Coupled quintessence and curvature-assisted acceleration

Spatially homogeneous models with a scalar field non-minimally coupled to the space-time curvature or to the ordinary matter content are analysed with respect to late-time asymptotic behaviour, in particular to accelerated expansion and isotropization. It is found that a direct coupling to the curvature leads to asymptotic de Sitter expansion in arbitrary exponential potentials, thus yielding a positive cosmological constant although none is apparent in the potential. This holds true regardless of the steepness of the potential or the smallness of the coupling constant. For matter-coupled scalar fields, the asymptotics are obtained for a large class of positive potentials, generalizing the well-known cosmic no-hair theorems for minimal coupling. In this case it is observed that the direct coupling to matter does not impact the late-time dynamics essentially.Comment: 17 pages, no figures. v2: typos correcte

Establishment of a Developmental Compartment Requires Interactions between Three Synergistic Cis-regulatory Modules

The subdivision of cell populations in compartments is a key event during animal development. In Drosophila, the gene apterous (ap) divides the wing imaginal disc in dorsal vs ventral cell lineages and is required for wing formation. ap function as a dorsal selector gene has been extensively studied. However, the regulation of its expression during wing development is poorly understood. In this study, we analyzed ap transcriptional regulation at the endogenous locus and identified three cis-regulatory modules (CRMs) essential for wing development. Only when the three CRMs are combined, robust ap expression is obtained. In addition, we genetically and molecularly analyzed the trans-factors that regulate these CRMs. Our results propose a three-step mechanism for the cell lineage compartment expression of ap that includes initial activation, positive autoregulation and Trithorax-mediated maintenance through separable CRMsThis study was supported by a grant from the MINECO to CE (No. BFU2012-34353) and grants from the Kantons Basel-Stadt and Basel-Land, and the Swiss National Science Foundation to MA. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscrip

Late-time oscillatory behaviour for self-gravitating scalar fields

This paper investigates the late-time behaviour of certain cosmological models where oscillations play an essential role. Rigorous results are proved on the asymptotics of homogeneous and isotropic spacetimes with a linear massive scalar field as source. Various generalizations are obtained for nonlinear massive scalar fields, $k$-essence models and $f(R)$ gravity. The effect of adding ordinary matter is discussed as is the case of nonlinear scalar fields whose potential has a degenerate zero.Comment: 17 pages, additional reference

Intermediate inflation and the slow-roll approximation

It is shown that spatially homogeneous solutions of the Einstein equations coupled to a nonlinear scalar field and other matter exhibit accelerated expansion at late times for a wide variety of potentials $V$. These potentials are strictly positive but tend to zero at infinity. They satisfy restrictions on $V'/V$ and $V''/V'$ related to the slow-roll approximation. These results generalize Wald's theorem for spacetimes with positive cosmological constant to those with accelerated expansion driven by potentials belonging to a large class.Comment: 19 pages, results unchanged, additional backgroun

Algebraic expansions for curvature coupled scalar field models

A late time asymptotic perturbative analysis of curvature coupled complex scalar field models with accelerated cosmological expansion is carried out on the level of formal power series expansions. For this, algebraic analogues of the Einstein scalar field equations in Gaussian coordinates for space-time dimensions greater than two are postulated and formal solutions are constructed inductively and shown to be unique. The results obtained this way are found to be consistent with already known facts on the asymptotics of such models. In addition, the algebraic expansions are used to provide a prospect of the large time behaviour that might be expected of the considered models.Comment: 16 pages, no figures; v2: typos corrected, references adde

Blocking and its response to climate change

Purpose of review: Atmospheric blocking events represent some of the most high-impact weather patterns in the mid-latitudes, yet they have often been a cause for concern in future climate projections. There has been low confidence in predicted future changes in blocking, despite relatively good agreement between climate models on a decline in blocking. This is due to the lack of a comprehensive theory of blocking and a pervasive underestimation of blocking occurrence by models. This paper reviews the state of knowledge regarding blocking under climate change, with the aim of providing an overview for those working in related fields. Recent Findings: Several avenues have been identified by which blocking can be improved in numerical models, though a fully reliable simulation remains elusive (at least, beyond a few days lead time). Models are therefore starting to provide some useful information on how blocking and its impacts may change in the future, although deeper understanding of the processes at play will be needed to increase confidence in model projections. There are still major uncertainties regarding the processes most important to the onset, maintenance and decay of blocking and advances in our understanding of atmospheric dynamics, for example in the role of diabatic processes, continue to inform the modelling and prediction efforts. Summary: The term ‘blocking’ covers a diverse array of synoptic patterns, and hence a bewildering range of indices has been developed to identify events. Results are hence not considered fully trustworthy until they have been found using several different methods. Examples of such robust results are the underestimation of blocking by models, and an overall decline in future occurrence, albeit with a complex regional and seasonal variation. In contrast, hemispheric trends in blocking over the recent historical period are not supported by different methods, and natural variability will likely dominate regional variations over the next few decades

Rule-Based Models of the Interplay between Genetic and Environmental Factors in Childhood Allergy

Peer reviewe

Early mobilization after flexor tendon repair in children

PURPOSE: Aim of the study was to provide an age-adapted rehabilitation protocol for flexor tendon repairs of children and to evaluate a patient series accordingly. METHODS: A modified Kessler's technique was used to repair 49 flexor tendon injuries in 39 children. All children had immediate postoperative mobilization according to the protocol that provides specific guidelines for preschoolers, children and teenagers. Range of motion was monitored and the final results were evaluated retrospectively. RESULTS: All children could be treated successfully according to the protocol with no occurrence of secondary tendon ruptures. Forty finger injuries were evaluated according to the Strickland classification, resulting in a median total active motion of 92.6 % with 29 (72.5 %) excellent results, 8 (20 %) good results, 3 (7.5 %) fair results and no poor result. All 7 thumbs had an excellent result according to the Buck-Gramcko score. There was no significant difference in outcomes between the three age groups. CONCLUSIONS: The rehabilitation protocol provided in this study allows an age-adapted early mobilization of children's hands after flexor tendon injuries. It respects age-specific limitations in rehabilitation and takes a child's superior healing capacity compared to adults into account. The good results and the very low complication rate observed in the present series suggest that the extra effort of early mobilization may be justified

Development and Application of Functionalized Protein Binders in Multicellular Organisms

Protein-protein interactions are crucial to almost all biological processes. Studying such interactions in their native environment is critical but not easy to perform. Recently developed genetically encoded protein binders were shown to function inside living cells. These molecules offer a new, direct way to assess protein function, distribution and dynamics in vivo. A widely used protein binder scaffold are the so-called nanobodies, which are derived from the variable domain of camelid heavy-chain antibodies. Another commonly used scaffold, the DARPins, is based on Ankyrin repeats. In this review, we highlight how these binders can be functionalized in order to study proteins in vivo during the development of multicellular organisms. It is to be anticipated that many more applications for such synthetic protein binders will be developed in the near future