Pillararenes as Promising Carriers for Drug Delivery

Since their discovery in 2008 by N. Ogoshi and co-authors, pillararenes (PAs) have become popular hosts for molecular recognition and supramolecular chemistry, as well as other practical applications. The most useful property of these fascinating macrocycles is their ability to accommodate reversibly guest molecules of various kinds, including drugs or drug-like molecules, in their highly ordered rigid cavity. The last two features of pillararenes are widely used in various pillararene-based molecular devices and machines, stimuli-responsive supramolecular/host–guest systems, porous/nonporous materials, organic–inorganic hybrid systems, catalysis, and, finally, drug delivery systems. In this review, the most representative and important results on using pillararenes for drug delivery systems for the last decade are presented. © 2023 by the authors.Ministry of Education and Science of the Russian Federation, Minobrnauka: 075-15-2022-1118This research was funded by the Ministry of Science and Higher Education of the Russian Federation (Agreement # 075-15-2022-1118 accessed on 29 June 2022)

SYNTHESIS OF NEW 3-(PYRIDIN-2-YL)-1,2,4-TRIAZINE COMPLEXES OF RUTHENIUM (II)

This work was supported by Russian Science Foundation Grant # 23-23-00539

SIMPLE COLORIMETRIC SCHIFF’S BASE PROBES FOR THE NAKED-EYE DETECTION ON CN- ION

This work was funded by the Grants Council of the President of the Russian Federation (#NSh-1223.2022.1.3)

SYNTHESIS AND PHOTOPHYSICAL PROPERTIES OF MONOAZATRIPHENYLENE DERIVATIVES AND ANALOGUES WITH EXTENDED CONJUGATION SYSTEM

This work was supported by Russian Science Foundation grants # 19-73-10144-Р and # 23-13-00318

TM-Free and TM-Catalyzed Mechanosynthesis of Functional Polymers

Highlights: The most representative examples for the TM-free and TM-catalyzed mechano-synthesis of functional polymers are reported; The most common applications for the various types of functional polymers are precented; The advantage of solvent-free mechanosynthesis over conventional solvent-based synthesis are highlighted; In many cases the better performance of the mechanchemically-prepared polymers over those obtained by using conventional methods are demonstrated. Mechanochemically induced methods are commonly used for the depolymerization of polymers, including plastic and agricultural wastes. So far, these methods have rarely been used for polymer synthesis. Compared to conventional polymerization in solutions, mechanochemical polymerization offers numerous advantages such as less or no solvent consumption, the accessibility of novel structures, the inclusion of co-polymers and post-modified polymers, and, most importantly, the avoidance of problems posed by low monomer/oligomer solubility and fast precipitation during polymerization. Consequently, the development of new functional polymers and materials, including those based on mechanochemically synthesized polymers, has drawn much interest, particularly from the perspective of green chemistry. In this review, we tried to highlight the most representative examples of transition-metal (TM)-free and TM-catalyzed mechanosynthesis of some functional polymers, such as semiconductive polymers, porous polymeric materials, sensory materials, materials for photovoltaics, etc. © 2023 by the authors.Ministry of Education and Science of the Russian Federation, Minobrnauka: 075-15-2022-1118; Council on grants of the President of the Russian Federation: NSh-1223.2022.1.3This research was funded by the Council for Grants of the President of the Russian Federation, Grant # NSh-1223.2022.1.3 (for the Section 2.3), Ministry of Science and Higher Education of the Russian Federation, Reference # 075-15-2022-1118, dated 29 June 2022 (all other sections)

Mechanosynthesis of Polyureas and Studies of Their Responses to Anions

Polyureas (PUs) have already found wide practical applications, and various methods of their synthesis have been reported. In this manuscript, we wished to report the very first mechanochemical approach towards aromatic PUs via reactions between isomeric 2,2′-, 3,3′-, and 4,4′-diaminobiphenyls and triphosgene under solvent-free conditions following ball-milling. By using this synthetic approach, both PUs and azomethine-capped Pus were obtained. The fluorescence response of the above-mentioned PUs towards various anions in solutions were studied and selective fluorescence responses towards the hydroxyl and fluoride anions were observed. © 2023 by the authors.Ministry of Education and Science of the Russian Federation, Minobrnauka: 075-15-2022-1118; Council on grants of the President of the Russian Federation: NSh-1223.2022.1.3This research was funded by the Council for Grants of the President of the Russian Federation, Grant # NSh-1223.2022.1.3 (Mechanosynthesis of polyureas 7 –9), Ministry of Science and Higher Education of the Russian Federation, Reference # 075-15-2022-1118, dated 29 June 2022

Germline variation at 8q24 and prostate cancer risk in men of European ancestry

An Author Correction to this article was published on 17 January 2019.Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10 −15 ), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62–4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification. © 2018, The Author(s).Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 × 10 −15 ), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95%CI = 3.62–4.40) greater risk compared to the population average. These 12 variants account for ~25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification. © 2018, The Author(s).Peer reviewe