SARS-CoV-2 and interferon blockade

© 2020, The Author(s). The response to viral infection generally includes an activation of the adaptive immune response to produce cytotoxic T cells and neutralizing antibodies. We propose that SARS-CoV-2 activates the innate immune system through the renin-angiotensin and kallikrein-bradykinin pathways, blocks interferon production and reduces an effective adaptive immune response. This model has therapeutic implications

Rotation periods of late-type stars in the young open cluster IC 2602

We present the results of a monitoring campaign aimed at deriving rotation periods for a representative sample of stars in the young (30 Myr) open cluster IC 2602. Rotation periods were derived for 29 of 33 stars monitored. The periods derived range from 0.2d (one of the shortest known rotation periods of any single open cluster star) to about 10d (which is almost twice as long as the longest period previously known for a cluster of this age). We are able to confirm 8 previously known periods and derive 21 new ones, delineating the long period end of the distribution. Despite our sensitivity to longer periods, we do not detect any variables with periods longer than about 10d. The combination of these data with those for IC 2391, an almost identical cluster, leads to the following conclusions: 1) The fast rotators in a 30 Myr cluster are distributed across the entire 0.5 < B-V < 1.6 color range. 2) 6 stars in our sample are slow rotators, with periods longer than 6d. 3) The amplitude of variability depends on both the color and the period. The dependence on the latter might be important in understanding the selection effects in the currently available rotation period database and in planning future observations. 4) The interpretation of these data in terms of theoretical models of rotating stars suggests both that disk-interaction is the norm rather than the exception in young stars and that disk-locking times range from zero to a few Myr.Comment: 23 pages, 8 figures, accepted for publication in the Astrophysical Journa

Will the recently approved LARES mission be able to measure the Lense-Thirring effect at 1%?

After the approval by the Italian Space Agency of the LARES satellite, which should be launched at the end of 2009 with a VEGA rocket and whose claimed goal is a about 1% measurement of the general relativistic gravitomagnetic Lense-Thirring effect in the gravitational field of the spinning Earth, it is of the utmost importance to reliably assess the total realistic accuracy that can be reached by such a mission. The observable is a linear combination of the nodes of the existing LAGEOS and LAGEOS II satellites and of LARES able to cancel out the impact of the first two even zonal harmonic coefficients of the multipolar expansion of the classical part of the terrestrial gravitational potential representing a major source of systematic error. While LAGEOS and LAGEOS II fly at altitudes of about 6000 km, LARES will be placed at an altitude of 1450 km. Thus, it will be sensitive to much more even zonals than LAGEOS and LAGEOS II. Their corrupting impact \delta\mu has been evaluated by using the standard Kaula's approach up to degree L=70 along with the sigmas of the covariance matrices of eight different global gravity solutions (EIGEN-GRACE02S, EIGEN-CG03C, GGM02S, GGM03S, JEM01-RL03B, ITG-Grace02s, ITG-Grace03, EGM2008) obtained by five institutions (GFZ, CSR, JPL, IGG, NGA) with different techniques from long data sets of the dedicated GRACE mission. It turns out \delta\mu about 100-1000% of the Lense-Thirring effect. An improvement of 2-3 orders of magnitude in the determination of the high degree even zonals would be required to constrain the bias to about 1-10%.Comment: Latex, 15 pages, 1 table, no figures. Final version matching the published one in General Relativity and Gravitation (GRG

Conservative evaluation of the uncertainty in the LAGEOS-LAGEOS II Lense-Thirring test

We deal with the test of the general relativistic gravitomagnetic Lense-Thirring effect currently ongoing in the Earth's gravitational field with the combined nodes \Omega of the laser-ranged geodetic satellites LAGEOS and LAGEOS II. One of the most important source of systematic uncertainty on the orbits of the LAGEOS satellites, with respect to the Lense-Thirring signature, is the bias due to the even zonal harmonic coefficients J_L of the multipolar expansion of the Earth's geopotential which account for the departures from sphericity of the terrestrial gravitational potential induced by the centrifugal effects of its diurnal rotation. The issue addressed here is: are the so far published evaluations of such a systematic error reliable and realistic? The answer is negative. Indeed, if the difference \Delta J_L among the even zonals estimated in different global solutions (EIGEN-GRACE02S, EIGEN-CG03C, GGM02S, GGM03S, ITG-Grace02, ITG-Grace03s, JEM01-RL03B, EGM2008, AIUB-GRACE01S) is assumed for the uncertainties \delta J_L instead of using their more or less calibrated covariance sigmas \sigma_{J_L}, it turns out that the systematic error \delta\mu in the Lense-Thirring measurement is about 3 to 4 times larger than in the evaluations so far published based on the use of the sigmas of one model at a time separately, amounting up to 37% for the pair EIGEN-GRACE02S/ITG-Grace03s. The comparison among the other recent GRACE-based models yields bias as large as about 25-30%. The major discrepancies still occur for J_4, J_6 and J_8, which are just the zonals the combined LAGEOS/LAGOES II nodes are most sensitive to.Comment: LaTex, 12 pages, 12 tables, no figures, 64 references. To appear in Central European Journal of Physics (CEJP

Major depression, fibromyalgia and labour force participation: A population-based cross-sectional study

BACKGROUND: Previous studies have documented an elevated frequency of depressive symptoms and disorders in fibromyalgia, but have not examined the association between this comorbidity and occupational status. The purpose of this study was to describe these epidemiological associations using a national probability sample. METHODS: Data from iteration 1.1 of the Canadian Community Health Survey (CCHS) were used. The CCHS 1.1 was a large-scale national general health survey. The prevalence of major depression in subjects reporting that they had been diagnosed with fibromyalgia by a health professional was estimated, and then stratified by demographic variables. Logistic regression models predicting labour force participation were also examined. RESULTS: The annual prevalence of major depression was three times higher in subjects with fibromyalgia: 22.2% (95% CI 19.4 – 24.9), than in those without this condition: 7.2% (95% CI 7.0 – 7.4). The association persisted despite stratification for demographic variables. Logistic regression models predicting labour force participation indicated that both conditions had an independent (negative) effect on labour force participation. CONCLUSION: Fibromyalgia and major depression commonly co-occur and may be related to each other at a pathophysiological level. However, each syndrome is independently and negatively associated with labour force participation. A strength of this study is that it was conducted in a large probability sample from the general population. The main limitations are its cross-sectional nature, and its reliance on self-reported diagnoses of fibromyalgia

LARES/WEBER-SAT and the equivalence principle

It has often been claimed that the proposed Earth artificial satellite LARES/WEBER-SAT-whose primary goal is, in fact, the measurement of the general relativistic Lense-Thirring effect at a some percent level-would allow to greatly improve, among (many) other things, the present-day (10^-13) level of accuracy in testing the equivalence principle as well. Recent claims point towards even two orders of magnitude better, i.e. 10^-15. In this note we show that such a goal is, in fact, unattainable by many orders of magnitude being, instead, the achievable level of the order of 10^-9.Comment: LaTex, 4 pages, no figures, no tables, 26 references. Proofs corrections included. To appear in EPL (Europhysics Letters

Near and Mid-IR Photometry of the Pleiades, and a New List of Substellar Candidate Members

We make use of new near and mid-IR photometry of the Pleiades cluster in order to help identify proposed cluster members. We also use the new photometry with previously published photometry to define the single-star main sequence locus at the age of the Pleiades in a variety of color-magnitude planes. The new near and mid-IR photometry extend effectively two magnitudes deeper than the 2MASS All-Sky Point Source catalog, and hence allow us to select a new set of candidate very low mass and sub-stellar mass members of the Pleiades in the central square degree of the cluster. We identify 42 new candidate members fainter than Ks =14 (corresponding to 0.1 Mo). These candidate members should eventually allow a better estimate of the cluster mass function to be made down to of order 0.04 solar masses. We also use new IRAC data, in particular the images obtained at 8 um, in order to comment briefly on interstellar dust in and near the Pleiades. We confirm, as expected, that -- with one exception -- a sample of low mass stars recently identified as having 24 um excesses due to debris disks do not have significant excesses at IRAC wavelengths. However, evidence is also presented that several of the Pleiades high mass stars are found to be impacting with local condensations of the molecular cloud that is passing through the Pleiades at the current epoch.Comment: Accepted to ApJS; data tables and embedded-figure version available at http://spider.ipac.caltech.edu/staff/stauffer/pleiades07

The chromospheric emission of solar-type stars in the young open clusters IC 2391 and IC 2602

In this paper we present chromospheric emission levels of the solar-type stars in the young open clusters IC 2391 and IC 2602. High resolution spectroscopic data were obtained for over 50 F, G, and K stars from these clusters over several observing campaigns using the University College London Echelle Spectrograph on the 3.9-m Anglo-Australian Telescope. Unlike older clusters, the majority (28/52) of the solar-type stars in the two clusters are rapid-rotators (vsini > 20 km/s) with five of the stars being classified as ultra-rapid rotators (vsini > 100 km/s). The emission levels in the Calcium infrared triplet lines were then used as a measure of the chromospheric activity of the stars. When plotted against Rossby number (NR) the star's chromospheric emission levels show a plateau in the emission for Log(NR) < -1.1 indicating chromospheric saturation similar to the coronal saturation seen in previously observed X-ray emission from the same stars. However, unlike the coronal emission, the chromospheric emission of the stars show little evidence of a reduction in emission (i.e. supersaturation) for the ultra-rapid rotators in the clusters. Thus we believe that coronal supersaturation is not the result of an overall decrease in magnetic dynamo efficiency for ultra-rapid rotators.Comment: 19 pages, 14 figures, Landscape tables in separate tex file, Accepted by MNRA

Accretion-related properties of Herbig Ae/Be stars. Comparison with T Tauris

We look for trends relating the mass accretion rate (Macc) and the stellar ages (t), spectral energy distributions (SEDs), and disk masses (Mdisk) for a sample of 38 HAeBe stars, comparing them to analogous correlations found for classical T Tauri stars. Our goal is to shed light on the timescale and physical processes that drive evolution of intermediate-mass pre-main sequence objects. Macc shows a dissipation timescale \tau = 1.3^{+1.0}_{-0.5} Myr from an exponential law fit, while a power law yields Macc(t) \propto t^{-\eta}, with \eta = 1.8^{+1.4}_{-0.7}. This result is based on our whole HAeBe sample (1-6 Msun), but the accretion rate decline most probably depends on smaller stellar mass bins. The near-IR excess is higher and starts at shorter wavelengths (J and H bands) for the strongest accretors. Active and passive disks are roughly divided by 2 x 10^{-7} Msun/yr. The mid-IR excess and the SED shape from the Meeus et al. classification are not correlated with Macc. We find Macc \propto Mdisk^{1.1 +- 0.3}. Most stars in our sample with signs of inner dust dissipation typically show accretion rates ten times lower and disk masses three times smaller than the remaining objects. The trends relating Macc with the near-IR excess and Mdisk extend those for T Tauri stars, and are consistent with viscous disk models. The differences in the inner gas dissipation timescale, and the relative position of the stars with signs of inner dust clearing in the Macc-Mdisk plane, could be suggesting a slightly faster evolution, and that a different process - such as photoevaporation - plays a more relevant role in dissipating disks in the HAeBe regime compared to T Tauri stars. Our conclusions must consider the mismatch between the disk mass estimates from mm fluxes and the disk mass estimates from accretion, which we also find in HAeBe stars.Comment: 11 pages, 7 figures, 1 appendix. Accepted in A&