Estudio geológico - económico de las canteras graníticas del partido de Azul, pcia. de Bs. As.

El presente trabajo se efectuó con el propósito de informar sobre aspectos petrológicos, estructurales, geotécnicos y geológico económicos de las canteras de granito del Partido de Azul, Provincia de Buenos Aires. Este estudio, solicitado por la Municipalidad del Partido de Azul a la Comisión de Investigaciones Científicas de la Provincia de Buenos Aires, fue realizado bajo la dirección del Dr. Isidoro B. Schalamuk, por los Licenciados Miguel A., Del Blanco y Fernando E. Piantanida y el estudiante Claudio Falconaro. Durante su desarrollo se contó con el importante apoyo de: la Dirección de Geología, Minería y Aguas Subterráneas; la Dirección de Vialidad de la Provincia de Buenos Aires; Municipalidad del Partido de Azul y de las Empresas Vicente Robles S.A., Marengo S.A., y Novobra S.R.L., propietarias de las canteras "El Peregrino","Azul" y "Novobra" respectivamente.Digitalizado en SEDICI-CIC Digita

Modeling the unsaturated flow associated with a border irrigation event on an alfalfa plot

HYDRUS-1D, un modelo unidimensional de movimiento de agua y transporte de solutos, se utilizó en el contexto de un evento de riego por fajas en una parcela de alfalfa ubicada en el polígono de riego de "La Violada" (España) a fin de analizar la interacción suelo-planta-agua en la zona no saturada del suelo. El evento de riego se monitoreó para derivar información adecuada para establecer el modelo numérico de la zona de estudio así como para evaluarlo. El protocolo de modelización, de carácter determinista-estocástico, incluyó calibración, evaluación y análisis de sensibilidad. Tanto las predicciones del modelo como los datos de campo revelaron que el contenido de humedad del suelo fue alto durante el período de monitoreo; el modelo inclusive predijo un decrecimiento pequeño de la evapotranspiración inducido por el humedecimiento significativo del suelo, y la contribución importante al balance de agua del ascenso capilar como consecuencia del ascenso del nivel freático causado por el riego previo en la parcela adyacente. Los resultados de la presente modelización sugieren la necesidad de mejorar la definición del modelo numérico de la zona no saturada y de las respectivas condiciones de contorno. Para ello, el estudio reveló la necesidad de (i) generar mejores valores experimentales para algunos de los parámetros más importantes del modelo; y (ii) obtener series temporales más precisas para las condiciones de frontera superiores e inferiores.HYDRUS-1D, a one dimensional water movement and solute transport model, was applied to analyze a border irrigation event in an alfalfa plot located in the irrigation district of "La Violada" (Spain). The research encompassed monitoring of the irrigation event, the setting-up of the numerical model, model calibration and evaluation, and sensitivity analysis of the van Genuchten-Mualem parameters. Both the model predictions and field measurements clearly indicated that the soil water content was high during and following the irrigation event. The model even predicted a small evapotranspiration decrease induced by water logging and a significant contribution of capillary rise subsequently the water table rise in the adjacent plot caused by an irrigation event prior to the monitored event in the study plot. The research revealed the need for (i) the improvement of the schematization of the soil profile and the better experimental definition of key model parameters; and (ii) the derivation of more accurate data series for respectively the upper and lower boundary conditions.HYDRUS-1Driego por fajassimulaciones Monte Carlozona vadosaBorder irrigationMonte Carlo simulationsvadose zonePublishe

Characterization of endosperm proteins and bread-making quality in wheat breeding lines carrying resistance genes for Mayetiola destructor and/or Heterodera avenae.

The experimental material included thirteen bread wheat-breeding lines that carry genes for resistance to M. destruc¬tor and/or H. avenae. The sources of these resistances are the wild species Ae. triuncialis and Ae. ventricosa (lines TR and H-93, respectively) (Delibes et al. 1993, 1997; Romero et al. 1998). We have determined the composition in HMW-glutenin subunits (related with bread-making quality), puroindoline proteins (related with hardness of grain), and waxy proteins (related with starch viscosity). In addition to, of prolamins by electrophoresis SDS-PAGE indicated the homogeneity of the lines

PTGER4 gene variant rs76523431 is a candidate risk factor for radiological joint damage in rheumatoid arthritis patients: a genetic study of six cohorts

[Introduction] Prostaglandin E receptor 4 (PTGER4) is implicated in immune regulation and bone metabolism. The aim of this study was to analyze its role in radiological joint damage in rheumatoid arthritis (RA).[Methods] Six independent cohorts of patients with RA of European or North American descent were included, comprising 1789 patients with 5083 sets of X-rays. The Hospital Clínico San Carlos Rheumatoid Arthritis, Princesa Early Arthritis Register Longitudinal study, and Hospital Universitario de La Paz early arthritis (Spain) cohorts were used as discovery cohorts, and the Leiden Early Arthritis Clinic (The Netherlands), Wichita (United States), and National Databank for Rheumatic Diseases (United States and Canada) cohorts as replication cohorts. First, the PTGER4 rs6896969 single-nucleotide polymorphism (SNP) was genotyped using TaqMan assays and available Illumina Immunochip data and studied in the discovery and replication cohorts. Second, the PTGER4 gene and adjacent regions were analyzed using Immunochip genotyping data in the discovery cohorts. On the basis of pooled p values, linkage disequilibrium structure of the region, and location in regions with transcriptional properties, SNPs were selected for replication. The results from discovery, replication, and overall cohorts were pooled using inverse-variance–weighted meta-analysis. Influence of the polymorphisms on the overall radiological damage (constant effect) and on damage progression over time (time-varying effect) was analyzed.[Results] The rs6896969 polymorphism showed a significant association with radiological damage in the constant effect pooled analysis of the discovery cohorts, although no significant association was observed in the replication cohorts or the overall pooled analysis. Regarding the analysis of the PTGER4 region, 976 variants were analyzed in the discovery cohorts. From the constant and time-varying effect analyses, 12 and 20 SNPs, respectively, were selected for replication. Only the rs76523431 variant showed a significant association with radiographic progression in the time-varying effect pooled analysis of the discovery, replication, and overall cohorts. The overall pooled effect size was 1.10 (95 % confidence interval 1.05–1.14, p = 2.10 × 10−5), meaning that radiographic yearly progression was 10 % greater for each copy of the minor allele.[Conclusions] The PTGER4 gene is a candidate risk factor for radiological progression in RA.This work was supported by the Instituto de Salud Carlos III (ISCIII), Ministry of Health, Spain [Miguel Servet research contract CP12/03129 (to LRR); Fondo de Investigaciones Sanitarias PI11/02413; and Red de Investigación en Inflamación y Enfermedades Reumáticas RD12/0009/0004, RD12/0009/0011, and RD12/0009/0017]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewe

Doc management: Proposal for a doctoral management system

Control is an essential function for good management, for which a bureaucratic organization, that is, a system of rules, regularized procedures, division of responsibilities, and hierarchy, contributes. This paper addresses the issues related to a problem encountered in the management of doctorate students. Traditionally manual, this process is no longer efficient. This brings problems such as difficulty in searching a student’s file and its information, difficulty in noticing if a student is undocumented, or in figuring out what tasks must be completed and turned in and what dates to do so. The current system is prone to delays, errors and requires unnecessary effort. The goal of this work was to develop a proposal to solve the problems described, by means of an application, with a simple interface, that can manage, create and edit students, their information, their grades and their deliveries, manage, create and edit curricular units and the related information, manage create and edit academic teachers and their functions. In other words, it is intended that the application is able to facilitate the management of all course processes and document a student's academic path. This will provide workers with a better quality of life, reducing the probability of error and generating gains in quality and efficiency in the management of student processes, thus improving the professional life of those who use the application.info:eu-repo/semantics/acceptedVersio

Instituto de Recursos Minerales (INREMI)

Exposición realizada en el marco del  Encuentro del Ministerio de la Producción, Ciencia y Tecnología de la Provincia de Buenos Aires con autoridades y centros de la Comisión de Investigaciones Científicas de la Provincia de Buenos Aires. Exposiciones de los directores de los Centros de Investigación propios, asociados y vinculados

Six-year follow-up of slaughterhouse surveillance (2008-2013): the Catalan Slaughterhouse Support Network (SESC)

Meat inspection has the ultimate objective of declaring the meat and offal obtained from carcasses of slaughtered animals fit or unfit for human consumption. This safeguards the health of consumers by ensuring that the food coming from these establishments poses no risk to public health. Concomitantly, it contributes to animal disease surveillance. The Catalan Public Health Protection Agency (Generalitat de Catalunya) identified the need to provide its meat inspectors with a support structure to improve diagnostic capacity: the Slaughterhouse Support Network (SESC). The main goal of the SESC was to offer continuing education to meat inspectors to improve the diagnostic capacity for lesions observed in slaughterhouses. With this aim, a web-based application was designed that allowed meat inspectors to submit their inquiries, images of the lesions, and samples for laboratory analysis. This commentary reviews the cases from the first 6 years of SESC operation (2008–2013). The program not only provides continuing education to inspectors but also contributes to the collection of useful information on animal health and welfare. Therefore, SESC complements animal disease surveillance programs, such as those for tuberculosis, bovine cysticercosis, and porcine trichinellosis, and is a powerful tool for early detection of emerging animal diseases and zoonoses

A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides

Introduction. Rheumatoid arthritis (RA) patients can be classified based on presence or absence of anticitrullinated peptide antibodies (ACPA) in their serum. This heterogeneity among patients may reflect important biological differences underlying the disease process. To date, the majority of genetic studies have focused on the ACPA-positive group. Therefore, our goal was to analyse the genetic risk factors that contribute to ACPA-negative RA. Methods. We performed a large-scale genome-wide association study (GWAS) in three Caucasian European cohorts comprising 1148 ACPA-negative RA patients and 6008 controls. All patients were screened using the Illumina Human Cyto-12 chip, and controls were genotyped using different genome-wide platforms. Population-independent analyses were carried out by means of logistic regression. Meta-analysis with previously published data was performed as follow-up for selected signals (reaching a total of 1922 ACPA-negative RA patients and 7087 controls). Imputation of classical HLA alleles, aminoacid residues and single nucleotide polymorphisms was undertaken. Results. The combined analysis of the studied cohorts resulted in identification of a peak of association in the HLA-region and several suggestive non-HLA associations. Meta-analysis with previous reports confirmed the association of the HLA region with this subset and an observed association in the CLYBL locus remained suggestive. The imputation and deep interrogation of the HLA region led to identification of a two aminoacid model (HLA-B at position 9 and HLA-DRB1 at position 11) that accounted for the observed genome-wide associations in this region. Conclusions. Our study shed light on the influence of the HLA region in ACPA-negative RA and identified a suggestive risk locus for this condition

Characterisation of bioenergetic pathways and related regulators by multiple assays in human tumour cells

Background: Alterations in cellular metabolism are considered as hallmarks of cancers, however, to recognize these alterations and understand their mechanisms appropriate techniques are required. Our hypothesis was to determine whether dominant bioenergetic mechanism may be estimated by comparing the substrate utilisation with different methods to detect the labelled carbon incorporation and their application in tumour cells. Methods: To define the bioenergetic pathways different metabolic tests were applied: (a) measuring CO2 production from [1-14C]-glucose and [1-14C]-acetate; (b) studying the effect of glucose and acetate on adenylate energy charge; (c) analysing glycolytic and TCA cycle metabolites and the number of incorporated 13C atoms after [U-13C]-glucose/[2-13C]-acetate labelling. Based on [1-14C]-substrate oxidation two selected cell lines out of seven were analysed in details, in which the highest difference was detected at their substrate utilization. To elucidate the relevance of metabolic characterisation the expression of certain regulatory factors, bioenergetic enzymes, mammalian target of rapamycin (mTOR) complexes (C1/C2) and related targets as important elements at the crossroad of cellular signalling network were also investigated. Results: Both [U-13C]-glucose and [1-14C]-substrate labelling indicated high glycolytic capacity of tumour cells. However, the ratio of certain 13C-labelled metabolites showed detailed metabolic differences in the two selected cell lines in further characterisation. The detected differences of GAPDH, β-F1-ATP-ase expression and adenylate energy charge in HT-1080 and ZR-75.1 tumour cells also confirmed the altered metabolism. Moreover, the highly limited labelling of citrate by [2-13C]-acetate-representing a novel functional test in malignant cells-confirmed the defect of TCA cycle of HT-1080 in contrast to ZR-75.1 cells. Noteworthy, the impaired TCA cycle in HT-1080 cells were associated with high mTORC1 activity, negligible protein level and activity of mTORC2, high expression of interleukin-1β, interleukin-6 and heme oxygenase-1 which may contribute to the compensatory mechanism of TCA deficiency. Conclusions: The applied methods of energy substrate utilisation and other measurements represent simple assay system using 13C-acetate and glucose to recognize dominant bioenergetic pathways in tumour cells. These may offer a possibility to characterise metabolic subtypes of human tumours and provide guidelines to find biomarkers for prediction and development of new metabolism related targets in personalized therapy. © 2016 Jeney et al

Simulating the midlatitude atmospheric circulation: what might we gain from high-resolution modeling of air-sea interactions?

Purpose of Review. To provide a snapshot of the current research on the oceanic forcing of the atmospheric circulation in midlatitudes and a concise update on previous review papers. Recent findings. Atmospheric models used for seasonal and longer timescales predictions are starting to resolve motions so far only studied in conjunction with weather forecasts. These phenomena have horizontal scales of ~ 10–100 km which coincide with energetic scales in the ocean circulation. Evidence has been presented that, as a result of this matching of scale, oceanic forcing of the atmosphere was enhanced in models with 10–100 km grid size, especially at upper tropospheric levels. The robustness of these results and their underlying mechanisms are however unclear. Summary. Despite indications that higher resolution atmospheric models respond more strongly to sea surface temperature anomalies, their responses are still generally weaker than those estimated empirically from observations. Coarse atmospheric models (grid size greater than 100 km) will miss important signals arising from future changes in ocean circulation unless new parameterizations are developed