Estudio de alternativas para el desarrollo de un sistema híbrido en un receptor solar de un Disco Stirling

En este trabajo se analiza la posibilidad de aplicación de nuevas tecnologías de apoyoenergético en un sistema de generación eléctrica termosolar tipo disco‐Stirling, con el fin deevaluar las soluciones consistentes en tecnologías de hibridación, como paliativo a lavariabilidad del recurso solar. En primer lugar, se evalua el beneficio real de instalar un sistemade apoyo auxiliar híbrido sobre un disco‐Stirling convencional. La siguiente fase del proyectoconsiste en llevar a cabo el diseño conceptual del sistema híbrido. Con este fin, habrá derealizarse una definición básica en un principio, y ajustada y precisa en fases posteriores, decada uno de los componentes necesarios para la instalación de un novedoso sistema decombustión sobre un equipo disco‐ Stirling. Destacar que no existen experiencias previas quepueden servir de guía en este proceso, ya que a día de hoy, no se ha encontrado una solucióntécnica viable para los problemas que presenta la integración de un sistema híbrido en elcabezal receptor de un disco‐Stirling. Por lo tanto, aquí reside el principal potencial deinnovación sobre la tecnología de generación termosolar disco‐Stirling, buscándose con eneste proyecto abrir una nueva línea de investigación para la mejora del funcionamiento actualde estos equipos de generación termoeléctrica

Influencia de la distribución del acero de refuerzo longitudinal en los diagramas de interacción de columnas sólidas circular

Se presenta la variación de los diagramas de interacción en columnas sólidas circulares considerando la posición del acero de refuerzo longitudinal. Se consideran dos posiciones: a) la primera barra coincide con el eje vertical, b) la primera barra se coloca desfasada a la derecha el semiángulo entre barras. Una diferencia de -4.2% a 6.6% se evaluó en 32 pares de diagramas de columnas armadas con cantidades variables de barras (6-11 barras) y cuantía de refuerzo entre 2.42% y 4.13%. El error entre curvas es 2%, 4% y 7% en columnas reforzadas con 10, 7 y 6 barras respectivamente. Así, se concluye la importancia de considerar la posición del acero de refuerzo en columnas circulares sólidas armadas con pocas barras de refuerzo (6-9 barras)

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent). Conclusion Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified

26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 - Meeting Abstracts - Antwerp, Belgium. 15–20 July 2017

This work was produced as part of the activities of FAPESP Research,\ud Disseminations and Innovation Center for Neuromathematics (grant\ud 2013/07699-0, S. Paulo Research Foundation). NLK is supported by a\ud FAPESP postdoctoral fellowship (grant 2016/03855-5). ACR is partially\ud supported by a CNPq fellowship (grant 306251/2014-0)

Influencia de la distribución del acero de refuerzo longitudinal en los diagramas de interacción de columnas sólidas circulares

The variation of the interaction diagrams for solid circular columns is presented considering the position of the longitudinal rebars. Two of them were considered: a) the first rebar coincides with the vertical longitudinal axis, and b) the first rebar is placed out of phase to the right of the semi-angle between two rebars. A variation of -4.2% to 6.6% was evaluated in 32 pairs of interaction diagrams for columns reinforced with a variable quantity of rebars (from 6 to 11 rebars) and steel ratios ranging from 2.42 to 4.13%; the error is 2%, 4%, and 7% in columns reinforced with 10, 7, and 6 rebars, respectively. Therefore, considering the position of the rebars in columns with a small amount of reinforcement (6 to 9 rebars) is very important for the design process.&nbsp;Se presenta la variación de los diagramas de interacción en columnas sólidas circulares considerando la posición del acero de refuerzo longitudinal. Se consideran dos posiciones: a) la primera barra coincide con el eje vertical, b) la primera barra se coloca desfasada a la derecha el semiángulo entre barras. Una diferencia de -4.2% a 6.6% se evaluó en 32 pares de diagramas de columnas armadas con cantidades variables de barras (6-11 barras) y cuantía de refuerzo entre 2.42% y 4.13%. El error entre curvas es 2%, 4% y 7% en columnas reforzadas con 10, 7 y 6 barras respectivamente. Así, se concluye la importancia de considerar la posición del acero de refuerzo en columnas circulares sólidas armadas con pocas barras de refuerzo (6-9 barras).&nbsp

A bioinformatic prediction of antigen presentation from SARS-CoV-2 spike protein revealed a theorical correlation of HLA-DRB1*01 with COVID-19 fatality in Mexican population: an ecological approach

SARS-CoV-2 infection is causing a pandemic disease that is reflected in challenging public health problems worldwide. Human leukocyte antigen (HLA)-based epitope prediction and its association with disease outcomes provide an important base for treatment design. A bioinformatic prediction of T cell epitopes and their restricted HLA Class I and II alleles was performed to obtain immunogenic epitopes and HLA alleles from the spike protein of the severe acute respiratory syndrome coronavirus 2 virus. Also, a correlation with the predicted fatality rate of hospitalized patients in 28 states of Mexico was done. Here, we describe a set of 10 highly immunogenic epitopes, together with different HLA alleles that can efficiently present these epitopes to T cells. Most of these epitopes are located within the S1 subunit of the spike protein, suggesting that this area is highly immunogenic. A statistical negative correlation was found between the frequency of HLA-DRB1*01 and the fatality rate in hospitalized patients in Mexico