A case of rocky mountain spotted fever without eschar as a cause of pyrexia with multiple organ failure

Rocky mountain spotted fever (RMSF) is a rickettsia disease frequently reported from North America and Europe and transmitted by tick bite. This disease is very rare in India and other parts of South East Asia. Fever with rash and thrombocytopenia are the hallmark clinical presentations of viral hemorrhagic fever but other diseases like malaria, typhoid, Leptospira and rickettsia diseases should also be considered in differential diagnosis. Knowledge of geographical distribution, evidence of exposure to the vector and a high degree of clinical suspicion of rickettsia diseases are very important for early differentiation from other diseases to prevent lethal complications and institute initial treatment. We report a rare case of rocky mountain spotted fever (RMSF) from New Delhi, which was confirmed by specific indirect immunofluorescence assay (IIF).

Macrocyclic cyclodiphosphazane [{P(mu-(BuN)-Bu-t)}(2)(O - m - C6H4 CHNCH2)(2)](2): synthesis of chalcogen derivatives and gold(I) complex

The synthesis of a Schiff base-appended macrocycle (1) containing cyclodiphosphazane moieties is described. Reactions of 1 with and elemental selenium yielded derivatives tetrakis(oxide) (2) and tetrakis(selenide) (3), in 80% yield. Tetragold complex ] (4) was prepared by reacting 1 with [] in 1:4 molar ratio. All the compounds have been characterized by various spectroscopic techniques. The molecular structure of 3 was confirmed by single crystal X-ray analysis

Six-membered ring systems: with O and/or S atoms

A large variety of publications involving O- and S-6-membered ring systems have appeared in 2018. The importance of these heterocyclic compounds is highlighted by the large number of publications on the total synthesis of natural oxygen derivatives and of other communications dedicated to natural and synthetic derivatives. Reviews on the ruthenium-catalyzed synthesis of various O-6-membered heterocycles (18SC1551), the enantioselective syntheses of 3,4-dihydropyran derivatives (18CR2080), and strategies for the synthesis of coumarins (18SC1534) have appeared. The synthesis of natural pyran-2-ones and pyran-4-ones starting from alkynes and promoted by gold complexes (18AGE4215) and cyclization strategies of substituted alkynyl acids and esters to afford pyran-2-one and isocoumarin derivatives (18SL1) have been detailed in minireviews. The synthesis of various O-6-membered derivatives was also achieved through ultrasound irradiation (18SC1235) and using 4-hydroxy-6-methylpyran-2-one as a building block in multicomponent reactions (18H(96)381).info:eu-repo/semantics/publishedVersio