mean flowtime criterion. Rules based on job due dates also outperform rules based on operation milestones in terms of tardiness related criteria at high levels of sequencing flexibility. The implications of these findings for the design of manufacturing systems and product design are noted.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73893/1/j.1540-5915.1993.tb00477.x.pd

The Top-Dog Index: A New Measurement for the Demand Consistency of the Size Distribution in Pre-Pack Orders for a Fashion Discounter with Many Small Branches

We propose the new Top-Dog-Index, a measure for the branch-dependent historic deviation of the supply data of apparel sizes from the sales data of a fashion discounter. A common approach is to estimate demand for sizes directly from the sales data. This approach may yield information for the demand for sizes if aggregated over all branches and products. However, as we will show in a real-world business case, this direct approach is in general not capable to provide information about each branch's individual demand for sizes: the supply per branch is so small that either the number of sales is statistically too small for a good estimate (early measurement) or there will be too much unsatisfied demand neglected in the sales data (late measurement). Moreover, in our real-world data we could not verify any of the demand distribution assumptions suggested in the literature. Our approach cannot estimate the demand for sizes directly. It can, however, individually measure for each branch the scarcest and the amplest sizes, aggregated over all products. This measurement can iteratively be used to adapt the size distributions in the pre-pack orders for the future. A real-world blind study shows the potential of this distribution free heuristic optimization approach: The gross yield measured in percent of gross value was almost one percentage point higher in the test-group branches than in the control-group branches.Comment: 22 pages, 15 figure