Recueil de vues prises sur la route de Basle à Bienne par l'ancien évêché

Analyse iconographique: Lieux représentés: [Pl. 1] Bâle (ville) et le Rhin (cours d'eau) ; [2] Münchenstein (BS) ; [3] Le château d'Angenstein (BL) et la Birse (cours d'eau) ; [4] La Birse à Grellingen (BL) ; [5] Le château de Zwingen (BL) et la Birse ; [6] Le Vorbourg (JU) et la Birse ; [7] Delémont (JU) ; [8] La Birse avant Courrendlin (JU) ; [9, 10 et 11] La Birse aux environs de Roches (BE) ; [12] Roches (BE) ; [13] Le pont des Pennes dans les gorges de Moutier (BE) ; [14 et 15] La Birse dans les gorges de Moutier ; [16] Moutier (BE) ; [17] La Birse dans les gorges de Court (BE) ; [18] Pierre-Pertuis (BE) ; [19] La Suze (cours d'eau) à Reuchenette (BE) ; [20] Chute d'eau à Rondchâtel (BE) ; [21] Frinvillier (BE) et, au loin, Orvin (BE) ; [22] Bienne (BE) et son lac

Utility of WHOQOL-BREF in measuring quality of life in Sickle Cell Disease

BACKGROUND: Sickle cell disease is the commonest genetic disorder in Jamaica and most likely exerts numerous effects on quality of life (QOL) of those afflicted with it. The WHOQOL-Bref, which is a commonly utilized generic measure of quality of life, has never previously been utilized in this population. We have sought to study its utility in this disease population. METHODS: 491 patients with sickle cell disease were administered the questionnaire including demographics, WHOQOL-Bref, Short Form-36 (SF-36), Flanagan's quality of life scale (QOLS) and measures of disease severity at their routine health maintenance visits to the sickle cell unit. Internal consistency reliabilities, construct validity and "known groups" validity of the WHOQOL-Bref, and its domains, were examined; and then compared to those of the other instruments. RESULTS: All three instruments had good internal consistency, ranging from 0.70 to 0.93 for the WHOQOL-Bref (except the 'social relationships' domain), 0.86-0.93 for the SF-36 and 0.88 for the QOLS. None of the instruments showed any marked floor or ceiling effects except the SF-36 'physical health' and 'role limitations' domains. The WHOQOL-Bref scale also had moderate concurrent validity and showed strong "known groups" validity. CONCLUSION: This study has shown good psychometric properties of the WHOQOL-Bref instrument in determining QOL of those with sickle cell disease. Its utility in this regard is comparable to that of the SF-36 and QOLS.Originally published at http://www.biomedcentral.com/content/pdf/1477-7525-7-75.pd

Photography-based taxonomy is inadequate, unnecessary, and potentially harmful for biological sciences

The question whether taxonomic descriptions naming new animal species without type specimen(s) deposited in collections should be accepted for publication by scientific journals and allowed by the Code has already been discussed in Zootaxa (Dubois & Nemésio 2007; Donegan 2008, 2009; Nemésio 2009a–b; Dubois 2009; Gentile & Snell 2009; Minelli 2009; Cianferoni & Bartolozzi 2016; Amorim et al. 2016). This question was again raised in a letter supported by 35 signatories published in the journal Nature (Pape et al. 2016) on 15 September 2016. On 25 September 2016, the following rebuttal (strictly limited to 300 words as per the editorial rules of Nature) was submitted to Nature, which on 18 October 2016 refused to publish it. As we think this problem is a very important one for zoological taxonomy, this text is published here exactly as submitted to Nature, followed by the list of the 493 taxonomists and collection-based researchers who signed it in the short time span from 20 September to 6 October 2016

Robust estimation of bacterial cell count from optical density

Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data

Juicios sobre la historia y los historiadores

Tabla de contenidos: La antigüedad. La edad media. La historia desde 1450 hasta 1598. La historia de los siglos XVII y XVIII (1598-1763)

The Civilization of the Renaissance in Italy, Volume 1

The Civilization of the Renaissance in Italy is an 1860 work on the Italian Renaissance by Swiss historian Jacob Burckhardt. Together with his History of the Renaissance in Italy (1867) it is counted among the classics of Renaissance historiography.https://scholar.dominican.edu/cynthia-stokes-brown-books-personal-research/1201/thumbnail.jp

La cultura del Renacimiento en Italia

Trad. tomado do v. por