68 research outputs found

    The Real Deal: What Judgments of "Really" Reveal About How People Think About Artifacts

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    In two experiments we investigate what drives judgments of what an artifact really is and what these judgments reveal about how people think about artifacts. We contrast an essentialist perspective with a pragmatics perspective. Results from both experiments favor the pragmatics perspective that judgments of really reflect how well properties of the object match properties evoked by the name in question

    Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders

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    Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting substantial pleiotropy of contributing loci. However, the nature and mechanisms of these pleiotropic effects remain unclear. We performed analyses of 232,964 cases and 494,162 controls from genome-wide studies of anorexia nervosa, attention-deficit/hyper-activity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, and Tourette syndrome. Genetic correlation analyses revealed a meaningful structure within the eight disorders, identifying three groups of inter-related disorders. Meta-analysis across these eight disorders detected 109 loci associated with at least two psychiatric disorders, including 23 loci with pleiotropic effects on four or more disorders and 11 loci with antagonistic effects on multiple disorders. The pleiotropic loci are located within genes that show heightened expression in the brain throughout the lifespan, beginning prenatally in the second trimester, and play prominent roles in neurodevelopmental processes. These findings have important implications for psychiatric nosology, drug development, and risk prediction.Peer reviewe

    The role of familiarity in determining typicality

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    Bibliography: leaves 24-26Supported in part by the National Institute of Education under contract no. HEW-NIE-C-400-76-011
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