Benefits of Looking for Coincident Events, Taus, and Muons with the Askaryan Radio Array

Ultra-High Energy (UHE) neutrinos over $10^{16}$ eV have yet to be observed but the Askaryan Radio Array (ARA) is one in-ice neutrino observatory attempting to make this discovery. In anticipation of a thorough full-observatory and full-livetime neutrino search, we estimate how many neutrino events can be detected accounting for secondary interactions, which are typically ignored in UHE neutrino simulations. Using the NuLeptonSim and PyREx simulation frameworks, we calculate the abundance and usefulness of cascades viewed by multiple ARA stations and observations made of taus, muons, and neutrinos generated during and after initial neutrino cascades. Analyses that include these scenarios benefit from a considerable increase in effective area at key ARA neutrino energies, one example being a 30% increase in ARA's effective area when simulating taus and muons produced in $10^{19}$ eV neutrino interactions. These analysis techniques could be utilized by other in-ice radio neutrino observatories, as has been explored by NuRadioMC developers. Our contribution showcases full simulation results of neutrinos with energies $3\times10^{17}$ - $10^{21}$ eV and visualizations of interesting triggered event topologies.Comment: For 2023 ICRC, 8 pages, 7 figures, 1 tabl

Poor access to kidney disease management services in susceptible patient populations in rural Australia is associated with increased aeromedical retrievals for acute renal care

Background Inequalities in access to renal services and acute care for rural and remote populations in Australia have been described but not quantified. Aim To describe: the coverage of renal disease management services in rural and remote Australia; and the characteristics of patients who had an aeromedical retrieval for renal disease by Australia's Royal Flying Doctor Service (RFDS). Methods Data from the RFDS, the Australian Bureau of Statistics, and Health Direct were used to estimate provision of renal disease management services by geographic area. RFDS patient diagnostic data were prospectively collected from 2014 to 2018. Results Many rural and remote areas have limited access to regular renal disease management services. Most RFDS retrievals for renal disease are from regions without such services. The RFDS conducted 1636 aeromedical retrievals for renal disease, which represented 1.6% of all retrievals. Among retrieved patients, there was a higher proportion of men than women (54.6% vs 45.4%, P < 0.01), while indigenous patients (n = 546, 33.4%) were significantly younger than non‐indigenous patients (40.9 vs 58.5, P < 0.01). There were significant differences in underlying diagnoses triggering retrievals between genders, with males being more likely than females to be transferred with acute renal failure, calculus of the kidney and ureter, renal colic, obstructive uropathy, and kidney failure (all P < 0.01). Conversely, females were more likely to have chronic kidney disease, disorders of the urinary system, acute nephritic syndrome, tubulo‐interstitial nephritis, and nephrotic syndrome (all P < 0.01). Conclusion Aeromedical retrievals for acute care were from rural areas without regular access to renal disease prevention or management services

Rural and remote dental care: Patient characteristics and health care provision

Objective: To describe the characteristics of patients who used the Royal Flying Doctor Service dental clinics and determine Royal Flying Doctor Service and nonRoyal Flying Doctor Service dental service provision in mainland Australia. Design: A prospective cohort study. Setting: All Royal Flying Doctor Service dental clinics located throughout rural and remote Australia. Participants: All patients who accessed an Royal Flying Doctor Service dental clinic from April 2017 to September 2018. Interventions: Royal Flying Doctor Service mobile dental clinics. Main outcome measures: Patient demographics and dental procedures conducted (by age, sex and Indigenous status); and the dental service provision and coverage (Royal Flying Doctor Service and non-Royal Flying Doctor Service) within mainland rural and remote Australia. Results: There were 8992 patient episodes comprising 3407 individual patients with 27 897 services completed. There were 920 (27%) Indigenous and 1465 (43%) nonIndigenous patients (n = 1022 missing ethnicity data). The mean (SD) age was 31.5 (24.8) years; the age groups 5-9 years and 10-14 years received 17.6% and 15.1% of the services, respectively. There were 1124 (33%) men and 1295 (38%) women (n = 988 with missing sex data). Women were more likely (all P < .05) to receive preventive services, diagnostic services, restorative services, general services, endodontics and periodontics. Men were more likely (both P < .05) to receive oral surgery and prosthodontics. There are many rural and remote people required to travel more than 60 minutes by vehicle to access dental care. Conclusion: Without increasing dental provision and preventive services in rural areas, it seems likely that there are and will be unnecessary oral emergencies and hospitalisations

The Student Movement Volume 108 Issue 7: Not Throwing Away Our Shot: Honoring Hamilton\u27s Legacy

HUMANS An Arboretum of Beauty, Anneliese Tessalee Serving with All She\u27s Got: Natalia\u27s Mission Experience in the Dominican Republic, Nick Bishop WAUS Fall Fundraiser, Grace No ARTS & ENTERTAINMENT Art: A Window Into Another Reality, Madison Vath Filipino Art Through Filipino Eyes: Celebrating A Culture, Amelia Stefanescu Free-Falling Into Autumn : A Fall Playlist, Amelia Stefanescu Upcoming Events in the Art Department, Katrina Johnson What to do about Inhospitality?: A Review of Mitski\u27s Newest Album, Reagan McCain NEWS Andrews Autumn Conference Promotes Peaceful Scientific Discourse, Andrew Francis Honors Goes to Hamilton, Melissa Moore Unraveling the Historical Threads: The SDA Church\u27s Journey with the Trinity, Brendan Oh IDEAS Cats or Dogs?, Abby Shim Exploring Student Perspectives on Jewelry, Reagan Westerman Israeli- Gaza, the Split of Public Opinion, United Nations Resolutions and What We Can Do, Robert Zhang PULSE Everything Happens For A Reason , Nicole Compton-Gray Moral Conflict: What is the Right Thing to Do?, Katie Davis Productivity & Success, Anna Rybachek Social Media and the College Student: A Useful Tool or a Destructive Spiral?, Rodney Bell II LAST WORD To Be Loved and to Love, Wambui Karanjahttps://digitalcommons.andrews.edu/sm-108/1006/thumbnail.jp

Population gene introgression and high genome plasticity for the zoonotic pathogen Streptococcus agalactiae

The influence that bacterial adaptation (or niche partitioning) within species has on gene spillover and transmission among bacteria populations occupying different niches is not well understood. Streptococcus agalactiae is an important bacterial pathogen that has a taxonomically diverse host range making it an excellent model system to study these processes. Here we analyze a global set of 901 genome sequences from nine diverse host species to advance our understanding of these processes. Bayesian clustering analysis delineated twelve major populations that closely aligned with niches. Comparative genomics revealed extensive gene gain/loss among populations and a large pan-genome of 9,527 genes, which remained open and was strongly partitioned among niches. As a result, the biochemical characteristics of eleven populations were highly distinctive (significantly enriched). Positive selection was detected and biochemical characteristics of the dispensable genes under selection were enriched in ten populations. Despite the strong gene partitioning, phylogenomics detected gene spillover. In particular, tetracycline resistance (which likely evolved in the human-associated population) from humans to bovine, canines, seals, and fish, demonstrating how a gene selected in one host can ultimately be transmitted into another, and biased transmission from humans to bovines was confirmed with a Bayesian migration analysis. Our findings show high bacterial genome plasticity acting in balance with selection pressure from distinct functional requirements of niches that is associated with an extensive and highly partitioned dispensable genome, likely facilitating continued and expansive adaptation

Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution.

The early detection of relapse following primary surgery for non-small-cell lung cancer and the characterization of emerging subclones, which seed metastatic sites, might offer new therapeutic approaches for limiting tumour recurrence. The ability to track the evolutionary dynamics of early-stage lung cancer non-invasively in circulating tumour DNA (ctDNA) has not yet been demonstrated. Here we use a tumour-specific phylogenetic approach to profile the ctDNA of the first 100 TRACERx (Tracking Non-Small-Cell Lung Cancer Evolution Through Therapy (Rx)) study participants, including one patient who was also recruited to the PEACE (Posthumous Evaluation of Advanced Cancer Environment) post-mortem study. We identify independent predictors of ctDNA release and analyse the tumour-volume detection limit. Through blinded profiling of postoperative plasma, we observe evidence of adjuvant chemotherapy resistance and identify patients who are very likely to experience recurrence of their lung cancer. Finally, we show that phylogenetic ctDNA profiling tracks the subclonal nature of lung cancer relapse and metastasis, providing a new approach for ctDNA-driven therapeutic studies

Pregnancy and neonatal outcomes of COVID-19: The PAN-COVID study

Objective To assess perinatal outcomes for pregnancies affected by suspected or confirmed SARS-CoV-2 infection. Methods Prospective, web-based registry. Pregnant women were invited to participate if they had suspected or confirmed SARS-CoV-2 infection between 1st January 2020 and 31st March 2021 to assess the impact of infection on maternal and perinatal outcomes including miscarriage, stillbirth, fetal growth restriction, pre-term birth and transmission to the infant. Results Between April 2020 and March 2021, the study recruited 8239 participants who had suspected or confirmed SARs-CoV-2 infection episodes in pregnancy between January 2020 and March 2021. Maternal death affected 14/8197 (0.2%) participants, 176/8187 (2.2%) of participants required ventilatory support. Pre-eclampsia affected 389/8189 (4.8%) participants, eclampsia was reported in 40/ 8024 (0.5%) of all participants. Stillbirth affected 35/8187 (0.4 %) participants. In participants delivering within 2 weeks of delivery 21/2686 (0.8 %) were affected by stillbirth compared with 8/4596 (0.2 %) delivering ≥ 2 weeks after infection (95 % CI 0.3–1.0). SGA affected 744/7696 (9.3 %) of livebirths, FGR affected 360/8175 (4.4 %) of all pregnancies. Pre-term birth occurred in 922/8066 (11.5%), the majority of these were indicated pre-term births, 220/7987 (2.8%) participants experienced spontaneous pre-term births. Early neonatal deaths affected 11/8050 livebirths. Of all neonates, 80/7993 (1.0%) tested positive for SARS-CoV-2. Conclusions Infection was associated with indicated pre-term birth, most commonly for fetal compromise. The overall proportions of women affected by SGA and FGR were not higher than expected, however there was the proportion affected by stillbirth in participants delivering within 2 weeks of infection was significantly higher than those delivering ≥ 2 weeks after infection. We suggest that clinicians’ threshold for delivery should be low if there are concerns with fetal movements or fetal heart rate monitoring in the time around infection

Research Letter - Health care for older people in rural and remote Australia: challenges for service provision

Many Australians living in rural and remote areas of Australia need to travel hundreds of kilometres for health care service, or to wait for health service providers, such as the Royal Flying Doctor Service (RFDS), to visit them. The levels of acute and subacute hospital services in rural and remote areas are reported to be inadequate,1 as is, to a lesser extent, access to aged care services.2 The need to travel long distances is a major barrier for people in remote locations, particularly older people, seeking health care