Compliance externalities and the role model effect on law abidance : field and survey-experimental evidence

Recent theories of compliance predict that, apart from utilitarian considerations, individual decisions to respect or break the law account for virtuous motives and nonutilitarian willingness to promote the social good. We test whether empirical evidence supports these theories by collecting data on cyclists' decisions to ignore a red traffic light in a natural setting. We consider different situations where noncompliance is costly, but without risk, and where material deterrence incentives from legal sanctions remain constant. The only difference between the situations lies in who is observing the cyclists' decision at the traffic light at the intersection of a footpath with the cycle track. We find that about 68 percent of cyclists ignore the red traffic light when there is the opportunity to do so. This frequency does not change substantially when adult bystanders are observing at the pedestrian traffic light. Interestingly, the violation frequency drops to about 10 percent when children are present. Robustness checks rule out the alternative explanations that this change is driven by concerns for children's unpredictable actions, or by the simultaneous presence of other adult bystanders. In a vignette study, we additionally dissect the cyclists' motives for being compliant. Results suggest a “role‐model effect” on compliance. When asked, the majority of participants report that the willingness to educate and be a good example is the most important reason for their decision to abide by the law, hence supporting the empirical observation that promoting the social good can be an important nonutilitarian motive of compliance decisions

A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.

In spite of the recent increase in endoperoxide antimalarials under development, it remains unclear if all these chemotypes share a common mechanism of action. This is important since it will influence cross-resistance risks between the different classes. Here we investigate this proposition using novel clickable 1,2,4-trioxolane activity based protein-profiling probes (ABPPs). ABPPs with potent antimalarial activity were able to alkylate protein target(s) within the asexual erythrocytic stage of Plasmodium falciparum (3D7). Importantly, comparison of the alkylation fingerprint with that generated from an artemisinin ABPP equivalent confirms a highly conserved alkylation profile, with both endoperoxide classes targeting proteins in the glycolytic, hemoglobin degradation, antioxidant defence, protein synthesis and protein stress pathways, essential biological processes for plasmodial survival. The alkylation signatures of the two chemotypes show significant overlap (ca. 90 %) both qualitatively and semi-quantitatively, suggesting a common mechanism of action that raises concerns about potential cross-resistance liabilities

Privacy in Transport? Exploring Perceptions of Location Privacy Through User Segmentation

Unanticipated accumulation and dissemination of accurate location information flows is the latest iteration of the privacy debate. This mixed-methods research contributes a grounded understanding of risk perceptions, enablers and barriers to privacy preserving behaviour in a cyber-physical environment. We conducted the first representative survey on internet privacy concerns, cyber and physical risk taking, privacy victimisation, usage of location sharing apps and transport choices in the UK with 466 participants. The responses segregated participants into four distinct, novel clusters (cyber risk takers, physical risk takers, transport innovators, and risk abstainers) with cross-validated prediction accuracy of 92%. In the second part of the study, we qualitatively explored these clusters through 12 homogeneous focus groups with 6 participants each. The predominant themes of the groups matched their clusters with little overlap between the groups. The differences in risk perception and behaviours varied greatly between the clusters. Future transport systems, apps and websites that rely on location data therefore need a more personalised approach to information provision surrounding location sharing. Failing to recognise these differences could lead to reduced data sharing, riskier sharing behaviour or even total avoidance of new forms of technology in transport

Crying and feeding problems in infancy and cognitive outcome in preschool children born at risk : a prospective population study

Objective: To investigate whether regulatory problems, i.e., crying and feeding problems in infants > 3 months of age, predict cognitive outcome in preschool children born at risk even when controlled for confounding factors. Methods: A prospective longitudinal study of children born in a geographically defined area in Germany. N = 4427 children of 6705 eligible survivors (66%) participated at all four assessment points (neonatal, 5, 20, and 56 months of age). Excessive crying and feeding problems were measured at 5 months. Mental development was assessed with the Griffiths Scale at 20 months, and cognitive assessments were conducted at 56 months. Neonatal complications, neurological, and psychosocial factors were controlled as confounders in structural equation modeling and analyses of variance. Results: One in five infants suffered from single crying or feeding problems, and 2% had multiple regulatory problems, i.e., combined crying and feeding problems at 5 months. In girls, regulatory problems were directly predictive of lower cognition at 56 months, even when controlled for confounders, whereas in boys, the influence on cognition at 56 months was mediated by low mental development at 20 months. Both in boys and girls, shortened gestational age, neonatal neurological complications, and poor parent-infant relationship were predictive of regulatory problems at 5 months and lower cognition at 56 months. Conclusion: Regulatory problems in infancy have a small but significant adverse effect on cognitive development