71 research outputs found
The Challenges Facing Training in Pediatric Surgery Worldwide
- Author
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/01/2013
- Field of study
Like most specialties, pediatric surgery is becoming more complex, and changes to health systems have not always been in the best interests of trainees or their surgical teachers. This paper outlines four of the current challenges faced by training boards in pediatric surgery worldwide, and documents their implications for the future training of pediatric surgeons
The effect of bedrest on various parameters of physiological function. part xii- the effect of bedrest on bone mass and calcium balance
- Publication venue
- Publication date
- Field of study
Bed rest effect on various parameters of physiological functions - bone mass and calcium balanc
The Role of Parvalbumin-positive Interneurons in Auditory Steady-State Response Deficits in Schizophrenia
- Author
- A.M. Lavoie
- AR Woodruff
- C Börgers
- C-G Hahn
- CA Brenner
- Chi-Ming A. Chen
- CL Beasley
- D Vierling-Claassen
- D Vierling-Claassen
- David A. Lewis
- David W. Volk
- E Salinas
- G Gonzalez-Burgos
- GA Light
- GP Krishnan
- Hanna Thuné
- Henry Markram
- I Wonodi
- J. Szabadics
- Joshua T. Kantrowitz
- JS Kwon
- KM Spencer
- KM Spencer
- KM Spencer
- L KRISTIANSEN
- LS Overstreet
- M Bartos
- M Carlén
- Monica Beneyto
- Monika P. Jadi
- MW Howard
- N Hajos
- Nadezhda V. Povysheva
- P Fries
- P Steullet
- P Teale
- Pascal Fries
- R Tsuchimoto
- Robin Tremblay
- RY Cho
- S Keros
- T Hashimoto
- T MĂ€ki-Marttunen
- T-U Woo
- Tuomo MĂ€ki-Marttunen
- Y Kawaguchi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 06/12/2019
- Field of study
© The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the articleâs Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the articleâs Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.Despite an increasing body of evidence demonstrating subcellular alterations in parvalbumin-positive (PV+) interneurons in schizophrenia, their functional consequences remain elusive. Since PV+ interneurons are involved in the generation of fast cortical rhythms, these changes have been hypothesized to contribute to well-established alterations of beta and gamma range oscillations in patients suffering from schizophrenia. However, the precise role of these alterations and the role of different subtypes of PV+ interneurons is still unclear. Here we used a computational model of auditory steady-state response (ASSR) deficits in schizophrenia. We investigated the differential effects of decelerated synaptic dynamics, caused by subcellular alterations at two subtypes of PV+ interneurons: basket cells and chandelier cells. Our simulations suggest that subcellular alterations at basket cell synapses rather than chandelier cell synapses are the main contributor to these deficits. Particularly, basket cells might serve as target for innovative therapeutic interventions aiming at reversing the oscillatory deficits.Peer reviewe
Developmental disruption of perineuronal nets in the medial prefrontal cortex after maternal immune activation
- Author
- A Faissner
- A Klausmeyer
- AA Curley
- AE Takesian
- AR Wolff
- AR Wolff
- AS Brown
- AS Brown
- BK Bitanihirwe
- C Basar-Eroglu
- CJ Machado
- CL Beasley
- CV Vorhees
- CY Pietersen
- D Bavelier
- D Ibi
- D Nakayama
- D Wang
- DA Lewis
- DD Dickerson
- DD Dickerson
- DW Volk
- E Domenici
- F Passetti
- G BrĂŒckner
- G BrĂŒckner
- G BuzsĂĄki
- G Gonzalez-Burgos
- G Gonzalez-Burgos
- G Koppe
- H Pantazopoulos
- H Pantazopoulos
- H Pantazopoulos
- H Yamamori
- J Richetto
- J Zahrt
- JF Enwright
- JG Howland
- JJ Tukker
- JR Glausier
- K Fox
- KE Rhodes
- KM Spencer
- LA Miner
- M Sur
- N Berardi
- N Gogolla
- N Mellios
- NV Malkova
- PE Gottschall
- RY Cho
- S Berretta
- S Canetta
- S Devanarayanan
- S Giovanoli
- S Hockfield
- S Sangha
- S Smolders
- S Wiese
- SA Ballendine
- SA Mauney
- SJ Fung
- SN Cassella
- T Hashimoto
- T Pizzorusso
- T Reinert
- U Meyer
- U Meyer
- U Meyer
- VS Sohal
- W HĂ€rtig
- W HĂ€rtig
- WW Eaton
- WY Li
- Y Piontkewitz
- Y Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
© The Author(s) 2016. Maternal infection during pregnancy increases the risk of offspring developing schizophrenia later in life. Similarly, animal models of maternal immune activation (MIA) induce behavioural and anatomical disturbances consistent with a schizophrenia-like phenotype in offspring. Notably, cognitive impairments in tasks dependent on the prefrontal cortex (PFC) are observed in humans with schizophrenia and in offspring after MIA during pregnancy. Recent studies of post-mortem tissue from individuals with schizophrenia revealed deficits in extracellular matrix structures called perineuronal nets (PNNs), particularly in PFC. Given these findings, we examined PNNs over the course of development in a well-characterized rat model of MIA using polyinosinic-polycytidylic acid (polyI:C). We found selective reductions of PNNs in the PFC of polyI:C offspring which did not manifest until early adulthood. These deficits were not associated with changes in parvalbumin cell density, but a decrease in the percentage of parvalbumin cells surrounded by a PNN. Developmental expression of PNNs was also significantly altered in the amygdala of polyI:C offspring. Our results indicate MIA causes region specific developmental abnormalities in PNNs in the PFC of offspring. These findings confirm the polyI:C model replicates neuropathological alterations associated with schizophrenia and may identify novel mechanisms for cognitive and emotional dysfunction in the disorder
Basic science232.âCertolizumab pegol prevents pro-inflammatory alterations in endothelial cell function
- Author
- Abdulkader Rita
- Abozaid Hanan S.
- Adab Peymané
- Adizie Tochukwu
- Adshead Rebecca
- Ahmad Yasmeen
- Ahmed Azeem A.
- Akil Mohammed
- Alavi Azita
- Alcorn Desmond
- Alexander Yvonne
- Alexander Yvonne
- Alexander Yvonne
- Allen Maggie
- Amarasena Roshan
- Amarasena Roshan I.
- Ambler Nick
- Amft Nicole
- Amft Nicole
- Amissah-Arthur Maame
- Amos Nicholson
- Anderson David
- Andres Mariano
- Andrews Jacqueline
- Arthur Catherine
- Ashton Simon
- Axford John
- Ayalew Yezenash
- Baburaj Krishnan
- Bacon Paul A.
- Baguley Elaine
- Ball Elisabeth
- Banik Snehashish
- Bari Syed F.
- Barone Francesca
- Barone Francesca
- Barton Anne
- Barton Anne
- Basu Neil
- Bateman James
- Bavakunji Riaz
- Bayley Rachel
- Beasley Marcus
- Bell Aubrey
- Bell Aubrey L.
- Birnbaum Julius
- Bombardieri M.
- Bombardieri Michele
- Bombardieri Michele
- Bombardieri Michele
- Bond Christine
- Bond Ursula
- Borg Frances
- Borg Frances A.
- Bosworth Ailsa
- Boulton John
- Bowman Simon
- Bowness Paul
- Bowness Paul
- Bowness Paul
- Braude Simon
- Brooksby Alan
- Brophy Sinead
- Brown Deborah
- Brown Nina
- Brown Sue J.
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Bruce Ian
- Buckley Chris
- Buckley Chris
- Buckley Chris
- Buckley Chris D.
- Bukhari Marwan
- Bukhari Marwan
- Bukhari Marwan
- Bullock Craig
- Bunn Diane
- Bunn Diane
- Bunning Rowena
- Bunning Rowena A. D.
- Bunning Rowena D.
- Calnan Michael
- Cardy Caroline M.
- Casey Matthew
- Caswell Richard
- Ceeraz Sabrina
- Chan Antoni
- Chana Jasroop K.
- Chapman Victoria
- Chen Liye
- Cheng K. K.
- Chitale Sarang
- Chitale Sarang
- Chiverton Neil
- Chiverton Neil
- Choy Ernest
- Choy Ernest H.
- Christidis Dimitrios
- Cloake Tom
- Cloake Tom
- Clunie Gavin
- Coady David
- Coady David
- Coady David
- Colaco Bernard
- Cole Zoe A.
- Coles Mark
- Collins Fraser
- Cooksey Roxanne
- Cooper Annie
- Cooper Cyrus
- Cooper Cyrus
- Cooper Nicola
- Cope Andrew
- Cordingley Lis
- Corrigall Valerie
- Coward Lucy
- Crawford Aileen
- Crilly Anne
- Cross Alison
- Cross Alison K.
- Crouch Carina
- Crozier Sarah R.
- Cumming Jo
- Curtis Elizabeth M.
- D'Cruz David
- Danda Debashish
- Daniel Priya
- Daniels Jodie
- Darroch James
- Dasgupta Bhaskar
- Dasgupta Bhaskar
- Dasgupta Bhaskar
- Davies Charlotte
- Davies David
- Davies Rebecca
- Davies Ursula M.
- Dent Caroline
- Devanny Ian
- Dey Ida D.
- Dhanjal Mandish
- Dhillon Veena
- DiCicco Maria
- Dixey Josh
- Dixey Josh
- Doherty Teresa
- Donnelly Simon P.
- Driscoll Paul C.
- Duncan G.
- Duncan Rosie
- Dunn Sara
- Dures Emma
- Edgar Suzanne
- Edmonds Sally
- Edwards Christopher J.
- Edwards Christopher J.
- Edwards Steven W.
- Ellis Benjamin
- Ellis Corrinne
- Else Sara
- Emery Paul
- Ennis H.
- Estrach Cristina
- Estrach Cristina
- Evans Bronwen
- Evans Hayley G.
- Evans Laura
- Eyre Tracey
- Fang Hong
- Farrow Luke
- Fattah Zozik
- Ferrell William R.
- Field Max
- Finlay Ron
- Fisher Roman
- Fleming S.
- Fletcher Debbie
- Fluess Elisa
- Foggo Heather
- Fortune F.
- Fu Bo
- Gainsborough Nicola
- Galloway James
- Galloway James
- Garner Rozeena
- Garza-Garcia Acely
- Gathany Tim
- Gayed Mary
- Gayed Mary
- Georgia Ntani
- Giles Ian
- Giles Ian
- Giles Ian
- Giles Joanna L.
- Godfrey Keith M.
- Goff Iain
- Golor G.
- Goodson Nicola J.
- Goodson Nicola J.
- Goodson Nicola J.
- Gordon Caroline
- Gordon Caroline
- Gordon Caroline
- Gorman Claire L.
- Greenbank Cathi
- Griffiths Bridget
- Griffiths Bridget
- Gullick Nicola J.
- Gullick Nicola J.
- Gupta Monica
- Haddock Gail
- Haddock Gail
- Hakim Alan J.
- Halsey John
- Han Chenglong
- Hands Rebecca
- Harper Lorraine
- Harris Claire L.
- Harta N.
- Harvey Nicholas C.
- Hashmi Tahir M.
- Hassan Ahmed I.
- Hassell Andrew
- Hayes Fiona
- Hayes Fiona
- Heaney Jonathan
- Heathfield Sarah
- Heron Louise
- Herrick Ariane
- Hewlett Sarah
- Hewlett Sarah
- Hickling M.
- Horan Michael
- Hsia Elizabeth
- Hughes Michael
- Hui Michelle
- Hull Richard
- Hull Richard G.
- Humby Frances
- Humphreys Jennifer
- Hunter John
- Hunter John
- Husain Muhammad J.
- Hutchinson David
- Hyrich Kimme
- Hyrich Kimme
- Ibrahim Ibrahim
- Inskip Hazel M.
- Ioannou John
- Ioannou Yiannis
- Iqbal Itrat
- Irvine Elizabeth
- Isaacs John
- Isenberg David
- Isenberg David
- Isenberg David
- Isenberg David
- Isenberg David
- Ismajli Mediola
- Jani Meghna
- Jani Meghna
- Jayaraj David M.
- Jayne David
- Jenkins Jessica
- Jennens Hannah
- Jiang C. Q.
- John Elizabeth
- Johnson Phil
- Jones Gareth T.
- Jones Gareth T.
- Jones Simon A.
- Jullion A.
- Kallankara Sathish
- Kate I.
- Kay Lesley
- Keeley Philip
- Keidel Sarah
- Kelly Sara
- Kelly Stephen
- Kendall David
- Kenu Ernest
- Kessler Benedikt M.
- Khamashta Munther
- Khattak Fazlihakim
- Kiely Patrick D.
- Kindness Kathy
- Kollnberger Simon
- Kollnberger Simon
- Kollnberger Simon
- Kretsos K.
- Kumar Kanta
- Kumar Namita
- Kuvikova Inna
- Lam T. H.
- Lane Peter
- Lanyon Peter
- Lanyon Peter
- Lanyon Peter
- Lawton Sally
- Le Maitre Christine
- Le Maitre Christine L.
- Le Maitre Christine L.
- Ledingham Jo
- Lendrem Dennis
- Leung Jansen
- Lewis Cathryn M.
- Lim Ken
- Ling Stephanie
- Lip Stefanie
- Little Jayne
- Littlewood Alison
- Lockhart John
- Loke Yoon
- Lovell Karina
- Low Audrey
- Lunt Mark
- Lunt Mark
- Lutalo Pamela M.
- Macfarlane Gary J.
- Macfarlane Gary J.
- Macfarlane Gary J.
- Macfarlane Matthew V.
- MacGregor Alex
- MacGregor Alex
- MacGregor Alex
- Mackie Sarah L.
- Macphie Elizabeth
- Mahadik Younis
- Mahendranath K. M.
- Main Wong Way
- Malaviya Anshuman P.
- Marks Jonathan
- Marroquin Osiris
- Mason Justin
- Mc Laughlin Maeve
- McBeth John
- McBeth John
- McBurney H.
- McHugh Kirsty
- McHugh Kirsty
- McHugh Neil
- McHugh Neil
- McHugh Neil
- McInnes Iain
- McInnes Ian
- McKenna Frank
- McKeogh John
- Mckew Jennifer R.
- McLaren John
- McLoughlin Yokemei
- Mehta Puja
- Mehta Puja
- Meldrum Gillian
- Mercer Louise
- Middleton Jim
- Millar Auleen M.
- Misra Ramnath
- Mitchell Adam
- Mitchell Sheryl
- Mobasheri Ali
- Moots Robert J.
- Moots Robert J.
- Moots Robert J.
- Morgan Anne
- Morgan Matthew
- Morris Marianne
- Mugford Miranda
- Mulvey Matthew
- Mulvey Matthew R.
- Murfitt Lucy
- Murphy Helen
- Murray-Brown William
- MĂ©rida Angeles Acosta
- Nayar Saba
- Nayar Saba
- Nazeer Moideen Abdul
- Nelson-Piercy Catherine
- Newman W.
- Ng Nora
- Ng Wan-Fai
- Nicholl Karl
- Nikiphorou Elena
- Nikiphorou Elena
- Nowell Mari A.
- O'Connor Mortimer B.
- O'Neill Terence
- Ogunbambi Olabambo
- Oldroyd Alexander G.
- Oomatia Amin
- Oreffo Richard O.
- Osei-Bordom Daniel-Clement
- Osgood Louise
- Ostor Andrew J.
- Owens Martina
- Palmer Helen
- Parker Ben
- Parker Ben
- Parker Ben
- Patel Dipti
- Patel Yusuf
- Patil Pravin
- Paudyal Priya
- Paul Morgan B.
- Pauling John D.
- Payeli Sravan
- Pearce Fiona
- Pease Colin T.
- Pease Colin T.
- Pendleton Neil
- Pericleous Charis
- Pericleous Charis
- Perry Liz
- Petri Michelle
- Phelan Mark J.
- Phillips Ceri J.
- Phillips E.
- Phillips Kate L. E.
- Picarelli G.
- Pierangeli Silvia
- Pierangeli Silvia S.
- Pilling Claire
- Pitzalis C.
- Pitzalis Costantino
- Pitzalis Costantino
- Pitzalis Costantino
- Plant Darren
- Plant Darren
- Platt Philip N.
- Plevin Robin
- Pope Denise
- Popham Maria
- Price Elizabeth
- Price Elizabeth
- Price-Forbes Alec
- Priori R.
- Pushpakom S.
- Rahman Anisur
- Rahman Anisur
- Rahman Anisur
- Rankin Elizabeth
- Rao Chandini
- Ray David W.
- Raza Karim
- Rees Frances
- Regan Marian
- Regan Marian
- Reid David M.
- Renner Christoph
- Reynolds John A.
- Reynolds Piero
- Rhys-Dillon Brian
- Ridley Anna
- Robertson Calum
- Robinson Frances
- Robinson Sandra
- Robinson SiĂąn M.
- Rooke Royston
- Rooney Madeleine
- Roskell S.
- Roussou Thalia
- Roussou Thalia
- Rump-Goodrich Lisa
- Russell M.
- Rutherford Michelle
- Ryan Sarah
- Rysnik Oliwia J.
- Sanderson Tessa
- Sayer Avan A.
- Scott David L.
- Scott Ian C.
- Segeda Iuliia
- Selvan Shilpa
- Semenova Olga
- Sensky T.
- Seoudi N.
- Severn Andrew
- Shah Preeti
- Sharp Charlotte A.
- Shastri Nilabh
- Shaw Jackie
- Shaw Jacqueline
- Shaw S.
- Sheldon Jo
- Shevchuk Sergii
- Siebert Stefan
- Siebert Stefan
- Simpson John
- Sivakumar Rajappa
- Skeoch Sarah
- Sofat Nidhi
- Solymossy Csilla
- Spandley A.
- Spector Tim
- Spencer Jo
- Srikanth Asha
- Steer Sophia
- Stewart Kirsty
- Stockton Marie
- Stone Michael
- Strand V.
- Sutcliffe Nurhan
- Sutton Emily J.
- Swan Joan
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Symmons Deborah
- Taams Leonie S.
- Tahir Hasan
- Tan Shaun
- Tandon Neeta
- Tappuni T.
- Tarelli Edward
- Taylor P.
- Taylor Peter
- Taylor Peter
- Teh Lee-Suan
- Thapper Muryum
- Thapper Muryum
- Thomas Huw B.
- Thompson Helen
- Timoshanko J.
- Tugnet Nicola
- Tysoe Carolyn
- Vadivelu Saravanan
- Valesini G.
- Vartoukian S.
- Varughese Sneha
- Venning Michael
- Verstappen Suzanne M.
- Viatte Sebastien
- Vincent Tonia
- Walker David
- Walker-Bone Karen
- Walker-Bone Karen
- Walsh David A.
- Wang Edward
- Watson Kath
- Watson Kath D.
- Watts Richard
- Weaver Dan
- West Louise
- West Lucy
- Wilkinson Mark
- Williams Anwen S.
- Williams Anwen S.
- Williams Emma L.
- Williams Frances M.
- Williams Mark
- Williams Mark R.
- Wilson Anthony
- Wilson Gillian
- Wilson Jo
- Win Maw Win
- Woby Steve
- Wong-Baeza Isabel
- Wood Elizabeth F.
- Worthington J.
- Worthington Jane
- Wright Helen L.
- Wright Stephen A.
- Yates Max
- Yee Chee-Seng
- Young Adam
- Young Adam
- Young Stephen
- Young Stephen P.
- Zaki Awal
- Zeef Leo
- Zoma Asad
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Background: Cardiovascular disease is a major comorbidity of rheumatoid arthritis (RA) and a leading cause of death. Chronic systemic inflammation involving tumour necrosis factor alpha (TNF) could contribute to endothelial activation and atherogenesis. A number of anti-TNF therapies are in current use for the treatment of RA, including certolizumab pegol (CZP), (Cimzia Âź; UCB, Belgium). Anti-TNF therapy has been associated with reduced clinical cardiovascular disease risk and ameliorated vascular function in RA patients. However, the specific effects of TNF inhibitors on endothelial cell function are largely unknown. Our aim was to investigate the mechanisms underpinning CZP effects on TNF-activated human endothelial cells. Methods: Human aortic endothelial cells (HAoECs) were cultured in vitro and exposed to a) TNF alone, b) TNF plus CZP, or c) neither agent. Microarray analysis was used to examine the transcriptional profile of cells treated for 6 hrs and quantitative polymerase chain reaction (qPCR) analysed gene expression at 1, 3, 6 and 24 hrs. NF-ÎșB localization and IÎșB degradation were investigated using immunocytochemistry, high content analysis and western blotting. Flow cytometry was conducted to detect microparticle release from HAoECs. Results: Transcriptional profiling revealed that while TNF alone had strong effects on endothelial gene expression, TNF and CZP in combination produced a global gene expression pattern similar to untreated control. The two most highly up-regulated genes in response to TNF treatment were adhesion molecules E-selectin and VCAM-1 (q 0.2 compared to control; p > 0.05 compared to TNF alone). The NF-ÎșB pathway was confirmed as a downstream target of TNF-induced HAoEC activation, via nuclear translocation of NF-ÎșB and degradation of IÎșB, effects which were abolished by treatment with CZP. In addition, flow cytometry detected an increased production of endothelial microparticles in TNF-activated HAoECs, which was prevented by treatment with CZP. Conclusions: We have found at a cellular level that a clinically available TNF inhibitor, CZP reduces the expression of adhesion molecule expression, and prevents TNF-induced activation of the NF-ÎșB pathway. Furthermore, CZP prevents the production of microparticles by activated endothelial cells. This could be central to the prevention of inflammatory environments underlying these conditions and measurement of microparticles has potential as a novel prognostic marker for future cardiovascular events in this patient group. Disclosure statement: Y.A. received a research grant from UCB. I.B. received a research grant from UCB. S.H. received a research grant from UCB. All other authors have declared no conflicts of interes
Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.
- Author
- Aamir A
- Abbas J
- Abbas N
- Abbott TEF
- Abdalla M
- Abdikadir H
- Abuhussein N
- Acquaah F
- Adamson R
- Adeleye O
- Adeogun A
- Adlan A
- Aftab R
- Afzal Z
- Agarwal M
- Aglan H
- Agnew CJF
- Agrawal R
- Ahern D
- Ahluwalia J
- Ahluwalia V
- Ahmad A
- Ahmad K
- Ahmed H
- Ahmed I
- Ahmed L
- Ahmed N
- Ahmed P
- Ainger E
- Ainsworth P
- Aishwarya G
- Ajibola-Taylor O
- Akhbari M
- Akhtar A
- Akhtar R
- Akpenyi O
- Al-Ausi M
- Al-Huneidi R
- Al-Khudairi R
- Al-Masri S
- Al-Mousawi A
- Al-Saadi N
- Alagappan A
- Alberts J
- Alfa-Wali M
- Ali A
- Ali B
- Ali I
- Ali M
- Ali Q
- Ali S
- Alturki N
- Alwandi A
- Amani L
- Amarnath T
- Amer M
- Amin H
- Amin MN
- Amoah R
- Amoah-Arko A
- Anandarajah C
- Ananthavarathan P
- Andah EJE
- Andrew K
- Andrews H
- Ang A
- Ang HL
- Ang JJ
- Ani C
- Anilkumar A
- Anto N
- Anwar S
- Apperley H
- Appleton S
- Aquilina T
- Archer M
- Arif T
- Arneill M
- Arnell S
- Arnold TJ
- Arshad A
- Arthur J
- Arulkumaran N
- Arya J
- Asad M
- Asemota N
- Ashaye T
- Ashdown T
- Ashour R
- Ashraf MR
- Ashwood J
- Asif U
- Atkin G
- Atkins B
- Attalla M
- Aubrey-Jones D
- Auckburally S
- Auld F
- Auluck I
- Azam S
- Aziz R
- Azizi A
- Azmi F
- Babatunde F
- Babu VS
- Bachi A
- Bagga R
- Bains H
- Bajwa DS
- Baker A
- Baker C
- Balai E
- Balian V
- Ball M
- Bamford M
- Bana R
- Banfield DA
- Bannard-Smith J
- Barai I
- Barclay J
- Barfi L
- Barker C
- Barker M
- Barmayehvar B
- Barnfield J
- Barnor-Ahiaku E
- Baron C
- Barr CJ
- Barraclough J
- Baryan HK
- Basra M
- Bassam N
- Bath MF
- Battle J
- Beasley W
- Beattie G
- Beattie S
- Beatty M
- Beghal G
- Begum F
- Behranwala K
- Belchos J
- Belgaid DR
- Belgaumkar A
- Bell S
- Ben-Gal O
- Benchetrit S
- Bennett M
- Benons N
- Bernal TL
- Bertelli M
- Berthaume-Hawkins SD
- Best R
- Betts A
- Bevan K
- Bews-Hair M
- Bhambra R
- Bhamra N
- Bhangu A
- Bhatte S
- Bhatti A
- Bhide I
- Bhome R
- Bhudia R
- Bhullar S
- Bienias A
- Billyard C
- Bird C
- Birkinshaw F
- Black J
- Blake E
- Blazeby JM
- Bleakley A
- Bloom I
- Bogle R
- Bolton W
- Borakati A
- Boraluwe-Rallage H
- Borg CM
- Botha A
- Boualbanat Y
- Boulton APR
- Bountra K
- Bowley D
- Boyd G
- Boyles L
- Bradley P
- Brannick S
- Brayley J
- Brecher J
- Breen H
- Bristow S
- Britton N
- Broad J
- Brobbey P
- Brock E
- Brooke M
- Brown A
- Brown B
- Brown F
- Brown FS
- Brown H
- Brown K
- Brown LR
- Brown M
- Brown N
- Brown R
- Brown S
- Brown T
- Bruce C
- Bruce P
- Budd E
- Bull K
- Burgin A
- Burke D
- Burke J
- Burnage S
- Burns N
- Burrows A
- Busti S
- Butler A
- Cabdi NMO
- Cadden F
- Cairns C
- Calabria C
- Calciu A
- Campbell A
- Campbell B
- Campbell G
- Campbell HS
- Cannon SP
- Cant M
- Capella S
- Cardus C
- Cardwell A
- Cargill Z
- Caroll P
- Carr G
- Carr R
- Carr W
- Carse S
- Carter N
- Carter R
- Castle A
- Cato L
- Cave D
- Cecil E
- Chadwick H
- Chadwick M
- Chan F
- Chan L
- Chan M
- Chan SSN
- Chan-lam N
- Chandler E
- Chandler S
- Chandramoorthy L
- Chandramoorthy S
- Chang A
- Chang LH
- Chang M
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- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators
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- Publication venue
- 'Wiley'
- Publication date
- 18/05/2018
- Field of study
Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability
Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study
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- 'American Society of Clinical Oncology (ASCO)'
- Publication date
- 01/01/2021
- Field of study
PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19âfree surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19âfree surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19âfree surgical pathways. Patients who underwent surgery within COVID-19âfree surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19âfree surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity scoreâmatched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19âfree surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19âfree surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks
Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.
- Author
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- Publication venue
- J Clin Oncol
- Publication date
- 01/01/2020
- Field of study
PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
- Ait-Zahra Mostafa
- Aizu Tomoyuki
- Alcivare Dana
- Alegria Michelle
- Ali Alla
- Ali Johar
- Allegria-hartmann Michelle
- Alleman Jennifer
- Allen Carlana C.
- Allen Heather
- Allen Nicole R.
- Allen Susan
- Allen Thaddeus
- Almeida Jeff
- Almond Claire
- Alsbrooks Stephen L.
- Altherr Michael R.
- Amaratunge Harshinie C.
- Ambler Andrew
- Ambrose Karen
- Ambrose Kerrie
- Amemiya Chris
- Amico-Keller Gina
- Amin Amita G.
- Anderson Mechele
- Anderson Scott
- Anderson Scott
- Andora Janice
- Andredesz Carol
- Andrew Robert
- Andrews Dan
- Andrews Daniel
- Andrews Neil
- Andrews Stephanie
- Andriese Tim
- Anthouard VĂ©ronique
- Antonarakis Stylianos E.
- Anyalebechi Vivian
- Aoki Norie
- Apostolou Sinoula
- Apweiler Eva
- Arachchi Harindra
- Arai Rie
- Arbery Hazel
- Arcaina Marlon
- Arcaina Terisita
- Archer Beth
- Arellano Andre
- Arellano-Jones Perry
- Armbruster Jeff
- Armstrong Jon
- Arredondo Dilrukshi P.
- Arredondo Heather Hope
- Artiguenave François
- Asakawa Shuichi
- Asakawa Teruyo
- Ash Gareth
- Ashcroft Kevin
- Ashurst Jennifer
- Ashwell Robert
- Ashworth Linda K.
- Aslanidis Cara
- Asomugha Chinwe O.
- Asuncion Lawreen
- Atkin Deborah
- Atkinson Andrea
- Atkinson Barry
- Attix Cristina
- Attwood John
- Aubin Keith
- Auger Katherine
- Austin Shannon Michelle
- Avila Aaron
- Avis Terry
- Ayele Mulu
- Babayan Primo
- Babbage Anne
- Babbage Sarah
- Bach Phil
- Bachatsang Pasang
- Bacon Joanne
- Badri Hummy
- Baertsch Robert
- Bagguley Claire
- Bailey Jonathan
- Bajorek Eva
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- Baker Dan
- Baker M.
- Baker Richard
- Bakis Michele
- Baldwin Jennifer
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- Banerjee Ruby
- Bao Jingyue
- Bao Qiyu
- Bao Weidong
- Bao Weidong
- Baptiste Pertrice
- Barbaria Joseph A.
- Barbe Valérie
- Bardill Simon
- Barker Daniel
- Barker Darren
- Barker Gary
- Barlow Karen
- Baron Laurent
- Barrett Anika
- Bartlett Rebecca
- Basham Victoria
- Bashman David
- Basu Suba
- Bateman Alex
- Bates Karen
- Battles John
- Batzer Mark
- Baumgart Cornelia
- Baumohl Jason
- Baynes Caroline
- Bayul Tashi
- Beall Keith
- Beard Lisa
- Beard Susan
- Beare David
- Beasley Alastair
- Beasley Helen
- Beasley Oliver
- Beaucham Leslie
- Beaudet Arthur
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- Bell George I.
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- Bensasson Douda
- Bentley Andrew
- Bentley Dan
- Bentley David
- Berardinis VĂ©ronique de
- Bercovitz John
- Berghoff Amy
- Bergmann Anne
- Berkowicz Nicolas
- Berks Mary
- Berks Michael
- Bethel Graeme
- Beugelsdijk Tony J.
- Bhakta Rita
- Bhuchar Venita
- Bi Shihua
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- Bieri Tamberlyn
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- Bird Christine
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- Birney Ewan
- Birren Bruce
- Bissell Helen
- Biswalo Kaneza
- Bituin Aleksandr
- Black Stacey
- Blackburne-Maze Suzanne
- Blair Jessica Anne
- Blakey Sarah
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- Blitshsteyn Berta
- Blomstrom David B.
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- Blumer Heather
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- Boguslavskiy Leonid
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- Bonnin David
- Border Richard
- Borowsky Mark
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- Brandriff Brigitte F.
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- Maheshwari Manjula
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- Malfatti Stephanie
- Malloy Kevin
- Maltbie Mary I.
- Mangum Brian
- Manning Jonathan
- Manohar Chitra
- Mapua Patricia
- Marabella Dick
- Mardis Elaine R.
- Mareth David
- Mariano Marisa
- Marinelli Lisa
- Mark Graham A.
- Marquis-Homeyer Catherine
- Marr Thomas G.
- Marra Marco
- Marriott Neil
- Marrone Anne
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- Matthews Charles D.
- Matthews Lucy
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- Matthews Paul
- Matthews Sterling D.
- Mauceli Evan
- Maunes Cynthia
- Maupin Rachel
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- McLellan Michael D.
- McLeod Michael P.
- McMurdo John
- McMurray Amanda
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- Meidi Patrick
- Meier Elke
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- Nair Latha
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- Naka Maho
- Nakagawa Masayo
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- O\u27Loughlin Jennifer
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- Olarnpunsagoon Alisa
- Olivas Jason
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- Olson Maynard V.
- Omotosho Bamidele
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- Ow David
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- Percy Chantel
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- Song Liping
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- Taudien Stefan
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- Wangdi Tsering
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- Wu Chungen
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- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
- Yoon Lillienne
- Yoon Vivienne
- Yoshida Satoru
- You Bo
- Young Geneva
- Young Louise
- Young Shelia
- Younger Ruth
- Yu Bing
- Yu Charles
- Yu Fuli
- Yu Jun
- Yu Jun
- Yu Jun
- Yuan Kaiwen
- Yuan Ye
- Yuan Yida
- Yue Shujie
- Yumae Brian
- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers âŒ99% of the euchromatic genome and is accurate to an error rate of âŒ1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Motherâs education and offspring asthma risk in 10 European cohort studies
- Author
- A Ruijsbroek
- A Strina
- AA Cruz
- AL Kozyrskyj
- AM Sonnenschein-van der Voort
- Anja Taanila
- B Galobardes
- C Almqvist
- C Borrell
- C Papoutsakis
- Carmen Iniguez
- CK Lai
- D Anxo
- D Pillas
- Daniel Hryhorczuk
- Daniela Porta
- E Chen
- E Civelek
- E Civelek
- E Mangrio
- E Regidor
- Francesco Forastiere
- G Cesaroni
- GJ Gibson
- GJ Gibson
- Henrique Barross
- Hynek Pikhart
- Isabel Larranaga
- Isabella Annesi-Maesano
- J Bousquet
- J Higgins
- Jan Svancara
- Jana Klanova
- JE Lang
- Joana Morrison
- Johnny Ludvigsson
- JP Mackenbach
- JP Mackenbach
- JP Mackenbach
- Kate Marie Lewis
- KC Prickett
- L Panico
- M Goddard
- M Magnusson
- M Ruiz
- M Wickman
- Margreet W. Harskamp-van Ginkel
- Marie-Josephe Saurel-Cubizolles
- Marjo-Riitta Jarvelin
- Martine Vrijheid
- Maties Torrent
- MC McCormack
- Michael Marmot
- Milagros Ruiz
- MJ Renfrew
- N Spencer
- Oleksandr Zvinchuk
- Peter Goldblatt
- R Beasley
- R Beasley
- S Juarez
- S Putnam
- Sandrine Lioret
- SB Nijs de
- Sofia Correia
- SS Braman
- StataCorp
- T Gong
- Tanja G. M. Vrijkotte
- Tomas Faresjo
- X Basagana
- Z Jakab
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
- âŠ