Quantitative Separation Logic - A Logic for Reasoning about Probabilistic Programs

We present quantitative separation logic ($\mathsf{QSL}$). In contrast to classical separation logic, $\mathsf{QSL}$ employs quantities which evaluate to real numbers instead of predicates which evaluate to Boolean values. The connectives of classical separation logic, separating conjunction and separating implication, are lifted from predicates to quantities. This extension is conservative: Both connectives are backward compatible to their classical analogs and obey the same laws, e.g. modus ponens, adjointness, etc. Furthermore, we develop a weakest precondition calculus for quantitative reasoning about probabilistic pointer programs in $\mathsf{QSL}$. This calculus is a conservative extension of both Reynolds' separation logic for heap-manipulating programs and Kozen's / McIver and Morgan's weakest preexpectations for probabilistic programs. Soundness is proven with respect to an operational semantics based on Markov decision processes. Our calculus preserves O'Hearn's frame rule, which enables local reasoning. We demonstrate that our calculus enables reasoning about quantities such as the probability of terminating with an empty heap, the probability of reaching a certain array permutation, or the expected length of a list

Actionable Patient Safety Solution (APSS) #3B: Improve Prevention of Severe Hypoglycemia

Severe hypoglycemia (SH) causes significant morbidity and occasional mortality in hospitalized patients. The establishment of an effective program to reduce errors in the recognition and treatment of SH requires an implementation plan that includes the following actionable steps[.

Toxoplasmosis: Overview from a One Health perspective

Toxoplasmosis is paradigmatic of the One Health approach, as the causative parasite Toxoplasma gondii infects virtually all warm-blooded animals, including humans. This makes T. gondii one of the most successful parasites on earth, infecting up to a third of the global human population. Moreover, the T. gondii disease burden has been ranked among the highest of all parasitic diseases. To reduce the disease burden of toxoplasmosis in humans, interventions are needed in the animal reservoirs, necessitating close collaboration between both the human and veterinary medical sectors. In the present special issue of FAWPAR, several of the most pertinent topics related to the impact and control of toxoplasmosis are addressed by leading experts in the field. This collection of papers highlights state-of-the-art knowledge, gaps in knowledge and future perspectives, as well as the benefits of current and proposed future activities to tackle toxoplasmosis within the One Health context

EFSA BIOHAZ Panel (EFSA Panel on Biological Hazards), 2013. Scientific Opinion on the public health hazards to be covered by inspection of meat (bovine animals).

A risk ranking process identified Salmonella spp. and pathogenic verocytotoxin-producing Escherichia coli (VTEC) as current high-priority biological hazards for meat inspection of bovine animals. As these hazards are not detected by traditional meat inspection, a meat safety assurance system for the farm-to-chilled carcass continuum using a risk-based approach was proposed. Key elements of the system are risk-categorisation of slaughter animals for high-priority biological hazards based on improved food chain information, as well as risk-categorisation of slaughterhouses according to their capability to control those hazards. Omission of palpation and incision during post-mortem inspection for animals subjected to routine slaughter may decrease spreading and cross-contamination with the high-priority biological hazards. For chemical hazards, dioxins and dioxin-like polychlorinated biphenyls were ranked as being of high potential concern; all other substances were ranked as of medium or lower concern. Monitoring programmes for chemical hazards should be more flexible and based on the risk of occurrence, taking into account the completeness and quality of the food chain information supplied and the ranking of chemical substances, which should be regularly updated to include new hazards. Control programmes across the food chain, national residue control programmes, feed control and monitoring of environmental contaminants should be better integrated. Meat inspection is a valuable tool for surveillance and monitoring of animal health and welfare conditions. Omission of palpation and incision would reduce detection effectiveness for bovine tuberculosis and would have a negative impact on the overall surveillance system especially in officially tuberculosis free countries. The detection effectiveness for bovine cysticercosis, already low with the current meat inspection system, would result in a further decrease, if palpation and incision are removed. Extended use of food chain information could compensate for some, but not all, the information on animal health and welfare lost if only visual post-mortem inspection is applied

Agile service engineering in the industrial Internet of Things

The emerging Industrial Internet of Things (IIoT) will not only leverage new and potentially disruptive business models but will also change the way software applications will be analyzed and designed. Agility is a need in a systematic service engineering as well as a co-design of requirements and architectural artefacts. Functional and non-functional requirements of IT users (in smart manufacturing mostly from the disciplines of mechanical engineering and electrical engineering) need to be mapped to the capabilities and interaction patterns of emerging IIoT service platforms, not to forget the corresponding information models. The capabilities of such platforms are usually described, structured, and formalized by software architects and software engineers. However, their technical descriptions are far away from the thinking and the thematic terms of end-users. This complicates the transition from requirements analysis to system design, and hence the re-use of existing and the design of future platform capabilities. Current software engineering methodologies do not systematically cover these interlinked and two-sided aspects. The article describes in a comprehensive manner how to close this gap with the help of a service-oriented analysis and design methodology entitled SERVUS (also mentioned in ISO 19119 Annex D) and a corresponding Web-based Platform Engineering Information System PEIS)

High occupancy vehicle treatments, impacts and parameters. Volume I - procedures and conclusions. Final report.

Mode of access: Internet.Author corporate affiliation: New Jersey Department of Transportation, TrentonSubject code: CDCMSubject code: IJDHMSubject code: SDBLSubject code: SDBL