13 research outputs found
Prospects for e+e- physics at Frascati between the phi and the psi
We present a detailed study, done in the framework of the INFN 2006 Roadmap,
of the prospects for e+e- physics at the Frascati National Laboratories. The
physics case for an e+e- collider running at high luminosity at the phi
resonance energy and also reaching a maximum center of mass energy of 2.5 GeV
is discussed, together with the specific aspects of a very high luminosity
tau-charm factory. Subjects connected to Kaon decay physics are not discussed
here, being part of another INFN Roadmap working group. The significance of the
project and the impact on INFN are also discussed. All the documentation
related to the activities of the working group can be found in
http://www.roma1.infn.it/people/bini/roadmap.html.Comment: INFN Roadmap Report: 86 pages, 25 figures, 9 table
A História da Alimentação: balizas historiográficas
Os M. pretenderam traçar um quadro da História da Alimentação, não como um novo ramo epistemológico da disciplina, mas como um campo em desenvolvimento de práticas e atividades especializadas, incluindo pesquisa, formação, publicações, associações, encontros acadêmicos, etc. Um breve relato das condições em que tal campo se assentou faz-se preceder de um panorama dos estudos de alimentação e temas correia tos, em geral, segundo cinco abardagens Ia biológica, a econômica, a social, a cultural e a filosófica!, assim como da identificação das contribuições mais relevantes da Antropologia, Arqueologia, Sociologia e Geografia. A fim de comentar a multiforme e volumosa bibliografia histórica, foi ela organizada segundo critérios morfológicos. A seguir, alguns tópicos importantes mereceram tratamento à parte: a fome, o alimento e o domÃnio religioso, as descobertas européias e a difusão mundial de alimentos, gosto e gastronomia. O artigo se encerra com um rápido balanço crÃtico da historiografia brasileira sobre o tema
Flap endonuclease 1 mutations A159V and E160D cause genomic instability by slowing reaction on double-flap substrates
Flap endonuclease 1 (FEN1) is a structure-selective nuclease best known for its roles in the penultimate steps of Okazaki fragment maturation, long-patch base excision repair and ribonucleotide excision repair. To better understand the role of FEN1 in genome maintenance in yeast and mammals, FEN1 active site mutations (A159V and E160D) have been used as tools to dissect its involvement in DNA metabolic pathways. However, discrepancies concerning the biochemistry and molecular etiology of genomic instability when FEN1 function is altered exist. Here, a detailed biochemical and biophysical characterization of mouse FEN1 and mutants is presented. Kinetic measurements showed that the active site mutants A159V and E160D reduce the rates of hydrolysis under multiple- and single-turnover conditions on all substrates. Consistent with their dominant negative effects in heterozygotes, neither mutation affects the adoption of the substrate duplex arms in the bent conformation on the enzyme surface, although decreases in substrate binding affinity are observed. The ability of the mutants to induce the requisite local DNA conformational change near the scissile phosphate is adversely affected, suggesting that the ability to place the scissile phosphate optimally in the active site causes the reduction in rates of phosphate diester hydrolysis. Further analysis suggests that the A159V mutation causes the chemistry of phosphate diester hydrolysis to become rate-limiting, whereas the wild-type and E160D proteins are likely rate-limited by a conformational change. On the basis of these results, the proposed roles of FEN1 in genome maintenance derived from studies involving these mutations are reassessed
Mitochondrial Membrane-Bound Hexokinase of Ascites Tumor Cells. Functional Implications of Lysine Residues Studied by Modification with Imidoesters
Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age
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This article is open access.The genetic contribution to the variation in human lifespan is ∼ 25%. Despite the large number of identified disease-susceptibility loci, it is not known which loci influence population mortality. We performed a genome-wide association meta-analysis of 7729 long-lived individuals of European descent (≥ 85 years) and 16 121 younger controls (<65 years) followed by replication in an additional set of 13 060 long-lived individuals and 61 156 controls. In addition, we performed a subset analysis in cases aged ≥ 90 years. We observed genome-wide significant association with longevity, as reflected by survival to ages beyond 90 years, at a novel locus, rs2149954, on chromosome 5q33.3 (OR = 1.10, P = 1.74 × 10(-8)). We also confirmed association of rs4420638 on chromosome 19q13.32 (OR = 0.72, P = 3.40 × 10(-36)), representing the TOMM40/APOE/APOC1 locus. In a prospective meta-analysis (n = 34 103), the minor allele of rs2149954 (T) on chromosome 5q33.3 associates with increased survival (HR = 0.95, P = 0.003). This allele has previously been reported to associate with low blood pressure in middle age. Interestingly, the minor allele (T) associates with decreased cardiovascular mortality risk, independent of blood pressure. We report on the first GWAS-identified longevity locus on chromosome 5q33.3 influencing survival in the general European population. The minor allele of this locus associates with low blood pressure in middle age, although the contribution of this allele to survival may be less dependent on blood pressure. Hence, the pleiotropic mechanisms by which this intragenic variation contributes to lifespan regulation have to be elucidated.Augustinus Foundation
Avera Institute for Human Genetics (AIHG)
AXA Research Fund
Belfast City Hospital Trust Fund
Biobanking and Biomolecular Resources Research Infrastructure (BBMRI -NL)
184.021.007
Biotechnology and Biological Sciences Research Council (BBSRC)
Bristol-Myers Squibb
Center for Inherited Disease Research (CIDR)
Centre for Medical Systems Biology (CMSB)
CERA Foundation
Commissariat a L'Energie Atomique (CEA)-Centre National de Genotypage (CNG)
Danish Agency for Science, Technology and Innovation (DASTI)/The Danish Council for Independent Research (DCIR)
11-107308
Danish National Research Foundation (DNRF)
Department of Health and Social Services (Northern Ireland)
DFG-Cluster of Excellence 'Inflammation at Interfaces'
Dunhill Medical Trust
R124/0509
Egmont Foundation
Estonian Science Foundation
7859
Estonian Government
SF0180142s08
European Research Council (ERC)
230374
European Science Foundation (ESF)
EU/QLRT-2001-01254
European Union
FP5-QLK6-CY-2001-00128
FP6-LIFESCIHEALTH-36894
FP6-LSH M-CT-2004-503270
FP7-HEALTH-2007-B-223004
FP7-HEALTH-F4-2007-201413
FP7-HEALTH-F4-2008-202047
FP7-HEALTH-2009-single-stage-242244
FP7-HEALTH-2010-two-stage-259679
Fondation Caisse d'Epargne Rhone-Alpes Lyon CERAL
Genetic Association Information Network (GAIN) of the Foundation for the US National Institutes of Health (NIMH)
MH081802
GenomEUtwin
EU/QLRT-2001-01254
QLG2-CT-2002-01254
Guy's & St Thomas' NHS Foundation Trust
Health Foundation
Heart and Lung foundation
20070481
Innovation-Oriented Research Program on Genomics (SenterNovem)
IGE05007
Institute for Ageing and Health
Institut National de la Recherche Agronomique (INRA)
Institut National de la Sante et de la Recherche Medicale (INSERM)
King's College London
Medical Research Council (MRC)
G0500997
G0601333
Ministere de l'Enseignement superieur et de la Recherche (MESR)
National Institutes of Health (NIH)/National Institute of Aging (NIA)
P01AG08761
R01D0042157-01A
U01DK066134
National Institute for Health Research (NIHR) Newcastle Biomedical Research Centre
NBIC BioAssist
NWO-NBIC/BioAssist/RK/2008.024
Netherlands Consortium for Healthy Ageing (NCHA)
050-060-810
Netherlands Genomics Initiative (NGI)
Netherlands Heart Foundation (NHF)
2001 D 032
Netherlands Organization for Scientific Research (NWO, MagW/ZonMW)
904-61-090
904-61-193
480-04-004
400-05-717
Spinozapremie 56-464-14192
175.010.2005.011
911-03-012
985-10-002
Addiction-31160008
Middelg-root-911-09-032
Netspar - Living longer for a good health
NHS North of Tyne (Newcastle Primary Care Trust)
Pharmacy Foundation
Regione Autonoma della Sardegna
Rutgers University Cell and DNA Repository
NIMH U24 MH068457-06
Swedish Research Council
M-2005-1112
Tampere University Hospital and Academy of Finland
Danish Interdisciplinary Research Council
Health Foundation (Helsefonden)
Ministry for Higher Education
National Program for Research Infrastructure
09-063256
March of Dimes Birth Defects Foundation
Swedish Foundation for Strategic Research (SSF)
Unilever Discover Colworth
Universite Paris 13
University of Calabria
University of Tartu
SP1GVAR-ENG
Velux Foundation
VU University's Institute for Health and Care Research (EMGO+) and Neuroscience Campus Amsterdam (NCA)
Wellcome Trust
084762
085475
087436
IDEAL
FP7-HEALTH-2010-two-stage-259679
Research and Education into Ageing-0153
European Regional Development Fundinfo:eu-repo/grantAgreement/EC/FP7/201413info:eu-repo/grantAgreement/EC/FP7/223004info:eu-repo/grantAgreement/EC/FP7/242244info:eu-repo/grantAgreement/EC/FP7/25967