Assessment of strip tillage systems for maize production in semi-arid Ethiopia: effects on grain yield and water balance

International audienceThe traditional tillage implement, the Maresha plow, and the tillage systems that require repeated and cross plowing have caused poor rainfall partitioning, land degradation and hence low water productivity in Ethiopia. Conservation tillage could alleviate these problems. However, no-till can not be feasible for smallholder farmers in semi-arid regions of Ethiopia because of difficulties in maintaining soil cover due to low rainfall and communal grazing and because of high costs of herbicides. Strip tillage systems may offer a solution. This study was initiated to test strip tillage systems using implements that were modified forms of the Maresha plow, and to evaluate the impacts of the new tillage systems on water balance and grain yields of maize (Zea mays XX). Experiments were conducted in two dry semi arid areas called Melkawoba and Wulinchity, in the central Rift Valley of Ethiopia during 2003?2005. Strip tillage systems that involved cultivating planting lines at a spacing of 0.75 m using the Maresha plow followed by subsoiling along the same lines (STS) and without subsoiling (ST) were compared with the traditional tillage system of 3 to 4 times plowing with the Maresha plow (CONV). Soil moisture was monitored to a depth of 1.8 m using Time Domain Reflectometer while surface runoff was measured using rectangular trough installed at the bottom of each plot. STS resulted in the least surface runoff (Qs=17 mm-season?1), the highest transpiration (T=196 mm-season?1), the highest grain yields (Y=2130 kg-ha?1) and the highest water productivity using total evaporation (WPET=0.67 kg-m?3) followed by ST (Qs=25 mm-season?1, T=178 mm-season?1, Y=1840 kg-ha?1, WPET=0.60 kg-m?3) and CONV (Qs=40 mm-season?1,T=158 mm-season?1, Y=1720 kg-ha?1, WPET=0.58 kg-m?3). However, when the time between the last tillage operation and planting of maize was more than 26 days, the reverse occurred. There was no statistically significant change in soil physical and chemical properties after three years of experimenting with different tillage systems

Исследование информационных процессов в некоторых повторяющихся играх

Рассматривается неантагонистическая повторяющаяся игра с непрерывным временем. Один раз за всю игру может подействовать возмущающий фактор. Он изменяет существующую ситуацию равновесия на другую. При этом выигрыш второго игрока уменьшается. Найдены равновесные стратегии и оптимальный дискретный режим получения информации. Показано, что наблюдатель оценивает режим получения информации как оптимальный или избыточный в зависимости от модели реальности, которой он пользуется.The non-antagonistic repeated game are considered. The disturbance is able to act once the game. It changes the existing situation of equilibrium for another one. For this the second player gain decreases. The equilibrium strategies and the optimum discrete regime of the information receipt are found. It is shown that observer estimates the regime of the information receipt as the optimum or surplus regime depending on the model of reality which is used by him

Nearly one in every six HIV-infected children lost from ART follow-up at Debre Markos Referral Hospital, Northwest Ethiopia: A 14-year retrospective follow-up study.

BackgroundAlthough antiretroviral therapy (ART) significantly improves the survival status and quality of life among human immunodeficiency virus (HIV)-infected children, loss to follow-up (LTFU) from HIV-care profoundly affecting the treatment outcomes of this vulnerable population. For better interventions, up-to-date information concerning LTFU among HIV-infected children on ART is vital. However, only a few studies have been conducted in Ethiopia to address this concern. Thus, this study aims to identify the predictors of LTFU among HIV-infected children receiving ART at Debre Markos Referral Hospital.MethodsAn institution-based retrospective follow-up study was done among 408 HIV-infected children receiving ART at Debre Markos Referral Hospital between 2005 and March 15, 2019. Data were abstracted from the medical records of HIV-infected children using a standardized data abstracted checklist. We used Epi-Data Version 3.1 for data entry and Stata Version 14 for statistical analysis. The Kaplan-Meier survival curve was used to estimate the survival time. A generalized log-rank test was used to compare the survival curves of different categorical variables. Finally, both bi-variable and multivariable Cox proportional hazard regression models were used to identify the predictors of LTFU.ResultsOf 408 HIV-infected children included in the final analysis, 70 (17.1%) children were LTFU at the end of the study. The overall incidence rate of LTFU among HIV-infected children was found to be 4.5 (95%CI: 3.5-5.7) per 100-child years of observation. HIV-infected children living in rural areas (AHR: 3.2, 95%CI: 2.0-5.3), having fair or poor ART drug adherence (AHR: 2.3, 95%CI: 1.4-3.7), children started ART through test and treat approach (AHR: 2.7, 95%CI: 1.4-5.5), and children started protease inhibiter (PI)-based ART regimens (AHR: 2.2, 95%CI: 1.1-4.4) were at higher risk of LTFU.ConclusionThis study found that one in every six HIV-infected children lost form ART follow-up. HIV-infected children living in rural areas, having fair or poor ART drug adherence, started ART based on test and treat approach, and taking PI-based ART regimens were at higher risk of LTFU

Exploring barriers to the use of formal maternal health services and priority areas for action in Sidama zone, southern Ethiopia.

In 2015 the maternal mortality ratio for Ethiopia was 353 per 100,000 live births. Large numbers of women do not use maternal health services. This study aimed to identify factors influencing the use of maternal health services at the primary health care unit (PHCU) level in rural communities in Sidama zone, south Ethiopia in order to design quality improvement interventions. We conducted a qualitative study in six woredas in 2013: 14 focus group discussions (FGDs) and 44 in-depth interviews with purposefully selected community members (women, male, traditional birth attendants, local kebele administrators), health professionals and health extension workers (HEWs) at PHCUs. We digitally recorded, transcribed and thematically analysed the interviews and FGDs using Nvivo. The 'three delay model' informed the analytical process and discussion of barriers to the use of maternal health services. Lack of knowledge on danger signs and benefits of maternal health services; cultural and traditional beliefs; trust in TBAs; lack of decision making power of women, previous negative experiences with health facilities; fear of going to an unfamiliar setting; lack of privacy and perceived costs of maternal health services were the main factors causing the first delay in deciding to seek care. Transport problems in inaccessible areas were the main contributing factor for the second delay on reaching care facilities. Lack of logistic supplies and equipment, insufficient knowledge and skills and unprofessional behaviour of health workers were key factors for the third delay in accessing quality care. Use of maternal health services at the PHCU level in Sidama zone is influenced by complex factors within the community and health system. PHCUs should continue to implement awareness creation activities to improve knowledge of the community on complications of pregnancy and benefits of maternal health services. The health system has to be responsive to community's cultural norms and practices. The mangers of the woreda health office and health centres should take into account the available budgets; work on ensuring the necessary logistics and supplies to be in place at PHCU

Incidence of common opportunistic infections among HIV-infected children on ART at Debre Markos referral hospital, Northwest Ethiopia: a retrospective cohort study.

BACKGROUND:Opportunistic infections (OIs) are the leading cause of morbidity and mortality among children living with human immunodeficiency virus (HIV). For better treatments and interventions, current and up-to-date information concerning occurrence of opportunistic infections in HIV-infected children is crucial. However, studies regarding the incidence of common opportunistic infections in HIV-infected children in Ethiopia are very limited. Hence, this study aimed to determine the incidence of opportunistic infections among HIV-infected children on antiretroviral therapy (ART) at Debre Markos Referral Hospital. METHODS:A facility-based retrospective cohort study was undertaken at Debre Markos Referral Hospital for the period of January 1, 2005 to March 31, 2019. A total of 408 HIV-infected children receiving ART were included. Data from HIV-infected children charts were extracted using a data extraction form adapted from ART entry and follow-up forms. Data were entered using Epi-data™ Version 3.1 and analyzed using Stata™ Version 14. The Kaplan Meier survival curve was used to estimate the opportunistic infections free survival time. Both bi-variable and multivariable Cox proportional hazard models were fitted to identify the predictors of opportunistic infections. RESULTS:This study included the records of 408 HIV-infected children-initiated ART between the periods of January 1, 2005 to March 31, 2019. The overall incidence rate of opportunistic infections during the follow-up time was 9.7 (95% CI: 8.13, 11.48) per 100 child-years of observation. Tuberculosis at 29.8% was the most commonly encountered OI at follow-up. Children presenting with advanced disease stage (III and IV) (AHR: 1.8, 95% CI: 1.2, 2.7), having "fair" or "poor" ART adherence (AHR: 2.6, 95% CI: 1.8, 3.8), not taking OI prophylaxis (AHR:1.6, 95% CI: 1.1, 2.4), and CD4 count or % below the threshold (AHR:1.7, 95% CI: 1.1, 2.6) were at a higher risk of developing opportunistic infections. CONCLUSIONS:In this study, the incidence rate of opportunistic infections among HIV-infected children remained high. Concerning predictors, such as advanced disease stage (III and IV), CD4 count or % below the threshold, "fair" or "poor" ART adherence, and not taking past OI prophylaxis were found to be significantly associated with OIs

Global, regional, and national incidence, prevalence, and mortality of HIV, 1980–2017, and forecasts to 2030, for 195 countries and territories: a systematic analysis for the Global Burden of Diseases, Injuries, and Risk Factors Study 2017

Background Understanding the patterns of HIV/AIDS epidemics is crucial to tracking and monitoring the progress of prevention and control efforts in countries. We provide a comprehensive assessment of the levels and trends of HIV/AIDS incidence, prevalence, mortality, and coverage of antiretroviral therapy (ART) for 1980–2017 and forecast these estimates to 2030 for 195 countries and territories. Methods We determined a modelling strategy for each country on the basis of the availability and quality of data. For countries and territories with data from population-based seroprevalence surveys or antenatal care clinics, we estimated prevalence and incidence using an open-source version of the Estimation and Projection Package—a natural history model originally developed by the UNAIDS Reference Group on Estimates, Modelling, and Projections. For countries with cause-specific vital registration data, we corrected data for garbage coding (ie, deaths coded to an intermediate, immediate, or poorly defined cause) and HIV misclassification. We developed a process of cohort incidence bias adjustment to use information on survival and deaths recorded in vital registration to back-calculate HIV incidence. For countries without any representative data on HIV, we produced incidence estimates by pulling information from observed bias in the geographical region. We used a re-coded version of the Spectrum model (a cohort component model that uses rates of disease progression and HIV mortality on and off ART) to produce age-sex-specific incidence, prevalence, and mortality, and treatment coverage results for all countries, and forecast these measures to 2030 using Spectrum with inputs that were extended on the basis of past trends in treatment scale-up and new infections. Findings Global HIV mortality peaked in 2006 with 1·95 million deaths (95% uncertainty interval 1·87–2·04) and has since decreased to 0·95 million deaths (0·91–1·01) in 2017. New cases of HIV globally peaked in 1999 (3·16 million, 2·79–3·67) and since then have gradually decreased to 1·94 million (1·63–2·29) in 2017. These trends, along with ART scale-up, have globally resulted in increased prevalence, with 36·8 million (34·8–39·2) people living with HIV in 2017. Prevalence of HIV was highest in southern sub-Saharan Africa in 2017, and countries in the region had ART coverage ranging from 65·7% in Lesotho to 85·7% in eSwatini. Our forecasts showed that 54 countries will meet the UNAIDS target of 81% ART coverage by 2020 and 12 countries are on track to meet 90% ART coverage by 2030. Forecasted results estimate that few countries will meet the UNAIDS 2020 and 2030 mortality and incidence targets. Interpretation Despite progress in reducing HIV-related mortality over the past decade, slow decreases in incidence, combined with the current context of stagnated funding for related interventions, mean that many countries are not on track to reach the 2020 and 2030 global targets for reduction in incidence and mortality. With a growing population of people living with HIV, it will continue to be a major threat to public health for years to come. The pace of progress needs to be hastened by continuing to expand access to ART and increasing investments in proven HIV prevention initiatives that can be scaled up to have population-level impact

Assessment of Improved Tef (Eragrostis tef L.) Varieties for Yield and Yield Related Traits at Nono Benja and Cheliya Districts, Oromia, Ethiopia

Tef (Eragrostis tef) is one of the most important and strategic cereal crop grown to drought prone areas of Ethiopia. Genetic variability, genotypic correlations and yield components are prerequisite for selection of crop breeding, cultivation of improved varieties that provides optimum seed yield is one of the major constraints of the crop. The present study was aimed to investigate the adaptive and best performing tef varieties based on their yield and related traits under rain fed conditions at Nono Benja and Celia districts in Ethiopia. The experiment was conducted by using split plot design with three replications, sixteen improved varieties and one local landrace. The combined analysis of variance revealed that varieties were significantly different for studied characters except panicle length, total tiller number and spikelet length. The mean yields of nine improved  varieties (Dukem, Asgori, Tesfa, Negus, Quncho, Kora, Koye, Boset and key tena) were relatively higher than the local check comparing with mean values of grain yield ranged from Welkomi (372.08 kg/ ha) to Dukem (1315.41 kg/ ha).Grain yields were studied high in four varieties across two locations were (Dukem (1315.4 kg/ ha), asgori (1279.6 kg/ ha), Tesfa (1206.02 kg/ ha), Negus (1072.61 kg/ ha) with 72.8%, 68.2%, 58.5 %, and 41% over local check. The genotypic coefficient variation was observed that from 4.6% to 82.9% for loading index and the phenotypic coefficient variation range from 5.8% to 91.0% for loading index at Cheliya, respectively, the fertilizer application (0, 60/40 P/N kgha-1) showed highly differences among all traits except in GFP, PH and TGW traits. The varieties Gibe, Koye, Boset, Gimbichu, Enat and Kora were observed highly strong association with the environment, similarly Asgori and Gedo varieties were showed highly significant and strong connection with the environment Nono Benja with fertilization. Results reveal that the correlation studies provide a better understanding of yield components during the selection of tef genotypes

Assessment of Improved Tef (Eragrostis tef L.) Varieties for Yield and Yield Related Traits at Nono Benja and Cheliya Districts, Oromia, Ethiopia

Tef (Eragrostis tef) is one of the most important and strategic cereal crop grown to drought prone areas of Ethiopia. Genetic variability, genotypic correlations and yield components are prerequisite for selection of crop breeding, cultivation of improved varieties that provides optimum seed yield is one of the major constraints of the crop. The present study was aimed to investigate the adaptive and best performing tef varieties based on their yield and related traits under rain fed conditions at Nono Benja and Celia districts in Ethiopia. The experiment was conducted by using split plot design with three replications, sixteen improved varieties and one local landrace. The combined analysis of variance revealed that varieties were significantly different for studied characters except panicle length, total tiller number and spikelet length. The mean yields of nine improved  varieties (Dukem, Asgori, Tesfa, Negus, Quncho, Kora, Koye, Boset and key tena) were relatively higher than the local check comparing with mean values of grain yield ranged from Welkomi (372.08 kg/ ha) to Dukem (1315.41 kg/ ha).Grain yields were studied high in four varieties across two locations were (Dukem (1315.4 kg/ ha), asgori (1279.6 kg/ ha), Tesfa (1206.02 kg/ ha), Negus (1072.61 kg/ ha) with 72.8%, 68.2%, 58.5 %, and 41% over local check. The genotypic coefficient variation was observed that from 4.6% to 82.9% for loading index and the phenotypic coefficient variation range from 5.8% to 91.0% for loading index at Cheliya, respectively, the fertilizer application (0, 60/40 P/N kgha-1) showed highly differences among all traits except in GFP, PH and TGW traits. The varieties Gibe, Koye, Boset, Gimbichu, Enat and Kora were observed highly strong association with the environment, similarly Asgori and Gedo varieties were showed highly significant and strong connection with the environment Nono Benja with fertilization. Results reveal that the correlation studies provide a better understanding of yield components during the selection of tef genotypes

Increased indoleamine-2,3-dioxygenase activity is associated with poor clinical outcome in adults hospitalized with influenza in the INSIGHT FLU003Plus study

BACKGROUND: Indoleamine-2,3-dioxygenase (IDO) mediated tryptophan (TRP) depletion has antimicrobial and immuno-regulatory effects. Increased kynurenine (KYN)-to-TRP (KT) ratios, reflecting increased IDO activity, have been associated with poorer outcomes from several infections. METHODS: We performed a case-control (1:2; age and sex matched) analysis of adults hospitalized with influenza A(H1N1)pdm09 with protocol-defined disease progression (died/transferred to ICU/mechanical ventilation) after enrollment (cases) or survived without progression (controls) over 60 days of follow-up. Conditional logistic regression was used to analyze the relationship between baseline KT ratio and other metabolites and disease progression. RESULTS: We included 32 cases and 64 controls with a median age of 52 years; 41% were female, and the median durations of influenza symptoms prior to hospitalization were 8 and 6 days for cases and controls, respectively (P = .04). Median baseline KT ratios were 2-fold higher in cases (0.24 mM/M; IQR, 0.13-0.40) than controls (0.12; IQR, 0.09-0.17; P ≤ .001). When divided into tertiles, 59% of cases vs 20% of controls had KT ratios in the highest tertile (0.21-0.84 mM/M). When adjusted for symptom duration, the odds ratio for disease progression for those in the highest vs lowest tertiles of KT ratio was 9.94 (95% CI, 2.25-43.90). CONCLUSIONS: High KT ratio was associated with poor outcome in adults hospitalized with influenza A(H1N1)pdm09. The clinical utility of this biomarker in this setting merits further exploration. CLINICALTRIALSGOV IDENTIFIER: NCT01056185

A comparison of selected parametric and imputation methods for estimating snag density and snag quality attributes

Snags (standing dead trees) are an essential structural component of forests. Because wildlife use of snags depends on size and decay stage, snag density estimation without any information about snag quality attributes is of little value for wildlife management decision makers. Little work has been done to develop models that allow multivariate estimation of snag density by snag quality class. Using climate, topography, Landsat TM data, stand age and forest type collected for 2356 forested Forest Inventory and Analysis plots in western Washington and western Oregon, we evaluated two multivariate techniques for their abilities to estimate density of snags by three decay classes. The density of live trees and snags in three decay classes (D1: recently dead, little decay; D2: decay, without top, some branches and bark missing; D3: extensive decay, missing bark and most branches) with diameter at breast height (DBH) ≥ 12.7 cm was estimated using a nonparametric random forest nearest neighbor imputation technique (RF) and a parametric two-stage model (QPORD), for which the number of trees per hectare was estimated with a Quasipoisson model in the first stage and the probability of belonging to a tree status class (live, D1, D2, D3) was estimated with an ordinal regression model in the second stage. The presence of large snags with DBH ≥ 50 cm was predicted using a logistic regression and RF imputation. Because of the more homogenous conditions on private forest lands, snag density by decay class was predicted with higher accuracies on private forest lands than on public lands, while presence of large snags was more accurately predicted on public lands, owing to the higher prevalence of large snags on public lands. RF outperformed the QPORD model in terms of percent accurate predictions, while QPORD provided smaller root mean square errors in predicting snag density by decay class. The logistic regression model achieved more accurate presence/absence classification of large snags than the RF imputation approach. Adjusting the decision threshold to account for unequal size for presence and absence classes is more straightforward for the logistic regression than for the RF imputation approach. Overall, model accuracies were poor in this study, which can be attributed to the poor predictive quality of the explanatory variables and the large range of forest types and geographic conditions observed in the data.Keywords: Snag size class, Ordinal regression, Snag density, Snag decay class, Nearest neighbor imputatio