12 research outputs found
Topological sound in active-liquid metamaterials
Liquids composed of self-propelled particles have been experimentally
realized using molecular, colloidal, or macroscopic constituents. These active
liquids can flow spontaneously even in the absence of an external drive. Unlike
spontaneous active flow, the propagation of density waves in confined active
liquids is not well explored. Here, we exploit a mapping between density waves
on top of a chiral flow and electrons in a synthetic gauge field to lay out
design principles for artificial structures termed topological active
metamaterials. We design metamaterials that break time-reversal symmetry using
lattices composed of annular channels filled with a spontaneously flowing
active liquid. Such active metamaterials support topologically protected sound
modes that propagate unidirectionally, without backscattering, along either
sample edges or domain walls and despite overdamped particle dynamics. Our work
illustrates how parity-symmetry breaking in metamaterial structure combined
with microscopic irreversibility of active matter leads to novel
functionalities that cannot be achieved using only passive materials
Traffic and Related Self-Driven Many-Particle Systems
Since the subject of traffic dynamics has captured the interest of
physicists, many astonishing effects have been revealed and explained. Some of
the questions now understood are the following: Why are vehicles sometimes
stopped by so-called ``phantom traffic jams'', although they all like to drive
fast? What are the mechanisms behind stop-and-go traffic? Why are there several
different kinds of congestion, and how are they related? Why do most traffic
jams occur considerably before the road capacity is reached? Can a temporary
reduction of the traffic volume cause a lasting traffic jam? Under which
conditions can speed limits speed up traffic? Why do pedestrians moving in
opposite directions normally organize in lanes, while similar systems are
``freezing by heating''? Why do self-organizing systems tend to reach an
optimal state? Why do panicking pedestrians produce dangerous deadlocks? All
these questions have been answered by applying and extending methods from
statistical physics and non-linear dynamics to self-driven many-particle
systems. This review article on traffic introduces (i) empirically data, facts,
and observations, (ii) the main approaches to pedestrian, highway, and city
traffic, (iii) microscopic (particle-based), mesoscopic (gas-kinetic), and
macroscopic (fluid-dynamic) models. Attention is also paid to the formulation
of a micro-macro link, to aspects of universality, and to other unifying
concepts like a general modelling framework for self-driven many-particle
systems, including spin systems. Subjects such as the optimization of traffic
flows and relations to biological or socio-economic systems such as bacterial
colonies, flocks of birds, panics, and stock market dynamics are discussed as
well.Comment: A shortened version of this article will appear in Reviews of Modern
Physics, an extended one as a book. The 63 figures were omitted because of
storage capacity. For related work see http://www.helbing.org
Quantifying Quantum Nonlocality
Quantum mechanics is nonlocal, meaning it cannot be described by any classical local hidden variable model. In this thesis we study two aspects of quantum nonlocality.
Part I addresses the question of what classical resources are required to simulate nonlocal quantum correlations. We start by constructing new local models for noisy entangled quantum states. These constructions exploit the connection between nonlocality and Grothendieck's inequality, first noticed by Tsirelson. Next, we consider local models augmented by a limited amount of classical communication. After generalizing Bell inequalities to this setting, we show that (i) one bit of communication is sufficient to simulate the correlations of projective measurements on a maximally entangled state of two qubits, and (ii) five bits of communication are sufficient to simulate the joint correlation of two-outcome measurements on any bipartite quantum state. The latter result can be interpreted as a stronger (constrained) version of Grothendieck's inequality.
In part II, we investigate the monogamy of nonlocal correlations. In a setting where three parties, A, B, and C, share an entangled quantum state of arbitrary dimension, we: (i) bound the trade-off between AB's and AC's violation of the CHSH inequality, obtaining an intriguing generalization of Tsirelson's bound, and (ii) demonstrate that forcing B and C to be classically correlated prevents A and B from violating certain Bell inequalities. We study not only correlations that arise within quantum theory, but also arbitrary correlations that do not allow signaling between separate groups of parties. These results are based on new techniques for obtaining Tsirelson bounds, or bounds on the quantum value of a Bell inequality, and have applications to interactive proof systems and cryptography.</p
Anti-apoptotic treatment of warm ischemic male rat livers in machine perfusion improves symptoms of ischemia-reperfusion injury
Background: Liver donation after cardiac death (DCD) makes up a small percentage of the organs used in transplantation and poses a higher risk of graft loss compared to donation after brain death (DBD); this is a result of ischemia reperfusion for which the exact injury mechanisms are currently not fully understood. However, reperfusion injury has been shown to lead to necrosis as well as apoptosis through oxidative stress and mitochondrial dysfunction. In this work, we propose that use of the pro-survival, anti-apoptotic CEPT cocktail in post-ischemia normothermic machine perfusion (NMP) may improve recovery in rat livers subjected to extended durations of warm ischemia. Materials and Methods: Livers procured from male Lewis rats were subjected to 90Â min of warm ischemia, followed by 6Â h of NMP where they were treated either with the survival-enhancing anti-apoptotic cocktail (CEPT), the vehicle (DMSO) or the base media with no additives. Results: The CEPT-treated group exhibited lower expression of hepatic injury biomarkers, and improvement in a range of hepatocellular symptoms associated with the hepatic parenchyma, biliary epithelium and the sinusoidal endothelium, including recovery of bile secretion and lowered vascular resistance. Conclusions: This study's findings suggest apoptosis plays a more significant role in ischemia-reperfusion injury than previously understood, and provide useful insight for further investigation of the specific underlying mechanisms and development of novel treatment methods
Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts
Small cell lung cancer (SCLC) patient-derived xenografts (PDX) can be generated from biopsies or circulating tumor cells (CTC), though scarcity of tissue and low efficiency of tumor growth have previously limited these approaches. Applying an established clinical-translational pipeline for tissue collection and an automated microfluidic platform for CTC enrichment, we generated 17 biopsy-derived PDXs and 17 CTC-derived PDXs in a 2-year timeframe, at 89% and 38% efficiency, respectively. Whole-exome sequencing showed that somatic alterations are stably maintained between patient tumors and PDXs. Early-passage PDXs maintain the genomic and transcriptional profiles of the founder PDX. In vivo treatment with etoposide and platinum (EP) in 30 PDX models demonstrated greater sensitivity in PDXs from EP-naive patients, and resistance to EP corresponded to increased expression of a MYC gene signature. Finally, serial CTC-derived PDXs generated from an individual patient at multiple time points accurately recapitulated the evolving drug sensitivities of that patient's disease. Collectively, this work highlights the translational potential of this strategy. SIGNIFICANCE: Effective translational research utilizing SCLC PDX models requires both efficient generation of models from patients and fidelity of those models in representing patient tumor characteristics. We present approaches for efficient generation of PDXs from both biopsies and CTCs, and demonstrate that these models capture the mutational landscape and functional features of the donor tumors. (C) 2018 AACR